Following a successful first edition, this new book updates the revolutionary advances in stem cell science that may potentially impact human reproductive medicine. The contents cover the production and regeneration of female and male germ cells, trophoblasts and endometrium from human embryonic and adult stem cells. New developments in hESC derivation that will impact clinical use are covered, and cutting-edge technologies such as reprogramming and imprinting are addressed in relation to stem cells and reproductive medicine. A new section on actual clinical translation to IVF clinics from the stem cell perspective is also included.
1. Gamete Generation from Stem Cells: Will It ever Be Applicable?
2.
Gamete Generation from Stem Cells: Will It ever Be Ethically Acceptable?
3.
Molecular Biology of Gametes
4. Controlled Differentiation from ESC to
Oocyte-like Cells
5. Germ Cell Specific Methylation Pattern
6. Germline
Stem Cells and Adult Ovarian Function
7. Somatic Stem Cells Derived from
Non-Gonadal Tissues
8. The Male Gamete
9. Growth Factor Signaling in
Germline Specification and Maintenance of Stem Cell Pluripotency
10. Stem
Cell Therapeutic Approaches for Treatment of Male Infertility
11. Adult Stem
Cell Population in the Testes
12. Human Embryonic Stem Cells: A Model for
Trophoblast Differentiation and Placental Morphogenesis
13. Reproductive
Stem Cells of Embryonic Origin: Comparative Properties and Benefits
14.
Amniotic Fluid and Placental Stem Cells
15. Adult Stem Cells in the Human
Endometrium
16. Stem Cell Populations in Adult Bone Marrow
17. Models of
Trophoblast Development and Embryo Implantation Using hESC
18.
Embryo-Friendly Approaches to hESC Derivation
19. Reprogramming of Somatic
Cells
20. Somatic Nuclear Transfer to In Vitro Matured Human Germinal
Vesicle Oocytes
21. Derivation and Banking of hESC for Potential Clinical Use
Instituto Valenciano de Infertilidad, Valencia, Spain Instituto Vanenciano de Infertilidad, Valencia, Spain
