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Practical Pediatric Hematology Vol. 2nd Edition [Minkštas viršelis]

  • Formatas: Paperback / softback, 349 pages, aukštis x plotis: 279x216 mm, weight: 890 g, 10 Halftones, color; 176 Illustrations
  • Išleidimo metai: 31-Aug-2012
  • Leidėjas: Jaypee Brothers Medical Publishers
  • ISBN-10: 9350259214
  • ISBN-13: 9789350259214
Kitos knygos pagal šią temą:
  • Formatas: Paperback / softback, 349 pages, aukštis x plotis: 279x216 mm, weight: 890 g, 10 Halftones, color; 176 Illustrations
  • Išleidimo metai: 31-Aug-2012
  • Leidėjas: Jaypee Brothers Medical Publishers
  • ISBN-10: 9350259214
  • ISBN-13: 9789350259214
Kitos knygos pagal šią temą:
This second edition brings postgraduates and paediatricians fully up to date with the latest knowledge and developments in paediatric haematology. Beginning with an introduction to interpreting the complete blood count, the following chapters examine in detail different conditions such as anaemia, white blood cell disorders, von Willebrands disease, stroke and myelodysplastic syndrome.





The final sections discuss therapies including hemato-oncology, hematopoietic stem cell transplantation, vascular access and specialised techniques for drug delivery, as well as psychological support of chronic blood disorders.





With emphasis put on the development of new diagnostic tests for these disorders, this comprehensive guide includes almost 200 images and illustrations to assist understanding.





Key Features









New edition brings postgraduates up to date with latest developments in paediatric haematology







Discusses in detail numerous conditions and disorders Nearly 200 images and illustrations Author trained in paediatric haematology-oncology at the Royal Marsden Hospital, Surrey and University College Hospital, London, UK First edition published 2006
1 Interpretation of the Complete Blood Count
1(14)
Vikas Dua
Vinita Jain
SP Yadav
Anupam Sachdeva
Red Cell Distribution Width
1(1)
Hematocrit
1(1)
Rule of 3s
2(1)
Blood Smear
2(1)
Role of MCV, RDW and Reticulocyte Count in Evaluating Anemia
3(3)
Discriminant Function
6(1)
Newborn Infants
7(2)
Platelets
9(1)
White Blood Cells
10(1)
Target Cells
11(1)
Spherocytes
11(1)
Acanthocytes
11(1)
Echinocytes
12(1)
Schistocytes
12(1)
Basophilic Stippling (Aggregated Ribosomes)
12(1)
Howell-Jolly Bodies
13(1)
Siderocytes (Nonhemoglobin Iron)
13(1)
Cabot's Rings (Nuclear Remnants)
13(1)
Polychromasia
13(1)
Nucleated RBCs
13(1)
Elliptocytes
13(1)
Spiculated/Crenated Cells
13(1)
Bizarre Poikilocytes
13(2)
2 Clinical Approach to a Child with Anemia
15(6)
Nitin K Shah
Himani Manchanda
MR Lokeshwar
Approach to a Child with Anemia
15(1)
Is the Patient Anemic?
15(1)
Definition
15(1)
Clinical Judgment of Anemia
15(1)
How Severe is Anemia?
15(1)
What is the Type and Cause of Anemia?
