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El. knyga: RNA and DNA Editing: Molecular Mechanisms and Their Integration into Biological Systems

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  • Formatas: PDF+DRM
  • Išleidimo metai: 11-Mar-2008
  • Leidėjas: Wiley-Interscience
  • Kalba: eng
  • ISBN-13: 9780470262252
Kitos knygos pagal šią temą:
  • Formatas: PDF+DRM
  • Išleidimo metai: 11-Mar-2008
  • Leidėjas: Wiley-Interscience
  • Kalba: eng
  • ISBN-13: 9780470262252
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In a field this highly charged there are bound to be open questions and avenues of new research, and the contributors of these articles give readers not only the most up-to-date advances but ideas for further studies building upon their own. They concentrate on the interrelationship of RNA and DNA editing with other chemical and biological processes, working on the diversification of the proteome through RNA and DNA editing (including diversification of the exon code, antibody gene diversification, interactions in RNA editing processes, and the machinery of RNA editing in plant organelles), functional coordination of RNA editing with other cellular mechanisms (including transfer DNA editing enzymes, A-to-1 editing as a co-transcritional RNA processing event, ribonucleoprotein catalysts, spliceosomal RNA modifications, gene silencing, APOBEC-1 and APOBEC-1 complementation factor, and antiviral functions of APOBEC-3 cytidine deaminases) predictive structures (including editing of repeats) and structural approaches (including the features of the ADAR family of enzymes and their substrates). Annotation ©2008 Book News, Inc., Portland, OR (booknews.com)

RNA and DNA Editing assembles a team of leading experts who present the latest discoveries in the field alongside the latest models and methodology. In addition, the authors set forth the many open questions and suggest routes for further investigation. Overall, the book serves as a practical guide for professionals in the field who need to understand the interrelationship of RNA and DNA editing with other chemical and biological processes.

Recenzijos

"This volume is a very good compilation of the state of the art in RNA and DNA editing, and will be useful and fascinating reading for both researchers in the field and anyone with an interest in joining it." (The Quarterly Review of Biology, June 2009)

Preface.
Acknowledgements.
Contributors.
Part I: Diversification of the Proteome through RNA and DNA Editing.
Chapter
1. Diversifying Exon Code Through A-To-I RNA Editing.
Chapter
2. Antibody Gene Diversification by Aid-Catalyzed DNA Editing.
Chapter
3. Protein-Protein and RNA-Protein Interactions in U-Insertion/Deletion RNA Editing Complexes.
Chapter
4. Machinery of RNA editing in Plant Organelles.
Part II: Functional Coordination of RNA Editing With Other Cellular Mechanisms.
Chapter
5. Transfer RNA Editing Enzymes: At the Crossroads of Affinity and Specificity.
Chapter
6. A-To-I Editing as a Co-Transcriptional RNA Processing Event.
Chapter
7. Studying and Working with Ribonucleoproteins that Catalyze H/ACA Guided RNA Modification.
Chapter
8. Functional Roles of Spliceosomal SNRNA Modifications in Pre-mRNA Splicing.
Chapter
9. A Role for A-To-I Editing in Gene Silencing.
Chapter
10. biological Implications and Broader-Range Functions For Apobec-1 and Apobec-1 Complementation Factors (ACF)
Chapter
11. Antiviral Function of APOEC3 Cytidine Deaminases.
Part III: Predictive Structures.
Chapter
12. A-To-I Editing of ALU Repeats.
Chapter
13. RNA Editing in Dinoflagellates and Implications for the Evolutionary History of the Editing Machinery.
Part IV: Structural Approaches.
Chapter
14. The Box C/D RNPs: Evolutionarily Ancient Nucleotide Modification Complexes.
Chapter
15. Structural Features of the Adar Family of Enzymes and Their Substrates.
Chapter
16. Chemistry, Phylogeny, and three-Dimensional Structure of the Apobec Protein Family.
Index.


Harold C. Smith, PhD, is Professor in the Department of Biochemistry and Biophysics at the University of Rochester and the founder and Chief Scientific Officerof OyaGen, a biotech company that develops drugs that target editing enzymes. Dr. Smith organized the first Gordon Research Conference on RNA Editing in 1997 and holds four patents.