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Swine in the Laboratory: Surgery, Anesthesia, Imaging, and Experimental Techniques, Second Edition 2nd New edition [Kietas viršelis]

Edited by (Medical University of South Carolina, Charleston, USA)
  • Formatas: Hardback, 496 pages, aukštis x plotis: 254x178 mm, weight: 1066 g, 277 Halftones, black and white; 48 Tables, black and white; 381 Illustrations, black and white
  • Išleidimo metai: 01-Mar-2007
  • Leidėjas: CRC Press Inc
  • ISBN-10: 0849392780
  • ISBN-13: 9780849392788
Kitos knygos pagal šią temą:
  • Formatas: Hardback, 496 pages, aukštis x plotis: 254x178 mm, weight: 1066 g, 277 Halftones, black and white; 48 Tables, black and white; 381 Illustrations, black and white
  • Išleidimo metai: 01-Mar-2007
  • Leidėjas: CRC Press Inc
  • ISBN-10: 0849392780
  • ISBN-13: 9780849392788
Kitos knygos pagal šią temą:
Given the complexity of porcine anatomy and the frequent appearance of swine in veterinary, agricultural and biomedical labs, newcomers have a steep learning curve and little time to learn pigs properly. This reference gives students comprehensive directions to preoperative care all the way through to recovery in a variety of experimental and practical settings, covering biology, handling, husbandry, anatomy, anesthetics and analgesia, perioperative care, wound closure and integument, and directions to procedures throughout the body systems, including the gastrointestinal, liver and biliary, urinary and reproductive, cardiovascular and pulmonary. Sections address catheterization and imagery endoscopy, xeno-transplantation and transgenic technologies, toxicology, and radiobiology. The illustrations and photographs are particularly well done. Annotation ©2007 Book News, Inc., Portland, OR (booknews.com)

To diminish the learning curve associated with using swine as models, Swine in the Laboratory: Surgery, Anesthesia, Imaging, and Experimental Techniques, Second Edition provides practical technical information for the use of swine in biomedical research. The book focuses on models produced by surgical and other invasive procedures, supplying the basic principles for performing experiments with an organ or system of interest.

New to the Second Edition
  • Updated sections on anesthesia and perioperative care, including practical information for more complex models
  • Expansion of anatomic and physiologic details
  • Additional detail in the endoscopy section
  • Chapters on toxicology and radiobiology
  • Chapters that include angiographic, echocardiographic, CT, MRI, and PET imaging techniques with a corresponding DVD of the images
  • More tables of normal values on the most commonly used minipigs and domestic breeds

    Beneficial for investigators, veterinarians, and technicians using swine for experimental and agricultural procedures, Swine in the Laboratory is certain to foster the appropriate, humane use of swine in biomedical research.
  • Biology, Handling, Husbandry, and Anatomy
    1(34)
    Introduction
    1(1)
    Breed Selection
    1(3)
    Biology
    4(1)
    Taxonomy and Nomenclature
    5(1)
    Reproduction
    6(1)
    Growth and Development
    6(1)
    Nutrition
    7(1)
    Hematology
    8(1)
    Behavior
    9(1)
    Husbandry
    9(5)
    Disease Prevention
    14(1)
    Restraint and Handling
    15(1)
    Administration of Medications and Injections
    16(9)
    General Anatomy
    25(5)
    Model Selection
    30(2)
    References
    32(3)
    Anesthesia, Analgesia, and Perioperative Care
    35(46)
    Introduction
    35(1)
    Anesthetic Induction and Animal Prep Room Activities
    35(5)
    Endotracheal Intubation
    40(2)
    Special Perioperative Considerations
    42(5)
    Preoperative Fasting
    42(1)
    Intravenous Fluid Administration
    43(1)
    Thermal Support
    43(1)
    Cardiac Monitoring and Arrhythmias
    43(2)
    Specialized Intraoperative Monitoring
    45(2)
    Malignant Hyperthermia
    47(1)
    Paralytic Agents
    47(2)
    Anesthetic Monitoring
    48(1)
    Ventilation Rates
    48(1)
    Postoperative Monitoring
    49(4)
    Pain Assessment
    49(1)
    Nonpharmacological Control of Pain and Distress
    49(2)
