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Pediatric Lymphomas 2007 ed. [Kietas viršelis]

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  • Formatas: Hardback, 292 pages, aukštis x plotis: 242x193 mm, weight: 794 g, 52 Illustrations, color; 4 Illustrations, black and white; XII, 292 p. 56 illus., 52 illus. in color., 1 Hardback
  • Serija: Pediatric Oncology
  • Išleidimo metai: 27-Nov-2006
  • Leidėjas: Springer-Verlag Berlin and Heidelberg GmbH & Co. K
  • ISBN-10: 3540203567
  • ISBN-13: 9783540203568
Kitos knygos pagal šią temą:
Pediatric Lymphomas 2007 ed.Didesnis paveikslėlis
  • Formatas: Hardback, 292 pages, aukštis x plotis: 242x193 mm, weight: 794 g, 52 Illustrations, color; 4 Illustrations, black and white; XII, 292 p. 56 illus., 52 illus. in color., 1 Hardback
  • Serija: Pediatric Oncology
  • Išleidimo metai: 27-Nov-2006
  • Leidėjas: Springer-Verlag Berlin and Heidelberg GmbH & Co. K
  • ISBN-10: 3540203567
  • ISBN-13: 9783540203568
Kitos knygos pagal šią temą:
Pastovi nuoroda: https://www.kriso.lt/db/9783540203568.html
Raktažodžiai:
The book covers the epidemiology, pathology, molecular biology, clinical features, diagnosis, and treatment of Hodgkin and non-Hodgkin lymphomas in children and adolescents. It is a combined effort of investigators who are leaders in the field of childhood lymphomas. Introductory chapters on Hodgkin and non-Hodgkin lymphomas in children provide a concise historical overview. All chapters have a standalone structure and those regarding the individual subtypes of lymphomas provide up-to-date results of recent clinical trials and practical guidelines for work-up and treatment. The pathology chapters are comprehensive and include excellent photographs as well as detailed review of the scientific advances pertaining to the molecular pathogenesis of each type of malignant lymphoma seen in childhood. There is also a concise chapter on post-transplant lymphoproliferative disease and lymphomas associated with congenital and acquired immunodeficiency states. The book is at the level of subspecialists in pediatric hematology and oncology, radiation oncology, pediatric surgery and hematopathology.

This is a comprehensive textbook of Hodgkin's and non-Hodgkin's lymphomas written by leaders in the field of childhood lymphomas. It includes clinical, pathologic and molecular biology of each subtype of lymphoma. The pathology chapters are comprehensive and include excellent photographs. The book is at the level of subspecialists in pediatric hematology and oncology, radiation oncology, pediatric surgery and hematopathology.

Recenzijos

From the reviews:









"This slim book contains nearly everything a practicing oncologist needs to know about the pathogenesis, diagnosis, therapy, and delayed complications of pediatric lymphomas. Overall, this book is an exceptional, highly accessible resource for oncologists or anyone caring for children and adolescents who are receiving treatment for lymphoma or are in long-term follow-up. The general principles and the specific pearls, tables, and figures are illuminating and helpful for all who are interested in understanding pediatric lymphomas." (Leslie S. Kersun and Beverly J. Lange, The New England Journal of Medicine, July, 2007)



"This book covers the epidemiology, pathology, molecular biology, clinical features, diagnosis, and treatment of Hodgkin and non-Hodgkin lymphomas in children and adolescents. it is written at a level most appropriate for pediatric oncologists and perhaps, hematopathologists. it might be added to libraries as a reference for pediatricians in-training to use when they manage these patients. The quality of this book is excellent . It will be an important quick read for pediatric oncologists to prepare for their boards or recertification." (Russell Steele, Doody's Book Reviews, October, 2007)



"This is a multicenter treatise reviewing updated knowledge on the genetics, diagnosis, treatment and sequelae of lymphomas in childhood. The book is divided into 12 chapters . Clearly written, with many illustrations and tables in color, and extensive references after each chapter. For pediatric oncologists and general pediatricians." (Pediatric Endocrinology Reviews, Vol. 5 (3), March, 2008)

