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xv | |
Biographies |
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xix | |
Foreword |
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xxi | |
Preface |
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xxxv | |
Acknowledgments |
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xxxvii | |
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1 Pharmaceuticals and personal care product (PPCP) contamination---a global discharge inventory |
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1 | (26) |
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1 | (3) |
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1.1.1 Water, pollution, and the world |
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1 | (1) |
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1.1.2 Emerging contaminants in the environment |
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2 | (1) |
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1.1.3 Pharmaceuticals and personal care products |
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3 | (1) |
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1.2 What are pharmaceuticals and personal care products? |
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4 | (9) |
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1.2.1 Pharmaceuticals and personal care products: widest category of emerging contaminants |
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4 | (2) |
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1.2.2 Categorization of pharmaceuticals and personal care products |
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6 | (4) |
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1.2.3 Sources, pathways, and occurrences |
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10 | (3) |
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1.3 Environmental studies and impact of pharmaceuticals and personal care products |
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13 | (5) |
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1.3.1 Environmental risks with pharmaceuticals and personal care products |
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13 | (3) |
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1.3.2 Treatment of pharmaceuticals and personal care products |
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16 | (2) |
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1.4 Global research and prospects |
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18 | (1) |
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19 | (8) |
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20 | (7) |
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2 Pharmaceutical and personal care product contamination: a global scenario |
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27 | (36) |
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27 | (1) |
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2.2 Distribution of pharmaceutical and personal care products in the environment |
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28 | (35) |
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28 | (11) |
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39 | (3) |
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42 | (3) |
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45 | (1) |
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45 | (1) |
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2.2.6 Australia and New Zealand |
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46 | (1) |
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46 | (1) |
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2.2.8 Impact of pharmaceutical and personal care products on health of aquatic organisms |
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47 | (4) |
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51 | (1) |
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51 | (1) |
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51 | (10) |
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61 | (2) |
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3 Pharmaceuticals and personal care products in aquatic environment: chemicals of emerging concern? |
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63 | (24) |
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63 | (7) |
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3.1.1 Definition and classification |
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63 | (2) |
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3.1.2 Sources of pharmaceuticals and personal care products in aquatic environment |
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65 | (1) |
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3.1.3 Environmental pathways, fate, and persistence in aquatic environment |
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65 | (2) |
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3.1.4 Ecotoxicological profile and impact |
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67 | (3) |
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70 | (6) |
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70 | (1) |
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3.2.2 Water treatment systems: removal efficiency for pharmaceuticals and personal care products |
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71 | (4) |
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75 | (1) |
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3.3 Regulatory status: global perspective |
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76 | (11) |
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78 | (7) |
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85 | (2) |
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4 Uptake and accumulation of pharmaceuticals and personal care products in leafy vegetables |
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87 | (28) |
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87 | (1) |
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4.2 Modes of pharmaceuticals and personal care product contamination of leafy vegetables |
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88 | (2) |
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4.2.1 Application of amended biosolids |
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88 | (1) |
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4.2.2 Use of reclaimed water for irrigation |
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89 | (1) |
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4.3 Common pharmaceuticals and personal care products in leafy vegetables |
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90 | (6) |
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90 | (1) |
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4.3.2 Personal care products |
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91 | (5) |
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4.4 Factors influencing uptake of pharmaceuticals and personal care products |
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96 | (2) |
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4.4.1 Soil organic matter |
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96 | (1) |
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96 | (1) |
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4.4.3 Source of pharmaceuticals and personal care products |
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96 | (1) |
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4.4.4 Chemical hydrophobicity |
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96 | (1) |
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4.4.5 Molecular ionization |
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97 | (1) |
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4.4.6 Plant lipid content |
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97 | (1) |
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98 | (1) |
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4.5 Determining accumulation of PPCPs in different plant tissues |
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98 | (3) |
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4.5.1 Bioconcentration factor/Bioaccumulation factor |
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98 | (1) |
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4.5.2 Translocation factor |
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99 | (2) |
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4.6 Human exposure implications of pharmaceuticals and personal care products in leafy vegetables |
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101 | (2) |
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4.6.1 Average daily consumption |
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101 | (1) |
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101 | (1) |
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4.6.3 Lowest observable effect concentration |
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102 | (1) |
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103 | (1) |
