| Preface |
|
v | |
| Contributors |
|
xvii | |
|
SECTION I: GENERAL PRINCIPLES |
|
|
|
Supportive Care of the Pediatric Hematopoietic Stem-Cell Transplant Patient |
|
|
1 | (26) |
|
|
|
|
|
|
|
1 | (1) |
|
Prevention and Management of Mucositis |
|
|
1 | (1) |
|
Hepatic Veno-occlusive Disease |
|
|
2 | (4) |
|
|
|
6 | (1) |
|
|
|
7 | (1) |
|
Prevention and Management of Renal Disease |
|
|
7 | (2) |
|
Neurologic Complications of Hematopoietic Stem-Cell Transplant |
|
|
9 | (2) |
|
|
|
11 | (5) |
|
Hematopoietic Growth Factor Support |
|
|
16 | (3) |
|
|
|
19 | (1) |
|
|
|
19 | (8) |
|
Prevention and Treatment of Infectious Disease |
|
|
27 | (38) |
|
|
|
|
|
|
|
|
|
|
|
27 | (8) |
|
Invasive Fungal Infections |
|
|
35 | (8) |
|
|
|
43 | (12) |
|
|
|
55 | (10) |
|
Acute Graft-Versus-Host Disease |
|
|
65 | (20) |
|
|
|
|
|
|
|
65 | (1) |
|
Staging/Clinical Description |
|
|
66 | (2) |
|
|
|
68 | (3) |
|
|
|
71 | (5) |
|
Treatment of Acute Graft-Versus-Host Disease |
|
|
76 | (1) |
|
|
|
77 | (8) |
|
Chronic Graft-Versus-Host Disease in Children |
|
|
85 | (26) |
|
|
|
|
|
|
|
Overview of the Biology of Chronic Graft-Versus-Host Disease |
|
|
85 | (6) |
|
Chronic Graft-Versus-Host Disease---Incidence and Risk Factors in Children |
|
|
91 | (2) |
|
Classification of Chronic Graft-Versus-Host Disease |
|
|
93 | (5) |
|
Treatment of Chronic Graft-Versus-Host Disease |
|
|
98 | (2) |
|
|
|
100 | (11) |
|
Cellular Engineering of the Hematopoietic Graft |
|
|
111 | (26) |
|
|
|
|
|
111 | (1) |
|
|
|
111 | (6) |
|
Minimally Manipulated Products |
|
|
117 | (1) |
|
Extensively Manipulated Products |
|
|
118 | (1) |
|
T-Cell Depletion to Prevent Graft-Versus-Host Disease |
|
|
119 | (3) |
|
Purging of Tumor Cells from Autologous Hematopoietic Stem Cells |
|
|
122 | (4) |
|
Translational Research and the Future: Gene Therapy and Stem-Cell Expansion |
|
|
126 | (1) |
|
|
|
127 | (1) |
|
|
|
128 | (9) |
|
Issues in Pediatric Peripheral Blood Stem-Cell Collection |
|
|
137 | (10) |
|
|
|
|
|
137 | (1) |
|
Pheresis and Vascular Access |
|
|
137 | (2) |
|
|
|
139 | (1) |
|
Techniques for Stem-Cell Mobilization |
|
|
139 | (1) |
|
Target Dose for PBSC Infusion |
|
|
140 | (2) |
|
Processing and Storage of Peripheral Blood Stem Cells |
|
|
142 | (1) |
|
|
|
142 | (1) |
|
|
|
143 | (1) |
|
|
|
143 | (4) |
|
Pediatric Unrelated Donor Stem-Cell Transplantation |
|
|
147 | (14) |
|
|
|
|
|
|
|
147 | (1) |
|
Unrelated Stem Cell Donor Registries |
|
|
148 | (1) |
|
|
|
148 | (1) |
|
|
|
149 | (1) |
|
Registries and Donor Selection |
|
|
149 | (2) |
|
|
|
151 | (1) |
|
|
|
151 | (1) |
|
