Preface |
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xv | |
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1 Brief Review of Hypothesis Testing Concepts/Issues and Confidence Intervals |
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1 | (16) |
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1.1 Basic Concepts of Hypothesis Testing |
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1 | (4) |
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1.2 Review of Confidence Intervals and Their Relationship to Hypothesis Tests |
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5 | (4) |
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9 | (1) |
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1.4 Observed Power, Retrospective Power, Conditional Power, and Predictive Power |
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9 | (1) |
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1.5 Testing for Equality, Equivalence, Noninferiority, or Superiority |
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10 | (7) |
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11 | (1) |
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12 | (2) |
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14 | (3) |
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2 Methods of Determining Sample Sizes |
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17 | (40) |
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2.1 Internal Pilot Study Versus External Pilot Study |
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20 | (4) |
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2.2 Examples: Frequentist and Bayesian |
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24 | (8) |
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2.2.1 Bayesian Approaches |
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30 | (1) |
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2.2.2 Probability Assessment Approach |
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31 | (1) |
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2.2.3 Reproducibility Probability Approach |
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32 | (1) |
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2.2.4 Competing Probability Approach |
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32 | (1) |
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2.2.5 Evidential Approach |
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32 | (1) |
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32 | (1) |
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2.4 Sample Sizes for Confidence Intervals |
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33 | (6) |
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2.4.1 Using the Finite Population Correction Factor |
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36 | (2) |
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2.4.1.1 Estimating Population Totals |
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38 | (1) |
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2.5 Confidence Intervals on Sample Size and Power |
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39 | (1) |
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2.6 Specification of Power |
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39 | (1) |
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40 | (1) |
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2.8 Ethical Considerations |
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40 | (2) |
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2.9 Standardization and Specification of Effect Sizes |
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42 | (1) |
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43 | (2) |
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2.11 Software and Applets |
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45 | (2) |
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47 | (10) |
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47 | (6) |
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53 | (4) |
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57 | (46) |
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3.1 One Mean, Normality, and Known Standard Deviation |
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58 | (8) |
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3.1.1 Using the Coefficient of Variation |
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65 | (1) |
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3.2 One Mean, Standard Deviation Unknown, Normality Assumed |
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66 | (1) |
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3.3 Confidence Intervals on Power and/or Sample Size |
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67 | (3) |
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3.4 One Mean, Standard Deviation Unknown, Nonnormality Assumed |
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70 | (1) |
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3.5 One Mean, Exponential Distribution |
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71 | (1) |
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3.6 Two Means, Known Standard Deviations---Independent Samples |
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71 | (3) |
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3.6.1 Unequal Sample Sizes |
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74 | (1) |
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3.7 Two Means, Unknown but Equal Standard Deviations---Independent Samples |
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74 | (3) |
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3.7.1 Unequal Sample Sizes |
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76 | (1) |
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3.8 Two Means, Unequal Variances and Sample Sizes---Independent Samples |
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77 | (1) |
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3.9 Two Means, Unknown and Unequal Standard Deviations---Independent Samples |
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77 | (1) |
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3.10 Two Means, Known and Unknown Standard Deviations---Dependent Samples |
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78 | (3) |
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3.11 Bayesian Methods for Comparing Means |
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81 | (1) |
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3.12 One Variance or Standard Deviation |
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81 | (2) |
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83 | (1) |
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3.14 More Than Two Variances |
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84 | (1) |
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3.15 Confidence Intervals |
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84 | (9) |
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3.15.1 Adaptive Confidence Intervals |
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85 | (1) |
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3.15.2 One Mean, Standard Deviation Unknown---With Tolerance Probability |
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85 | (3) |
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3.15.3 Difference Between Two Independent Means, Standard Deviations Known and Unknown---With and Without Tolerance Probability |
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88 | (2) |
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3.15.4 Difference Between Two Paired Means |
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90 | (1) |
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91 | (1) |
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3.15.6 One-Sided Confidence Bounds |
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92 | (1) |
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93 | (1) |
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94 | (1) |
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94 | (1) |
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95 | (8) |
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95 | (1) |
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96 | (3) |
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99 | (4) |
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103 | (42) |
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103 | (12) |
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4.1.1 One Proportion---With Continuity Correction |
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107 | (1) |
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4.1.2 Software Disagreement and Rectification |
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108 | (1) |
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4.1.3 Equivalence Tests and Noninferiority Tests for One Proportion |
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109 | (1) |
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4.1.4 Confidence Interval and Error of Estimation |
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110 | (3) |
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4.1.5 One Proportion--Exact Approach |
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113 | (2) |
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4.1.6 Bayesian Approaches |
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115 | (1) |
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115 | (11) |
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4.2.1 Two Proportions---With Continuity Correction |
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119 | (2) |
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4.2.2 Two Proportions---Fisher's Exact Test |
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121 | (1) |
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4.2.3 What Approach Is Recommended? |
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122 | (1) |
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4.2.4 Correlated Proportions |
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123 | (1) |
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4.2.5 Equivalence Tests for Two Proportions |
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124 | (1) |
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4.2.6 Noninferiority Tests for Two Proportions |
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125 | (1) |
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4.2.7 Need for Pilot Study? |
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125 | (1) |
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4.2.8 Linear Trend in Proportions |
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125 | (1) |
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4.2.9 Bayesian Method for Estimating the Difference of Two Binomial Proportions |
