Abbreviations |
|
xv | |
Drug nomenclature |
|
xviii | |
|
Fate of a drug in the body |
|
|
|
|
3 | (1) |
|
|
3 | (1) |
|
The movement of drugs across cell membranes |
|
|
4 | (1) |
|
Drug absorption and routes of administration |
|
|
5 | (4) |
|
|
9 | (1) |
|
|
9 | (2) |
|
Drug metabolism (biotransformation) |
|
|
11 | (3) |
|
|
14 | (2) |
|
|
16 | (4) |
|
|
20 | (1) |
|
|
20 | (3) |
|
Mechanisms of drug action: pharmacodynamics |
|
|
|
|
23 | (1) |
|
|
23 | (6) |
|
Drug targets other than receptors |
|
|
29 | (1) |
|
Agonist concentration-response curves |
|
|
30 | (2) |
|
|
32 | (2) |
|
|
34 | (1) |
|
Therapeutic index (ratio) |
|
|
34 | (1) |
|
|
34 | (1) |
|
|
35 | (4) |
|
|
|
|
39 | (2) |
|
Some factors influencing prescribing |
|
|
41 | (1) |
|
Standard reference books and data sheets |
|
|
42 | (2) |
|
The Misuse of Drugs Act, 1971 |
|
|
44 | (2) |
|
Selected list regulations (NHS Act, 1977) |
|
|
46 | (1) |
|
|
46 | (3) |
|
Pharmacology of inflammation and immunopharmacology |
|
|
|
Chemical mediators of inflammation |
|
|
49 | (6) |
|
|
55 | (1) |
|
5-HT agonists/antagonists |
|
|
56 | (1) |
|
|
56 | (2) |
|
|
58 | (3) |
|
|
61 | (2) |
|
|
63 | (4) |
|
|
|
Neuroanatomy of pain: nociceptive pathways |
|
|
67 | (4) |
|
Neuroanatomy of dental pain |
|
|
71 | (2) |
|
|
73 | (3) |
|
Peripheral mediators of pain |
|
|
76 | (1) |
|
Central mediators of pain |
|
|
77 | (5) |
|
Central processing of pain and its control by therapeutic agents |
|
|
82 | (1) |
|
|
83 | (2) |
|
Rational treatment of dental pain |
|
|
85 | (1) |
|
Future developments in analgesia |
|
|
85 | (1) |
|
|
85 | (1) |
|
|
86 | (3) |
|
Aspirin, other non-steroidal anti-inflammatory drugs, and paracetamol |
|
|
|
|
89 | (3) |
|
|
92 | (1) |
|
|
93 | (1) |
|
|
94 | (3) |
|
|
|
Opioids and opioid antagonists |
|
|
97 | (4) |
|
Use of opioids in dentistry |
|
|
101 | (1) |
|
|
102 | (3) |
|
Local anaesthetics (local analgesics) and vasoconstrictors) |
|
|
|
|
105 | (3) |
|
Pharmacological actions of local anaesthetics |
|
|
108 | (5) |
|
Ester-type local anaesthetics |
|
|
113 | (1) |
|
Amide-type local anaesthetics |
|
|
114 | (3) |
|
|
117 | (2) |
|
Other constituents of dental local anaesthetic solutions |
|
|
119 | (1) |
|
Unwanted effects of dental local anesthesia |
|
|
120 | (4) |
|
|
124 | (3) |
|
General anaesthesia and sedation |
|
|
|
|
127 | (10) |
|
|
137 | (4) |
|
Recommendations on general anaesthesia and sedation in dentistry |
|
|
141 | (1) |
|
|
141 | (1) |
|
|
141 | (4) |
|
Antiseptics and disinfectants |
|
|
|
|
145 | (1) |
|
Mechanism of action of antiseptics and disinfectants |
|
|
145 | (1) |
|
Individual antiseptics and disinfectants |
|
|
145 | (3) |
|
|
148 | (1) |
|
|
149 | (1) |
|
|
149 | (4) |
|
Antimicrobial chemotherapy |
|
|
|
|
153 | (18) |
|
|
171 | (2) |
|
|
173 | (3) |
|
|
176 | (1) |
|
|
176 | (3) |
|
Pharmacological control of dental caries and periodontal disease |
|
|
|
|
179 | (3) |
|
|
182 | (13) |
|
|
195 | (1) |
|
|
196 | (3) |
|
Haemostasis and haemostatic agents |
|
|
|
|
199 | (2) |
|
|
201 | (2) |
|
|
203 | (1) |
|
Fibrinolytic and antifibrinolytic agents |
|
|
204 | (1) |
|
Dental management of patients with haemostatic problems |
|
|
205 | (1) |
|
The management of postextraction haemorrhage |
|
|
206 | (1) |
|
|
206 | (3) |
|
Drugs and the autonomic nervous system |
|
|
|
|
209 | (1) |
|
Parasympathetic and sympathetic nervous systems |
|
|
210 | (2) |
|
|
212 | (3) |
|
Noradrenergic transmission |
|
|
215 | (5) |
|
|
220 | (3) |
|
Drugs and the central nervous system |
|
|
|
Psychoses and neuroleptic drugs |
