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Principles of Toxicology: Environmental and Industrial Applications 4th edition [Kietas viršelis]

Edited by (College of Public Health, University of Georgia, Athens, Georgia, USA), Edited by (ToxStrategies, Boise, ID ), Edited by (Center for Environmental and Human Toxicology, University of Florida, Gainesville, Florida, USA)
  • Formatas: Hardback, 592 pages, aukštis x plotis x storis: 274x218x31 mm, weight: 1406 g
  • Išleidimo metai: 15-Apr-2022
  • Leidėjas: John Wiley & Sons Inc
  • ISBN-10: 1119635179
  • ISBN-13: 9781119635178
Kitos knygos pagal šią temą:
Principles of Toxicology: Environmental and Industrial Applications 4th editionDidesnis paveikslėlis
  • Formatas: Hardback, 592 pages, aukštis x plotis x storis: 274x218x31 mm, weight: 1406 g
  • Išleidimo metai: 15-Apr-2022
  • Leidėjas: John Wiley & Sons Inc
  • ISBN-10: 1119635179
  • ISBN-13: 9781119635178
Kitos knygos pagal šią temą:
Pastovi nuoroda: https://www.kriso.lt/db/9781119635178.html
Raktažodžiai:
"This book presents compactly and efficiently the scientific basis for toxicology as it applies to the workplace and the environment. The book covers diverse chemical hazards encountered in the modern workplace and natural environment and provides a practical understanding of these hazards for those concerned with protecting the health of humans and ecosystems. It presents not only theory, but also practical information regarding chemical hazards to give the student and new professional a working knowledge of the practice of toxicology and the ability to solve problems in environmental and industrial settings. The goal of the fourth edition is to build upon the success of the previous three editions, providing updated information on the latest developments in the field of toxicology. As with previous editions, this book is primarily intended to serve as a textbook for advanced undergraduate, graduate, and professional students in a range of environmental and health fields. It is intended to provide information on the principles of toxicology and the application of those principles to solve problems in environmental and industrial settings"--

This book presents compactly and efficiently the scientific basis for toxicology as it applies to the workplace and the environment. The book covers diverse chemical hazards encountered in the modern workplace and natural environment and provides a practical understanding of these hazards for those concerned with protecting the health of humans and ecosystems.  It presents not only theory, but also practical information regarding chemical hazards to give the student and new professional a working knowledge of the practice of toxicology and the ability to solve problems in environmental and industrial settings.

The goal of the fourth edition is to build upon the success of the previous three editions, providing updated information on the latest developments in the field of toxicology.  As with previous editions, this book is primarily intended to serve as a textbook for advanced undergraduate, graduate, and professional students in a range of environmental and health fields.  It is intended to provide information on the principles of toxicology and the application of those principles to solve problems in environmental and industrial settings.
List of Contributors
xi
Preface xv
1 General Principles of Toxicology
1(30)
Robert C. James
Stephen M. Roberts
Phillip L. Williams
1.1 Basic Definitions and Terminology
1(2)
1.2 Toxicology: A Diverse Science With Two Basic Goals
3(1)
1.3 The Hazard Identification Function
4(4)
1.4 The Dose-Response/Risk Assessment Function
8(7)
1.5 How Dose-Response Data Can be Used
15(2)
1.6 Avoiding Incorrect Conclusions from Dose--Response and Hazard Identification Data
17(6)
1.7 Additional Factors Influencing Hazard Identification and Dose--Response Data