    Chronic Pain and Distress
    51(2)
    Preanesthetic Agents
    53(1)
    Anticholinergics
    53(1)
    Tranquilizers and Sedatives
    53(1)
    Injectable Anesthetic Agents
    53(6)
    Dissociative Agents and Combinations
    54(2)
    Barbiturates
    56(1)
    Opioid Infusions
    57(1)
    Miscellaneous Agents
    57(2)
    Inhalant Anesthetics
    59(2)
    Cardiopulmonary Bypass (CPB)
    61(4)
    Cardiopulmonary Bypass Equipment
    63(1)
    Surgery
    63(1)
    Monitoring and Perfusionist Parameters
    63(1)
    Anesthesia
    64(1)
    Weaning from CPB
    64(1)
    Postoperative Considerations
    65(1)
    Regional Low-Flow Perfusion and Neural Protection
    65(1)
    Analgesics
    65(5)
    Opioids
    66(2)
    Nonsteroidal Anti-Inflammatory Drugs
    68(1)
    Reversal Agents for Injectable Anesthetics, Sedatives, and Analgesics
    69(1)
    Local and Regional Analgesia
    69(1)
    Commonly Recommended Protocols
    70(2)
    Nonsurvival Teaching Protocols
    70(1)
    General Surgery (without Physiological Measurements)
    71(1)
    General Surgery (with Physiological Measurements)
    71(1)
    Cardiothoracic Surgery (with Cardiovascular Manipulations)
    71(1)
    Cardiothoracic Surgery (with Cardiovascular Compromise)
    71(1)
    Coronary Artery Catheterization
    72(1)
    General Physiological Effects of Anesthetics
    72(3)
    Dissociative Agents
    72(1)
    Barbiturates
    72(1)
    Sedatives/Hypnotics
    72(2)
    Opioids
    74(1)
    Nonsteroidal Anti-Inflammatory Drugs (Nsaids)
    74(1)
    Inhalant Anesthetics
    74(1)
    Euthanasia
    75(1)
    References
    75(6)
    Wound Closure and Integument
    81(16)
    General Principles and Surgical Preparation
    81(1)
    Suture Selection for Wound Closure
    82(9)
    Wound Closure and Bandaging Techniques
    86(5)
    Skin Flaps and Grafts
    91(3)
    Random Skin Flaps
    92(1)
    Arterial Skin Flaps
    93(1)
    Myocutaneous Flaps
    93(1)
    Wound-Healing Models
    94(1)
    References
    95(2)
    Gastrointestinal Procedures
    97(26)
    Surgical Anatomy
    97(4)
    General Principles of Abdominal Surgery
    101(3)
    Postoperative Care
    104(2)
    Gastrotomy and Gastrostomy Techniques
    106(2)
    Pyloroplasty
    108(1)
    Enterotomy and Intestinal Fistulation
    108(2)
    Intestinal Infusion Catheter Implantation
    110(2)
    Intestinal Anastomosis
    112(1)
    Intestinal Diversion or Intestinal Bypass
    113(2)
    Colonic Anastomosis and Fistulation
    115(1)
    Total Colectomy
    116(1)
    Rectal Prolapse
    116(1)
    Intestinal and Multivisceral Transplantation
    117(2)
    Vagotomy
    119(1)
    Intraperitoneal Sepsis, Septic Shock, and Hemorrhagic Shock
    120(1)
    References
    120(3)
    Liver and Biliary System
    123(18)
    Surgical Anatomy and General Principles of Surgery
    123(3)
    Cholecystectomy
    126(2)
    Cannulation or Constriction of the Common Bile Duct
    128(4)
    Partial Hepatectomy, Liver Biopsy, and Intrahepatic Cannulation
    132(1)
    Liver Transplantation
    133(2)
    Donor Liver
    134(1)
    Allograft and Autograft Implantation
    134(1)
    Segmental Liver Grafts
    135(1)
    Hepatic Xenoperfusion
    135(2)
    References
    137(4)
    Pancreas and Spleen
    141(16)
    Surgical Anatomy and General Principles of Surgery
    141(1)
    Pancreatectomy, Islet Cell Ablation, and Diabetes
    141(6)
    Segmental Pancreatectomy, Pancreatic Transplant, and Islet Cell Isolation
    147(2)
    Pancreatic Duct Ablation, Cannulation, and Pancreatitis
    149(1)
    Splenectomy, Splenic Vascular Catheterization, and Splenic Transplantation
    150(3)
    References
    153(4)
    Urinary System and Adrenal Glands
    157(18)
    General Principles of Surgery and Surgical Anatomy
    157(4)
    Nephrectomy
    161(2)
    Partial Nephrectomy and Intrarenal Surgery
    163(1)
    Renal Transplant
    164(2)
    Cystotomy and Ureteral Diversion
    166(1)
    Urinary Tract Obstruction, Reflux Nephropathy, and Hydronephrosis
    167(1)
    Perineal Urethrostomy and Urinary Diversion
    168(1)
    Preputial Diverticulum Ablation
    169(3)
    Adrenalectomy