16(5)
3 Laboratory Evaluation of a Patient with Anemia
21(10)
Ushma Singh
Shirish Kumar
SP Yadav
Anupam Sachdeva
Mechanisms and Pathophysiology of Anemia
21(7)
Signs of Accelerated Erythropoiesis
28(1)
Signs of Accelerated RBC Destruction
29(1)
Investigations for Hemolytic Anemia
29(2)
4 Anemia of Prematurity
31(3)
Himani Manchanda
Sachin Thakur
Dhiren Gupta
Anupam Sachdeva
Pathophysiology
31(1)
Signs and Symptoms
31(1)
Evaluation
31(1)
Differential Diagnosis
32(1)
Treatment
32(2)
5 Anemia in the Newborn
34(7)
Neha Rastogi
Anupam Sachdeva
SP Yadav
Arun Soni
Fetal Erythropoiesis
34(1)
Normal Hematological Values in the Neonatal Period
34(2)
Etiology
36(2)
Diagnostic Approach to Anemia in a Newborn
38(1)
Treatment of Anemia in Newborn
38(3)
6 Nutritional Anemia
41(12)
Neha Rastogi
Anupam Sachdeva
SP Yadav
Panna Choudhury
Prevalence
41(1)
Iron Deficiency Anemia
41(1)
Iron Metabolism
42(1)
Clinical Features of IDA
43(1)
Consequences of Iron Deficiency
44(1)
Assessment of Iron Status and Screening for Anemia
44(2)
Treatment
46(1)
Prevention of Nutritional Anemia
47(2)
Macrocytic-Megaloblastic Anemia
49(4)
7 National Nutritional Anemia Control Program
53(4)
Neha Rastogi
Panna Choudhury
Anupam Sachdeva
National Nutritional Anemia Prophylaxis Program
53(1)
Evaluation of Iron Supplementation Program
53(1)
National Nutritional Anemia Control Program
53(4)
8 Aplastic Anemia: Current Issues in Diagnosis and Management
57(12)
Bharat R Agarwal
Nivedita Dhingra
Pancytopenia in Children
57(1)
Immune Physiology of AA
57(1)
Diagnosis of AA
57(2)
Etiology of Aplastic Anemia: Recognized Causes
59(4)
Management of Aplastic Anemia
63(1)
Definitive Therapy
64(5)
Appendix 1 Practical Issues with Immunosuppressive Therapy in Aplastic Anemia
66(3)
9 Approach to the Diagnosis of Hemolytic Disorders
69(6)
Mohammed Ramzan
SP Yadav
Anupam Sachdeva
History and Physical Examination
69(2)
Specific Tests to Establish the Cause of Hemolysis
71(1)
Salient Laboratory Features of Common Disorders Associated with Hemolytic Anemia
71(4)
10 Management of β-Thalassemia Major
75(10)
Mohammed Ramzan
SP Yadav
Anupam Sachdeva
Transfusion Therapy
75(3)
Splenectomy
78(1)
Folic Acid
78(1)
Chelation Therapy
78(1)
Iron Chelators
78(2)
Deferiprone (Ferripox, Kelfer, L1) Therapy
80(1)
Newer Chelating Agents
81(1)
Bone Marrow Transplantation
82(1)
Cord Blood Transplantation
82(1)
Alternative Therapies in Thalassemia
83(1)
Gene Therapy
83(2)
11 Hemolytic Anemia (Other than Thalassemia) Management
85(5)
MB Agarwal
Hereditary Hemolytic Anemias (Intracorpuscular Defect)
85(2)
Acquired Hemolytic Anemias
87(2)
Chemical Agents
89(1)
Physical Agents
89(1)
Paroxysmal Nocturnal Hemoglobinuria
89(1)
12 Thrombocytosis
90(7)
Vikas Dua
SP Yadav
Vinita Jain
Anupam Sachdeva
Normal Upper Thrombocyte Levels in Childhood
90(1)
Physiology of Platelet Production
90(1)
Classification
90(1)
Essential Thrombocytosis
90(1)
Clinical Manifestations
91(1)
Treatment Options
91(1)
Reactive Thrombocytosis
92(1)
Tissue Damage
93(1)
Hypoxia
93(1)
Autoimmune Disease
94(1)
Gastrointestinal Disease without Infection
94(1)
Renal Disease
94(1)
Oncologic Disease
94(1)
Medications
94(1)
Other Causes
94(1)
Complications
94(1)
Indications for Prophylaxis
95(1)
Primary Familial Thrombocytosis
95(2)
