The present volume consists of peer-reviewed contributions representing modern trends in the theory of generalized functions and pseudo-differential operators. It is dedicated to Professor Michael Oberguggenberger (Innsbruck University, Austria), on occasion of his 60th birthday. The collection has been suggested by the ISAAC Group in Generalized Functions (GF) and the ISAAC Group in Pseudo-Differential Operators (IGPDO) which met at the 9th ISAAC congress in Krakow, Poland in August 2013. Topics include Columbeau algebras, ultra-distributions, partial differential equations, micro-local analysis, harmonic analysis, global analysis, geometry, quantization, mathematical physics, and time-frequency analysis. Containing both essays and research articles, the book will be of great interest to graduate students and researchers in analysis, PDE and mathematical physics. It is also a valuable complement to the volumes on this topic previously published in the OT series.