23(3)
1.8 Evidence-Based Toxicology
26(1)
1.9 Summary
27(4)
References and Suggested Reading
28(3)
2 Xenobiotic Absorption, Distribution, Metabolism, and Excretion
31(36)
Michael R. Franklin
2.1 Absorption
32(5)
2.2 Distribution
37(1)
2.3 Metabolism
37(25)
2.4 Excretion
62(3)
2.5 Summary
65(2)
References and Suggested Reading
65(2)
3 Toxicokinetics
67(32)
Rebecca A. Clewell
Harvey J. Clewell
3.1 Introduction
67(3)
3.2 Toxicokinetic Modeling Fundamentals
70(7)
3.3 Applications of Toxicokinetics
77(7)
3.4 Case Study: Toxicokinetics of Dibutyl Phthalate
84(9)
3.5 Toxicokinetics in the Future
93(2)
3.6 Summary
95(4)
References and Suggested Reading
96(3)
4 Regulatory Toxicology
99(26)
Raymond M. David
4.1 The "Alphabet Soup" that is Regulation
99(2)
4.2 Standards that We Live By
101(4)
4.3 Registration of Chemicals and Products in the US
105(8)
4.4 Registration of Chemicals, Non-US Regulations
113(1)
4.5 Regulations of Nanomaterials
114(1)
4.6 Designing and Conducting Studies
115(4)
4.7 Guidelines and Guidance Documents
119(1)
4.8 Communicating Hazards and Setting Safe Levels
120(3)
4.9 Summary
123(2)
References and Suggested Reading
123(2)
5 Alternative Methods in Toxicity Testing
125(18)
Leona D. Scanlan
Xuefei Cao
Christopher D. Vulpe
5.1 Introduction to Alternative Methods
125(1)
5.2 Rationale for Alternative Method Development and Utilization in Toxicity Testing
126(1)
5.3 Alternative Methods
126(10)
5.4 Chemical Regulations and Alternative-to-Animal Toxicity Testing Methods
136(3)
5.5 Summary
139(4)
References and Suggested Reading
140(3)
6 Computational Toxicology
143(16)
Richard S. Judson
David M. Reif
Keith A. Houck
Thomas B. Knudsen
Joshua Harrill
Katie Paul Friedman
6.1 Data Relevant to Computational Toxicology Applications
143(6)
6.2 Data, Databases, Knowledgebases, and Ontologies
149(2)
6.3 Example Computational Toxicology Applications
151(5)
6.4 Summary
156(3)
References and Suggested Reading
157(2)
7 Hematotoxicity: Toxic Efects on the Hematopoietic System
159(32)
Lila Ramaiah
Tara Arndt
Michelle Cora
7.1 Structure and Function of the Hematopoietic System
159(5)
7.2 Evaluation of the Hematopoeitic System
164(4)
7.3 Mechanisms of Hematotoxicity
168(9)
7.4 Interpretation of Drug (Xenobiotic) Effects and Hematopoietic Response Patterns
177(12)
7.5 Summary
189(2)
References and Suggested Reading
189(2)
8 Hepatotoxicity: Toxic Effects on the Liver
191(14)
Robert C. James
Stephen M. Roberts
8.1 The Physiologic and Morphologic Bases of Liver Injury
191(3)
8.2 Types of Liver Injury
194(6)
8.3 Evaluation of Liver Injury
200(3)
8.4 Summary
203(2)
References and Suggested Reading
203(2)
9 Nephrotoxicity: Toxic Effects on the Kidney
205(18)
Lawrence H. Lash
9.1 Renal Structure and Physiology
205(4)
9.2 Classifications of Renal Injury
209(2)
9.3 Assessment of Renal Function and Injury in the Clinic and in In Vivo Animal Models
211(4)
9.4 In Vitro Models to Study Renal Function and Injury
215(3)
9.5 Examples of Environmental, Industrial, and Therapeutic Chemicals That Produce Nephrotoxicity
218(4)
9.6 Summary
222(1)
References and Suggested Reading
222(1)
10 Neurotoxicology: Toxic Effects on the Nervous System
223(16)
W. Michael Caudle
Meghan L. Bucher
Alexandria C. White
Gary W. Miller
10.1 The Nervous System
224(4)
10.2 Neurotoxicological Agents
228(6)
10.3 Role for Glia in Neurotoxicity
234(1)
10.4 Evaluation of Neurotoxic Injury
235(2)
10.5 Summary
237(2)
References and Suggested Reading
238(1)
11 Dermal Toxicology: Toxic Effects on the Skin
239(10)
Sailesh Konda
Howard I. Maibach
11.1 Histology
239(1)
11.2 Functions
240(1)
11.3 Types of Dermal Toxicity
241(6)
11.4 Summary
247(2)
References and Suggested Reading
248(1)
12 Pulmonotoxicity: Toxic Effects in the Respiratory System
249(18)
Cuiqing Liu
Qinghua Sun
12.1 Anatomy and Physiology of the Respiratory System
249(1)
