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El. knyga: Ocular Pharmacology and Toxicology

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Covering ocular pharmacokinetics, pharmacodynamics, and toxicology, Ocular Pharmacology and Toxicology provides ophthalmologists, toxicologists, and pharmacologists with both an introduction to the proper methods for ocular pharmacology and toxicology as well as providing practical methodologies for conducting ocular studies. Expert authors have contributed detailed chapters on study design, analysis, and routes to regulatory approval for various types and routes of ophthalmic drugs. As a volume in the Methods in Pharmacology and Toxicology series, chapters feature the kind of in-depth specifics and implementation advice to ensure successful results.

Practical and authoritative, Ocular Pharmacology and Toxicology serves as an ideal basis of training in the proper design and conduct of essential studies to accurately determine pharmacokinetics and ocular toxicity from the systemic, topical, periocular, or intraocular administration of drugs or compounds, from the use of ocular medical devices and from ocular surgical procedures.

Preface v
Contributors ix
1 Challenges in Ocular Pharmacokinetics, Pharmacodynamics, and Toxicology
1(6)
Brian C. Gilger
2 Selection of Appropriate Animal Models in Ocular Research: Ocular Anatomy and Physiology of Common Animal Models
7(26)
Brian C. Gilger
Eva Abarca
Jacklyn H. Salmon
3 Challenges and Strategies in Drug Residue Measurement (Bioanalysis) of Ocular Tissues
33(20)
Poonam R. Velagaleti
Michael H. Buonarati
4 Chemistry, Manufacturing, and Control of Ophthalmic Formulations
53(28)
Malay Ghosh
Imran Ahmed
5 ADME and Ocular Therapeutics: Retina
81(10)
Cornelis J. Van der Schyf
Samuel D. Crish
Christine Crish
Denise Inman
Werner J. Geldenhuys
6 Compositions, Formulation, Pharmacology, Pharmacokinetics, and Toxicity of Topical, Periocular, and Intravitreal Ophthalmic Drugs
91(28)
Kishore Cholkar
Aswani Dutt Vadlapudi
Hoang M. Trinh
Ashim K. Mitra
7 Sustained-Release Ocular Drug Delivery Systems: Bench to Bedside Development
119(24)
Susan S. Lee
Michael R. Robinson
Scott M. Whitcup
8 The Ophthalmic Examination as It Pertains to General Ocular Toxicology: Basic and Advanced Techniques and Species-Associated Findings
143(62)
David A. Wilkie
9 Study Design and Methodologies for Evaluation of Anti-glaucoma Drugs
205(38)
Paul E. Miller
10 Study Design and Methodologies for Study of Ocular Medical Devices
243(24)
Joseph W. Carraway
Elaine M. Daniel
11 Methodologies for Microscopic Characterization of Ocular Toxicity
267(24)
Leandro B.C. Teixeira
James A. Render
12 Nanoparticles for Drug and Gene Delivery in Treating Diseases of the Eye
291(26)
Shreya S. Kulkarni
Uday B. Kompella
Index 317