Atnaujinkite slapukų nuostatas

El. knyga: Nanotechnology Methods for Neurological Diseases and Brain Tumors: Drug Delivery across the Blood-Brain Barrier

Edited by (Koē University, Istanbul, Turkey), Edited by (Ko University, Istanbul, Turkey), Edited by (Hacettepe University, Ankara, Turkey)
  • Formatas: PDF+DRM
  • Išleidimo metai: 14-Jul-2017
  • Leidėjas: Academic Press Inc
  • Kalba: eng
  • ISBN-13: 9780128038000
  • Formatas: PDF+DRM
  • Išleidimo metai: 14-Jul-2017
  • Leidėjas: Academic Press Inc
  • Kalba: eng
  • ISBN-13: 9780128038000

DRM apribojimai

  • Kopijuoti:

    neleidžiama

  • Spausdinti:

    neleidžiama

  • El. knygos naudojimas:

    Skaitmeninių teisių valdymas (DRM)
    Leidykla pateikė šią knygą šifruota forma, o tai reiškia, kad norint ją atrakinti ir perskaityti reikia įdiegti nemokamą programinę įrangą. Norint skaityti šią el. knygą, turite susikurti Adobe ID . Daugiau informacijos  čia. El. knygą galima atsisiųsti į 6 įrenginius (vienas vartotojas su tuo pačiu Adobe ID).

    Reikalinga programinė įranga
    Norint skaityti šią el. knygą mobiliajame įrenginyje (telefone ar planšetiniame kompiuteryje), turite įdiegti šią nemokamą programėlę: PocketBook Reader (iOS / Android)

    Norint skaityti šią el. knygą asmeniniame arba „Mac“ kompiuteryje, Jums reikalinga  Adobe Digital Editions “ (tai nemokama programa, specialiai sukurta el. knygoms. Tai nėra tas pats, kas „Adobe Reader“, kurią tikriausiai jau turite savo kompiuteryje.)

    Negalite skaityti šios el. knygos naudodami „Amazon Kindle“.

Nanotechnology Methods for Neurological Diseases and Brain Tumors: Drug Delivery across the Blood-Brain Barrier compiles the latest (and future potential) treatment strategies for brain tumors and neurological diseases, in particular Alzheimer’s, Parkinson’s and stroke, those that bypass the blood/brain barrier.

The current understanding of brain drug delivery and access is discussed in Chapter One, with the next section focusing on the implementation of the nose-to-brain intranasal route in brain-targeted drug delivery.

In addition, nanotechnology-based brain drug delivery is covered in Chapter Three. This avenue offers impressive improvement in the treatment of neurological diseases and brain tumors by using bio-engineered systems that interact with biological systems at a molecular level. In Chapter Four, emphasis is placed on the need for brain-targeted experimental models that mimic disease conditions. Final chapters discuss the very latest advances in targeted treatment strategies for neurological diseases and brain tumors.

  • Comprehensive guide for up-to-date views on the latest advances in targeted treatment strategies for brain tumors and neurological diseases
  • Designed with a multidisciplinary approach that links neurology, neuro-oncology and nanoscience to drug delivery to the brain with an emphasis on the blood-brain-barrier
  • Written in a language that makes it easy to understand nanotechnology drug delivery techniques
  • Presents a unique book that also covers advanced treatment approaches of neurological diseases and brain tumors