|
|
223 | (32) |
|
Depression and antidepressants |
|
|
255 | |
|
Parkinson's disease and its drug treatment |
|
|
229 | (2) |
|
Hypnotics and anxiolytics |
|
|
231 | (4) |
|
Epilepsy, facial neuralgias, and anticonvulsants |
|
|
235 | (5) |
|
|
240 | (1) |
|
|
241 | (4) |
|
Drugs used in the treatment of cardiovascular disease |
|
|
|
|
245 | (6) |
|
|
251 | (2) |
|
Heart (myocardial) failure |
|
|
253 | (4) |
|
|
257 | (1) |
|
|
257 | (5) |
|
|
262 | (3) |
|
Drugs acting on the respiratory system |
|
|
|
Regulation of the airway glands and smooth muscle |
|
|
265 | (1) |
|
|
265 | (3) |
|
|
268 | (1) |
|
|
269 | (1) |
|
Cough suppressants (antitussives) |
|
|
269 | (1) |
|
|
269 | (4) |
|
Drugs and the gastrointestinal tract |
|
|
|
The control of gastric acid secretion |
|
|
273 | (1) |
|
Inhibitors of gastric acid secretion |
|
|
274 | (1) |
|
|
275 | (1) |
|
Agents that protect the mucosa |
|
|
275 | (1) |
|
Eradication of Helicobacter pylori |
|
|
275 | (1) |
|
Gastroesophageal reflux disease |
|
|
276 | (1) |
|
|
277 | (1) |
|
Drugs used for the treatment of diarrhoea |
|
|
277 | (1) |
|
|
278 | (2) |
|
|
280 | (3) |
|
Chemotherapeutic agents in neoplastic disease |
|
|
|
|
283 | (1) |
|
Principles of chemotherapy |
|
|
283 | (1) |
|
Classification of chemotherapeutic agents |
|
|
283 | (1) |
|
Oral and dental problems associated with chemotherapy |
|
|
284 | (3) |
|
|
287 | (4) |
|
|
|
Posterior pituitary hormones |
|
|
291 | (1) |
|
Anterior pituitary hormones |
|
|
292 | (1) |
|
|
293 | (1) |
|
|
294 | (3) |
|
|
297 | (3) |
|
|
300 | (3) |
|
|
303 | (4) |
|
|
|
|
307 | (1) |
|
|
308 | (2) |
|
Vitamin C (ascorbic acid) |
|
|
310 | (1) |
|
|
310 | (1) |
|
|
310 | (1) |
|
|
310 | (1) |
|
|
311 | (4) |
|
|
|
|
315 | (1) |
|
|
316 | (1) |
|
|
316 | (2) |
|
Parathyroid hormone (PTH) |
|
|
318 | (1) |
|
|
319 | (1) |
|
|
319 | (1) |
|
|
319 | (4) |
|
|
|
|
323 | (6) |
|
Prevention of the unwanted effects of drugs |
|
|
329 | (1) |
|
|
330 | (2) |
|
|
332 | (1) |
|
|
332 | (3) |
|
Drug interactions (drug-drug interactions) |
|
|
|
Incidence and importance of drug interactions |
|
|
335 | (1) |
|
Classification of drug interactions |
|
|
335 | (2) |
|
|
337 | (3) |
|
|
340 | (5) |
|
Drug abuse and dental patients |
|
|
|
|
345 | (1) |
|
|
346 | (1) |
|
|
346 | (1) |
|
|
347 | (1) |
|
Central nervous system depressants |
|
|
347 | (1) |
|
Central nervous system stimulants |
|
|
348 | (1) |
|
Amfetamines (amphetamines) and Ecstasy |
|
|
348 | (1) |
|
|
349 | (1) |
|
|
349 | (1) |
|
Anabolic steroids and performance-enhancers |
|
|
349 | (1) |
|
|
350 | (1) |
|
|
350 | (3) |
|
Medical emergencies in dental practice |
|
|
|
|
353 | (1) |
|
Angina pectoris and myocardial infarction |
|
|
354 | (1) |
|
|
354 | (1) |
|
|
355 | (1) |
|
|
355 | (1) |
|
|
355 | (1) |
|
|
355 | (1) |
|
|
356 | (1) |
|
|
356 | (3) |
|
Treatments for common dental conditions |
|
|
|
|
359 | (1) |
|
|
359 | (1) |
|
|
359 | (1) |
|
|
359 | (1) |
|
|
360 | (1) |
|
|
360 | (1) |
|
|
360 | (1) |
|
|
360 | (1) |
|
Acute necrotizing ulcerative gingivitis (ANUG) |
|
|
361 | (1) |
|
Acute herpetic gingivostomatitis |
|
|
361 | (1) |
|
|
361 | (1) |
|
|
361 | (1) |
|
Postoperative dental pain |
|
|
361 | (1) |
|
Postoperative swelling and trismus |
|
|
362 | (1) |
|
Dry socket (alveolar osteitis) |
|
|
362 | (1) |
|
|
362 | (1) |
|
|
362 | (1) |
|
|
362 | (1) |
|
|
362 | (1) |
|
|
363 | (1) |
|
|
363 | (1) |
|
Recurrent aphthous ulceration |
|
|
363 | (1) |
|
Other types of oral ulceration |
|
|
363 | (1) |
|
|
363 | (2) |
Index |
|
365 | |