12.2 Acute Responses of the Respiratory System to Injury
250(4)
12.3 Chronic Response of the Respiratory System to Injury
254(3)
12.4 Inhalation Toxicology of Gases and Particles
257(5)
12.5 Evaluation of Toxic Damage in the Respiratory System
262(2)
12.6 Summary
264(3)
Acknowledgments
265(1)
References and Suggested Readings
265(2)
13 Immunotoxicity: Toxic Effects on the Immune System
267(16)
Eric S. Sobel
Stephen M. Roberts
13.1 Biology of the Immune Response
267(5)
13.2 Types of Immune Reactions and Disorders
272(1)
13.3 Clinical Tests for Detecting Immunotoxicity
273(2)
13.4 Tests for Detecting Immunotoxicity in Animal Models
275(2)
13.5 Specific Chemicals that Adversely Affect the Immune System
277(3)
13.6 Summary
280(3)
References and Suggested Reading
280(3)
14 Reproductive and Developmental Toxicity: Toxic Effects on The Female and Male Reproductive Tracts and Offspring
283(24)
Shuo Xiao
Krista Symosko
Charles A. Easley
14.1 Overview of the Reproductive System
283(5)
14.2 Physiology and Hormone Control of the Adult Female and Male Reproductive Systems
288(2)
14.3 Human Reproductive Toxicants
290(4)
14.4 Current and Novel Methodologies for Assessing Reproductive Toxicology
294(1)
14.5 Developmental Toxicology
295(3)
14.6 Preconception Exposure Impacts on Development
298(1)
14.7 Lifestyle Impacts on Epigenetics and Development
299(1)
14.8 Other Developmental Toxicants and Modes of Action
300(2)
14.9 Current and Novel Methodologies for Assessing Developmental Toxicology
302(1)
14.10 Summary
303(4)
References and Suggested Reading
303(4)
15 Mutagenesis and Genetic Toxicology
307(26)
Martha M. Moore
Meagan B. Myers
Robert H. Heflich
15.1 Fundamentals of Chemically Induced Genetic Damage
307(5)
15.2 Genetic Damage and its Impact on Human Disease
312(1)
15.3 Genetic Toxicology Tests
312(10)
15.4 Human Biomonitoring
322(1)
15.5 Regulatory Use of Genetic Toxicology Data
323(4)
15.6 Promising New Approaches
327(3)
15.7 Summary
330(3)
References and Suggested Reading
330(3)
16 Chemical Carcinogenesis
333(24)
James E. Klaunig
Luma Melo
Karen Tilmant
16.1 History of Cancer Research
333(2)
16.2 Nomenclature and Definitions of Neoplasia
335(1)
16.3 Classification of Carcinogens: Genotoxic Versus Nongenotoxic
336(3)
16.4 Multistage Carcinogenesis
339(4)
16.5 Proto-Oncogenes and Tumor Suppressor Genes
343(1)
16.6 Polymorphism in Carcinogenesis
344(1)
16.7 Well-Known Classes of Chemical Carcinogens
344(4)
16.8 Nongenotoxic (Epigenetic) Carcinogens
348(2)
16.9 The Hallmarks of Cancer
350(1)
16.10 The Major Causes of Human Cancer
350(2)
16.11 Chemoprevention
352(1)
16.12 Test Systems for Carcinogenicity Assessment
353(1)
16.13 Classification of the Carcinogenic Risk for Humans
354(2)
16.14 Summary
356(1)
References and Suggested Reading
356(1)
17 Properties and Effects of Metals
357(24)
David B. Mayfield
Lisa A. Bailey
Joel M. Cohen
Barbara D. Beck
17.1 Basic Characteristics of Metals
357(5)
17.2 General Properties of Absorption, Distribution, Metabolism, and Excretion of Metals
362(1)
17.3 Biomarkers
363(1)
17.4 General Mechanisms of Toxicity
363(1)
17.5 Essentiality Versus Toxic Effects
364(1)
17.6 Toxicology of Specific Metals
364(15)
17.7 Summary
379(2)
References and Suggested Reading
379(2)
18 Pesticides
381(18)
Janice Britt
18.1 Pesticide Classes and Regulations
381(2)
18.2 Organophosphate and Carbamate Insecticides
383(4)
18.3 Organochlorine Insecticides
387(1)
18.4 Inecticides of Biological Origin
388(2)
18.5 Herbicides
390(2)
18.6 Fungicides
392(1)
18.7 Rodenticides
393(1)
18.8 Fumigants
394(1)
18.9 Summary
395(4)
References and Suggested Reading
395(4)
19 Properties and Toxicology of Organic Solvents and Solvent-Like Chemicals
399(34)
Christopher M. Teaf
Michele M. Garber
19.1 General Concepts
399(1)
19.2 Exposure Potential and Toxicokinetics
400(3)
19.3 Regulation of Solvents Exposure Potential
403(4)
19.4 Review of Solvent Effects and Target Organ Systems
