The book presents the currently available clinical, epidemiological, and experimental data on short bowel syndrome (SBS), with special emphasis on the medical, surgical, and nutritional care of patients affected by SBS, based on the most up-to-date, evidence-based data available.
The prevalence of SBS has been rising along with significant advances in medicine and the overcoming of barriers such as more aggressive cancer resections and the increase in life expectancy, which has led to a higher prevalence of mesenteric ischemia and thrombosis. More recently, the SARS-CoV-2 infection has caused an increase in the incidence of thrombosis. The rising prevalence of SBS has prompted researchers and healthcare professionals to explore innovative treatments such as intestinal transplantation and the development of specialized diets and medications to improve patients' quality of life.
The volume emphasizes the use of growth factors, which are likely to become increasingly important for promoting the structural adaptability of the intestine. It also highlights the need for ongoing research in the field of SBS to further understand the underlying mechanisms and develop new treatment options. Additionally, it highlights the importance of patient education and empowerment in managing their condition and making informed decisions about their care.
The importance of a skilled interdisciplinary team in providing care for these individuals is also outlined. This book will serve as a quick reference on the medical, surgical, and nutritional care of complex patients with SBS, for nutritionists, dietitians, general practitioners, gastroenterologists, surgeons, nurses, and pharmacists alike.
Chapter 1: Definition and classification of short bowel syndrome.-
Chapter 2: Epidemiology and survival of short bowel syndrome.
Chapter 3:
Pathophysiology and anatomical considerations in short bowel syndrome.-
Chapter 4: Humanistic burden of short bowel syndrome.
Chapter 5: Intestinal
adaptation mechanisms and therapy goals.
Chapter 6: Free water,
electrolytes, and acid-base balance disturbances in short bowel syndrome.-
Chapter 7: Refeeding syndrome: prevention, diagnosis, and treatment.
Chapter
8: Cholelithiasis and nephrolithiasis in short bowel syndrome.
Chapter 9:
D-lactate encephalopathy in patients with short bowel syndrome.
Chapter 10:
Metabolic bone disease in short bowel syndrome diagnosis and management.-
Chapter 11: Intestinal failure-associated liver disease.
Chapter 12:
Insights into nutritional management of short bowel syndrome - nutritional
assessment and diet considerations.
Chapter 13: Home parenteral nutrition in
long-term intestinal failure.
Chapter 14: Long-term venous access for HPN:
types, devices, and complications.- Chapter 15: Monitoring and management of
trace elements in short bowel syndrome.
Chapter 16: Enteral feeding and
parenteral nutrition in short bowel syndrome current recommendations and
unmet needs.
Chapter 17: Drug pharmacokinetics and pharmacodynamics in short
bowel syndrome special considerations Liliana Mirea
Chapter 18:
Antisecretory, antimotility and luminally active agents in the management of
short bowel syndrome.
Chapter 19: Growth-stimulating effects of
glucagon-like peptide-2, growth hormone and other agents.
Chapter 20:
Surgical management of short bowel syndrome - ostomy, fistula, autologous
gastrointestinal reconstruction.
Chapter 21: Intestinal transplantation in
short bowel syndrome.
Chapter 22: Multidisciplinary approach in short bowel
syndrome.
Chapter 23: Education of patients with short bowel syndrome.-
Chapter 24: Future perspectives in short bowel syndrome - organoid-based
tissue-engineered small intestine and SIC, xenotransplantation.
Anca Trifan, MD, PhD, FEBGH, FRCP (London), Professor of Gastroenterology and Internal Medicine, and Director of the Department of Internal Medicine of the Grigore T. Popa University of Medicine and Pharmacy, Iasi, Romania, is also Head of the Institute of Gastroenterology and Hepatology, Iasi, Romania. Her research interests include inflammatory bowel disease, viral hepatitis, liver cirrhosis, liver transplant, acute-on-chronic liver failure, non-invasive assessment of liver fibrosis, biliary tract disorders, and Clostridioides difficile infection. She has published numerous original papers, books, and chapters of books and has been actively involved in the peer-review process of many high-impact factor journals. She has been involved in medical teaching since the beginning of her career. She received many prizes from scientific organizations (e.g., Rising Stars in Gastroenterology awarded by UEG). She is a past president of the Romanian Society of Gastroenterology and Hepatology, a member of the Academy of Medical Sciences, a member of the European Board of Gastroenterology, an AGA fellow, and a member of the American Association for the Study of Liver Diseases. Carol Stanciu, MD, PhD, FRCP (London), Professor of Gastroenterology and Internal Medicine at the University of Medicine and Pharmacy Gr. T. Popa, Iasi, Fellow of the Academy of Medical Sciences, and Fellow of the Romanian Academy, Dr. Carol Stanciu (born May 17, 1937; Hasdat, Hunedoara, Romania) is one of the main founders of gastroenterology, diagnostic and therapeutic endoscopy in Romania. He graduated from the Faculty of Medicine, University of Medicine and Pharmacy Gr.T.Popa Iasi (1963) where he also received his PhD and DSc, and served as Assistant, Associate Professor, and Professor of the Department of Internal Medicine and Gastroenterology. He is the former Rector of the University of Medicine and Pharmacy Gr.T.Popa Iasi (1992-2004), Dean of the Faculty of Medicine (2004-2008), President of the Romanian Society of Endoscopy (1996-2000), President of the Romanian Society of Gastroenterology and Hepatology (2000-2008), and Chairman of the Ethics Committee of the World Organization of Gastroenterology (1994-2002). He has always been involved in all areas of academic life: medical training, especially therapeutic endoscopy, patient care, administrative work, and mentorship. His research interests include gastrointestinal motility, viral hepatitis, liver cirrhosis, liver transplant, acute-on-chronic liver failure, non-invasive assessment of liver fibrosis, inflammatory bowel disease, biliary tract disorders, and Clostridium difficile infection. He has published numerous original papers, books, and chapters of books and has been actively involved in the peer-review process of prestigious high-impact factor journals. He received many awards from the Romanian Presidency, French Presidency, WGO, Romanian Society of Gastroenterology and Hepatology, and many universities. Liana Gheorghe, MD, PhD, Professor of Gastroenterology and Hepatology, Department of Clinical Education of the Carol Davila University of Medicine and Pharmacy, Bucharest, Romania, and Head of the 3rd Clinic of Gastroenterology and Hepatology, Fundeni Clinical Institute, Bucharest, Romania. She is the President of the Romanian Association for Liver Disease, a highly active, non-profit medical association founded in 2018 aiming to disseminate science and the practice of hepatology in Romania. Also, she is the current president of the Romanian Society of Gastroenterology and Hepatology, an active member of the European Crohn's and Colitis Organization, the Romanian Crohn's and Colitis Club, and the European Society for Parenteral and Enteral Nutrition. Her research interests include inflammatory bowel disease, liver transplantation, viral hepatitis, liver cirrhosis, acute-on-chronic liver failure, non-invasive assessment of liver fibrosis, and biliary tract disorders. She has published numerous original papers, books, and chapters of books and has been actively involved in the peer-review process of many high-impact journals. She has been involved in medical teaching since the beginning of her career. Furthermore, she has been invited as a speaker at various international conferences, further solidifying her reputation as a leading expert in the field. Her work has been internationally recognized by receiving many prizes from well-known scientific organizations.
