Summary |
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1 | (10) |
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11 | (6) |
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The Exploration Imperative |
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11 | (2) |
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Study Context, Challenges, and Organization |
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13 | (1) |
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Organization of This Report |
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13 | (2) |
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15 | (2) |
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2 Review Of Nasa's Program Evolution In The Life And Physical Sciences In Low-Gravity And Microgravity Environments |
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17 | (6) |
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Origin of the Research Program |
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17 | (1) |
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Evolution of the Research Mission |
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18 | (2) |
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The Apollo Program and Skylab |
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18 | (1) |
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Dedicated Life Sciences Missions on the Shuttle |
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19 | (1) |
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Dedicated Physical Sciences Missions on the Shuttle |
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20 | (1) |
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Current Status and Potential of the Life and Physical Sciences Research Programs |
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20 | (1) |
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21 | (2) |
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3 Conducting Microgravity Research: U.S. And International Facilities |
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23 | (34) |
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International Space Station |
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24 | (10) |
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25 | (3) |
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U.S. Partner ISS Facilities and Modules |
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28 | (1) |
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Laboratory Support Equipment |
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29 | (1) |
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Major ISS Facilities by Discipline |
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29 | (5) |
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Global Space Transportation Systems |
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34 | (3) |
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34 | (2) |
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36 | (1) |
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36 | (1) |
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37 | (1) |
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37 | (1) |
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37 | (1) |
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37 | (1) |
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38 | (12) |
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General Types by Field of Research |
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38 | (1) |
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U.S. Ground-based Facilities |
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39 | (6) |
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European Ground-Based Facilities |
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45 | (4) |
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Russian Ground-Based Facilities |
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49 | (1) |
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Japanese Ground-Based Facilities |
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49 | (1) |
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Chinese Ground-Based Facilities |
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50 | (1) |
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50 | (7) |
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4 Plant And Microbial Biology |
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57 | (24) |
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The Role of Plant and Microbial Research in Exploring the Effects of Microgravity |
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57 | (1) |
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58 | (11) |
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Overview: The Need for Modern Analyses Applied to Model Systems |
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58 | (1) |
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Sensory Mechanisms I Gravity Sensing and Response Mechanisms in Plants |
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58 | (2) |
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Sensory Mechanisms II Gravity and Mechanical Sensing in Microbes |
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60 | (2) |
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Sensory Mechanisms III Cells |
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62 | (1) |
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Radiation Effects on Plants and Microbes |
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63 | (1) |
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Plant and Microbial Growth Under Altered Atmospheric Pressures |
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63 | (1) |
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Spaceflight Syndrome I Response to the Integrated Spaceflight Environment |
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64 | (1) |
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Spaceflight Syndrome II Microbial Ecosystems and Environments |
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65 | (1) |
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Spaceflight Syndrome III Changes in the Virulence of Pathogens |
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66 | (1) |
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Role of Plants and Microbes in Long-Term Life Support Systems |
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67 | (2) |
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Available and Needed Platforms |
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69 | (2) |
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69 | (1) |
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69 | (1) |
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The Lunar Surface as a Platform |
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70 | (1) |
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71 | (1) |
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Prioritized Research Recommendations |
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71 | (2) |
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Programmatic Issues and Recommendations |
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73 | (2) |
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75 | (6) |
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5 Behavior And Mental Health |
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81 | (18) |
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82 | (2) |
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82 | (1) |
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83 | (1) |
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84 | (4) |
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84 | (1) |
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84 | (1) |
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85 | (1) |
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85 | (1) |
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86 | (1) |
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87 | (1) |
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88 | (3) |
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89 | (1) |
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89 | (1) |
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Autonomy and Other Environmentally Mediated Factors |
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90 | (1) |
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90 | (1) |
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90 | (1) |
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90 | (1) |
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90 | (1) |
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91 | (1) |
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91 | (3) |
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Effects of Acute Sleep Loss |
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92 | (1) |
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Effects of Chronic Sleep Restriction |
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92 | (1) |
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93 | (1) |
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94 | (1) |
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Highest-Priority Recommendations |
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94 | (1) |
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95 | (4) |
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6 Animal And Human Biology |
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99 | (106) |