13 Hemostasis: Developmental Aspects and Rare Congenital Bleeding Disorders
97(18)
Nivedita Dhingra
SP Yadav
Anupam Sachdeva
Neonatal Hemostasis
97(2)
Intrinsic Pathway
99(1)
Extrinsic Pathway
100(1)
Common Pathway
100(1)
Protein C/Protein S Anticoagulant Pathway
100(1)
Thrombomodulin
100(1)
Antithrombin
100(1)
Fibrinolysis Pathway
100(1)
Causes of Neonatal Bleeding (Deranged Hemostasis)
101(1)
Hemophilias A and B
101(1)
Clinical Features
102(1)
von Willebrand Disease
102(1)
Deficiencies of the Intrinsic Pathway Contact Activating System
102(1)
Factor XI Deficiency
103(1)
Factor X (Stuart-Prower Factor) Deficiency
104(1)
Factor V Deficiency
105(1)
Factor VII Deficiency
106(1)
Deficiencies of the Common Pathway Prothrombin Deficiency
106(1)
Fibrinogen Deficiency
107(2)
Factor XIII Deficiency
109(1)
Congenital Factor XIII Deficiency
110(1)
Acquired Coagulation Disorders
111(1)
Vitamin K Deficiency Bleeding
112(3)
14 von Willebrand's Disease
115(5)
Neha Rastogi
Vinita Jain
SP Yadav
Anupam Sachdeva
Clinical Presentation
115(1)
Laboratory Diagnosis and Monitoring
115(2)
von Willebrand's Disease Classification
117(3)
15 Management of Hemophilia
120(5)
Vikram Mathews
Products for Replacement Therapy
120(1)
Nonfactor Pharmacological Agents
121(1)
Management of Acute Bleeds
121(1)
Management of Chronic Complications
122(1)
Physical Therapy and Rehabilitation
122(1)
Surgical Management
123(1)
Management of Patients with Inhibitors
123(1)
Carrier Detection and Antenatal Diagnosis
124(1)
Recent Advances
124(1)
16 Thrombocytopenia Other than ITP and Thrombasthenia
125(5)
Sunil Gomber
Clinical Presentation
125(1)
Drug-Induced Thrombocytopenia
125(2)
Decreased or Absent Megakaryocytes in the Marrow
127(3)
17 Immune Thrombocytopenia: Diagnosis and Management
130(14)
Vasant Chinnabhandar
MR Lokeshwar
Trupti Dongre
What are Various Types of ITP?
130(1)
Pathophysiology of ITP
131(1)
Diagnosis of ITP
131(1)
Important Factors in Diagnosis
131(3)
Other Investigations
134(1)
Evaluation of Patients with Persistent/Early Refractory ITP
134(1)
Management of ITP
134(3)
Specific Therapy in ITP
137(1)
Intravenous Immunoglobulin
138(1)
Anti-D in ITP
138(1)
Rituximab
139(1)
Thrombopoietin-Receptor Agonists: Romiplostim and Eltrombopag
139(1)
Dapsone (Diamino-Diphenyl Sulfone)
140(1)
Splenectomy in ITP
140(1)
Splenectomy in Chronic ITP
140(1)
Are Immunosuppressant Drugs Useful in Chronic ITP?
141(3)
18 Vitamin K Deficiency Bleeding
144(4)
Jagdish Chandra
Definition and Inclusion Criteria
144(1)
Incidence
145(1)
Clinical Features
145(1)
Diagnosis
145(1)
Treatment
146(1)
Prognosis
146(1)
Prevention
146(2)
19 Neonatal Thrombocytopenia
148(5)
Nivedita Dhingra
Sachin Thakur
Anupam Sachdeva
Neonatal Autoimmune Thrombocytopenia
150(1)
Nonimmune Thrombocytopenia
151(1)
Hereditary Thrombocytopenia
151(2)
20 Hypercoagulable Disease in Children and its Diagnostic Approach
153(3)
R Saxena
Acquired Hypercoagulable State
153(1)
Inherited Hypercoagulable States
153(3)
21 Antithrombotic Therapy in Pediatrics
156(9)
ATK Rau
Shruti Patil
Anupam Sachdeva
Unfractionated Heparin
156(1)
Mechanism of Action and Pharmacology
156(1)
Dosing and Administration
157(1)
Prophylactic Therapy
157(1)
Monitoring
157(1)
Adverse Effects, Reversal of Action and Antidote of UHF
157(1)
Heparin-induced Thrombocytopenia
158(1)
Low Molecular Weight Heparin
