A comprehensive guide for integrating pathology into a clinical setting.
Pathological Basis of Oral and Maxillofacial Diseases presents the basic principles involved in disease mechanisms in an easy-to-understand way. By integrating recent advances in molecular, immunologic, and genetic understanding of oral disease, the book helps readers enhance their knowledge and its application in a clinical setting.
This book is divided into nine sections, covering key topics such as inflammation, genetic diseases, and neoplasia, with contributions from over 50 international authors. Diagrams, clinical, radiographic, and histopathology images and tables supplement the text, and the editors have ensured a consistent approach throughout.
Topics covered in Pathological Basis of Oral and Maxillofacial Diseases include:
- The influences of nutrition and the environment
- Cellular structure and function, causes and mechanisms of cellular pathology.
- Immunity and host defence mechanisms, immune dysfunctions affecting the oro-facial complex.
- Inflammation and inflammatory diseases of the oro-facial complex
- Human microbiome, with reference to dysbiosis in dental caries and periodontal diseases
- Oral manifestations of systemic diseases and the oral-systemic link and its impact on general and oral health
- Oral potentially malignant and malignant disorders that are a major threat to global public health.
Bridging the gap in dental training programs from basic medical science in the initial years to clinical practice, Pathological Basis of Oral and Maxillofacial Diseases is an essential reference for dental students, trainees and practitioners seeking to grasp the pathological basis of disease and apply that knowledge to the oral and maxillofacial regions.
Recenzijos
An impressive and noteworthy contribution to the field of oral diagnostics, particularly oral pathology, delivering an insightful exploration of the pathological processes underlying orofacial disorders. It succeeds in bridging the often wide gap between foundational biomedical science and clinical application, rendering it a critical resource for students, educators, and dental practitioners alike. - S. M. Balaji Department of Oral and Maxillofacial Surgery, Balaji Dental and Craniofacial Hospital, India. Review published in Indian Journal of Dental Research (May 25)
Scientific advances are presented in a clear and understandable way that the reader would find it easy to grasp rather than having to grapple through journals or very extensive published literature... For dentists looking to study fundamental aspects of oral and maxillofacial diseases, the textbook is a valuable resource. I highly recommend this book to the target readership and to university libraries. -Saman Warnakulasuriya, Emeritus Professor, King's College London, UK. Review published in British Dental Journal (May 25)
About the Editors xi
List of Contributors xiii
Foreword xviii
Preface xix
Section 1 Pathology as the Foundation of Medicine 1
1 Introduction to Pathology 3
S. R. Prabhu and Suja Pillai
2 Global Scenario, Aetiology and Risk Factors Associated with Oral and
Maxillofacial Diseases: An Overview 11
Nesa Aurlene Jayadhas and Santosh Kumar Tadakamadla
3 The Role of Laboratory Diagnosis in Oral and Maxillofacial Pathology: An
Overview 27
Hannah Walsh and Daniel J. Brierley
Section 2 Homeostasis and Cellular Pathology 39
4 Homeostasis and Influences of Environment and Nutrition 41
A. V. Chalapathi Rao and S. R. Prabhu
5 Cellular Structure and Function 51
Suheyla Kaya Copyrighted Material
6 Cell Injury: Causes, Mechanisms and Responses 64
S. R. Prabhu
7 The Structure and Function of the Oral Mucosa 82
Gargi Sarode and Sachin Sarode
8 Cellular Mechanisms of Ageing of Oral Tissues 99
Jeremy Lau, Agnieszka Frydrych and Omar Kujan
9 Endocrine and Metabolic Dysfunction and Oro- Facial Diseases 108
Prazwala Chirravur and Pradeep Chirravur
