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El. knyga: Nucleic Acids in Medicinal Chemistry and Chemical Biology: Drug Development and Clinical Application s: Drug Development and Clinical Applications [Wiley Online]

Edited by (Peking University, Beijing, China), Edited by (University of Uppsala, Uppsala, Sweden), Edited by (Peking University, Beijing, China), Edited by (Nankai University, Tianjin, China)
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Nucleic Acids in Medicinal Chemistry and Chemical Biology An up-to-date and comprehensive exploration of nucleic acid medicinal chemistry and its applications

In Nucleic Acids in Medicinal Chemistry and Chemical Biology: Drug Development and Clinical Applications, a team of distinguished researchers delivers a comprehensive overview of the chemistry and biology of nucleic acids and their therapeutic applications. The book emphasizes the latest research in the field, including new technologies like CRISPR that create novel possibilities to edit mutated genes at the genomic DNA level and to treat inherited diseases and cancers.

The authors explore the application of modified nucleosides and nucleotides in medicinal chemistry, a variety of current topics on nucleic acid chemistry and biology, nucleic acid drugs used to treat disease, and more. They also probe new domains of pharmaceutical research, offering the reader a wealth of new drug discovery opportunities emerging in this dynamic field.

Readers will also find:





A thorough introduction to the basic terminology and knowledge of the field of nucleic acid medicinal chemistry Comprehensive explorations of the methods used to determine the development of nucleic acid drugs Practical discussions of new technologies, like CRISPR, nanotechnology-based delivery systems, synthetic biology, and DNA-encoded chemical libraries In-depth examinations of the latest, cutting-edge developments in nucleic acid medicinal chemistry

Perfect for medicinal and nucleic acid chemists, Nucleic Acids in Medicinal Chemistry and Chemical Biology will also earn a place in the libraries of biochemists, chemical biologists, and pharmaceutical researchers.
Contributors vii
Foreword xi
1 Design, Synthesis, and Applications of Nucleoside Phosphate and Phosphonate Prodrugs
1(40)
Junbiao Chang
Wenquan Yu
2 Cyclic Dinucleotides: A New-Generation Drug for Immune Therapy
41(43)
Zhenghua Wang
Dejun Ma
Zhen Xi
3 Enzymatic and Endogenous Synthesis of Nad(P)-Derived Calcium-Mobilizing Messengers
84(29)
Hon Cheung Lee
Yong Juan Zhao
4 Selenium Atom-Modified Nucleic Acids for Structural, Functional, and Diagnostic Studies
113(19)
Cen Chen
Fukang Yang
Zhen Huang
5 Sequence-Specific Chromosomal DNA Binders: An Unfulfilled Promise?
132(25)
Zutao Yu
Ganesh N. Pandian
Hiroshi Sugiyama
6 DNA Synthesis and Synthetic Genome
157(25)
Ze-Xiong Xie
Rui Ying Zhu
Yue Liu
Ying Jin Yuan
7 Methods for Mapping of Nucleic Acids Epigenetic Modifications and Its Clinic Applications
182(45)
Xiaocheng Weng
Shuang Peng
Guangrong Zou
Kexin Yuan
Xiang Zhou
8 DNA-Encoded Chemical Libraries Used for Drug Discovery
227(49)
Guixian Zhao
Shilian Yang
Xiaoyu Li
Yizhou Li
9 Nucleic Acid-Based Nanocarriers as Drug Delivery System
276(69)
Sangwoo Han
Dajeong Kim
Yoonbin Ji
Sunghyun Moon
Jong Bum Lee
10 Fluorescence Hybridization Imaging of Neurological Disease Messenger RNAs
345(28)
Eric Wickstrom
11 Progress of Oligonucleotide Therapeutics Target to Rna: Review On Modification, Conjugation, and Delivery
373(55)
Yufei Pan
Xinyang Zhou
Zhenjun Yang
12 Crispr/Cas9: A Therapeutic Solution By Manipulating Nucleic Acids
428(15)
Hongkui Deng
Yulin Liu
Shicheng Sun
13 Aptamer Properties, Functions, and Applications
443(40)
Weihong Tan
Zilong Zhao
Liqin Zhang
14 G-Quadruplex as a Platform for New Perspectives In Nucleic Acid Targeting for Therapeutic Applications
483(28)
Manlio Palumbo
Claudia Sissi
Index 511
Lihe Zhang is President of the Academic Committee of State Key Laboratory of Natural & Biomimetic Drugs and Professor of Medicinal Chemistry at Peking University.

Xinjing Tang is Professor of Medicinal Chemistry at Peking University.

Zhen Xi is Chairman of the Department of Chemical Biology, Deputy Director of the State Key Laboratory of Element-Organic Chemistry, Professor of Pesticide Science and Chemical Biology, and Vice Dean for Academic Affairs of the College of Chemistry at Nankai University.

Jyoti Chattopadhyaya is Chairman of the Department of Cell and Molecular Biology and Chair of Bioorganic Chemistry at the University of Uppsala.