The Role of Unrelated Donor Transplants in Specific Diseases |
|
|
152 | (3) |
|
|
|
155 | (6) |
|
Umbilical Cord Blood Transplantation |
|
|
161 | (28) |
|
|
|
|
|
|
|
161 | (1) |
|
Biological Features of Umbilical Cord Blood Grafts |
|
|
162 | (1) |
|
Umbilical Cord Blood Transplantation Clinical Experience |
|
|
163 | (16) |
|
Practical Considerations When Selecting a Donor Graft |
|
|
179 | (2) |
|
Umbilical Cord Blood Transplantation for Larger Sized Recipients |
|
|
181 | (1) |
|
Summary and Future Considerations |
|
|
181 | (1) |
|
|
|
181 | (8) |
|
Cellular Immunotherapeutic Approaches to the Hematopoietic Stem-Cell Transplant Patient |
|
|
189 | (12) |
|
|
|
|
|
|
|
189 | (1) |
|
Immunotherapy and Loss of Immunologic Control of Leukemia |
|
|
190 | (2) |
|
|
|
192 | (2) |
|
Nonmyeloablative Transplant |
|
|
194 | (2) |
|
|
|
196 | (1) |
|
|
|
196 | (5) |
|
Partially Mismatched Related Donor Transplantation |
|
|
201 | (22) |
|
|
|
|
|
|
|
|
|
201 | (1) |
|
Terminology of Partially Mismatched Related Donor (Haplo-Identical) Transplant |
|
|
202 | (1) |
|
|
|
202 | (2) |
|
|
|
204 | (1) |
|
Methods to Cross Major-Human Leukocyte Antigen Barriers |
|
|
205 | (2) |
|
Granulocyte-Colony Stimulating Factor Primed Bone Marrow Cells and Peripheral Blood Stem Cells |
|
|
207 | (1) |
|
Conditioning of the Recipient |
|
|
208 | (1) |
|
|
|
208 | (1) |
|
Graft-Versus-Host Disease and Outcomes |
|
|
209 | (2) |
|
Infection and Immune Reconstitution |
|
|
211 | (1) |
|
Comparison Between Alternative Donor Transplants |
|
|
212 | (3) |
|
|
|
215 | (1) |
|
|
|
215 | (8) |
|
Nursing Care of the Pediatric Blood and Marrow Transplant Patient |
|
|
223 | (12) |
|
|
|
|
|
|
|
223 | (1) |
|
Nursing Roles and Practice Settings |
|
|
223 | (2) |
|
|
|
225 | (1) |
|
Professional Nursing Organizations |
|
|
226 | (1) |
|
|
|
227 | (1) |
|
|
|
228 | (4) |
|
|
|
232 | (3) |
|
Psychological Dimensions of Pediatric Hematopoietic Stem-Cell Transplantation |
|
|
235 | (16) |
|
|
|
|
|
|
|
|
|
Process-Related Stressors of Pediatric Hematopoietic Stem-Cell Transplantation on the Child and Family |
|
|
235 | (2) |
|
Psychosocial Outcomes of Pediatric HSCT |
|
|
237 | (4) |
|
Influences on Adjustment to Bone Marrow Transplantation |
|
|
241 | (3) |
|
Psychosocial Intervention |
|
|
244 | (2) |
|
|
|
246 | (1) |
|
Caring for the Professional and Psychosocial Team |
|
|
247 | (1) |
|
|
|
247 | (4) |
|
Ethical Considerations in Pediatric Hematopoietic Stem-Cell Transplantation |
|
|
251 | (20) |
|
|
|
|
|
|
|
251 | (1) |
|
|
|
252 | (1) |
|
Consent for Stem-Cell Transplantation |
|
|
253 | (5) |
|
|
|
258 | (4) |
|