Section 3 Defence Mechanisms Against Disease 133
10 Immunity and Host Defence Mechanisms in Oral Health and Disease 135
Irene Lafuente-Ibįńez de Mendoza and José M. Aguirre-Urizar
11 Immune Dysfunctions Affecting the Oro-Facial Complex 147
Yeshwant Rawal
12 Pathology of Inflammation and Inflammatory Diseases of the Oro- Facial
Complex: An Overview 175
S. R. Prabhu
13 Cellular and Molecular Mechanisms of Healing of Cutaneous and Oral
Mucosal Wounds 196
H. Ibrahim Korkmaz and Susan Gibbs
14 Healing of the Dental Pulp and Periodontal Tissues, Extraction Socket and
BoneFracture 204
Sachin Sarode and Gargi Sarode
Section 4 Clinical Genetics and Developmental Pathology 227
15 The Human Genome and Inheritance: Key Concepts 229
Yucel Erbilgin and Muge Sayitoglu
16 Heritable Diseases with Examples Involving the Oro- Facial Complex 245
Fadi Titinchi and Johan Opperman
17 Non- heritable Developmental Disorders with Examples Involving the Oral-
Maxillofacial Complex 274
John Anthony Ozolek
Section 5 Infectious and Systemic Diseases 293
18 Human Microbiome in Health and Disease with Reference to Dysbiosis in
Dental Caries and Periodontal Diseases 295
Preethi Balan, Nadeeka Udawatte and Chaminda Jayampath Seneviratne
19 Pathology of Infection and Infectious Diseases of the Oro-Facial Complex
310
Nagamani Narayana and John Casey
20 Oral-systemic Link and Its Impact on General and Oral Health 339
Dįire Shanahan and Sarah Jane George
21 Orofacial Manifestations of Systemic Diseases: An Overview 362
Philip Atkin
22 Adverse Drug Reactions in the Orofacial Complex 377
Sue-Ching Yeoh
Section 6 Disorders of Cell and Tissue Growth 407
23 Neoplasia: Basic Concepts 409
Omar Kujan and Philip Sloan
24 Molecular Basis of Cancer 415
Lalima Tiwari and Omar Kujan
25 Host Defences Against Cancer 429
Andreia Bufalino
26 WHO Classification of Tumours: An Overview 440
Muhammed Yakin and Richard Logan
27 Dysplasia, Precancer and Oral Potentially Malignant Disorders 449
Agnieszka Frydrych and Omar Kujan
Section 7 Neoplastic Diseases of the Oral Mucosa and Salivary Glands 475
28 Global Burden, Risk factors and Pathobiology of Malignant Neoplasms of
the Oral Mucosa and the Oropharynx 477
Paul Hankinson and Syed Ali Khurram
29 Presentation, Diagnosis and Prognosis of Squamous Cell Carcinomas of the
Oral Mucosa and Oropharynx 498
Selvam Thavaraj and Adam Jones
30 Global Burden, Classification, Pathobiology, Genetics and Prognosis of
Salivary Gland Neoplasms 531
Lucas Lacerda de Souza, Marcio Ajudarte Lopes, Pablo Agustin Vargas and Syed
Ali Khurram
Section 8 Diseases of the Oral and Maxillofacial Skeleton 567
31 Classification and Pathogenesis of Odontogenic and Non- odontogenic Jaw
Cysts 569
Paul M. Speight and Merva Soluk Tekkesin
32 Global Burden, Pathobiology, Genetics and Behaviour of Odontogenic
Neoplasms 585
Keith Hunter and Merva Soluk Tekkesin
33 Pathogenesis and Behaviour of Fibro- osseous and Giant- Cell Lesions of
the Jaw Bones 604
Lisette Collins and Merva Soluk Tekkesin
Section 9 Pain Disorders 615
34 Pathophysiology of Orofacial Pain 617
Janani Ravichandran, Guru O., Ramesh Balasubramaniam and Barry Sessle
35 Genetics, Lifestyle and Psychosocial Considerations in Orofacial Pain
639
Lasanthini Weerakkody, Jeremy Lau, Kavitha Vegunta, Davis C. Thomas and
Ramesh Balasubramaniam
Index 658
The Editors
S. R. Prabhu is an Honorary Associate Professor at the University of Queensland School of Dentistry in Brisbane, Australia, a Fellow of the Dental Faculty of all four Royal Surgical Colleges of the UK and Ireland and a former Commonwealth Medical Scholar.
Syed Ali Khurram is a Professor of Pathology and Honorary Consultant Pathologist at the University of Sheffield, UK.
Omar Kujan is an Associate Professor and the discipline lead in Oral Pathology at UWA Dental School, The University of Western Australia, Perth, Australia.
Merva Soluk Tekkesin is a Professor of Oral and Maxillofacial Pathology at Istanbul University, Turkey.