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103 | (12) |
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107 | (8) |
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5 Health effects of pharmaceuticals and personal care products |
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115 | (14) |
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115 | (1) |
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5.2 Defining nanomaterials |
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116 | (1) |
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5.3 Classification of pharmaceuticals and personal care products |
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117 | (1) |
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5.4 Methods to detect cytotoxicity of pharmaceuticals and personal care product components |
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118 | (5) |
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5.4.1 3-(4, 5-Dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide assays |
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118 | (1) |
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5.4.2 Cytotoxicity assays |
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118 | (1) |
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5.4.3 Cell viability assays |
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119 | (1) |
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5.4.4 Mitotoxicity assays |
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119 | (1) |
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5.4.5 Lipotoxicity assays |
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120 | (1) |
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5.4.6 Genotoxicity assays |
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120 | (1) |
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5.4.7 Cytotoxicity assays |
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120 | (3) |
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5.5 Modern nanotechnology and biotechnology methods developed in determining toxicity of pharmaceuticals and personal care product components |
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123 | (1) |
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5.6 Alternatively, computational screening approaches |
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124 | (1) |
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5.6.1 In silico methodologies |
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124 | (1) |
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124 | (5) |
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125 | (1) |
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125 | (1) |
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126 | (3) |
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6 Treatment methods for removal of pharmaceuticals and personal care products from domestic wastewater |
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129 | (22) |
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129 | (1) |
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130 | (10) |
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6.2.1 Conventional treatment methods |
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130 | (3) |
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133 | (7) |
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6.3 Conclusion and future prospects |
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140 | (11) |
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141 | (9) |
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150 | (1) |
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7 Removal of pharmaceuticals and personal care products by ozonation, advance oxidation processes, and membrane separation |
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151 | (22) |
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7.1 Removal of pharmaceuticals and personal care products by ozonation, advanced oxidation, and membrane separation |
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151 | (14) |
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7.1.1 Classification of pharmaceuticals and personal care products |
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152 | (2) |
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7.1.2 Sources and fate of pharmaceuticals and personal care products in the environment |
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154 | (4) |
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7.1.3 Removal of pharmaceutical and personal care products by advanced oxidation processes |
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158 | (4) |
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7.1.4 Removal of pharmaceutical and personal care products by membrane separation |
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162 | (3) |
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165 | (8) |
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166 | (7) |
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8 Removal of pharmaceutical and personal care products from wastewater using advanced materials |
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173 | (40) |
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173 | (1) |
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8.2 Environmental risk of pharmaceuticals and personal care products |
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174 | (1) |
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8.3 Environmental fate and behavior of pharmaceuticals and personal care products |
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174 | (2) |
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8.4 Challenges presented by pharmaceuticals and personal care products in wastewater treatment |
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176 | (1) |
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8.5 Pharmaceuticals and personal care product removal technologies |
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176 | (13) |
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8.5.1 Primary and secondary treatment |
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177 | (3) |
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180 | (1) |
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8.5.3 Separation technologies |
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180 | (1) |
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8.5.4 Natural or passive treatment technologies |
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181 | (1) |
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182 | (1) |
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8.5.6 Advanced oxidation processes |
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183 | (5) |
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188 | (1) |
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8.6 Advanced materials for pharmaceuticals and personal care product removal |
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189 | (14) |
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8.6.1 Advanced materials for adsorption |
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189 | (10) |
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8.6.2 Advanced materials for advanced oxidation processes |
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199 | (4) |
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203 | (10) |
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203 | (10) |
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9 Sorptive removal of pharmaceutical and personal care products from water and wastewater |
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213 | (26) |
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Anushka Upamali Rajapaksha |
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Kadupitige Shashikala Dilrukshi Premarathna |
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213 | (2) |
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9.2 Technologies available for pharmaceutical and personal care products removal |
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215 | (1) |
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9.3 Pharmaceutical and personal care products removal using commercial activated carbons |
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216 | (1) |
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9.4 Nonconventional low-cost sorbents for the removal of pharmaceutical and personal care products |
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217 | (6) |
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9.4.1 Agricultural solid waste |
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217 | (2) |
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9.4.2 Industrial by-products |
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219 | (1) |
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9.4.3 Natural clay minerals |
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220 | (1) |
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221 | (1) |