158(1)
Mechanism of Action
158(1)
Therapeutic Range
158(1)
Dosing
158(1)
Reversal and Antidote
158(1)
Side Effects
159(1)
Vitamin K Antagonists
159(1)
Mechanism of Action
159(1)
Monitoring
159(1)
Adverse Effects
159(1)
Reversal and Antidote
160(1)
Antiplatelet Therapy
160(1)
Thrombolytic Therapy
160(1)
Dosing in Thrombolytic Therapy
161(1)
Adverse Effects
162(1)
Treatment of Bleeding
162(1)
Contraindications of Thrombolytic Therapy
162(1)
Treatment of Pediatric Venous Thromboembolism in Children
162(1)
Treatment of Kawasaki Disease in Children
163(1)
Children Undergoing Fontan Procedure
163(1)
Children with Homozygous Protein C and S Deficiency
163(2)
22 Stroke in Children
165(13)
Vasant Chinnabhandar
Vinita Jain
SP Yadav
Anupam Sachdeva
Ischemic Stroke
165(3)
Hemorrhagic Stroke
168(1)
Clinical Features
169(2)
Diagnosis
171(1)
Treatment
172(6)
23 Polycythemia in Newborn
178(3)
Mohammed Ramzan
Anupam Sachdeva
SP Yadav
Pathophysiology
178(1)
Causes of Neonatal Polycythemia
178(1)
Clinical Features
178(1)
Treatment
179(1)
Complications of Exchange Transfusion
180(1)
24 Blood Component Therapy
181(18)
Vasant Chinnabhandar
VP Choudhary
Samridh Nagar
Anupam Sachdeva
The Appropriate Use of Blood and Blood Products
181(1)
Whole Blood
182(1)
Red Blood Cells
182(4)
Special Considerations for Newborns
186(1)
Plasma
187(2)
Special Considerations for Newborns
189(1)
Platelets
189(3)
Granulocytes
192(1)
Cryoprecipitate
193(1)
Albumin
193(1)
Immunoglobulins
194(1)
Discussion on Special Topics
194(1)
Component and Procedure Specification
195(4)
25 Transfusion Transmitted Infections
199(9)
Deepak Bansal
RK Marwaha
Hepatitis B Virus
199(2)
Hepatitis C Virus
201(1)
Hepatitis D Virus
202(1)
Hepatitis A Virus
202(1)
Hepatitis E Virus
202(1)
Hepatitis GB Virus C/Hepatitis G Virus
202(1)
TT Virus
202(1)
Human Immunodeficiency Virus Types 1 and 2 (HIV1 and HIV2)
202(1)
Human T-Lymphotropic Virus I and II
203(1)
Cytomegalovirus
203(1)
Epstein-Barr Virus
204(1)
Syphilis
204(1)
Malaria
204(1)
Creutzfeldt-Jakob Disease
205(1)
Bacterial Contamination of Blood
205(1)
Rarely Transmitted Parasites
205(1)
Inactivation of Viruses in Blood Products
205(1)
The Indian Scenario
205(3)
26 Supportive Care in Children with Cancer
208(24)
Mohammed Ramzan
Anupam Sachdeva
SP Yadav
Who Provides Supportive Care?
208(1)
Prevention and Management of Infection in Immunocompromised Hosts
208(1)
Management
209(1)
Febrile Splenectomized Patients
210(1)
Bacterial Infections
211(1)
Fungal Infections
212(3)
Viral Infections
215(2)
Protozoan Infections
217(1)
Hematopoietic Growth Factors: Basic Biology of Growth Factors
218(3)
Prevention of Organ Toxicity
221(1)
Pain Management
222(2)
General Guidelines for Management of Pain in Oncology Patients
224(1)
Management of Nausea and Vomiting
225(2)
Nutritional Support
227(2)
Immunizations
229(1)
Psychosocial Support and End-of-Life Care
230(2)
27 Hematological Manifestations of Systemic Diseases
232(15)
Himani Manchanda
SP Yadav
Anupam Sachdeva
Chronic Illness
232(1)
Connective Tissue Disorders
233(1)
Infections
233(2)
Viral Illnesses with Marked Hematologic Sequel
235(3)
Hematologic Changes Associated with Specific Infections in the Tropics
238(2)
Hyper-reactive Malarial Splenomegaly Syndrome
240(1)
Clinical Features
241(6)
