The first edition was published in 1972 as Tutorials in Postgraduate Haematology (William Heinemann); and the fifth edition was published in 2005. This sixth edition has four editors: A. Victor Hoffbrand (emeritus, University College London), Daniel Catovsky (emeritus, Institute of Cancer Research, UK), Edward GD Tuddenham (University College London), and Anthony R. Green (Cambridge Institute for Medical Research, U. of Cambridge, UK). They've incorporated the considerable advances of the last five years, particularly in oncology, and yet, with careful editing, have managed to maintain the size of the volume by combining some of the older chapters. Fifty-two contributed chapters begin with coverage of stem cells and haemopoiesis, erthropoiesis, iron metabolism and disorders of haem synthesis, iron overload, and megaloblastic anaemia; the collection concludes with primary immune thrombocytopenia, haemtological aspects of system disease, and of tropical diseases, and neonatal haematology. The contributors are from Europe, the US, and the UK; readership will also be international. A companion website offers figures and tables for downloading as well as interactive multiple-choice questions prepared by the authors. Annotation ©2011 Book News, Inc., Portland, OR (booknews.com)
The textbook of choice for trainees in haematology Over five editions Postgraduate Haematology has built a reputation as an extremely practical, user-friendly, reliable source of information for examination preparation and clinical practice. Completely revised to reflect the latest research in the field, this edition continues to provide trainees with up-to-date knowledge on the pathogenesis, clinical and laboratory features, and management of blood disorders. It covers the significant advances which have occurred in the application of cytogenetics and molecular genetics in the diagnosis, classification and understanding of haematological disorders.
Coupled with the expertise of 34 new contributors from across Europe, the editors have been joined by Professor Anthony Green, from the University of Cambridge, and they have reorganised the book into 52 accessible chapters.
Postgraduate Haematology is richly illustrated throughout with over 200 colour illustrations including line drawings, photomicrographs of blood cells and tissues, and algorithms to help aid treatment decision making. It is an indispensable resource for trainees and an essential read for all specialists who are interested in updating their knowledge.
Contributors |
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vii | |
Preface to the sixth edition |
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Preface to the first edition |
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xii | |
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1 Stem cells and haemopoiesis |
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1 | (11) |
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12 | (14) |
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3 Iron metabolism, iron deficiency and disorders of haem synthesis |
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26 | (21) |
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47 | (14) |
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61 | (22) |
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6 Haemoglobin and the inherited disorders of globin synthesis |
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83 | (26) |
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109 | (17) |
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8 Hereditary disorders of the red cell membrane |
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126 | (14) |
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9 Disorders of red cell metabolism |
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140 | (18) |
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10 Acquired haemolytic anaemias |
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158 | (18) |
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11 Paroxysmal nocturnal haemoglobinuria |
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176 | (10) |
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12 Inherited aplastic anaemia/bone marrow failure syndromes |
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186 | (20) |
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13 Acquired aplastic anaemia |
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206 | (20) |
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14 Red cell immunohaemotology: introduction |
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226 | (18) |
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15 Antigens in human blood |
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244 | (24) |
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16 Clinical blood transfusion |
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268 | (32) |
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300 | (30) |
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18 Lysosomal storage disorders |
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330 | (13) |
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19 Normal lymphocytes and non-neoplastic lymphocyte disorders |
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343 | (25) |
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368 | (12) |
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21 The molecular basis of leukaemia and lymphoma |
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380 | (15) |
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22 Laboratory diagnosis of haematological neoplasms |
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395 | (20) |
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23 Acute myeloid leukaemia |
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415 | (18) |
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24 Adult acute lymphoblastic leukaemia |
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433 | (15) |
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25 Childhood acute lymphoblastic leukaemia |
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448 | (15) |
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26 Supportive care in the management of leukaemia |
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463 | (20) |
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27 Chronic myeloid leukaemia |
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483 | (20) |
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28 The myelodysplastic syndromes |
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503 | (27) |
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29 Chronic lymphocytic leukaemia and other B-cell disorders |
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530 | (28) |
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30 T-cell lymphoproliferative disorders |
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558 | (19) |
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577 | (22) |
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599 | (15) |
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33 The classification of lymphoma: updating the WHO classification |
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614 | (25) |
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639 | (16) |
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655 | (31) |
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36 Myeloproliferative neoplasms |
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686 | (24) |
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710 | (12) |
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38 Stem cell transplantation |
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722 | (24) |
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746 | (26) |
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40 The vascular function of platelets |
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772 | (21) |
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41 Inherited bleeding disorders |
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793 | (20) |
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42 Rare bleeding disorders |
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813 | (26) |
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43 Acquired coagulation disorders |
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839 | (21) |
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44 Thrombotic thrombocytopenic purpura and haemolytic-uraemic syndrome (congenital and acquired) |
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860 | (12) |
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45 Heritable thrombophilia |
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872 | (16) |
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46 Acquired venous thrombosis |
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888 | (12) |
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47 Management of venous thromboembolism |
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900 | (15) |
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48 Congenital platelet disorders |
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915 | (13) |
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49 Primary immune thrombocytopenia |
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928 | (12) |
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50 Haematological aspects of systemic disease |
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940 | (16) |
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51 Haematological aspects of tropical diseases |
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956 | (15) |
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971 | (14) |
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Appendix I Normal values |
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985 | (1) |
Appendix II World Health Organization classification of tumours of the haematopoietic and lymphoid tissues |
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986 | (3) |
Index |
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A. Victor Hoffbrand MA, DM, FRCP, FRCPath, FRCP (Edin),DSc, FMedSci Emeritus Professor of Haematology at University College London and Honorary Consultant Haematologist at the Royal Free Hospital, London, UK Daniel Catovsky MD, DSc (Med), FRCPath, FRCP, FMedSci Emeritus Professor of Haematology, Institute of Cancer Research, Sutton, Surrey, UK Edward G.D. Tuddenham MD, FRCP, FRCPath Professor of Haemophilia at University College London and Director of the Haemophilia Centre at Royal Free Hospital, London, UK Anthony R. Green PhD, FRCP, FRCPath, FMedSci Professor of Haemato-oncology, Department of Haematology and Cambridge Institute for Medical Research, University of Cambridge; Honorary Consultant at Addenbrooke's Hospital, Cambridge, UK