Navigating Non-coding RNA: From Biogenesis to Therapeutic Application provides a concise overview of the field of non-coding RNA (ncRNA). The book begins with a brief history of the discoveries that have occurred in the area of ncRNA, then moving on to more detailed chapters on specific types of ncRNA. Housekeeping ncRNAs such as ribosomal RNA, transfer RNA, small nuclear RNA and telomerase RNA are discussed, followed by regulatory ncRNAs such as microRNA, small interfering RNA, long non-coding RNA and Y RNA. Biogenesis, structure, function, and regulation of each of these are explored, in addition to traditional and cutting-edge methods for identification, functional characterization and structural characterization of ncRNA. The book also focuses on the different types of epitranscriptomic modifications and their involvement in regulating ncRNA structure, stability, and intermolecular interactions, in addition to the role of ncRNAs in a range of diseases and potential therapeutic applications.
- Covers a wide range of non-coding RNAs, including ribosomal RNA, transfer RNA, telomerase RNA, microRNA, small interfering RNA, and circular RNA
- Features both traditional and novel methodologies for investigating ncRNA, from microarray and conventional chemical probing to CAGE-seq and computational methods
- Includes chapters on ncRNAs in a range of diseases, including cancers, neurological disorders, cardiovascular conditions and infectious illnesses
- Discusses novel therapeutic strategies for targeting ncRNAs, including CRISP/Ca9 applications and RNAi-based strategies
- Explores the molecular mechanisms and intermolecular interactions of ncRNA
1. Non-coding RNAs: history and definition
2. Housekeeping ncRNAs
3. Regulatory ncRNAs
4. Non-coding RNAs: mechanisms of action
5. Identification of non-coding RNAs
6. Functional characterization of non-coding RNAs
7. Structural characterization of non-coding RNAs
8. Regulation of Non-coding RNAs
9. Non-coding RNAs in human non-infectious diseases
10. Non-coding RNAs in human infectious diseases
Joanna Sztuba-Solinska is an Assistant Professor at the Department of Biological Sciences, Auburn University, Alabama, US. She has more than ten years experience working across the fields of molecular virology and biochemistry, with specific training and expertise in the analysis of RNA structure, regulation, and function in different viral systems, including herpesviruses, filoviruses, and flaviviruses. Dr. Sztuba-Solinska is currently also Principal Investigator at Auburn University where she leads a laboratory team working at the interface of molecular biology and virology, where they use molecular, biochemical, and bioinformatic tools to study the structure, function, epitranscriptomic regulation of viral coding and non-coding RNAs. This research ultimately leads to understanding the viral RNAs structure-to-function relationship, and the potential identification of new antiviral targets and therapies.
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