Research, Therapy and Human Rights |
|
|
262 | (4) |
|
Quality of Life and End-of-Life Issues |
|
|
266 | (1) |
|
|
|
267 | (1) |
|
|
|
267 | (4) |
|
Immune Reconstitution in Pediatric Patients Following Hematopoietic Stem-Cell Transplantation |
|
|
271 | (16) |
|
|
|
|
|
271 | (1) |
|
Natural Killer Cell Reconstitution Post-hematopoietic Stem-Cell Transplantation |
|
|
272 | (1) |
|
|
|
273 | (4) |
|
|
|
277 | (1) |
|
Antigen-Specific Responses |
|
|
278 | (2) |
|
|
|
280 | (1) |
|
|
|
281 | (1) |
|
|
|
281 | (1) |
|
|
|
281 | (6) |
|
Endocrine Complications of Childhood Hematopoietic Stem-Cell Transplantation |
|
|
287 | (12) |
|
|
|
|
|
|
|
|
|
287 | (1) |
|
Impaired Linear Growth and Growth Hormone Deficiency |
|
|
287 | (3) |
|
Disturbances of the Other Hypothalamic-Pituitary Axes |
|
|
290 | (1) |
|
|
|
290 | (1) |
|
Gonadal and Reproductive Dysfunction |
|
|
291 | (2) |
|
|
|
293 | (1) |
|
Disorders of Glucose Homeostasis |
|
|
294 | (1) |
|
|
|
294 | (1) |
|
|
|
295 | (4) |
|
Future Directions in Pediatric Stem-Cell Transplantation |
|
|
299 | (22) |
|
|
|
Principles of Bone Marrow Cell Therapy |
|
|
299 | (2) |
|
Principles of Gene Therapy |
|
|
301 | (3) |
|
|
|
304 | (1) |
|
Fundamental Steps in the Development of Bone Marrow Cell Therapy |
|
|
305 | (1) |
|
Patient-Based Research of Bone Marrow Cell Therapy and Gene Therapy |
|
|
305 | (1) |
|
Bone Marrow Cell Therapy for Genetic Disorders of Bone |
|
|
306 | (4) |
|
Clinical Trials of Gene Therapy of Severe Combined Immunodeficiency Disorders |
|
|
310 | (1) |
|
Marrow Mesenchymal Stem Cells as Cell Therapy for Inborn Errors of Metabolism |
|
|
311 | (1) |
|
Mesenchymal Stem Cells as Modulators of Immune Function and the Treatment of Graft-Versus-Host Disease |
|
|
312 | (1) |
|
Mesenchymal Stem Cells to Facilitate Hematopoietic Stem-Cell Engraftment |
|
|
312 | (1) |
|
Preclinical Models and Clinical Trials of Blood and Marrow Transplantation as Cell Therapy for Nonhematopoietic Disorders |
|
|
313 | (2) |
|
|
|
315 | (1) |
|
|
|
315 | (6) |
|
SECTION II: NONMALIGNANT DISEASES |
|
|
|
Primary Immunodeficiencies |
|
|
321 | (16) |
|
|
|
|
|
|
|
321 | (1) |
|
|
|
321 | (4) |
|
|
|
325 | (6) |
|
|
|
331 | (1) |
|
|
|
332 | (5) |
|
Hematopoietic Stem-Cell Transplantation for the Inherited Bone Marrow Failure Syndromes |
|
|
337 | (32) |
|
|
|
|
|
|
|
|
|
337 | (2) |
|
|
|
339 | (20) |
|
Perspectives on the Future |
|
|
359 | (1) |
|
|
|
360 | (9) |
|
Hematopoietic Stem-Cell Transplantation for Acquired Aplastic Anemia |
|
|
369 | (14) |
|
|
|
|
|
|
|
|
|
369 | (1) |
|
|
|
370 | (1) |
|
|
|
371 | (1) |
|
|
|
371 | (1) |
