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El. knyga: Nanotechnology in Drug Delivery: Fundamentals, Design, and Applications [Taylor & Francis e-book]

Saurabh Bhatia (School of Medical and Allied Sciences, GD Goenka University, Gurgaon, Haryana, India)

Formatas: 390 pages, 7 Illustrations, color; 21 Illustrations, black and white
Išleidimo metai: 08-Jul-2016
Leidėjas: Apple Academic Press Inc.
ISBN-13: 9781315366296

Kitos knygos pagal šią temą:

Taylor & Francis e-book
Kaina: 156,95 €*
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Standartinė kaina: 224,21 €
Sutaupote 30%

Formatas: 390 pages, 7 Illustrations, color; 21 Illustrations, black and white
Išleidimo metai: 08-Jul-2016
Leidėjas: Apple Academic Press Inc.
ISBN-13: 9781315366296

Kitos knygos pagal šią temą:

More info about Taylor & Francis e-books

Partnerių interneto svetainė: https://www.taylorfrancis.com/books/9781315366296

This important new book provides the fundamental understanding of the peptide and protein drug delivery systems with a special focus on their nanotechnology applications. Addressing an increasing interest in peptide and protein drug delivery systems in both academic and industrial circles worldwide, this book fills the need for a comprehensive review and assessment of conventional and nonconventional routes of administration.

Abstract

(1)

1.1 Introduction

(2)

1.2 Structures of Proteins

(3)

1.2.1 Levels of Protein Structure

(1)

1.3 Chemical Synthesis of Protein and Peptides

(10)

1.3.1 Peptide Synthesis

(5)

1.3.1.1 Solid Phase Peptide Synthesis

(1)

1.3.2 Protein Synthesis by Peptide Ligation

(1)

1.3.3 Peptide Ligation with Sulfur

(1)

1.3.3.1 Prior Thiol Capture

(1)

1.3.4 Peptide Ligation with Selenium

(1)

1.3.5 General Strategies for Peptide Ligation

(1)

1.4 Instability Problems Associated with Proteins and Peptides

(33)

1.4.1 Molecular Stability (Bio) Thermodynamics

(2)

1.4.2 Thermodynamic Stability

(1)

1.4.3 Kinetic Stability

(1)

1.4.4 Structural and Functional Stabilization of Monomeric and Multimeric Entities

(21)

1.4.1.1 Stabilization of Protein Entities via Engineering at the Level of the Microenvironment

(10)

1.4.1.1.1 Stabilization via Physical Containment

(2)

1.4.1.1.2 Stabilization via Physical Adsorption onto Macroscopic Supports

(1)

1.4.1.1.3 Stabilization via Chemical Bonding onto Highly Activated Supports

(1)

1.4.1.1.4 Multipoint Covalent Immobilization

(2)

1.4.1.1.5 Co-Immobilization with Polycationic Moieties

(1)

1.4.1.1.6 Further Inter-Subunit Crosslinking with Polyfunctional Hydrophilic Macromolecules

(2)

1.4.1.2 Stabilization of Protein Entities via Engineering at the Level of the Macroenvironment

(9)

1.4.1.2.1 Medium Engineering

(8)

1.5 General Stability Issues

(6)

1.5.1 Physical Instability

(3)

1.5.1.1 Denaturation

(1)

1.5.1.2 Adsorption

(1)

1.5.1.3 Aggregation and Precipitation

(1)

1.5.2 Chemical Instability

(4)

1.5.2.1 Deamidation

(1)

1.5.2.2 Oxidation and Reduction

(1)

1.5.2.3 Proteolysis

(1)

1.5.2.4 Disulfide Exchange

(1)

1.5.2.5 Racemization

(1)

1.5.2.6 β-Elimination

(1)

1.6 Factors Affecting Delivery of Protein-Based Drugs

(1)

1.7 Physicochemical Properties of Peptides and Proteins

(1)

1.7.1 Solubility and Partition Coefficient

(1)

1.7.2 Aggregation, Self Association and Hydrogen Bonding

(1)