Daugiau informacijos

Comprehensive guide to nanotechnology drug delivery techniques that bypass the blood-brain barrier to treat neurological diseases and brain tumors
List of Contributors
xi
About the Editors xiii
Preface xv
Part 1 The Rationale to Reach the Brain
Chapter 1 Anatomy and Physiology of the Blood--Brain Barrier
3(12)
Yasemin Gursoy-Ozdemir
Yagmur Cetin Tas
1 Introduction
3(1)
2 Structure of the BBB
4(2)
3 BBB Developmental Steps
6(1)
4 Transport Across the BBB
7(4)
5 Conclusions
11(4)
Abbreviations
11(1)
References
11(4)
Chapter 2 Blood--Brain Barrier: Genomics, Proteomics, Disease Targets, and Drug Delivery
15(20)
Ozgun F. Duzenli
Ayse Filiz Oner
1 Introduction
15(1)
2 Blood--Brain Barrier Genomics
16(3)
3 Blood--Brain Barrier Proteomics
19(1)
4 Disease Targets
20(1)
5 Drug Delivery
21(5)
6 Conclusions
26(9)
Abbreviations
26(1)
References
27(8)
Chapter 3 Brain and the Drug Transporters
35(34)
Tugba Gulsun
Nihan Izat
Selma Sahin
1 Introduction
35(1)
2 Brain Transporters
36(14)
3 Conclusions
50(19)
Abbreviations
51(1)
References
51(18)
Chapter 4 Drug Delivery to the Brain: Pharmacokinetic Concepts
69(24)
Tugba Copur
Levent Oner
1 Introduction
69(1)
2 CNS Drug Delivery
70(7)
3 Intrabrain Distribution
77(2)
4 Conclusions
79(14)
Abbreviations
79(2)
References
81(12)
Part 2 Nose-to-Brain Drug Delivery
Chapter 5 Nasal Physiology and Drug Transport
93(10)
Emine Sekerdag
1 Introduction
93(1)
2 Anatomy of the Nose
94(2)
3 Nasal Transport Mechanisms
96(2)
4 Factors Affecting Nose-to-Brain Transport
98(1)
5 Principles of Drug Administration
99(1)
6 Conclusions
99(4)
Abbreviations
100(1)
References
100(3)
Chapter 6 Challenges of the Nose-to-Brain Route
103(14)
Emine Sekerdag
1 Introduction
103(1)
2 Nose-to-Brain Research
104(1)
3 Overcoming Barriers in Nasal Drug Delivery
105(2)
4 In Vitro and In Vivo Models for Nasal Drug Delivery
107(1)
5 Conclusions
108(9)
Abbreviations
109(1)
References
109(8)
Part 3 Nanoscience in Targeted Brain Drug Delivery
Chapter 7 Nanoscience in Targeted Brain Drug Delivery
117(34)
Meltem Cetin
Eren Aytekin
Burcin Yavuz
Sibel Bozdag-Pehlivan
1 Importance and Application of Nanotechnology-Based Brain Drug Delivery Systems
117(16)
2 Neurotoxicity
133(2)
3 Clinical Considerations
135(1)
4 Ethical and Regulatory Issues
136(1)
5 Conclusions
137(14)
Abbreviations
137(1)
References
138(13)
Part 4 Brain-Targeted Experimental Models
Chapter 8 In Vitro CNS Models
151(36)
Asli Kara
Naile Ozturk
Imran Vural
1 Introduction
151(1)
2 Cellular Structure of the BBB
152(2)
3 Tight Junctions and In Vitro Paracellular Barrier Characterization
154(3)
4 Cell Culture Models
157(12)
5 Comparison of In Vitro Cell Culture Models
169(1)
6 Conclusions and Future Outlook
169(18)
Abbreviations
172(1)
References
173(14)
Chapter 9 In Vivo/In Situ Animal Models
187(10)
Muhammed Abdur Rauf
1 Introduction
187(1)
2 Animal Models of Alzheimer's Disease
188(1)
3 Animal Models of Parkinson's Disease
189(1)
4 Animal Models of Huntington's Disease
189(1)
5 Animal Models of Depression
189(1)
6 Animal Models of Anxiety
190(1)
7 Animal Models of Schizophrenia
190(1)
8 Animal Models of Pain
191(1)
9 Animal Models of Stroke
192(1)
10 Animal Models of Brain Tumor
192(1)
11 Conclusions
193(4)
Abbreviations
193(1)
References
194(3)
Chapter 10 Microdialysis and Brain Perfusion
197(12)
Margareta Hammarlund-Udenaes
1 Introduction
197(2)
2 Techniques in Relation to Measured Entities
199(1)
3 Microdialysis
199(4)
4 Open Flow Microperfusion
203(1)
5 In Situ Brain Perfusion
204(1)
6 Discussion
204(5)
Abbreviations
205(1)
References
206(3)
Chapter 11 Neuroimaging: Techniques and General Applications
209(18)
Elif Bulut
Ayca Akgoz
Kader Karli Oguz
1 Introduction
209(1)
2 Ultrasonography
209(2)
3 Computed Tomography
211(3)
4 Magnetic Resonance Imaging
214(6)
5 Positron Emission Tomography
220(1)
6 Conclusions
221(6)
Abbreviations
221(1)
References
222(5)
Part 5 Targeted Treatment Strategies for Neurological Diseases
Chapter 12 Alzheimer
227(14)
Qizhi Zhang
Chi Zhang
1 Introduction
227(1)
2 Strategies for Brain Drug Delivery in AD Treatment
228(7)
3 Future Perspectives
235(6)
Abbreviations
235(2)
References
237(4)
Chapter 13 Parkinson's Disease
241(30)
Banu Cahide Tel
Gul Yalcin Cakmakli
1 Introduction
241(1)
2 Clinical Features
242(1)
3 Etiology and Pathogenesis
243(4)
4 Neuroanatomy of the Basal Ganglia
247(4)
5 Treatment of Parkinson's Disease
251(4)
6 Targeted Treatment Strategies for Parkinson's Disease
255(1)
7 Conclusions
256(15)
Abbreviations
257(1)
References
257(14)
Chapter 14 Stroke