|
Immunosuppressive (Immunomodulatory) Therapy for Severe Aplastic Anemia |
|
|
371 | (1) |
|
Other Immunologic Therapies |
|
|
372 | (1) |
|
Hematopoietic Stem-Cell Transplantation for Severe Aplastic Anemia |
|
|
372 | (2) |
|
Graft-Versus-Host Disease |
|
|
374 | (1) |
|
|
|
375 | (1) |
|
Hematopoietic Stem-Cell Transplantation Compared with Immunosuppressive Treatment |
|
|
375 | (2) |
|
Alternative Donor Transplant |
|
|
377 | (1) |
|
Unrelated Donor Transplant |
|
|
377 | (1) |
|
HLA-Nonidentical Related Donors |
|
|
378 | (1) |
|
Conclusions and Future Perspectives |
|
|
378 | (1) |
|
|
|
379 | (4) |
|
Hematopoietic Stem-Cell Transplantation for the Treatment of Beta Thalassemia |
|
|
383 | (14) |
|
|
|
|
|
383 | (1) |
|
Hematopoietic Stem-Cell Transplantation from HLA-Matched Siblings |
|
|
384 | (2) |
|
Hematopoietic Stem-Cell Transplantation Using Alternative Donors |
|
|
386 | (2) |
|
Hematopoietic Stem-Cell Transplantation Using Alternative Sources of Stem Cells |
|
|
388 | (1) |
|
Mixed Chimerism Posttransplant for Thalassemia |
|
|
388 | (1) |
|
Alternative Approaches for Allogeneic Stem-Cell Transplantation for Thalassemia |
|
|
389 | (1) |
|
Late Effects Posttransplantation---The ``Ex-thalassemic'' Patient |
|
|
390 | (2) |
|
|
|
392 | (1) |
|
|
|
393 | (4) |
|
Hematopoietic Stem-Cell Transplantation for Sickle Cell Disease |
|
|
397 | (16) |
|
|
|
|
|
397 | (1) |
|
Bone Marrow Transplantation for Sickle Cell Disease |
|
|
397 | (2) |
|
Umbilical Cord Blood Transplantation for Sickle Cell Disease |
|
|
399 | (1) |
|
Acute Toxicities of Hematopoietic Stem-Cell Transplantation |
|
|
399 | (1) |
|
|
|
400 | (3) |
|
Challenges to Transplantation |
|
|
403 | (1) |
|
Mixed Chimerism After Transplantation |
|
|
404 | (3) |
|
Alternate Sources of Allogeneic Hematopoietic Stem Cells |
|
|
407 | (1) |
|
Use of Peripheral Blood Stem Cells |
|
|
408 | (1) |
|
|
|
409 | (1) |
|
|
|
409 | (1) |
|
|
|
409 | (4) |
|
|
|
413 | (36) |
|
|
|
|
|
413 | (3) |
|
Hematopoietic-Cell Transplantation |
|
|
416 | (1) |
|
|
|
417 | (10) |
|
|
|
427 | (6) |
|
Glycoprotein Metabolic Disorders |
|
|
433 | (1) |
|
|
|
434 | (3) |
|
Developing Therapies and Future Directions |
|
|
437 | (1) |
|
|
|
438 | (11) |
|
Hematopoietic Stem-Cell Transplantation for Autoimmune Diseases in Children |
|
|
449 | (28) |
|
|
|
|
|
|
|
|
|
|
|
449 | (1) |
|
|
|
449 | (1) |
|
|
|
450 | (2) |
|
Stem-Cell Mobilization in Patients with Autoimmune Diseases |
|
|
452 | (1) |
|
Ex Vivo Stem-Cell Selection |
|
|
452 | (1) |
|
Rationale for Design of Autologous Autoimmune Hematopoietic Stem-Cell Transplantation (HSCT) Regimens |
