The hemostasis laboratory has a vital role in the diagnosis and management of patients with familial and acquired haemorrhagic and thrombotic disorders. Its role in the monitoring of traditional anticoagulant therapy, as well as therapy using new anticoagulants, presents new challenges to the laboratory. This new edition addresses these important issues, as well as international guidelines for testing, the development of international standard materials, management of haemostasis testing from the laboratory to the point-of-care, and molecular genetic testing.
Contributors, vii Foreword, x Preface, xii Steve Kitchen, John D.
Olson, & F. Eric Preston Part 1: General Quality Program 1 General quality
planning in the hemostasis laboratory, 3 John D. Olson 2 Hemostasis test
validation, performance, and reference intervals: international
recommendations and guidelines, 12 Richard A. Marlar 3 Causes of errors in
medical laboratories, 22 Giuseppe Lippi & Emmanuel J. Favaloro 4
International standards in hemostasis, 32 Trevor W. Barrowcliffe & Anthony
R. Hubbard 5 Sample integrity and preanalytical variables, 45 Dorothy
(Adcock) Funk 6 Internal quality control in the hemostasis laboratory, 57
Steve Kitchen, F. Eric Preston, & John D. Olson 7 External quality
assessment in hemostasis: its importance and significance, 65 F. Eric
Preston, Steve Kitchen, & Alok Srivastava 8 The unique challenges of
hemostatic testing in children, 77 M. Patricia Massicotte, Mary E. Bauman,
Vanessa Chan, & Anthony K.C. Chan Part 2: Quality in Coagulation Testing 9
Initial evaluation of hemostasis: reagent and method selection, 95 Wayne L.
Chandler 10 Assay of factor VIII and other clotting factors, 105 Steve
Kitchen & F. Eric Preston 11 Application of molecular genetics to the
investigation of inherited bleeding disorders, 115 Stefan Lethagen, Morten
Duno, & Lars Bo Nielsen 12 Detecting and quantifying acquired functional
inhibitors in hemostasis, 124 Bert Verbruggen, Myriam Dardikh, & Britta
Laros-van Gorkom 13 Standardization of d-dimer testing, 136 Guido Reber &
Philippe de Moerloose 14 Point-of-care testing in hemostasis, 147 Chris
Gardiner, Dianne Kitchen, Samuel Machin, & Ian Mackie Part 3: Quality in
Testing for Platelet Function and von Willebrand Disease 15 Diagnostic
assessment of platelet function, 159 Paquita Nurden, Alan Nurden, & Martine
Jandrot-Perrus 16 Laboratory evaluation of heparin-induced thrombocytopenia,
174 Theodore (Ted) E. Warkentin & Jane C. Moore 17 Laboratory evaluation of
von Willebrand disease: phenotypic analysis, 192 Emmanuel J. Favaloro 18
Laboratory analysis of von Willebrand disease: molecular analysis, 204 Anne
C. Goodeve & Ian R. Peake Part 4: Quality in Thrombophilia Testing and
Monitoring Anticoagulation 19 Quality issues in heritable thrombophilia
testing, 219 Isobel D. Walker & Ian Jennings 20 Evaluation of
antiphospholipid antibodies, 233 Michael Greaves 21 Monitoring heparin
therapy, 244 Marilyn Johnston 22 Monitoring oral anticoagulant therapy with
vitamin K antagonists, 253 Armando Tripodi 23 Monitoring new
anticoagulants, 264 Elaine Gray & Trevor W. Barrowcliffe Index, 273