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100 | (56) |
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Risks for Bone Loss During Long-Duration Space Missions |
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100 | (6) |
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Risks for Skeletal Muscle During Long-Duration Spaceflight |
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106 | (8) |
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Risks for Sensory-Motor and Vestibular Deficits During Long-Duration Spaceflight |
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114 | (5) |
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Effects of the Spaceflight Environment on Fluid Shifts |
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119 | (6) |
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Risks for the Cardiovascular System During Long-Duration Spaceflight |
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125 | (11) |
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Risks for Pulmonary Function During Long-Duration Space Missions |
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136 | (2) |
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Risks for Specific Endocrine Influences During Long-Duration Space Missions |
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138 | (7) |
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Effects of the Spaceflight Environment on the Immune System |
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145 | (4) |
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Reproduction and Development |
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149 | (5) |
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Merging of Disciplines to Study Gravity-Dependent Adaptations |
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154 | (2) |
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Research Priorities and Platforms |
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156 | (5) |
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157 | (1) |
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157 | (1) |
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158 | (1) |
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158 | (1) |
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158 | (1) |
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159 | (1) |
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159 | (1) |
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Reproduction and Development |
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160 | (1) |
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160 | (1) |
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Overarching and Programmatic Issues |
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161 | (4) |
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The Need for Animal Research on the ISS and Other Space Platforms |
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161 | (1) |
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Recommendation Concerning the National Laboratory |
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162 | (1) |
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Animal Research on Other Platforms |
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162 | (1) |
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Improved Access to Biological Samples and Data from Astronauts |
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163 | (1) |
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Limitations of Ground-Based Facilities |
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163 | (1) |
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Limitations on Sample Delivery Back to Earth |
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163 | (1) |
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Space Platform for Research Beyond 2020 Will Be Needed |
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163 | (1) |
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Relevance of the Report to NASA Fundamental Space Biology Strategic Planning |
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164 | (1) |
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165 | (40) |
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7 Crosscutting Issues For Humans In The Space Environment |
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205 | (44) |
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Solving Integrative Biomedical Problems Through Translational Research |
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206 | (23) |
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Stress---Physical and Physiological Considerations |
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206 | (7) |
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Food, Nutrition, and Energy Balance |
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213 | (4) |
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217 | (4) |
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221 | (1) |
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Biological Sex/Gender Considerations |
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222 | (3) |
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225 | (4) |
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Increasing Translational Research in the Space/Life Sciences |
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229 | (4) |
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Implementation of a Clinical and Translational Science Framework |
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229 | (2) |
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The ISS and the U.S. National Laboratory as an Analog of a CTSA Clinical Research Unit |
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231 | (1) |
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Aspects of Clinical and Translational Science Applicable to Space Biomedical Research |
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232 | (1) |
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Overarching Issues and Gaps in the Knowledge Base |
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233 | (2) |
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Educating the Next Generation of Space Translational Scientists |
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233 | (1) |
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The Procurement Process and Its Effect on Flight Research |
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234 | (1) |
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International Collaboration Between Space Agencies |
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234 | (1) |
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235 | (3) |
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235 | (1) |
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Food, Nutrition, and Energy Balance |
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236 | (1) |
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236 | (1) |
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237 | (1) |
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237 | (1) |
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Overarching Issue---Integrated Countermeasures Development |
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237 | (1) |
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238 | (11) |
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8 Fundamental Physical Sciences In Space |
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249 | (16) |
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250 | (8) |
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Thrust I Soft-Condensed-Matter Physics and Complex Fluids |
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250 | (1) |
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Thrust II Precision Measurements of Fundamental Forces and Symmetries |
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251 | (2) |
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253 | (3) |
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Thrust IV Condensed Matter and Critical Phenomena |
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256 | (2) |
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Available and Needed Platforms |
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258 | (1) |
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258 | (1) |
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258 | (1) |
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The International Space Station |
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258 | (1) |
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259 | (1) |
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259 | (1) |
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Program Recommendations for Experiment-Specific Support Facilities on Various Platforms |
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259 | (1) |
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Research Program Recommendations |
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260 | (1) |
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Recommended Program Element 1 Research on Complex Fluids and Soft Matter (FP1) |
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260 | (1) |
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Recommended Program Element 2 Research That Tests and Expands Understanding of the Fundamental Forces and Symmetries of Nature (FP2) |
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261 | (1) |
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Recommended Program Element 3 Research Related to the Physics and Applications of Quantum Gases (FP3) |
