This volume looks at classic and novel methods currently used by researchers to understand mood and anxiety disorders and foster precision medicine. Chapters in this book cover topics such as how the sucrose preference succeeds or fails as a measurement of anhedonia; fear conditioning in laboratory rodents; animal models for mania; rodent models for studying the impact of variation in early life mother-infant interactions on mood and anxiety; and prediction of susceptibility/resilience toward animal models of PTSD. In the Neuromethods series style, chapters include the kind of detail and key advice from the specialists needed to get successful results in your laboratory.
Comprehensive and cutting-edge, accommodating the novel views on how the neurobiology of psychiatric disorders should be reconceptualized, Psychiatric Vulnerability, Mood, and Anxiety Disorders: Tests and Models in Mice and Rats is a valuable resource for all researchers interested in learning more about this important and developing field.
Animal Models of Mood and Anxiety Disorders: The Pursuit of
Standardization and Recognition of the Complex Neurobiology of Human Mental
Health.- The Open Field Test.- The Light Dark Box Test in the Mouse.- The
Olfactory Bulbectomized Rodent Remains a Valuable Preclinical Model of
Depression and Antidepressant Activity.- Marble-Burying in Mice.- How the
Sucrose Preference Succeeds or Fails as a Measurement of Anhedonia.- A Vogel
Conflict Test Using Food Reinforcement in Mice.- Fear Conditioning in
Laboratory Rodents.- Learned Helplessness in Rodents.- Chronobiology of Mood
States: Introducing Circadian Animal Models.- Telemetry in Rats and Mice:
Methodological Considerations and Example Studies of Stress and Anxiety in
Ground-Based Spaceflight Analogs.- Utility and Implementation of Oral
Corticosteroid Exposure in Behavioral Neuroscience Research with
Rodents.- Animal Models for Mania.- Social Behavior Testing in Mice: Social
Interest, Recognition, and Aggression.- Rodent Models for Studying the Impact
of Variation in Early Life Mother-Infant Interactions on Mood and
Anxiety.- Principles of Recording Rodent Ultrasonic
Vocalizations.- Development of a Selectively Bred Mouse Model of Dominance
and Submissiveness: Technical Considerations.- Prediction of
Susceptibility/Resilience Toward Animal Models of Post-Traumatic Stress
Disorder (PTSD).
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