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El. knyga: Sleep Apnea: Pathogenesis, Diagnosis and Treatment

Edited by (Hospital of University of Pennsylvania, Philadelphia, USA)
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"Since the publication of Sleep Apnea: Pathogenesis, Diagnosis and Treatment - First Edition there have been many significant changes within the field of sleep disorders. This source will highlight the changes in the field of sleep apnea while examining new treatment techniques, new treatment data, and emerging data that relates to specific disorders"--Provided by publisher.

Sleep apnea is a common chronic condition affecting millions of people. Written by a multidisciplinary team including sleep medicine specialists, pulmonologists, scientists, psychiatrists, otorhinolaryngologists, and more, this text provides essential scientific and clinical information for those treating and researching the condition.

Since the previous edition published, sleep medicine has become a fully formed medical speciality. This second edition has been expanded to contain more clinically relevant information regarding diagnosis and treatment, and includes:

  • New developments regarding the cardiovascular effects of sleep apnea
  • New developments regarding the role of sleep apnea in insulin resistance
  • Developing research on intermittent hypoxia in the disorder
  • Latest pharmacotherapeutic trials, addressed in the last chapter

Organized into sections and subsections to make the book easier for the reader to use, this essential text also examines sleep apnea in special populations, such as children, older adults or pregnant women, and takes into account gender differences in the disorder.

Contributors ix
Preface xii
Pathogenesis Of Apnea
Anatomy/biomechanics
1 Pathogenesis of obstructive sleep apnea: Insights from upper airway imaging studies
1(26)
Murtuza M. Ahmed
Richard I. Schwab
2 Biomechanics of the upper airway during sleep
27(26)
Philip L. Smith
Jason P. Kirkness
Susheel Patil
Hartnett Schneider
Alan R. Schwartz
Neural mechanisms
3 Sleep-induced breathing instability
53(29)
Aihang Xie
Curtis A. Smith
Jerome A. Dempsey
4 Mechanisms of upper airway hypotonia
82(46)
Leszek Kubin
Richard O. Davies
5 Autonomic consequences of arousal from sleep and neural mechanisms of arousal
128(29)
Richard L. Homer
Genetics
Studies in humans
6 Airway reflexes: Changes with sleep
157(19)
David P. White
7 Gender differences in sleep-disordered breathing
176(16)
M. Salwan Badr
Jason H. Mateika
Pathogenesis Of Consequences Of Apnea
Sleepiness
8 Mechanisms of sleepiness in obstructive sleep apnea
192(13)
Mark S. Aloia
J. Todd Arnedt
9 Neuroimaging studies in obstructive sleep apnea
205(11)
Lint Ayalon
Sean P.A. Drummond
10 Biomarkers and obstructive sleep apnea
216(20)
Erna Sif Arnardottir
Bernie Sunwoo
Allan I. Pack
Cardiovascular consequences
11 Obstructive sleep apnea and hypertension: Interactions and clinical implications
236 (15)
Suraj Kapa
Apoor S. Gami
Virend K. Somers
12 Other cardiovascular consequences of sleep apnea
251(35)
Julio A. Chirinos
Frederick F. Somalia
Mark H. Sanders
Endocrine
13 Neuroendocrine aspects of sleep apnea
286(14)
Brendan J. Yee
Peter Y. Liu
Craig Phillips
Ronald R. Grunstein
14 Obstructive sleep apnea and glucose metabolism
300(17)
Jan Polak
Brock A. Beamer
Naresh M. Punjabi
Intermittent hypoxia
15 Intermittent hypoxia and neurocognitive function
317(12)
David Gozal
Leila Kheirandish-Gozal
Yang Wang
Shelley X.L. Zhang
16 Obstructive sleep apnea: Mechanisms of intermittent .hypoxemia neural injury
329(9)
Sigrid C. Veasey
Diagnosis of sleep apnea
17 Screening for sleep apnea
338(9)
Indira Gurubhagavatula
18 Alternative strategies for diagnosis of patients with obstructive sleep apnea
347(23)
Samuel T. Kuna
Sleep apnea in specialized groups
19 Obstructive sleep apnea: Children versus adults
370(29)
Eliot S. Katz
Carole L. Marcus
20 Sleep apnea in older adults
399(19)
Nalaka S. Gooneratne
21 Obstructive sleep apnea in pregnancy and menopause
418(17)
Grace W. Pier
Treatment of sleep apnea
22 Adherence to CI'AP treatment and functional status in adult obstructive sleep apnea
435(40)
Terri E. Weaver
Judith Reishlein
Amy M. Sawyer
23 CPAP therapy: Results of randomized controlled trials in obstructive sleep apnea
475(26)
Sophie D. West
John R. Stradling
24 Oral appliance therapy for snoring and sleep apnea
501(14)
Peter A. Cistulli
Ali M. Darendelder
25 Upper airway surgery for obstructive sleep apnea
515(20)
Edward M. Weaver
Andrew N. Goldberg
26 Phannacotherapeu tic trials for sleep-disordered breathing
535(16)
Jan Hedner
Ludger Grote
Ding Zou
Index 551
Allan I. Pack