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261 | (1) |
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Recommended Program Element 4 Investigations of Matter in the Vicinity of Critical Points (FP4) |
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261 | (1) |
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Programmatic Conclusions, Findings, and Recommendations |
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261 | (1) |
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262 | (3) |
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9 Applied Physical Sciences |
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265 | (34) |
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266 | (8) |
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Research in Support of NASA's Exploration Missions |
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268 | (4) |
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Fundamental Research in Complex Fluid Physics |
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272 | (1) |
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Recommended Research in Fluid Physics |
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273 | (1) |
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274 | (6) |
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Research in Support of NASA's Exploration Missions |
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275 | (1) |
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Fundamental Combustion Research |
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275 | (4) |
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Recommended Research in Combustion |
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279 | (1) |
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280 | (5) |
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Research in Support of NASA's Exploration Missions |
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280 | (3) |
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Fundamental Materials Research |
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283 | (2) |
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Recommended Research in Materials Science |
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285 | (1) |
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Research Prioritization and Recommendations |
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285 | (2) |
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Fluid Physics Recommendations |
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286 | (1) |
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Combustion Recommendations |
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287 | (1) |
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Materials Science Recommendations |
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287 | (1) |
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287 | (4) |
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Programmatic Recommendations |
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291 | (1) |
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292 | (7) |
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10 Translation To Space Exploration Systems |
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299 | (56) |
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Research Issues and Technology Needs |
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300 | (45) |
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Space Power and Thermal Management |
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300 | (10) |
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310 | (7) |
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Extravehicular Activity Systems |
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317 | (6) |
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323 | (2) |
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325 | (5) |
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Space Resource Extraction, Processing, and Utilization |
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330 | (5) |
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Planetary Surface Construction |
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335 | (10) |
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345 | (1) |
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346 | (9) |
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11 The Role Of The International Space Station |
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355 | (6) |
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Unique Status and Capabilities |
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355 | (1) |
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Areas of Research on the International Space Station |
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356 | (4) |
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Life Sciences Research on the ISS |
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356 | (2) |
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Physical Sciences Research on the ISS |
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358 | (1) |
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Utilizing the ISS for Research |
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359 | (1) |
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359 | (1) |
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360 | (1) |
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12 Establishing A Life And Physical Sciences Research Program: Programmatic Issues |
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361 | (18) |
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Programmatic Issues for Strengthening the Research Enterprise |
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362 | (11) |
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Elevating the Priority of Life and Physical Sciences Research in Space Exploration |
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362 | (2) |
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Establishing a Stable and Sufficient Funding Base |
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364 | (3) |
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Improving the Process for Solicitation and Review of High-Quality Research |
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367 | (1) |
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Rejuvenating a Strong Pipeline of Intellectual Capital Through Training and Mentoring Programs |
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368 | (1) |
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Linking Science to Mission Capabilities Through Multidisciplinary Translational Programs |
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369 | (3) |
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Developing Commercial Sector Interactions to Advance Science, Technology, and Economic Growth |
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372 | (1) |
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Synergies with Other National and International Agencies |
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373 | (2) |
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Administrative Oversight of Life and Physical Sciences Research |
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375 | (1) |
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375 | (1) |
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376 | (3) |
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13 Establishing A Life And Physical Sciences Research Program: An Integrated Microgravity Research Portfolio |
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379 | (22) |
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380 | (2) |
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Facility and Platform Requirements |
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382 | (11) |
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Ground-Based Research Platforms |
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382 | (10) |
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392 | (1) |
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392 | (1) |
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Planetary or Lunar Surfaces as Platforms |
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392 | (1) |
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Space Platforms for Research Beyond 2020 |
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393 | (1) |
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Highest-Priority Research Areas and Objectives |
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393 | (1) |
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Research Portfolio Selection Options |
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393 | (3) |
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Timeline for the Conduct of Research |
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396 | (1) |
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Impact of Science on Defining U.S. Space Exploration Policy |
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397 | (1) |
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397 | (4) |
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401 | (2) |
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B Glossary and Selected Acronyms |
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403 | (18) |
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C Committee, Panel, and Staff Biographical Information |
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421 | |