1.8 Barrier to Peptide and Protein Delivery

(11)

1.8.1 Enzymatic Barrier

(1)

1.8.2 Intestinal Epithelial Barrier

(4)

1.8.2.1 Passive and Carrier Mediated Transport

(1)

1.8.2.2 Endocytosis and Transcytosis

(3)

1.8.2.2.1 Fluid-Phase Type (Non Specific Endocytosis, Pinocytosis)

(1)

1.8.2.2.2 Adsorptive or Receptor-Mediated Type (Specific Endocytosis)

(1)

1.8.2.2.3 Transcytosis

(2)

1.8.2.3 Paracellular Movement

(1)

1.8.3 Capillary Endothelial Barrier

(3)

1.8.3.1 Mechanisms of Solute Transit

(6)

1.8.3.1.1 Passive, Non-Facilitated

(1)

1.8.3.1.2 Carrier-Mediated

(1)

1.8.3.1.3 Receptor-Mediated

(1)

1.8.3 Blood Brain Barrier (BBB)

(4)

1.9 Delivery of Protein and Peptide Drugs

(86)

1.9.1 Parenteral Systemic Delivery

(18)

1.9.1.1 Biomedical Applications

(2)

1.9.1.2 Parenteral Drug Delivery Systems

(14)

1.9.1.2.1 Particulates

(7)

1.9.1.2.2 Soluble Carriers (Macromolecules)

(2)

1.9.1.2.3 Others

(5)

1.9.1.3 Pharmaceutical Approaches Related to Systemic Delivery of Protein and Peptide Drugs

(2)

1.9.2 Non-Parenteral Systemic Delivery

(56)

1.9.2.1 Oral Route [ 160]

(33)

1.9.2.1.1 Strategies for Oral Delivery

(1)

1.9.2.1.2 Nobex Technology

(1)

1.9.2.1.3 Oral Delivery of Insulin

(1)

1.9.2.1.4 Potential Problem Associated with Oral Protein Delivery

(1)

1.9.2.1.5 Prodrug Approach

(1)

1.9.2.1.6 Modifications by Chemical Synthesis of Prodrugs and Analogs

(4)

1.9.2.1.7 Site-Specific Delivery

103

(4)

1.9.2.1.8 Use of Enzyme Inhibitors

107

(1)

1.9.2.1.9 Use of Absorption Enhancers

108

(4)

1.9.2.1.10 Formulation Vehicles

112

(3)

1.9.2.1.11 Dosage Form Modifications

115

(6)

1.9.2.1.12 Drug Delivery via the Mucous Membranes of the Oral Cavity

121

(2)

1.9.2.1.13 Emerging Trends in Oral Delivery of Peptide and Protein Drugs

123

(1)

1.9.2.1.14 Oral Delivery of Peptide Drugs: Barriers and Developments

123

(1)

1.9.2.1.15 Protein Drug Oral Delivery: The Recent Progress

124

(1)

1.9.2.2 Nasal Route [ 161]

125

(6)

1.9.2.2.1 Nasal Delivery of Proteins

127

(1)

1.9.2.2.2 Advantages of Nasal Route

128

(1)

1.9.2.2.3 Mechanism to Facilitate Nasal Peptide and Protein Absorption

128

(3)

1.9.2.3 Buccal Route

131

(4)

1.9.2.3.1 Various Adhesive Dosage Forms

133

(1)

1.9.2.3.2 Factors and Strategies for Improving Buccal Absorption of Peptides

134

(1)

1.9.2.4 Ocular Route

135

(1)

1.9.2.5 Rectal Route

136

(1)

1.9.2.6 Adjuvants to Enhance the Absorption

137

(2)

1.9.2.7 Importance of Lymphatic Uptake

139

(1)

1.9.2.8 Transdermal Route

140

(5)

1.9.2.8.1 Approaches for Transdermal Delivery

142

(3)

1.9.2.9 Pulmonary Route

145

(3)

1.9.3 Paracellular Delivery of Peptides

148

(1)