271(8)
Ozgur Oztop-Cakmak
Ebru N. Vanli-Yavuz
Yasemin Gursoy-Ozdemir
1 Introduction
271(1)
2 Current Treatment Strategies
271(1)
3 Saving Penumbral Tissue
272(1)
4 Neuroprotective Strategies
273(3)
5 Imaging Techniques
276(1)
6 Conclusions
276(3)
Abbreviations
277(1)
References
277(2)
Chapter 15 Nanotechnology-Based Management of Neurological Autoimmune Diseases
279(12)
Erdem Tuzun
1 General Concepts
279(1)
2 A Useful Model for Nanoparticle Experiments on CNS Autoimmunity
280(1)
3 Imaging of Inflammatory Nervous System Disorders by Nanoparticles
280(2)
4 Nanotechnology in the Treatment of Autoimmune Neurological Disorders
282(1)
5 Administration of Antiinflammatory Agents
282(1)
6 Tolerance Induction
283(1)
7 Neuroprotection
284(1)
8 Nanotechnology in Nonautoimmune Neuroinflammation
284(1)
9 Neuroinflammatory Adverse Effects of Nanoparticles
285(1)
10 Concluding Remarks
286(5)
Abbreviations
286(1)
References
287(4)
Chapter 16 Infectious Diseases of the Brain
291(28)
Melike Ekizoglu
1 Introduction
291(1)
2 Brain Infections
291(10)
3 Consideration of the Treatment of Brain Infections
301(2)
4 Nanotechnological Approach and Recent Trends in Brain Infection Treatments
303(5)
5 Conclusions
308(11)
Abbreviations
308(1)
References
309(10)
Part 6 Brain Tumors
Chapter 17 Brain Tumors
319(26)
Sibel Bozdag-Pehlivan
1 Introduction
319(1)
2 Types of Brain Tumors
320(3)
3 Conventional Treatment Approaches
323(1)
4 Blood--Brain Tumor Barrier
324(2)
5 Overcoming the BBB
326(3)
6 Nanotechnology-Based Drug Delivery Systems
329(4)
7 Dual Therapies and Clinical Studies
333(5)
8 Conclusions
338(7)
Abbreviations
338(1)
References
339(6)
Future Outlook 345(2)
Index 347
Yasemin Gürsoy Özdemir (M.D., Ph.D.) is a Professor of Neurology and Neuroscience at Koē University, School of Medicine in Istanbul, Turkey. Dr. Gürsoy Özdemirs main research interests are basic pathophysiological aspects of neurological diseases, especially migraine, headache, stroke, neurodegenerative diseases and their translation to clinical neurology. She conducted several experimental studies about blood brain barrier changes during neurological diseases and targeted drug delivery strategies. She is the author of several research articles published in peer-reviewed indexed journals. She did her post-doctoral studies at Mass General Hospital, Harvard University, Boston. She was associate director of Hacettepe University Institute of Neurological Sciences and Psychiatry between 2011-2014. She gave numerous lectures at both Faculty of Medicine during Neurology board and Institute of Neurological Sciences and Psychiatry at PhD programs. She received several awards such as Research Encouragement Award of Brain Research Organization, Young Researcher Awards of Hacettepe University, Turkish Academy of Sciences and Young Investigator Award from The Scientific and Technological Council of Turkey (TUBITAK). Dr. Bozda Pehlivan is an Associate Professor at Hacettepe University, Faculty of Pharmacy Pharmaceutical Technology Department in Ankara, Turkey. Her research interests are design and in vitro/in vivo evaluation of nanotechnology-based drug delivery systems, targeted drug delivery for brain tumors, and ocular drug delivery. She is author of several research articles published in peer-reviewed indexed journals on the topic. She is a member of American Association of Pharmaceutical Scientists. She received several awards such as the Hacettepe University Research Group Award and Awards in the Hacettepe Technopolis Innovation Competition: Health Sciences and Technologies category (2008 and 2009). Emine Sekerdag (MSc.), earned both her Bachelor of Science degree and Master of Science degree of Bio-Pharmaceutical Sciences at Leiden University in The Netherlands. She performed the first part of her Master study at the Drug Delivery Technology department of the Leiden Academic Center for Drug Research (LACDR) at Leiden University, where she worked on transdermal drug delivery with vaccine coated solid microneedles for which she developed a coating procedure. She also obtained in vitro/in vivo experience in this field, and drug delivery technologies became one of her passions. She completed the last part of her Master at the Pharmaceutical Technology department of Hacettepe University in Ankara, Turkey, working with hybrid nanoparticles for brain targeted nasal drug delivery. Currently, she is a PhD candidate at the Neuroscience Department of Ko University, working with targeted treatment strategies for neurological disorders.