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El. knyga: Nanotherapeutics in Cancer: Materials, Diagnostics, and Clinical Applications [Taylor & Francis e-book]

  • Formatas: 266 pages, 8 Tables, black and white; 11 Line drawings, color; 3 Line drawings, black and white; 11 Illustrations, color; 3 Illustrations, black and white
  • Išleidimo metai: 24-Nov-2022
  • Leidėjas: Jenny Stanford Publishing
  • ISBN-13: 9781003334538
Kitos knygos pagal šią temą:
  • Taylor & Francis e-book
  • Kaina: 207,73 €*
  • * this price gives unlimited concurrent access for unlimited time
  • Standartinė kaina: 296,75 €
  • Sutaupote 30%
Nanotherapeutics in Cancer: Materials, Diagnostics, and Clinical ApplicationsDidesnis paveikslėlis
  • Formatas: 266 pages, 8 Tables, black and white; 11 Line drawings, color; 3 Line drawings, black and white; 11 Illustrations, color; 3 Illustrations, black and white
  • Išleidimo metai: 24-Nov-2022
  • Leidėjas: Jenny Stanford Publishing
  • ISBN-13: 9781003334538
Kitos knygos pagal šią temą:
Taylor & Francis e-booksMore info about Taylor & Francis e-books
Partnerių interneto svetainė: https://www.taylorfrancis.com/books/9781003334538

This book provides complete information about each aspect of nanomaterials and nanotherapeutics, including synthesis, analysis, disease diagnosis, mechanistic insight, targetted drug delivery, and clinical implications in a concise and informative way.



The applications of nanoparticulate drug delivery have gained significant attention in cancer diagnosis and treatment. Owing to their unique features and design, nanomedicines have made remarkable progress in eliminating dreadful tumors. Research in cancer nanomedicine spans multitudes of drug-delivery systems that include high tumor-targeting ability, sensitivity toward tumor microenvironments, and improved efficacy. Various nanocarriers have been developed and approved for anti-tumor drug targeting. These nanocarriers, such as liposomes, micelles, nanotubes, dendrimers, and peptides, offer several advantages including high selectivity, multifunctionality, specificity, biocompatibility, and precise control of drug release. This book provides complete information about each aspect of nanomaterials and nanotherapeutics, including synthesis, analysis, disease diagnosis, mechanistic insight, targeted drug delivery, and clinical implications in a concise and informative way. It presents simple and reader-friendly representations of the mechanisms of action of nanomaterials on cellular targets and highlights the challenges in targeted drug delivery with ongoing chemotherapeutic drugs.

Preface xi
1 Introduction to Nanotherapeutics: A Synthetic Preview
1(22)
Nahid Rehman
Anjana Pandey
1.1 Introduction
1(2)
1.2 Designing Nanoparticles for Therapeutics
3(2)
1.3 Types of Nanoformulations
5(10)
1.3.1 Polymeric Nanoparticles
5(1)
1.3.1.1 Nanosponges
6(1)
1.3.1.2 Dendrimers
7(1)
1.3.1.3 Nanocapsules
7(1)
1.3.1.4 Nanogels
8(1)
1.3.2 Lipid-Based Nanoparticles
9(1)
1.3.2.1 Nanoemulsions
10(1)
1.3.2.2 Solid lipid nanoparticles
11(1)
1.3.2.3 Nanostructured lipid carriers
12(1)
1.3.3 Non-polymeric Nanoparticles
12(1)
1.3.3.1 Carbon nanotubes
12(1)
1.3.3.2 Nanodiamonds
13(1)
1.3.3.3 Metallic nanoparticles
13(1)
1.3.3.4 Quantum dots
14(1)
1.3.3.5 Silica-based nanoparticles
15(1)
1.4 Targeted Delivery Applications of Therapeutic Nanoparticles
15(1)
1.5 Limitations and Disadvantages of Therapeutic Nanoparticles
16(2)
1.6 Conclusion
18(5)
2 Synthesis, Characterization, and Application of Metal Oxide Nanoparticles
23(22)
Ashutosh Dixit
Renu Bala
Vivek Sheel Jaswal
2.1 Introduction
23(1)
2.2 Techniques for Synthesis of Nanoparticles
24(5)
2.2.1 Top-Down Approach
25(1)
2.2.1.1 Physical method
25(1)
