Regenerative Hepatology and Liver Transplantation, Volume Two in the
Regenerative and Transplant Medicine series, is an essential resource as no field in the biomedical sciences has seen more interest than organ transplantation with regard to regenerative medicine, primarily because of the urgent need to improve transplant outcomes and increase transplantation rates. The goal of this book is to bridge regenerative and transplant medicine by illustrating the state-of-the-art of clinical liver transplantation, as well as of the progress of regenerative medicine (RM) investigations aimed at the bioengineering, regeneration and repair of the liver.This volume will be well-recognized in the current global trend toward increasing organ donation by utilizing such cutting-edge technologies. Written by the worlds experts in the field of liver disease, it is perfect for transplant operators, researchers, regenerative medicine operators, tissue engineering operators, biotech operators, and those in academia, industry and regulatory agencies working to advance the field.
- Presents the latest volume in the Regenerative and Transplant Medicine series, focusing on the liver
- Covers the liver and diseases, transplantation, cell transplantation, liver preservation and machine perfusion
- Builds on previous works and demonstrates how regenerative and transplant medicine work together to provide an increased ability to improve health care outcomes for individuals
Part 1 The Liver and Liver Diseases1. The Liver: structure, physiology and metabolism2. Prevalence of liver disease around the world3. Viral Hepatitis4. Non-alcoholic steatohepatitis5. Alcoholic liver disease6. Inborn errors of metabolism7. Liver fibrosis/cirrhosis8. Biomarkers in liver diseases / Precision Medicine
Part 2 Liver Transplantation9.Living donor Liver Transplantation10.Pediatric Liver transplantation11.Small-for-size syndrome in Liver transplantation 12.New Indications for Liver Transplant13.Clinical trials design and endpoints in liver transplantation14.Oncologic liver Transplantation15. Hepatocellular carcinoma Management16.Marginal Donors to Expand the donor Pool17.Domino Transplantation18.Xenotransplantation
Part 3 Cell Transplantation19. Hepatocyte Transplantation20. Alginate encapsulated hepatocyte transplantation21. Mesenchymal Stem Cell Transplantation22. Fetal Hepatoblast Transplantation23. Biliary Tree Stem Cell Transplantation24. Liver Organoids
Part 4 Liver Preservation and Machine perfusion25. General Principles of Organ Preservation in Liver transplantation26. Machine perfusion preservation Types and Principles27. Ischemia-Reperfusion injury28. Clinical trials with liver machine preservation
Part 5 Regenerative Medicine in Liver Disease and Transplantation29. Liver Regeneration30. Gene Therapy in Liver Transplantation31. Liver Bioengineering32. Bioprinting of livers33. Nanotechnology application in Liver Transplantation34. Acute Liver Failure and Bioreactors/Liver Assist devices35. Liver Organoids36. Liver Bud37. hPSC-derived liver cells for transplantation38. Genome edited humanized pigs for human liver generation39. Liver aging
Paulo Martins MD, PhD, FAST, FEBS, FACS is a Transplant Surgeon and the lead of the Transplantation Lab. He is an associate Professor of Surgery and Adjunct Prof of Pathology at the University of Oklahoma. He graduated from the Federal University of Bahia in Brazil, completed a PhD in transplant immunology at the University of Berlin, and a transplant surgery fellowship at Harvard University (MGH). He is a member of the Sigma Xi Scientific Research Honor Society, Alpha Omega Alpha honor society. He was the previous chair of the International Liver Transplant Society Basic and Translational Science committee and current chair of the American Society of Transplantation Organ Preservation and Recovery committee. He is in the top 2% World Scientist list from Elsevier/Stanford University.
Pedro Baptista, PharmD, PhD, Marie Curie Alumni, is a Senior ARAID Researcher at IIS Aragon, Zaragoza, Spain, where he directs the Laboratory of Organ Bioengineering and Regenerative Medicine. He serves as a Visiting Professor of Biomedical Engineering at Universidad Carlos III de Madrid. Dr. Baptista earned his Pharmacy Degree from the University of Lisbon and completed his PhD training at the Wake Forest Institute for Regenerative Medicine in Winston-Salem, NC, USA. He is Secretary General of the European Society of Artificial Organs (ESAO) and Chair of the European Association for the Study of the Liver (EASL) Regenerative Hepatology Consortium. Dr. Baptista has published extensively in high-impact journals on organ bioengineering, organoids, and regenerative hepatology, holds four patents, and has successfully spun off several related technologies into companies.