Introduction and Historical Background: Pediatric Hodgkin Lymphoma
S.S. Donaldson
The Way It Was
1(2)
Lessons from the Children
3(1)
The Hidden Secrets -- The Discovery of Late Effects
3(1)
Current Optimal Management
4(3)
References
4(3)
Biology and Pathology of Hodgkin's Disease
R.E. Hutchinson
A. Uner
History of Hodgkin's Disease Pathologic Classification
7(2)
Lineage of Hodgkin Reed-Sternberg cells; B-cell phenotype
9(1)
Some Evidence of Antigen-Presenting Function
10(1)
Apoptosis
10(1)
NF-kappaB
11(1)
Jak/Stat Pathways
12(1)
Tumor Necrosis Factor Receptor (TNFR) Family
12(1)
Tumor Necrosis Factor Receptor-Associated Factors (TRAFs)
12(1)
Cytokines and Chemokines
13(1)
Cytogenetics
14(1)
Gene Profile
14(1)
Association with EBV
14(2)
Pathology of Classical Hodgkin Lymphoma
16(1)
Immunophenotype of Classical HRS cells
17(1)
Flow Cytometry
18(1)
Histologic Classification of CHL
19(3)
Nodular Sclerosis HL
19(1)
Mixed Cellularity HL
20(1)
Nodular Lymphocyte Rich CHL
21(1)
Lymphocyte Depleted HL
22(1)
Nodular Lymphocyte Predominant Hodgkin Lymphoma (NLPHL)
22(1)
Hodgkin Lymphoma in the Setting of HIV Infection
23(1)
Bone Marrow Involvement and Histologic Staging
23(1)
Pathology of Relapse and Second Malignancy
24(1)
Differential Diagnosis of HL
25(10)
References
27(8)
Treatment of Pediatric Hodgkin Lymphoma
M.M. Hudson
C. Schwartz
L.S. Constine
Introduction
35(1)
Clinical Presentation
36(3)
Systemic Symptoms
37(1)
Laboratory Evaluation
37(1)
Immunologic Status
38(1)
Differential Diagnosis
39(1)
Diagnostic Evaluation and Staging
40(3)
Prognostic Factors
43(2)
Combination Chemotherapy
45(4)
Chemotherapy Alone Versus Combined Modality Therapy
49(2)
Risk-Adapted Therapy
51(3)
Treatment of Low-Risk Disease
51(2)
Treatment of Intermediate- and High-Risk Disease
53(1)
Principles of Radiation Therapy
54(5)
Volume Considerations
56(2)
Dose Considerations
58(1)
Energy
59(1)
Summary Recommendations for Primary Disease/Selection of Therapy
59(1)
Acute Effects of Therapy
59(2)
Chemotherapy Side-Effects
59(2)
Radiation Side-Effects
61(1)
Future Directions
61(6)
References
61(6)
Treatment of Relapsed/Refractory Hodgkin Lymphoma
T.M. Trippett
A. Chen
Introduction
67(1)
Strategies for Re-induction
67(3)
Role of Re-induction Chemotherapy
68(1)
Standard Re-induction with ICE
68(1)
Re-induction with Ifosfamide/Vinorelbine (IV)
69(1)
High-Dose Therapy
70(2)
Immunomodulation as a Therapeutic Strategy to Augment High-Dose Therapy
71(1)
Reduced-Intensity/Non-myeloablative Allogeneic Stem cell Transplantation
72(1)
Salvage Strategies Following Transplantation
72(7)
Combination Chemotherapy with Gemcitabine/Vinorelbine (GEM/VRB)
73(1)
Molecular Targeting of the NF-kB Pathway
74(1)
Activation of NF-kB
74(1)
Inhibition of NF-kB Through Proteasome Inhibition
75(1)
Adult Clinical Trials
76(1)
Pediatric Clinical Trials
77(1)
Novel Retrieval Strategies Incorporating Proteasome Inhibition with Bortezomib
77(1)
Targeted Immunotherapy Strategies
77(1)
Epstein-Barr Virus Directed Therapy
77(1)
Monoclonal Antibodies Targeting Receptors Expressed in HL
78(1)
Radiolabeled Immunoglobulin Therapy in HL
79(1)
Future Considerations
79(6)
References
79(6)
Non-Hodgkin's Lymphoma: Introduction and Historical Background
S.B. Murphy
Introduction
85(1)
The Early Era, Pre-1970
86(1)
The Latter Era, Post-1970s
86(5)
References
88(3)
Biology and Pathology of Pediatric Non-Hodgkin Lymphoma
S.L. Perkins
S.W. Morris
Introduction
91(1)
Non-Hodgkin Lymphoma
91(2)
Pathologic Analysis
93(8)
Morphology
93(1)
Immunophenotypic Analysis
94(1)
Molecular and Cytogenetic Analysis
95(5)
WHO Classification of Hematolymphoid Tumors
100(1)
Molecular Pathogenesis of Pediatric NHL
101(1)
Burkitt Lymphomas
101(6)
Pathology
101(3)
Biology and Molecular Mechanisms
104(3)
Diffuse Large B-Cell Lymphomas
107(5)
Pathology
107(2)
Biology and Molecular Mechanisms
109(3)
Anaplastic Large-Cell Lymphoma
112(7)
Pathology
112(5)
Biology and Molecular Mechanisms
117(2)
Lymphoblastic Lymphoma
119(23)
Pathology
119(2)
Biology and Molecular Mechanisms
121(6)