2.2.1.2 Physical vapor deposition
25(1)
2.2.1.3 Sputtering
26(1)
2.2.1.4 Laser ablation
26(1)
2.2.1.5 Pulsed laser deposition
26(1)
2.2.1.6 Ball milling
26(1)
2.2.2 Bottom-Up Approach
26(1)
2.2.2.1 Chemical methods
27(1)
2.2.2.2 Sol-gel process
27(1)
2.2.2.3 Chemical vapor deposition
27(1)
2.2.2.4 Chemical precipitation method
28(1)
2.2.2.5 Sonochemical method
28(1)
2.2.2.6 Hydrothermal synthesis
29(1)
2.2.2.7 Polyol synthesis
29(1)
2.3 Characterization Techniques
29(16)
2.3.1 X-ray Diffraction
29(2)
2.3.2 Transmission Electron Microscopy
31(1)
2.3.3 Fourier Transform Infrared Spectroscopy
32(1)
2.3.4 UV-Visible Absorption Spectroscopy
33(1)
2.3.5 NMR Spectroscopy
34(1)
2.3.6 Thermal Analysis
35(1)
2.3.7 Scanning Electron Microscope
35(1)
2.3.8 Energy-Dispersive X-ray Analysis
36(1)
2.3.9 Selected Area Electron Diffraction
37(1)
2.3.10 Energy-Dispersive X-ray Spectroscopy
37(1)
2.3.11 X-ray Photoelectron Spectroscopy
38(1)
2.3.12 Differential Scanning Calorimetry
39(1)
2.3.13 Photoluminescence Spectroscopy
39(6)
3 Current Scenario of Nanomaterials in Cancer Diagnostics
45(34)
Jagjit Kaur
3.1 Introduction
45(2)
3.2 Advantages of Using Nanomaterials in Cancer Therapy
47(1)
3.3 Nanomaterials Used for Cancer Diagnostics
48(13)
3.3.1 Liposomes
48(1)
3.3.2 Dendrimers
49(1)
3.3.3 Polymeric Nanoparticles
50(1)
3.3.4 Polymeric Micelles
51(1)
3.3.5 Polymer Drug Conjugates
52(1)
3.3.6 Gold Nanoparticles
53(2)
3.3.7 Magnetic Nanoparticles
55(1)
3.3.8 Silica Nanoparticles
56(1)
3.3.9 Quantum Dots
57(2)
3.3.10 Carbon Nanotubes
59(1)
3.3.11 Nanographene
60(1)
3.4 Cytotoxicity Caused by Nanoparticles
61(1)
3.5 Conclusion
62(17)
4 Emerging Antineoplastic Potential of Nanoparticles Against Different Types of Cancer
79(18)
Vivek Kumar Garg
Abhilasha Sood
Deepika Kapoor
Katrin Sak
Sonam Mittal
Hardeep Singh Tuli
4.1 Introduction
79(2)
4.2 Nanotherapeutics in Diverse Range of Cancer
81(7)
4.2.1 Role of Nanoparticles in Brain Cancer
81(1)
4.2.2 Role of Nanoparticles in Head and Neck Cancer
82(1)
4.2.3 Role of Nanoparticles in Breast Cancer
83(1)
4.2.4 Role of Nanoparticles in Gastric Cancer
84(1)
4.2.5 Role of Nanoparticles in Lung Cancer
85(1)
4.2.6 Role of Nanoparticles in Pancreatic Cancer
85(1)
4.2.7 Role of Nanoparticles in Ovarian Cancer
86(1)
4.2.8 Role of Nanoparticles in Prostate Cancer
87(1)
4.3 Conclusion and Future Perspectives
88(9)
5 Nanomaterials-Mediated Oxidative Stress in Cancer: Recent Trends and Future Perspectives
97(40)
Tugba Oren Varol
Mehmet Varol
5.1 Introduction
97(3)
5.2 Molecular Mechanisms of Oxidative Stress in Carcinogenesis
100(2)
5.3 Mechanism of Nanomaterials-Mediated ROS Generation
102(5)
5.4 Metal-Based Nanoparticles-Mediated ROS Generation
107(4)
5.5 Carbon-Based Nanomaterials-Mediated ROS Generation
111(2)
5.6 Nanovehicles in ROS-Mediated Cancer Therapy
113(2)
5.7 Concluding Remarks and Future Prospects
115(22)
6 Role of Nanotherapeutics in Inhibiting Cancer Angiogenesis: A Novel Perspective
137(24)
Neha Atale
Vibha Rani
6.1 Introduction
137(3)
6.2 Angiogenesis: A Critical Hallmark in Cancer
140(2)
6.3 Antiangiogenic Nanotherapy
142(8)
6.3.1 Metal and Metallic Oxide NPs
144(1)
6.3.1.1 Gold NPs
145(1)
6.3.1.2 Silver NPs
146(1)
6.3.1.3 Copper NPs
146(1)
6.3.2 Non-metallic NPs
147(1)
6.3.3 Polymer-Based NPs
147(1)
6.3.4 Tertac NPs
148(1)
6.3.5 Peptide NPs
149(1)
6.3.6 Carbon-Based Nanomaterials
149(1)
6.4 Nanotechnology and Gene Therapy in Cancer
150(1)
6.5 Current Approved Nanotherapies for Cancer Treatment
150(1)
6.6 Conclusion and Future Perspectives
151(10)
7 Inhibition of Cancer Cell Metastasis by Nanotherapeutics: Current Achievements and Future Trends
161(50)
Hemant Joshi
Gaurav Kumar
Hardeep Singh Tuli
Sonam Mittal
7.1 Introduction
161(3)