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126 | (1) |
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126 | (3) |
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4.4 Multinomial Probabilities and Distributions |
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129 | (1) |
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130 | (2) |
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4.5.1 Pilot Study Needed? |
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132 | (1) |
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132 | (3) |
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4.7 Bayesian Sample Size Determination Methods for Rates |
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135 | (1) |
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135 | (1) |
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136 | (9) |
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136 | (4) |
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140 | (4) |
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144 | (1) |
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5 Regression Methods and Correlation |
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145 | (38) |
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145 | (10) |
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5.1.1 Simple Linear Regression |
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146 | (4) |
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5.1.2 Multiple Linear Regression |
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150 | (5) |
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5.1.2.1 Application: Predicting College Freshman Grade Point Average |
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155 | (1) |
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155 | (12) |
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5.2.1 Simple Logistic Regression |
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156 | (2) |
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5.2.1.1 Normally Distributed Covariate |
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158 | (4) |
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162 | (1) |
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5.2.2 Multiple Logistic Regression |
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163 | (2) |
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5.2.2.1 Measurement Error |
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165 | (1) |
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5.2.3 Polytomous Logistic Regression |
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165 | (1) |
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5.2.4 Ordinal Logistic Regression |
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166 | (1) |
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5.2.5 Exact Logistic Regression |
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167 | (1) |
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167 | (2) |
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169 | (3) |
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172 | (1) |
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5.6 Other Types of Regression Models |
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172 | (1) |
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172 | (4) |
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5.7.1 Confidence Intervals |
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174 | (1) |
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5.7.2 Intraclass Correlation |
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175 | (1) |
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175 | (1) |
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176 | (1) |
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177 | (6) |
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177 | (3) |
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180 | (3) |
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183 | (60) |
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6.1 One Factor---Two Fixed Levels |
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184 | (3) |
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6.1.1 Unequal Sample Sizes |
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186 | (1) |
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6.2 One Factor---More Than Two Fixed Levels |
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187 | (16) |
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6.2.1 Multiple Comparisons and Dunnett's Test |
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192 | (1) |
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6.2.2 Analysis of Means (ANOM) |
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193 | (2) |
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6.2.3 Unequal Sample Sizes |
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195 | (1) |
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6.2.4 Analysis of Covariance |
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196 | (1) |
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6.2.5 Randomized Complete Block Designs |
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197 | (1) |
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6.2.6 Incomplete Block Designs |
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198 | (1) |
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6.2.7 Latin Square Designs |
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199 | (3) |
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6.2.7.1 Graeco-Latin Square Designs |
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202 | (1) |
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203 | (2) |
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205 | (4) |
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6.4.1 22 Design with Equal and Unequal Variances |
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206 | (1) |
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6.4.2 Unreplicated 2k Designs |
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206 | (2) |
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6.4.3 Software for 2k Designs |
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208 | (1) |
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209 | (1) |
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6.6 Detecting Conditional Effects |
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210 | (1) |
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6.7 General Factorial Designs |
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211 | (1) |
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6.8 Repeated Measures Designs |
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212 | (6) |
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215 | (2) |
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217 | (1) |
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6.9 Response Surface Designs |
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218 | (1) |
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6.10 Microarray Experiments |
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219 | (1) |
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220 | (1) |
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220 | (5) |
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6.11.1 Plackett-Burman Designs |
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220 | (2) |
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6.11.2 Split-Plot and Strip-Plot Designs |
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222 | (2) |
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224 | (1) |
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225 | (1) |
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6.12 Designs for Nonnormal Responses |
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225 | (2) |
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6.13 Designs with Random Factors |
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227 | (1) |
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228 | (1) |
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6.15 Computer Experiments |
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228 | (1) |
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6.16 Noninferiority and Equivalence Designs |
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229 | (1) |
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6.17 Pharmacokinetic Experiments |
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229 | (1) |
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6.18 Bayesian Experimental Design |
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229 | (1) |
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230 | (2) |
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232 | (11) |
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233 | (1) |
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234 | (5) |
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239 | (4) |
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243 | (34) |
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245 | (6) |
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7.1.1 Cluster Randomized Trials |
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247 | (1) |
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247 | (1) |
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7.1.2.1 Phase II Cancer Trials |
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247 | (1) |
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247 | (1) |
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7.1.4 Longitudinal Clinical Trials |
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248 | (1) |
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7.1.5 Fixed Versus Adaptive Clinical Trials |
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248 | (1) |
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7.1.6 Noninferiority Trials |
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249 | (1) |
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7.1.7 Repeated Measurements |
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249 | (1) |
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250 | (1) |
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7.1.9 Use of Internal Pilot Studies for Clinical Trials |
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250 | (1) |
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7.1.10 Using Historical Controls |
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250 | (1) |
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7.1.11 Trials with Combination Treatments |
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251 | (1) |
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7.1.12 Group Sequential Trials |
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251 | (1) |
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7.1.13 Vaccine Efficacy Studies |
