In this book the authors review the field and explore the potential role of RNAi and other RNA technologies in cardiovascular medicine and research. They highlight the impressive recent progress but also the hurdles that still must be overcome before this promising technology is finally ready for translation and clinical use.
In this urgently needed book the authors review the field and explore the potential role of RNAi and other RNA technologies in cardiovascular medicine and research. They highlight the impressive recent progress but also the hurdles that must still be overcome.
MicroRNA.- An Overview of MicroRNA.- MicroRNAs and Their Potential.-
miRNAs and Their Emerging Role in Cardiac Hypertrophy.- MicroRNAs and the
Control of Heart Pathophysiology.- MicroRNA Systems Biology.- RNA
Interference.- Targeting Viral Heart Disease by RNA Interference.- Design of
siRNAs and shRNAs for RNA Interference: Possible Clinical Applications.- RNA
Interference and MicroRNA Modulation for the Treatment of Cardiac Disorders.-
Cardiac Delivery of Nucleic Acids by Transcriptional and Transductional
Targeting of Adeno-Associated Viral Vectors.- Ribozymes.- Characterization of
Hammerhead Ribozymes Potentially Suitable for the Treatment of
Hyper-Proliferative Vascular Diseases.- Applications of Ribozymes and
PyrroleImidazole Polyamides for Cardiovascular and Renal Diseases.-
Noncoding, Aptamer and Antisense RNAs.- Noncoding RNAs in Human Diseases.-
Aptamers and siRNAs in Cardiovascular Disease.- Nucleic Acid Aptamers for
Cardiovascular Therapeutics.- NF?B Decoy Oligodeoxynucleotide-Based Therapy
in Cardiovascular Diseases.- Antisense Therapy for Restenosis Following
Percutaneous Coronary Interventions.- Toxic RNA in Pathogenesis of Human
Neuromuscular Disorders.