407(3)
19.5 Toxic Properties of Representative Organic Solvents
410(3)
19.6 Toxic Properties of Halogenated Solvents
413(4)
19.7 Toxic Properties of Hydroxylated and Oxgenated Solvents
417(3)
19.8 Toxic Properties of Aldehydes, Ketones, and Carboxylic Acids
420(3)
19.9 Toxic Properties of Representative Esters, Ethers, and Epoxides
423(2)
19.10 Toxic Properties of Representative Nitrogen-Containing Solvents
425(4)
19.11 Toxic Properties of Sulfur-Containing Solvents
429(1)
19.12 Summary
430(3)
References and Suggested Reading
430(3)
20 Nanotoxicology
433(14)
Hongbo Ma
Stephen M. Roberts
20.1 Classification of Nanomaterials and Their Potential Applications
434(1)
20.2 Unique Challenges in Studying Nanotoxicology
434(3)
20.3 Human Nanotoxicology
437(1)
20.4 Environmental Nanotoxicology
438(3)
20.5 Mechanisms of Toxicity (Modes of Action)
441(2)
20.6 Summary
443(4)
Refereces and Suggested Reading
444(3)
21 Insights into Epidemiology
447(12)
Jon Fryzek
Cara Frankenfeld
Naimisha Movva
Lauren Bylsma
John Aquavella
21.1 Some Definitions and Basic Principles
447(1)
21.2 Disease Frequency Measures used in Epidemiology
448(2)
21.3 Study Designs Used in Epidemiology
450(4)
21.4 Meta-Analyses
454(2)
21.5 Interpretation of Epidemiologic Results
456(2)
21.6 Summary
458(1)
References and Suggested Reading
458(1)
22 Occupational and Environmental Health
459(18)
Laura Breeher
Fredric Gerr
T. Renee Anthony
22.1 History of Occupational Health
459(2)
22.2 Definition and Scope
461(1)
22.3 Data Sources and the Burden of Occupational and Environmental Illness and Injury
462(1)
22.4 Characteristics of Occupational Illness
462(1)
22.5 Prevention Goals
463(2)
22.6 Activities of Occupational and Environmental Health Specialists
465(2)
22.7 The Multidisciplinary Approach to Workers' Health
467(1)
22.8 Legal and Regulatory Issues Relevant to Occupational and Environmental Health
468(2)
22.9 Occupational Exposure Limits
470(2)
22.10 Ethical Considerations for the Occupational and Environmental Health Professional
472(1)
22.11 Summary
473(4)
Acknowledgment
474(1)
References and Suggested Reading
474(3)
23 Human Health Risk Assessment
477(34)
Leah D. Stuchal
23.1 Risk Assessment Basics
477(5)
23.2 Hazard Identification
482(2)
23.3 Dose--Response Assessment
484(10)
23.4 Exposure Assessment: Exposure Pathways and Resulting Dosages
494(4)
23.5 Risk Characterization
498(1)
23.6 Probabilistic Versus Deterministic Risk Assessments
499(2)
23.7 Evaluating Risk from Chemical Mixtures
501(2)
23.8 Comparative Risk Analysis
503(1)
23.9 Risk Communication
504(3)
23.10 Summary
507(4)
References and Suggested Reading
507(4)
24 Ecological Risk Assessment
511(22)
Brett Thomas
24.1 Basic Steps of Ecological Risk Assessment
512(1)
24.2 Habitat Types Often Involved in ERAs
513(1)
24.3 Selection of Receptors and their Representation in the ERA
513(1)
24.4 Toxicity Values
514(3)
24.5 Exposure Assessment
517(4)
24.6 Risk Estimation
521(2)
24.7 Ecological Risk Assessment Process
523(8)
24.8 Summary
531(2)
References and Suggested Reading
531(2)
25 The Dilemma of Selecting Safe Exposure Values
533(26)
Robert C. James
Phillip L. Williams
Stephen M. Roberts
25.1 Factors Producing Variations in Safe Exposure Values
533(5)
25.2 The Variations in Hazard Assessment Conclusions
538(6)
25.3 Variations in Occupational Exposure Limits (OELs)
544(5)
25.4 Variations in Environmental Exposure Limits
549(2)
25.5 Exposure Limits and the Courts
551(5)
25.6 Summary
556(3)
References and Suggested Reading
557(2)
Index 559
Stephen M. Roberts, PhD, is Professor and Program Director of the Center for Environmental and Human Toxicology at the University of Florida, Gainesville, FL.

Robert C. James, PhD, is Senior Science Advisor, ToxStrategies, Boise, ID.



Phillip L. Williams, PhD, is Dean and Professor Emeritus, College of Public Health, University of Georgia, Athens, GA.