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251 | (1) |
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7.2 Bioequivalence Studies |
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251 | (1) |
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7.3 Ethical Considerations |
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252 | (1) |
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7.4 The Use of Power in Clinical Studies |
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252 | (1) |
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7.5 Preclinical Experimentation |
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253 | (1) |
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7.6 Pharmacodynamic, Pharmacokinetic, and Pharmacogenetic Experiments |
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253 | (1) |
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7.7 Method of Competing Probability |
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254 | (1) |
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255 | (1) |
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7.9 Cost and Other Sample Size Determination Methods for Clinical Trials |
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256 | (1) |
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7.10 Meta-Analyses of Clinical Trials |
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256 | (1) |
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257 | (2) |
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7.12 Survey Results of Published Articles |
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259 | (1) |
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260 | (3) |
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263 | (14) |
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263 | (12) |
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275 | (2) |
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277 | (30) |
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277 | (19) |
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8.1.1 Shewhart Measurement Control Charts |
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278 | (3) |
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8.1.2 Using Software to Determine Subgroup Size |
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281 | (1) |
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282 | (2) |
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8.1.2.2 S-Chart and S2-Chart |
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284 | (2) |
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8.1.3 Attribute Control Charts |
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286 | (3) |
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8.1.4 CUSUM and EWMA Charts |
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289 | (1) |
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8.1.4.1 Subgroup Size Considerations for CUSUM Charts |
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290 | (1) |
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8.1.4.2 CUSUM and EWMA Variations |
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291 | (1) |
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8.1.4.3 Subgroup Size Determination for CUSUM and EWMA Charts and Their Variations |
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291 | (2) |
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8.1.4.4 EWMA Applied to Autocorrelated Data |
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293 | (1) |
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8.1.5 Adaptive Control Charts |
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293 | (1) |
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8.1.6 Regression and Cause-Selecting Control Charts |
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293 | (2) |
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8.1.7 Multivariate Control Charts |
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295 | (1) |
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296 | (1) |
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8.3 Process Capability Indices |
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297 | (1) |
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298 | (2) |
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8.5 Measurement System Appraisal |
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300 | (1) |
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300 | (1) |
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8.7 Reliability and Life Testing |
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301 | (1) |
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301 | (1) |
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302 | (5) |
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302 | (3) |
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305 | (2) |
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9 Survival Analysis and Reliability |
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307 | (16) |
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307 | (10) |
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308 | (3) |
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311 | (1) |
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312 | (1) |
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9.1.2 Wilcoxon-Breslow-Gehan Test |
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313 | (1) |
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313 | (1) |
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314 | (1) |
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9.1.5 Cox Proportional Hazards Model |
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314 | (1) |
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9.1.6 Joint Modeling of Longitudinal and Survival Data |
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315 | (1) |
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316 | (1) |
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9.1.8 Comparison of Software and Freeware |
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316 | (1) |
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317 | (1) |
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318 | (5) |
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319 | (2) |
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321 | (2) |
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323 | (18) |
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10.1 Wilcoxon One-Sample Test |
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324 | (3) |
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10.1.1 Wilcoxon Test for Paired Data |
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327 | (1) |
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10.2 Wilcoxon Two-Sample Test (Mann-Whitney Test) |
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327 | (4) |
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10.2.1 van Elteren Test---A Stratified Mann-Whitney Test |
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331 | (1) |
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10.3 Kruskal--Wallis One-Way ANOVA |
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331 | (1) |
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331 | (3) |
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334 | (1) |
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334 | (1) |
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10.7 Quasi-Likelihood Method |
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334 | (1) |
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10.8 Rank Correlation Coefficients |
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335 | (1) |
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335 | (1) |
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336 | (5) |
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336 | (3) |
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339 | (2) |
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341 | (22) |
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11.1 Case-Control Studies |
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341 | (1) |
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342 | (1) |
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11.3 Longitudinal Studies |
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342 | (1) |
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343 | (1) |
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11.5 Receiver Operating Characteristic ROC Curves |
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343 | (1) |
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343 | (1) |
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11.7 Sequential Sample Sizes |
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343 | (1) |
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344 | (1) |
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11.8.1 Vegetation Surveys |
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344 | (1) |
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345 | (1) |
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346 | (1) |
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11.11 Multivariate Analysis of Variance and Other Multivariate Methods |
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346 | (2) |
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11.12 Structural Equation Modeling |
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348 | (1) |
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11.13 Multilevel Modeling |
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349 | (1) |
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11.14 Prediction Intervals |
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349 | (1) |
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11.15 Measures of Agreement |
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350 | (1) |
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350 | (1) |
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11.17 Agricultural Applications |
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350 | (1) |
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11.18 Estimating the Number of Unseen Species |
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351 | (1) |
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351 | (1) |
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351 | (1) |
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11.21 Genome-wide Association Studies |
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351 | (1) |
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352 | (1) |
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352 | (1) |
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353 | (10) |
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354 | (9) |
Answers to Selected Exercises |
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363 | (6) |
Index |
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369 | |