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222 | (1) |
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9.5 Biochar and engineered/design biochar for pharmaceutical and personal care products removal |
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223 | (7) |
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9.5.1 Use of engineered design biochar for the removal of pharmaceutical and personal care product |
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224 | (3) |
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9.5.2 Adsorption mechanisms of pharmaceutical and personal care products by biochar/engineered biochar |
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227 | (3) |
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9.6 Environmental factors influence for sorptive removal |
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230 | (1) |
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9.7 Conclusions and future perspectives |
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231 | (8) |
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232 | (7) |
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10 Analytical techniques and challenges for removal of pharmaceuticals and personal care products in water |
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239 | (20) |
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10.1 Analytical techniques |
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239 | (6) |
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10.1.1 Sample preparation techniques |
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240 | (3) |
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10.1.2 Quantitative analysis |
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243 | (2) |
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10.2 Removal of pharmaceuticals and personal care products from water |
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245 | (14) |
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10.2.1 Removal of pharmaceuticals and personal care products in conventional treatment plant |
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245 | (2) |
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10.2.2 Advanced control strategies to remove pharmaceuticals and personal care products |
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247 | (4) |
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251 | (6) |
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257 | (2) |
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11 Microbial degradation of xenobiotics like aromatic pollutants from the terrestrial environments |
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259 | (20) |
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259 | (1) |
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11.2 Microbial degradation of aromatic compounds |
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260 | (1) |
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11.3 Enzymes involved in the biodegradation of aromatic compounds |
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261 | (2) |
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261 | (1) |
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261 | (1) |
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261 | (2) |
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263 | (1) |
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263 | (1) |
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11.4 Aromatic pollutants in the environment and their metabolism |
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263 | (8) |
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263 | (1) |
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264 | (2) |
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266 | (2) |
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268 | (1) |
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268 | (3) |
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11.5 Applications and future directions |
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271 | (1) |
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272 | (7) |
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273 | (6) |
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12 Nanotechnology applications for the removal of environmental contaminants from pharmaceuticals and personal care products |
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279 | (18) |
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279 | (1) |
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12.2 Nanotechnology-based methods for the removal of environmental contaminants from PPCPs |
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280 | (9) |
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12.2.1 Nanomaterial-based absorptive techniques |
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280 | (3) |
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283 | (1) |
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12.2.3 Nanofiltration techniques |
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284 | (5) |
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12.3 Concluding remarks and future implications |
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289 | (8) |
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289 | (6) |
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295 | (2) |
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13 Plant-based technologies for removal of pharmaceuticals and personal care products |
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297 | (24) |
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297 | (1) |
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13.2 Pharmaceuticals and personal care products: what it means |
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298 | (4) |
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300 | (1) |
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300 | (1) |
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301 | (1) |
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13.2.4 Sodium lauryl sulfate and sodium laureth sulfate |
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301 | (1) |
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13.2.5 Polyethylene glycol |
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302 | (1) |
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13.3 Pharmaceuticals in the aquatic environment |
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302 | (4) |
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13.4 Threats caused by the presence of pharmaceuticals and personal care products in the environment |
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306 | (1) |
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13.5 Removal of pharmaceuticals from water and sewage |
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307 | (2) |
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13.6 Legal regulations regarding pharmaceutical substances in the environment |
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309 | (5) |
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13.6.1 Legal regulations in Europe |
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309 | (3) |
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13.6.2 Legal regulations in the world |
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312 | (2) |
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13.7 Removal of impurities by hydrobotanic methods |
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314 | (2) |
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316 | (5) |
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316 | (3) |
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319 | (2) |
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14 Removal of pharmaceuticals and personal care products by aquatic plants |
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321 | (20) |
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321 | (3) |
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14.2 Uptake and accumulation of pharmaceuticals and personal care products by aquatic plants |
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324 | (2) |
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14.3 Degradation of pharmaceuticals and personal care products in plants |
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326 | (2) |
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14.4 Constructed wetlands |
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328 | (2) |
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330 | (11) |
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330 | (11) |
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15 The role of microorganisms in the removal of pharmaceutical and personal care products |
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341 | (42) |
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15.1 Biological sorption of typical pharmaceutical and personal care products |
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342 | (21) |
