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ix | |
Editors' preface |
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xxi | |
PART I PHYSIOLOGY |
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3 | (22) |
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Raelene L. Kinlough-Rathbone |
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25 | (16) |
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Morphology and ultrastructure of platelets |
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41 | (29) |
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Platelet heterogeneity: physiology and pathological consequences |
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70 | (10) |
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Platelet membrane proteins as adhesion receptors |
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80 | (13) |
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Dynamics of the platelet cytoskeleton |
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93 | (11) |
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104 | (9) |
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Platelet receptors for thrombin |
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113 | (14) |
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127 | (13) |
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Platelet receptors: prostanoids |
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140 | (18) |
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Platelet receptors: collagen |
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158 | (21) |
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Platelet receptors: von Willebrand factor |
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179 | (9) |
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Platelet receptors: fibrinogen |
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188 | (16) |
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Platelet signalling: GTP-binding proteins |
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204 | (17) |
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Platelet phospholipases A2 |
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221 | (17) |
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Roles of phospholipase C and phospholipase D in receptor-mediated platelet activation |
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238 | (22) |
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Platelet signalling: calcium |
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260 | (12) |
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Platelet signalling: protein kinase C |
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272 | (9) |
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Platelet signalling: tyrosine kinases |
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281 | (9) |
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Platelet signalling: cAMP and cGMP |
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290 | (14) |
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304 | (15) |
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The platelet shape change |
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319 | (19) |
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Renata K. Polanowsa-Grabowska |
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338 | (19) |
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Raelene L. Kinlough-Rathbone |
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Amplification loops: release reaction |
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357 | (12) |
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Amplification loops: thromboxane generation |
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369 | (12) |
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Platelet procoagulant activities: the amplification loops between platelets and the plasmatic clotting system |
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381 | (12) |
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393 | (19) |
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Platelet-leukocyte interactions relevant to vascular damage and thrombosis |
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412 | (20) |
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Vascular control of platelet function |
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432 | (27) |
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PART II METHODOLOGY |
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In vitro assays for evaluating platelet function |
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459 | (12) |
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Monitoring antiplatelet therapy |
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471 | (14) |
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Flow cytometric analysis of platelet function |
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485 | (14) |
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Animal models of platelet-dependent thrombosis |
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499 | (16) |
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PART III PATHOLOGY |
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A Hemostasis |
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Hereditary thrombocytopenias |
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515 | (13) |
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Thrombocytopenias due to bone marrow disorders |
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528 | (14) |
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Immune-mediated thrombocytopenia |
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542 | (14) |
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Thrombocytopenia in childhood |
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556 | (13) |
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Alloimmune thrombocytopenia |
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569 | (15) |
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Drug-induced and drug-dependent immune thrombocytopenias |
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584 | (26) |
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Thrombotic thrombocytopenic purpura and hemolytic uremic syndrome |
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610 | (13) |
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Thrombocytosis and thrombocythemia |
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623 | (16) |
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Platelet adhesive protein |
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639 | (16) |
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Congenital disorders of platelet secretion |
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655 | (19) |
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Congenital platelet signal transduction defects |
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674 | (15) |
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Acquired platelet function defects |
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689 | (18) |
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Platelet storage and transfusion |
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707 | (20) |
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B Thrombosis |
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Pathophysiology of arterial thrombosis |
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727 | (11) |
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Platelets and atherosclerosis |
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738 | (15) |
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Platelet involvement in venous thrombosis and pulmonary embolism |
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753 | (7) |
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Gene regulation of platelet function |
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760 | (23) |
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C Non-hemostatic disorders |
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Platelets and bacterial infections |
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783 | (24) |
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Interactions of viruses and platelets and the inactivation of viruses in platelet concentrates prepared far transfusion |
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807 | (8) |
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815 | (9) |
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824 | (13) |
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Platelets and renal diseases |
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837 | (15) |
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Platelets and allergic diseases |
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852 | (17) |
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Platelet interactions with other cells related to inflammatory diseases |
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869 | (16) |
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Platelets and the preimplantation stage of embryo development |
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885 | (9) |
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Platelets in psychiatric and neurological disorders |
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894 | (13) |
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Platelets in inflammatory bowel disease |
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907 | (12) |
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PART IV PHARMACOLOGY |
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919 | (10) |
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Pharmacology of ticlopidine and clopidogrel |
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929 | (11) |
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Platelet membrane glycoprotein (GP) IIb-IIIa antagonists and acute arterial thrombosis |
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940 | (15) |
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Other antiplatelet agents |
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955 | (9) |
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Pharmacogenetics as a new antiplatelet strategy |
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964 | (14) |
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Cardiovascular gene therapy: implications for platelet vessel wall interactions |
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978 | (13) |
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Pharmacological modulation of the inflammatory actions of platelets |
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991 | (12) |
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PART V THERAPY |
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Design of trials to evaluate antiplatelet agents |
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1003 | (10) |
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Antiplatelet therapy in cardiology |
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1013 | (27) |
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Antiplatelet therapies in neurology |
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1040 | (15) |
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Antiplatelet treatment in peripheral vascular disease |
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1055 | (8) |
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Afterword Platelets: a personal story |
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1063 | (10) |
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Index |
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1073 | |