    172(1)
    References
    172(3)
    The Reproductive System
    175(20)
    General Principles of Surgery
    175(2)
    Castration (Orchiectomy) and Vasectomy
    177(1)
    Ovariohysterectomy, Hysterectomy, Ovariectomy, or Tubal Ligation
    177(2)
    Cesarean Section (C-Section)
    179(1)
    Fetal Surgery and Fetal Catheterization
    180(7)
    Prolapse of the Reproductive Tract
    187(3)
    Endometriosis
    190(1)
    Pelvic Adhesions
    191(1)
    Artificial Insemination and Embryo Transfer
    191(1)
    Mammectomy
    192(1)
    References
    192(3)
    Cardiothoracic and Vascular Surgery/Chronic Intravascular Catheterization
    195(66)
    General Principles of Cardiothoracic Surgery and Surgical Anatomy
    195(16)
    Pulmonary System
    211(3)
    Tracheostomy and Tracheotomy
    211(1)
    Pneumonectomy and Lobectomy
    212(2)
    Pulmonary Transplant
    214(1)
    Cardiovascular System
    214(36)
    Peripheral Vascular Cannulation and Chronic Catheterization Techniques
    214(1)
    General Principles
    214(1)
    General Surgical Principles for Catheterization
    215(3)
    Catheter Design
    218(2)
    Catheter Maintenance
    220(1)
    Neck Vessels: External and Internal Jugular Veins and Carotid Artery
    221(6)
    Leg Vessels
    227(1)
    Portal Vein
    228(3)
    Other Blood Vessels
    231(1)
    Postoperative Considerations
    231(1)
    Vascular Anastomosis
    231(3)
    Arteriovenous and Venovenous Fistulas and Vascular Shunts
    234(1)
    Atriotomy and Ventriculotomy
    235(1)
    Valvular Surgery
    236(2)
    Aortic and Pulmonary Artery Banding, Ligation of the Ductus Arteriosus, and Chronic Instrumentation
    238(2)
    Myocardial Infarction and Associated Arrhythmias
    240(3)
    Vascular Aneurysms
    243(1)
    Bifurcation Aneurysms
    243(1)
    Terminal Aneurysms
    244(1)
    Fusiform Aneurysms
    244(1)
    Wide-Necked Aneurysms
    244(1)
    Coarctation of the Aorta
    245(1)
    Cardiomyoplasty
    246(1)
    Epicardial Pacemaker and Device Implantation
    247(2)
    Heart and Heart-Lung Transplantation
    249(1)
    Heart Transplant
    249(1)
    Donor
    249(1)
    Recipient
    249(1)
    Heart-Lung Transplant
    250(1)
    Miscellaneous Thoracic Procedures
    250(2)
    Thoracic Duct Cannulation
    250(1)
    Esophageal Surgery
    251(1)
    References
    252(9)
    Head and Neck Surgery/Central Nervous System
    261(28)
    General Principles of Surgery and Surgical Anatomy
    261(11)
    Dental Procedures and Tusk Trimming
    272(2)
    Maxillofacial and Craniotomy Procedures
    274(1)
    Ocular Surgery
    275(3)
    Pharyngostomy Tubes
    278(1)
    Thyroidectomy
    278(1)
    Parathyroidectomy
    278(1)
    Hypophysectomy
    279(1)
    Spinal Cord Ischemia and Hemorrhage
    280(1)
    Stroke Models
    281(1)
    Cerebrospinal Fluid (CSF) Collection and Epidural Injection
    281(3)
    Epidural Injection
    282(1)
    CSF Collection
    283(1)
    References
    284(5)
    Musculoskeletal System and Orthopedic Procedures
    289(10)
    General Principles of Surgery and Surgical Anatomy
    289(1)
    Amputation of a Digit and Hoof Trimming
    290(1)
    Tendon and Ligament Repair
    291(1)
    Tail Amputation
    292(1)
    Hernia Repair
    292(1)
    Surgical Approaches to Bones and Joints
    293(2)
    Foreleg
    294(1)
    Hind Limb
    294(1)
    Vertebral Column
    295(1)
    Bone Marrow Aspiration
    295(2)
    References
    297(2)
    Cardiovascular Catheterization, Electrophysiology, and Imaging Laboratory Procedures
    299(46)
    Introduction
    299(1)
    Peripheral Vascular Access for Cardiovascular Catheters
    299(5)
    Anesthetics and Adjunct Drugs
    304(1)
    Hemodynamics
    305(2)
    Angioplasty Balloon Techniques, Intravascular Device Implantations, and Restenosis
    307(7)
    Atherosclerosis
    314(2)
    Electrophysiology and Electrocardiography (ECG) and Telemetry
    316(8)
    Pacemaker Implantation and Endocardial Pacemaker Leads
    324(4)
    Conduction System Ablation
    328(1)
    Angiography
    329(5)
    Echocardiography
    334(6)
    References
    340(5)
    Endoscopic, Laparoscopic, and Minimally Invasive Surgery
