This volume summarizes the current knowledge about the mechanisms of the renal handling of xenobiotic metabolites and the mechanism by which xenobiotics produce nephrotoxicity. It focuses on three areas - the assessment of xenobiotic-induced nephrotoxicity, the renal disposition of xenobiotics, and the bioactivation and nephrotoxicity of xenobiotics. The authors represent several fields of specialization, and the multidisciplinary approach taken should enhance the understanding of the renal disposition and nephrotoxicity of xenobiotics.
Part 1 Assessment of xenobiotic-induced nephrotoxicity: isolated renal
cells in the study of nephron heterogeneity and nephrotoxicity, L.H. Lash;
the use of cultured renal epithelial cells "in vitro" assessment of
xenobiotic-induced nephrotoxicity, G. Gstraunthaler and W. Pfaller;
epithelial cell fusion of normal and pH-transformed madin darby canine kidney
cells - new tool for studying mechanisms of carcinogenesis, H. Oberleithner;
NMR - a tool for the study of renal function and nephrotoxicity, B.D. Ross
and J.C. Bellinger. Part 2 Renal disposition of xenobiotics: interaction of
xenobiotics with organic anion and cation transport systems in renal proximal
tubule cells, K.J. Ullrich, et al; renal transport of heavy metals, E.C.
Foulkes; renal transport and metabolism of mercapturic acids and their
precursors, the S-conjugates of glutathione and cysteine, S. Silbernagl and
A. Heuner; renal xenobiotic metabolism - role in bioactivation of nephrotoxic
xenobiotics. Biactivation and nephrotoxicity of xenobiotics, M.W. Anders and
W. Dekant; bioactivation of halogenated xenobiotics by S-conjugate formation,
W. Dekant, et al; a2h-globulin-related nephrotoxicity, E.A. Lock; cyclosporin
A induced nephrotoxicity - current concepts and controversies, P.H. Whiting;
the renal tubular transport and nephrotoxicity of beta-lactam antibiotics,
B.M. Tune; the nephrotoxicity of heavy metals, W.O. Berndt; the
nephrotoxicity of anticancer drugs, R.F. Borch; hormone-induced
nephrocarcinogenicity, M. Metzler; nephrocarcinogenicity of haloalkenes and
alkynes, S. Vamvakas, et al.
