Building on the foundation of the first edition, this thoroughly updated volume reflects the rapid advancements and expanding clinical relevance of navigated transcranial magnetic stimulation (nTMS) in neurosurgery. Once primarily a tool for preoperative mapping of cortical motor and language functions, nTMS is now increasingly recognized as a versatile instrument for individualized neurosurgical planning, risk stratification, and targeted neuromodulation.
This second edition presents these principles of perioperative neurophysiology with new insights into the integration of nTMS with cutting-edge technologies such as advanced tractography and connectomic analyses offering a more nuanced view of brain networks and their role in both mapping and therapeutic contexts. Emerging applicationssuch as closed-loop stimulation and post-spinal cord injury rehabilitationare covered in depth, reflecting the fields shift toward personalized neuromodulatory interventions.
As in the first edition, the book serves both as a practical guide and a reference: neurosurgeons and neuroscientists new to nTMS will find essential protocols and implementation strategies, while experienced users will benefit from expert analysis of the latest techniques and clinical applications. Each chapter is authored by leading figures in the field, selected for their pioneering contributions and international expertise.
With a spirit of collaboration and innovation at its core, this book captures the momentum and promise of nTMS in modern neurosurgerymoving from isolated functional regions to a network-based approach that is transforming patient care.
Chapter
1. Basic Principles of Navigated Tms.
Chapter
2. TMS, MEG and
fMRI: Comparing and Contrasting three Functional Mapping Techniques.
Chapter
3. Basic and Advanced Intraoperative Neurophysiological Monitoring and
Mapping in Supratentorial Brain Tumor Surgery.
Chapter
4. Integration of
Functional Data in The Clinical Workflow.
Chapter
5. Safety Issues for The
Use Of TMS.
Chapter
6. nTMS Motor Mapping: Basic Principles and Clinical
Use.
Chapter
7. nTMS-based DTI Fiber Tracking of Motor Pathways.
Chapter
8. nTMS Motor Mapping for Risk Stratification and Clinical Decision Making
Support.
Chapter
9. nTMS Language Mapping: Basic Principles and Clinical
Use.
Chapter
10. Combining nTMS And Tractography for Language Mapping: an
Integrated Paradigm for Neurosurgical Planning.
Chapter
11. Risk
Stratification by nTMS Language Mapping.
Chapter
12. Mapping of Further
Brain Functions.
Chapter
13. nTMS In Pediatrics: Special Issues and
Solutions.
Chapter
14. nTMS in Epilepsy: Functional Mapping and Therapeutic
Applications.
Chapter
15. Assessment of Chronic Cervical Myelopathy.-
Chapter
16. Navigated rTMS for the Treatment Of Pain.
Chapter
17. High-PAS:
Paired Associative Stimulation with High-Frequency Peripheral and
High-Intensity Central Component in Spinal Cord Injury Rehabilitation.-
Chapter
18. Treatment of Paresis.
Chapter
19. Closed-Loop TMS.
Chapter
20.
nTMS Depression Therapy.
Chapter
21. Harnessing Advanced Tractography in
Neurosurgical Practice.
Chapter
22. Analysis and Creation of Structural
Connectomes in Brain Tumour Patients: Methodological Challenges and Potential
Solutions.
Chapter
23. Brain Plasticity and Neurosurgery.
Chapter
24.
Outlook on The Potential of nTMS in Neurosurgery.
Prof. Thomas Picht (Charité Universitätsmedizin Berlin) and Prof. Sandro Krieg (Heidelberg University Hospital) have been at the forefront of advancing navigated transcranial magnetic stimulation (nTMS) in neurosurgery for over a decade. As internationally recognized experts in eloquent brain tumor surgery, they have relentlessly driven innovation in non-invasive brain mapping, helping to refine surgical strategies and improve patient outcomes. Their collaboration is marked by a strong commitment to international exchange, reflected in numerous joint publications with global partners and their long-standing role as co-hosts of the annual International Symposium on nTMS in Neurosurgery. Together, they have shaped the clinical translation of nTMS from cutting-edge research to a widely adopted tool in neurosurgical planning. Their combined efforts continue to push the boundaries of technology-driven, patient-centered neurosurgical care.