References
127(15)
B-Cell Lymphoma/Burkitt Lymphoma
I. Magrath
Introduction
142(1)
Diagnosis and Imaging
142(4)
Burkitt Lymphoma
142(1)
Diffuse Large B-cell Lymphoma
143(1)
Burkitt-like Lymphoma
144(1)
HIV-Associated B-cell Lymphomas
144(1)
Imaging Studies
144(2)
Clinical Features
146(2)
Staging
148(3)
Staging Procedures
150(1)
Treatment
151(12)
Early Studies in Africa
151(1)
Non-Cross-Resistant Drugs and Combination Therapy
152(2)
Therapy Directed Towards CNS Disease
154(1)
Early Studies in the USA
154(1)
Comparison with Leukemia Treatment
155(1)
Critical Components of Modern Treatment Protocols
155(1)
Basic Drugs
155(1)
High-Dose MTX
156(1)
The Role of Additional Drugs
156(1)
Dose Density
157(1)
Risk Adaptation
157(2)
Prevention of CNS Disease
159(1)
Treatment of DLBCL with Different Regimens
160(1)
Role of Surgery
160(1)
Role of Radiation
161(1)
Tumor Lysis Syndrome
162(1)
Prognostic Factors
163(2)
Tumor Burden and Stage
163(1)
Rapidity of Response
164(1)
Age and Sex
164(1)
Histology
164(1)
Molecular Characteristics
165(1)
Outcome
165(1)
Management of Relapse
166(1)
Follicle Center Cell and Marginal Zone Lymphomas
167(1)
Future Prospects
167(8)
References
168(7)
Anaplastic Large-Cell Lymphoma
A. Reiter
Introduction
175(2)
Diagnosis and Imaging
177(1)
Clinical Features
178(3)
Staging
181(1)
Treatment and Outcome
181(6)
Stratification of Treatment Intensity
185(1)
CNS Prophylaxis and CNS Therapy
185(1)
Role of Local Therapy Modalities and Pattern of Therapy Failure
186(1)
Prognostic Factors
187(2)
Management of Relapse
189(1)
Future Prospects
190(9)
References
192(7)
Precursor B and Precursor T-Cell Lymphoblastic Lymphoma
J.T. Sandlund
Introduction
199(1)
Diagnosis and Imaging
199(3)
Diagnosis
199(2)
Imaging/Staging
201(1)
Clinical Features
202(1)
Treatment
202(6)
Initial Management
202(1)
Treatment Overview
203(1)
Limited Stage Disease
203(1)
Advanced Stage Disease
204(1)
Central Nervous System Prophylaxis and Treatment
205(3)
Prognostic Factors
208(1)
Outcome
208(1)
Management of Relapse
208(1)
Future Prospects
208(7)
References
210(5)
Cutaneous T-Cell Lymphomas and Rare T-Cell Non-Hodgkin Lymphomas
M.E. Kadin
Introduction
215(1)
Mycosis Fungoides and Sezary Syndrome
216(5)
Clinical Features
216(1)
Pathology
217(1)
Immunophenotype
218(1)
Genetic Features
218(1)
Prognosis
219(1)
Therapy
220(1)
CD30+ Cutaneous T-Cell Lymphomas Including Lymphomatoid Papulosis
221(1)
Lymphomatoid Papulosis
221(3)
Clinical Features
221(1)
Pathology
222(1)
Immunophenotype
223(1)
Genetic Features
223(1)
Prognosis
223(1)
Primary Cutaneous Anaplastic Large-cell Lymphoma
224(1)
Clinical Features
224(1)
Pathology
224(1)
Differential Diagnosis
224(1)
Immunophenotype
225(1)
Genetic Features
225(1)
Therapy
225(1)
Subcutaneous Panniculitis-like T-Cell Lymphoma
225(2)
Clinical Features
226(1)
Pathology
226(1)
Immunophenotype
226(1)
Genetic Features
227(1)
Therapy
227(1)
Hepatosplenic T-Cell Lymphoma
227(6)
Clinical Features
227(1)
Pathology
227(1)
Immunophenotype
227(1)
Genetic Features
227(1)
Therapy
228(1)
References
228(5)
Lymphoproliferative Disorders Related to Immunodeficiencies
T.G. Gross
B. Shiramizu
Introduction
233(1)
Epstein-Barr Virus
234(2)
Post-transplant Lymphoproliferative Disease
236(6)
PTLD Following Blood or Marrow Transplantation
239(1)
PTLD Following Solid Organ Transplantation
240(2)
HIV-Related Malignancies
242(4)
Lymphoproliferative Disease in Primary Immunodeficiencies
246(4)
Summary
250(9)
References
250(9)
Late Effects Following Lymphoma Treatment
D.L. Friedman
A.T. Meadows
Introduction
259(1)
Second Malignant Neoplasms
260(1)
Neurocognitive
261(1)
Cardiovascular
261(2)
Pulmonary
263(1)
Bone and Body Composition
264(1)
Endocrine
264(1)
Thyroid Gland
264(1)
Reproductive Endocrine
265(2)
Male Gonadal Function
265(1)
Female Gonadal Function
265(1)
Reproduction
266(1)
Dental
267(1)
Spleen
267(1)
Psychosocial
268(1)
Mortality
268(1)
Monitoring for Late Effects
269(1)
Research Challenges for Lymphoma Survivors
269(4)
Future Directions
273(8)
References
274(7)
Subject Index 281