Atnaujinkite slapukų nuostatas

El. knyga: Progress in Medicinal Chemistry

Series edited by (Professor, University of Sussex, Brighton, UK), Series edited by (WITNET LTD, Cambridge, UK)
  • Formatas: EPUB+DRM
  • Serija: Progress in Medicinal Chemistry
  • Išleidimo metai: 09-Apr-2018
  • Leidėjas: Elsevier Science Publishing Co Inc
  • Kalba: eng
  • ISBN-13: 9780444641441
Kitos knygos pagal šią temą:
  • Formatas: EPUB+DRM
  • Serija: Progress in Medicinal Chemistry
  • Išleidimo metai: 09-Apr-2018
  • Leidėjas: Elsevier Science Publishing Co Inc
  • Kalba: eng
  • ISBN-13: 9780444641441
Kitos knygos pagal šią temą:

DRM apribojimai

  • Kopijuoti:

    neleidžiama

  • Spausdinti:

    neleidžiama

  • El. knygos naudojimas:

    Skaitmeninių teisių valdymas (DRM)
    Leidykla pateikė šią knygą šifruota forma, o tai reiškia, kad norint ją atrakinti ir perskaityti reikia įdiegti nemokamą programinę įrangą. Norint skaityti šią el. knygą, turite susikurti Adobe ID . Daugiau informacijos  čia. El. knygą galima atsisiųsti į 6 įrenginius (vienas vartotojas su tuo pačiu Adobe ID).

    Reikalinga programinė įranga
    Norint skaityti šią el. knygą mobiliajame įrenginyje (telefone ar planšetiniame kompiuteryje), turite įdiegti šią nemokamą programėlę: PocketBook Reader (iOS / Android)

    Norint skaityti šią el. knygą asmeniniame arba „Mac“ kompiuteryje, Jums reikalinga  Adobe Digital Editions “ (tai nemokama programa, specialiai sukurta el. knygoms. Tai nėra tas pats, kas „Adobe Reader“, kurią tikriausiai jau turite savo kompiuteryje.)

    Negalite skaityti šios el. knygos naudodami „Amazon Kindle“.

Progress in Medicinal Chemistry, Volume 57, provides a review of eclectic developments in medicinal chemistry, with this volume including chapters on the CaSR field, CFTR modulators in cystic fibrosis, macrocycles, VMAT2 inhibitors, and Big Data in Drug Discovery.

  • Provides extended, timely reviews of topics in medicinal chemistry
  • Contains targets and technologies relevant to the discovery of tomorrow’s drugs
  • Presents analyses of successful drug discovery programs
Contributors vii
Preface x
1 Discovery and Development of Calcimimetic and Calcilytic Compounds
1(86)
Edward F. Nemeth
Bradford C. Van Wagenen
Manuel F. Balandrin
1 Introduction
2(1)
2 The Extracellular Calcium Receptor
3(6)
3 Screening for Calcimimetics and Calcilytics
9(2)
4 Calcimimetics
11(32)
5 Calcilytics
43(23)
6 Molecular Mechanism of Action ol Calcimimetics and Calcilytics
66(7)
7 Conclusion
73(14)
References
74(13)
2 VMAT2 Inhibitors and the Path to Ingrezza (Valbenazine)
87(26)
Nicole D. Harriott
John P. Williams
Evan B. Smith
Haig P. Bozigian
Dimitri E. Grigoriadis
1 Introduction
87(2)
2 VMAT2 Inhibitors
89(3)
3 Tetrabenazine and Metabolites
92(1)
4 TBZ Metabolite Pharmacologic Characterization
93(2)
5 Prodrugs of R,R,R-DHTBZ
95(9)
6 Valbenazine in Humans
104(9)
References
108(5)
3 Current Trends in Macrocyclic Drug Discovery and beyond-Ro5
113(122)
Sulejman Alihodzic
Mirjana Bukvic
Ivaylo J. Elenkov
Antun Hutinec
Sanja Kostrun
Dijana Pesic
Gordon Saxty
Linda Tomaskovic
Dinko Ziher
1 Introduction
114(2)
2 Synthetic Approaches Towards Macrocycles
116(34)
3 Physicochemical Properties and Rational Design of Macrocycles
150(34)
4 Scale-Up Considerations for Macrocycles
184(9)
5 Novel !ethnologies Towards Macrocyclic Libraries
193(7)
6 Patent Overview (2015S to Aug. 2017)
200(8)
7 Future Perspectives
208(27)
Acknowledgement
210(1)
References
210(25)
4 Recent Progress in the Discovery and Development of Small-Molecule Modulators of CFTR
235(42)
Phil R. Kym
Xueqing Wang
Mathieu Pizzonero
Steven E. Van der Plas
1 Introduction
236(1)
2 CFTR Mutations Implicated in CF
237(1)
3 Molecular Structure of CFTR
238(1)
4 Drug Design/Discovery
239(3)
5 Discovery of Potentiators
242(12)
6 Discovery of CFTR Correctors/Amplifiers
254(13)
7 Therapeutic Potential of CFTR Modulators
267(2)
8 Summary and future Perspectives
269(8)
Acknowledgements
270(1)
References
270(7)
5 Big Data in Drug Discovery
277(67)
Nathan Brown
Jean Cambruzzi
Peter J. Cox
Mark Davies
James Dunbar
Dean Plumbley
Matthew A. Sellwood
Aaron Sim
Bryn I. Williams-Jones
Magdalena Zwierzyna
David W. Sheppard
1 Introduction
278(1)
2 What Is Big Data?
279(10)
3 Using Big Data
289(1)
4 Big Data in Biology
289(11)
5 Big Data in Chemistry
300(28)
6 Summary and Outlook
328(1)
7 Big Data in Clinical Trials and Health Care
329(14)
8 Conclusions
343(1)
References 344
Dr David Witty has more than 20 years experience in the pharmaceutical industry as a medicinal chemist and project leader working principally in areas of anti-infectives, metabolic diseases, cognition and pain, delivering clinical candidates for several conditions. He led IT Strategy within the Neurology division of GSK, developing and deploying the first Electronic Notebooks for drug discovery to sites in the UK and Singapore. He has contributed more than 90 scientific papers, reviews, patents and books on medicinal and synthetic chemistry.In 2010 David and several colleagues successfully raised $35M in venture funding to found Convergence Pharmaceuticals, a specialist ion channel company focused on the development of novel treatments for pain, based in Cambridge UK. David presently leads their discovery programme and manages scientific operations within the business.David is chairman of the Fine Chemicals Group of the Society of Chemical Industry, with responsibility for the delivery of conferences, seminars and training courses for chemists throughout the UK and Europe, and advising parliamentary bodies on matters of relevance to the UK chemical industry.Since 2008 David has been a STEM ambassador for SETPOINT, introducing school students at both primary and secondary level to the excitement and possibilities of pursuing scientific careers, through workshops, lectures and competitions. Professor Brian Cox is at University of Sussex, Brighton, UK