Although fluorescence in situ hybridization (FISH) is only now becoming the standard technique for in-situ chromosomal investigation, already primed in situ (PRINS) labeling and peptide nucleic acid (PNA) probes are providing alternatives for detecting chromosomes and quantifying chromosomal abnormalities. Here scientists in medical specialties that use such information introduce and overview the principles and applications of these two approaches. Most describe using one or the other for a particular purpose, among them identifying all fetal nucleated cells in maternal blood, plant cytogenetics and genomics, and assessing aneuploidy in human sperm. Annotation ©2007 Book News, Inc., Portland, OR (booknews.com)