28 Disseminated Intravascular Coagulation
247(12)
Mir Sadaqat Hassan Zafar
SP Yadav
Vinita Jain
Anupam Sachdeva
Epidemiology
247(1)
Etiology
248(2)
Genetic Risk Factors
250(1)
Pathophysiology
250(1)
Clinical Presentation
251(1)
Laboratory Evaluation
251(2)
Diagnosis
253(1)
Differential Diagnosis
254(1)
Scoring System
254(1)
Management (Acute Disseminated Intravascular Coagulation)
254(5)
29 Disorders of White Blood Cells
259(3)
AP Dubey
Leukocytosis
259(1)
Leukopenia
260(1)
Eosinophilia
260(1)
Eosinopenia
260(1)
Monocytosis
260(1)
Basophilia
260(1)
Lymphocytosis
260(1)
Lymphopenia
261(1)
30 Hematological Changes in HIV Infection
262(4)
Nitin K Shah
Hematological Changes Seen in HIV
262(1)
Pathophysiology
262(1)
Anemia in HIV
262(1)
Leukopenia in HIV
263(1)
Thrombocytopenia in HIV
263(1)
Bone Marrow Changes
263(1)
Coagulation Disorders in HIV
264(1)
Hematological Malignancies in HIV
264(1)
NHL in HIV
264(2)
31 Approach to a Patient with Splenomegaly and Lymphadenopathy
266(6)
Sunil Narain
LS Arya
32 Myelodysplastic Syndrome in Children
272(9)
Gauri Kapoor
Anshul Gupta
Definition
272(1)
Current Approach to the Classification of Childhood MDS
272(1)
Primary and Secondary MDS
273(1)
Down's Syndrome
273(1)
Juvenile Myelomonocytic Leukemia
274(1)
Monosomy 7
274(2)
Fanconi's Anemia
276(5)
33 Storage Diseases of the Reticuloendothelial System
281(8)
Nirmalya Roy Moulik
Archana Kumar
Incidence
281(1)
Pathogenesis
281(1)
Genetics
282(1)
Clinical Features
282(1)
Laboratory Diagnosis
282(1)
Morphological Diagnosis
282(4)
Biochemical Diagnosis
286(1)
Genetic Diagnosis
286(1)
Newborn Screening for Lysosomal Storage Disorders
286(1)
Approach to Diagnosis
286(1)
Principles of Treatment of Lysosomal Storage Disorders
287(2)
34 Molecular Biology Revolution in Hemato-Oncology---From Bench to the Bedside
289(9)
IC Verma
Vaishnavi Reddy
Primer of Molecular Biology
289(2)
Tools of the Trade
291(1)
Applications of Molecular Biology
292(6)
35 Hematopoietic Stem Cell Transplantation
298(7)
Mammen Chandy
Biju George
Leni Mathew
Complications
300(1)
Graft Versus Host Disease
300(2)
Alternate Donor Transplantation
302(3)
36 Psychological Support of Chronic Blood Disorders
305(4)
Roma Kumar
Ushma Singh
Anupam Sachdeva
Why is Psychological Support so Important?
305(1)
Communication by Doctors and Healthcare Professionals with Patients
305(1)
Coming to Terms with the Diagnosis
306(1)
Informed Consent
306(1)
Psychological Impact of Admissions to Hospital
306(1)
Adjustment in the Child with Chronic Blood Disorders
306(1)
Adjustment in the Family
307(1)
When Treatment Fails
307(1)
Pain Control
307(1)
Self-help Groups
307(2)
37 Vascular Access and Specialized Techniques of Drug Delivery
309(4)
R Parakh
Indications
309(1)
Types of Devices
309(1)
Purpose of Access
309(1)
Catheter and Port Insertion Techniques
309(1)
Catheter Insertion Complications
309(1)
Catheter Maintenance
310(1)
Technique of Catheter Insertion
310(1)
Problem Solving in Catheter Use
311(1)
Complications
311(1)
Catheter-related Venous Thrombosis
311(1)
Catheter-related Infections
312(1)
Index 313
Anupam Sachdeva





Incharge of Pediatric Hematology and Oncology Unit and Pediatric Bone Marrow Transplantation, Department of Pediatrics, Center of Child Health, Sir Ganga Ram Hospital, Rajinder Nagar, New Delhi, India