7.2 Impact of Nanocarriers Physicochemical Properties in Tumor Inhibition
164(2)
7.2.1 Nanoparticles Size and Morphology
164(1)
7.2.2 Nanoparticle Surface Charge
165(1)
7.2.3 Nanoparticle Surface Chemistry
165(1)
7.3 Nanomedicine-Based Strategies for Inhibition of Tumor Metastasis
166(14)
7.3.1 Active Targeting
168(3)
7.3.2 Passive Targeting
171(2)
7.3.3 Cancer Stem Cells Targeting
173(2)
7.3.4 Epithelial-Mesenchymal Transition Targeting
175(1)
7.3.5 Remodeling Tumor Microenvironment
176(1)
7.3.6 Circulating Tumor Cell Targeting
177(1)
7.3.7 Gene Editing
178(2)
7.4 Experiences from Clinical Trials
180(10)
7.5 Conclusion and Future Perspectives
190(21)
8 Nanotherapeutics as Potential Carriers for the Delivery of Anticancer Drugs
211(30)
Ruchira Joshi
Priyanka Shah
Hardeep Singh Tuli
Ginpreet Kaur
8.1 Introduction
211(2)
8.2 Various Nanotherapeutics Used for the Delivery of Anticancer Drugs
213(12)
8.2.1 Delivery of Baicalin and 5-Fluorouracil Using Polyamidoamine Dendrimers
213(1)
8.2.2 Delivery of Hydroxycamptothecin and Doxorubicin Using Biodegradable Dendrimers
214(1)
8.2.3 Delivery of Trastuzumab and Doxorubicin Using Amino Acid-Based Dendrimers
214(6)
8.2.4 Delivery of Cytarabine and Fludarabine Using Glycodendrimers
220(1)
8.2.5 Delivery of Paclitaxel and Doxorubicin Using Hydrophobic Dendrimers
220(1)
8.2.6 Delivery of Biotin-SB-T-1214 Taxoid and mAb Using Asymmetric Dendrimers
220(1)
8.2.7 Delivery of Hesperidin and Fluorodeoxyuridine Using Targeted Liposomal Approach
221(1)
8.2.8 Delivery of Silibinin and Gemcitabine Using Thermosensitivity-Based Liposomes
221(1)
8.2.9 Delivery of siRNA and Antisense Agent Using Enzyme-Sensitive Liposomes
222(1)
8.2.10 Delivery of Apigenin and Piplartine Using Nanoemulsions
222(1)
8.2.11 Delivery of Quercetin and Raloxifene Using Chitosan Nanoparticles
223(1)
8.2.12 Delivery of Curcumin and Docetaxel Using Silica Nanoparticles
223(2)
8.2.13 Delivery of Kaempferol and Docetaxel Using PLGA Nanoparticles
225(1)
8.3 Effect of Nanoformulations to Stabilize Therapeutic Agent
225(1)
8.4 Conclusion and Future Perspectives
226(15)
9 Nanoparticle-Associated Toxicity and Concept of Edible Nanoparticles: Promising Therapeutics in Near Future
241(18)
Priyanka Shah
Ruchira Joshi
Onkar Nigade
Hardeep Singh Tuli
Ginpreet Kaur
9.1 Introduction
241(2)
9.2 Nanoparticle-Associated Toxicity
243(4)
9.3 Plant-Derived Extracellular Vesicles as Vehicles for Delivery of Therapeutic Agents
247(1)
9.3.1 Composition of Plant-Derived Extracellular Vesicles and Their Biological Action
247(1)
9.3.2 Isolation of Plant-Derived Edible Nanoparticles
248(1)
9.4 Therapeutic Applications of Plant-Derived Edible Nanoparticles
248(3)
9.5 Discussion
251(1)
9.6 Conclusion and Future Perspectives
251(8)
Index 259
Hardeep Singh Tuli is an assistant professor at the Department of Biotechnology, Maharishi Markandeshwar (Deemed to be University), Mullana, Haryana, India. He has also been a lecturer at the Department of Applied Sciences, Institute of Science and Technology, Klawad, Yamunanagar, India. He has served as a reviewer for several international journals and a guest editor for the journal Frontiers in Pharmacology. He has more than 10 years of teaching and research experience in pharmacology, mammalian physiology, and natural products. Dr. Tuli has published more than 80 papers in peer-reviewed international journals, authored several book chapters, and edited three international books on natural products and chemoprevention. He has been placed in the top 2% of highly cited researchers in the world in the pharmacology area. His research is focused on the isolation, characterization, and biochemical evaluation of natural metabolites as anticancer agents.
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