    345(20)
    M. Michael Swindle
    Robert H. Hawes
    Introduction
    345(1)
    General Considerations
    345(1)
    Anatomic Considerations for Flexible Endoscopic Research
    345(1)
    Performing Endoscopy
    346(3)
    Endoscopic Retrograde Cholangiopancreatography (ERCP)
    349(1)
    Endoscopic Hemostasis (Gastrointestinal Bleeding)
    350(1)
    Colonoscopy
    351(1)
    Laryngoscopy and Bronchoscopy
    351(1)
    Training in Flexible Endoscopy
    351(2)
    Laparoscopic, Celioscopic, and Thoracoscopic Surgery
    353(5)
    Cholecystectomy
    354(1)
    Small Intestinal Anastomosis
    354(1)
    Colonic Anastomosis
    355(1)
    Vagotomy and Hiatal Procedures
    355(1)
    Nephrectomy and Renal Ablation
    356(1)
    Inguinal Herniorrhaphy
    356(1)
    Appendectomy
    357(1)
    Splenectomy
    357(1)
    Adrenalectomy
    357(1)
    Urinary Bladder Procedures
    357(1)
    Reproductive Procedures
    357(1)
    Thoracoscopy
    357(1)
    Laparoscopic Ultrasonography
    358(1)
    Postoperative Care for Laparoscopic and Endoscopic Procedures
    358(1)
    Natural Orifice Transluminal Endoscopic Surgery (Notes)
    358(1)
    Surgical Robotics
    359(1)
    References
    360(5)
    Xenotransplantation and Transgenic Technologies
    365(8)
    Introduction
    365(1)
    Ethical Considerations
    365(1)
    Immunologic and Physiological Considerations
    366(1)
    Strategies for Development of Transgenic Animals
    367(1)
    Regulatory Guidelines
    367(1)
    Public Health Considerations
    368(1)
    Management and Husbandry Strategies
    369(1)
    Other Considerations
    369(1)
    References
    370(3)
    Toxicology
    373(10)
    Ove Svendsen
    Introduction
    373(1)
    Domestic Pigs and Minipigs
    373(1)
    Strains of Minipigs
    373(1)
    Pharmacokinetics and Metabolism
    374(1)
    Repeat Dose Toxicology
    374(3)
    Routes of Dose Administration
    375(1)
    Observations and Sampling Techniques
    375(1)
    Necropsy Procedure
    375(1)
    Histopathology
    376(1)
    Reproductive Toxicology
    377(1)
    Juvenile Studies
    377(2)
    Regulatory Acceptance
    379(1)
    Conclusions for Toxicological Models
    379(1)
    Acknowledgments
    379(1)
    References
    380(3)
    Radiobiology
    383(4)
    References
    384(3)
    Imaging Techniques: CT, MRI, and PET Scanning
    387(10)
    Aage Kristian Olsen
    Dora Zeidler
    Kasper Pedersen
    Michael Sorenson
    Svend Borup Jensen
    Ole Lajord Munk
    Scanners
    387(1)
    Anesthesia
    387(1)
    Surgery
    388(1)
    Monitoring
    388(1)
    Scanning Procedures
    389(1)
    Technical Information for Each of the Images on the Attached DVD
    389(8)
    Instructions for Opening the DVD
    389(1)
    Scan 1: Contrast Radiograph of the Cerebral Artery
    390(1)
    Scan 2: MRI (Magnetic Resonance Imaging)
    391(1)
    Scan 3: PET (Positron Emission Tomography)
    392(1)
    Scan 4: Dopamine Receptors
    393(1)
    Scan 5: PET Scan of a 40-kg Female Pig after Injection of 18F Galactose
    394(1)
    Scan 6: CT and PET/CT of a Domestic Pig
    395(2)
    Ossabaw Island Miniature Swine: Cardiometabolic Syndrome Assessment
    397(6)
    Michael Sturek
    Mouhamad Alloosh
    James Wenzel
    James P. Byrd
    Jason M. Edwards
    Pamela G. Lloyd
    Johnathan D. Tune
    Keith L. March
    Michael A. Miller
    Eric A. Mokelke
    I. Lehr Brisbin, Jr.
    Introduction
    397(1)
    Characterization of the Model
    398(1)
    Summary and Conclusions
    399(1)
    Acknowledgments
    400(1)
    References
    400(3)
    Appendix
    403(48)
    Section 1: Growth Charts, Nutrition, and Physiological Parameters
    405(4)
    Section 2: Hematology and Serum Chemistry
    409(21)
    Section 3: Organ Weights and Measurements
    430(6)
    Section 4: Reproductive Parameters
    436(3)
    Section 5: Fetal Parameters
    439(7)
    Section 6: Section 6: Animal Health and General References
    446(3)
    General Reference Textbooks for Swine
    449(1)
    Review Articles
    449(1)
    Web Sites
    450(1)
    Index 451
    Medical University of South Carolina, Charleston, USA