|
|
453 | (1) |
|
Juvenile Idiopathic Arthritis |
|
|
454 | (4) |
|
|
|
458 | (3) |
|
Systemic Lupus Erythematosus |
|
|
461 | (4) |
|
|
|
465 | (1) |
|
|
|
466 | (1) |
|
Immunologic Mechanisms of Hematopoietic Stem-Cell Transplantation |
|
|
467 | (1) |
|
Allogeneic Hematopoietic Stem-Cell Transplantation |
|
|
468 | (1) |
|
|
|
468 | (9) |
|
SECTION III: MALIGNANT DISEASES |
|
|
|
Transplantation for Childhood Acute Lymphoblastic Leukemia |
|
|
477 | (20) |
|
|
|
|
|
|
|
|
|
477 | (1) |
|
Biology of Transplantation for Acute Lymphoblastic Leukemia |
|
|
477 | (1) |
|
Importance of Disease Control Pretransplant |
|
|
478 | (1) |
|
When to Transplant in Childhood Acute Lymphoblastic Leukemia |
|
|
478 | (4) |
|
|
|
482 | (1) |
|
Hematopoietic Stem-Cell Source |
|
|
483 | (3) |
|
Graft-Versus-Leukemia in Acute Lymphoblastic Leukemia: Fact or Fiction |
|
|
486 | (2) |
|
Strategies to Augment Posttransplant Immune Activity |
|
|
488 | (1) |
|
|
|
489 | (8) |
|
Bone Marrow Transplantation for Acute Myeloid Leukemia in Children |
|
|
497 | (32) |
|
|
|
|
|
|
|
497 | (1) |
|
Risk Groups and Prognostic Factors |
|
|
498 | (3) |
|
|
|
501 | (5) |
|
Allogeneic Transplantation |
|
|
506 | (4) |
|
Autologous Transplantation |
|
|
510 | (3) |
|
|
|
513 | (1) |
|
Future Directions and Controversies |
|
|
514 | (4) |
|
|
|
518 | (11) |
|
Hematopoietic Stem-Cell Transplantation for Children with Hodgkin's and Non-Hodgkin's Lymphoma |
|
|
529 | (26) |
|
|
|
|
|
|
|
529 | (10) |
|
|
|
539 | (10) |
|
|
|
549 | (6) |
|
Hematopoietic Stem-Cell Transplantation for Pediatric Malignant Brain Tumors |
|
|
555 | (14) |
|
|
|
|
|
|
|
555 | (1) |
|
|
|
555 | (3) |
|
|
|
558 | (1) |
|
|
|
558 | (1) |
|
|
|
559 | (2) |
|
Other Primitive Neuroectodermal Tumors |
|
|
561 | (1) |
|
|
|
561 | (1) |
|
|
|
562 | (1) |
|
|
|
563 | (2) |
|
|
|
565 | (4) |
|
Hematopoietic Stem-Cell Transplantation for Pediatric Solid Tumors |
|
|
569 | (20) |
|
|
|
|
|
Ewing's Sarcoma/Peripheral Primitive Neuroectodermal Tumors |
|
|
569 | (7) |
|
|
|
576 | (2) |
|
|
|
578 | (1) |
|
|
|
579 | (1) |
|
|
|
580 | (1) |
|
Extracranial Germ Cell Tumors |
|
|
580 | (3) |
|
|
|
583 | (6) |
|
Stem-Cell Transplantation in Neuroblastoma |
|
|
589 | (12) |
|
|
|
|
|
589 | (1) |
|
Autologous Transplant in Neuroblastoma |
|
|
590 | (8) |
|
|
|
598 | (3) |
|
Appendix: A Brief Overview of Hematopoietic Stem-Cell Transplantation |
|
|
601 | (24) |
|
|
|
|
|
|
|
601 | (2) |
|
Pretransplant Considerations |
|
|
603 | (3) |
|
|
|
606 | (17) |
|
|
|
623 | (1) |
|
|
|
624 | (1) |
| Index |
|
625 | |
Daugiau apie elektronines knygas