Describing recent developments in the engineering and generation of plants as production platforms for biopharmaceuticals, this book includes both vaccines and monoclonal antibodies. It has a particular emphasis on targeting diseases which predominate in less developed countries, encompassing the current state of technologies and describing expression systems and applications. This book also includes a variety of vaccine case studies, protecting against pervasive infectious diseases such as rabies, influenza and HIV.
1: Introduction, and the Promise of a Plant-derived Vaccine for
Hepatitis B Virus 2: Protein Body-inducing Fusions for Recombinant Protein
Production in Plants 3: Expression of Recombinant Proteins in Plant Cell
Culture 4: Plant-derived Monoclonal Antibodies as Human Biologics for
Infectious Disease and Cancer 5: Plant-produced Virus-like Particles 6:
Expression of the Capsid Protein of Human Papillomavirus in Plants as an
Alternative for the Production of Vaccines 7: Patenting of Plant-made
Recombinant Pharmaceuticals and Access in the Developing World 8: Case Study
1: Rabies 9: Case Study 2: Plant-made HIV Vaccines and Neutralizing
Antibodies 10: Case Study 3: The Search for a Plant-made Vaccine for Pandemic
Influenza Virus
Kathleen L Hefferon, Visiting scientist, University of Toronto, Canada
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