1.9.4 Lymphatic Transportation of Proteins

149

(3)

1.9.4.1 Colorectal Transport

152

(1)

1.9.4.2 Pulmonary Transport

152

(1)

1.9.5 Site-Specific Protein Modification (Protein Engineering)

152

(4)

1.9.5.1 Enzyme-Peg Conjugates

153

(1)

1.9.5.2 Protein Glycosylation

154

(1)

1.9.5.2.1 Expression Cell Processing

155

(1)

1.9.5.3 Modification of Proteases into Peptide Ligases

155

(1)

1.9.5.4 Production of Site Specific Nucleases

155

(1)

1.9.5.5 Production of Artificial Semisynthetic Oxidoreductase (Flavo-Enzymes)

156

(1)

1.9.7 Microencapsulation Of Protein Drugs For Drug Delivery: Strategy, Preparation, and Applications

156

(4)

1.10 Toxicity Profile Characterization

160

(2)

1.10.1 Classes of Toxicity of Proteins and Peptides SU

160

(9)

1.10.1.1 Exuberant Pharmacologic Responses BOH

160

(1)

1.10.1.2 Generic Toxicity

160

(2)

1.10.1.3 Idiopathic Toxicity

162

(1)

1.11 Pegylation and its Delivery Aspects

162

(1)

1.12 Novel Delivery Technologies

162

(1)

1.13 Recent Progress in Delivery of Protein and Peptide by Noninvasive Routes

163

(1)

1.14 Commercial Challenges of Protein Drug Delivery

164

(1)

1.15 Alternative Delivery Systems for Peptides and Proteins as Drugs

164

(1)

1.16 Polymeric Delivery of Proteins and Plasmid DNA for Tissue Engineering and Gene Therapy

165

(1)

1.17 Smart Polymer for Proteins and Peptides [ 186]

165

(1)

1.18 Hybrid Protein Delivery Systems [ 187]

166

(1)

1.19 Ligated Gene Fusion Hybrid Delivery Systems

166

(1)

1.20 Synthetically Linked Hybrid Conjugates

166

(1)

1.21 Peptide Targeting

166

(3)

1.22 Development of Delivery System for Peptide-Based Pharmaceuticals

169

(3)

1.22.1 Formulation Consideration

169

(1)

1.22.2 Pharmacokinetic Considerations

170

(1)

1.22.3 Analytical Consideration

170

(1)

1.22.4 Regulatory Consideration

170

(2)

1.23 Non-Covalent Peptide-Based Approach the Delivery of Proteins and Nucleic Acids

172

(2)

1.24 Protein Transduction Technology

174

(2)

1.25 Peptide and Protein Drugs: Delivery Problems

176

(1)

1.26 Intracellular Targets and Intracellular Drug Delivery

177

(2)

1.27 Homing Peptides as Targeted Delivery Vehicles

179

(2)

1.28 Drug Delivery of Oligonucleotides By Peptides

181

(1)

1.29 Nanotherapeutics for Nanobioconjugation of Peptide and Protein

182

(8)

1.29.1 Methodology of Peptide and Protein Nanoencapsulation

184

(3)

1.29.1.1 Emulsification—Polymerization

184

(1)

1.29.1.2 Interfacial Polymerization

185

(1)

1.29.1.3 Solvent Evaporation

185

(1)

1.29.1.4 Salting Out

186

(1)

1.29.1.5 Coacervation

186

(1)

1.29.2 Polymeric Nanocarriers

187

(3)

1.29.2.1 Natural Nanocarriers

187

(2)

1.29.2.2 Synthetic Nanocarriers

189

(1)

1.30 Therapeutic Use of Peptide and Proteins

190

(1)

Keywords

191

(1)

References

192

Bhatia, Saurabh||

Pastovi nuoroda: https://www.kriso.lt/db/9781315366296_pe.html

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El. knyga: Nanotechnology in Drug Delivery: Fundamentals, Design, and Applications [Taylor & Francis e-book]

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