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15.1.1 Biological sorption of pharmaceutical and personal care products |
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342 | (18) |
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15.1.2 Factors affecting sorption of pharmaceutical and personal care products |
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360 | (3) |
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15.2 Transmembrane mechanisms of pharmaceutical and personal care products |
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363 | (5) |
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15.2.1 Theoretical transmembrane flux |
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363 | (2) |
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15.2.2 Transmembrane route |
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365 | (3) |
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15.3 Biotransformation of pharmaceutical and personal care products |
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368 | (8) |
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15.3.1 Typical degrading strains, related enzymes and pathways of typical pharmaceutical and personal care products |
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368 | (4) |
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372 | (4) |
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376 | (7) |
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376 | (6) |
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382 | (1) |
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16 Development of antimicrobial resistance: future challenges |
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383 | (26) |
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Samantha M. Meza-Rodriguez |
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383 | (1) |
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16.2 History of antibiotics |
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384 | (1) |
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16.3 Development of antibiotic resistance |
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385 | (1) |
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16.4 Mechanisms of resistance |
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386 | (2) |
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16.5 Spread of antimicrobial resistance |
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388 | (3) |
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16.5.1 Conjugation, transformation, and transduction |
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388 | (2) |
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16.5.2 Mobile genetic elements |
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390 | (1) |
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391 | (3) |
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16.7 Antimicrobial resistance in the environment |
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394 | (1) |
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16.8 New therapeutic approaches |
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395 | (1) |
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396 | (3) |
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16.10 Signaling inhibitors |
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399 | (1) |
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16.11 Antimicrobial peptides |
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399 | (1) |
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16.12 Antibodies to treat infections |
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400 | (1) |
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400 | (9) |
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401 | (1) |
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402 | (7) |
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17 Pharmaceuticals and personal care products mediated antimicrobial resistance: future challenges |
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409 | (20) |
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409 | (2) |
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17.1.1 What are pharmaceuticals and personal care products? |
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410 | (1) |
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17.2 Types and source of pharmaceuticals and personal care products |
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411 | (8) |
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17.2.1 Cross-reactivity of pharmaceuticals and personal care products mediating antimicrobial resistance |
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414 | (1) |
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17.2.2 Status of antibiotic resistance in India |
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415 | (2) |
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17.2.3 Dissemination of antimicrobial resistance in diverse niche through biological route |
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417 | (2) |
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419 | (10) |
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17.3.1 Implementation of policy/laws for the judicious use of antibiotics |
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419 | (1) |
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17.3.2 Development of vaccine against deadly disease |
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419 | (2) |
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17.3.3 Application of microbial intelligence for combating antibiotic resistance |
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421 | (1) |
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17.3.4 Discovery of new antimicrobials compounds as therapeutics |
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421 | (2) |
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423 | (1) |
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424 | (5) |
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18 Antibiotics induced antibacterial resistance |
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429 | (20) |
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18.2 Sources and contamination status of antibiotics |
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430 | (1) |
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430 | (1) |
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18.3 Antibiotics in agriculture (aquaculture, animal farms, veterinary clinics) |
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431 | (2) |
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18.4 Metabolism of antibiotic compounds |
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433 | (1) |
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18.5 Major pathways of environmental contamination of antibiotics |
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434 | (3) |
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18.6 Development of antibiotic resistance |
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437 | (1) |
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18.7 Mechanisms of antibiotic resistance |
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438 | (1) |
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18.8 The changes that occur in the receptor that are connected to the drug |
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438 | (1) |
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18.9 Enzymatic inactivation of antibiotics |
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439 | (1) |
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18.10 Reduction of the inner and outer membrane permeability |
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439 | (1) |
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18.11 Flush out of the drug (active pump system) |
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439 | (1) |
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18.12 Using an alternative metabolic pathway |
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439 | (1) |
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18.13 Transfer of resistance genes |
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439 | (1) |
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18.14 Multidrug resistance in bacteria |
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440 | (1) |
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18.15 Risk of antibiotic resistance for human and animal health |
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440 | (1) |
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18.16 Bioremediation of antibiotic as a green solution |
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441 | (1) |
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18.17 Future challenges in aquaculture, livestock, and human health due to antibacterial resistance |
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442 | (7) |
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444 | (5) |
Index |
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449 | |