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El. knyga: Synthetic Biology Analysed: Tools for Discussion and Evaluation

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Synthetic biology is a dynamic, young, ambitious, attractive, and heterogeneous scientific discipline. It is constantly developing and changing, which makes societal evaluation of this emerging new science a challenging task, prone to misunderstandings. Synthetic biology is difficult to capture, and confusion arises not only regarding which part of synthetic biology the discussion is about, but also with respect to the underlying concepts in use. This book offers a useful toolbox to approach this complex and fragmented field. It provides a biological access to the discussion using a 'layer' model that describes the connectivity of synthetic or semisynthetic organisms and cells to the realm of natural organisms derived by evolution.Instead of directly reviewing the field as a whole, firstly our book addresses the characteristic features of synthetic biology that are relevant to the societal discussion. Some of these features apply only to parts of synthetic biology, whereas others are relevant to synthetic biology as a whole. In the next step, these new features are evaluated with respect to the different areas of synthetic biology. Do we have the right words and categories to talk about these new features? In the third step, traditional concepts like life and artificiality are scrutinized with regard to their discriminatory power. This approach may help to differentiate the discussion on synthetic biology. Lastly our refined view is utilized for societal evaluation. We have investigated the public views and attitudes to synthetic biology. It also includes the analysis of ethical, risk and legal questions, posed by present and future practices of synthetic biology.This book contains the results of an interdisciplinary research projectand presents the authors main findings and recommendations. They are addressed to science, industry, politics and the general public interested in this upcoming field of biotechnology.
1 The New Worlds of Synthetic Biology---Synopsis
1(26)
Margret Engelhard
Michael Bolker
Nediljko Budisa
Kristin Hagen
Christian Illies
Rafael Pardo-Avellaneda
Georg Toepfer
Gerd Winter
1.1 Attraction of Synthetic Biology
2(1)
1.2 A Mosaic-like Field on the Move
3(3)
1.3 Challenges to the Societal and Ethical Evaluation
6(1)
1.4 Relevant Features and Concepts of Synthetic Biology
7(1)
1.5 Layer Model
8(2)
1.6 Challenge to the Concept of "Life"
10(2)
1.7 Ethical Evaluation
12(4)
1.8 Synthetic Biology as an Object of Public Perceptions
16(3)
1.9 Legal Challenges
19(3)
1.9.1 Law Enabling and Regulating Synthetic Biology
20(1)
1.9.2 Law Fostering Synthetic Biology
21(1)
1.9.3 Law Ensuring Benefit Sharing
22(1)
1.10 Outlook
22(5)
References
23(4)
2 Synthetic Biology: Diverse Layers of Live
27(24)
Michael Bolker
Margret Engelhard
Nediljko Budisa
2.1 Introduction
28(2)
2.2 The Main Research Agendas of Synthetic Biology
30(6)
2.2.1 The Engineering Branch of Synthetic Biology
31(1)
2.2.2 Orthogonal Biology
32(3)
2.2.3 Protocell Biology---Recapitulation of Evolution
35(1)
2.3 A Layer Model to Describe and Classify Natural and Synthetic Organisms in Different Fields of Synthetic Biology
36(11)
2.3.1 Layer of Genetically Modified and Artificially Designed Cells
40(3)
2.3.2 Layer of Orthogonal Cells (Xenobiology)
43(3)
2.3.3 Layer of Simple Life Forms and Protocells
46(1)
2.4 Conclusions
47(4)
References
47(4)
3 Old and New Risks in Synthetic Biology: Topics and Tools for Discussion
51(20)
Margret Engelhard
Michael Bolker
Nediljko Budisa
3.1 Synthetic Biology in the Risk Discussion
52(7)
3.1.1 Background: The Mosaic-like Structure of the Field
53(2)
3.1.2 Dichotomy of the Attributes Novelty and Continuity
55(1)
3.1.2.1 Novelty in the Synthetic Biology Context
56(1)
3.1.2.2 Invalidity of the "Continuity Argument" in the Context of Risk Evaluation of Synthetic Biology
57(1)
3.1.3 Scope of the Synthetic Biology Politicized
58(1)
3.1.4 Time Point and Speed of the Scientific Development Differentiated
58(1)
3.2 Level of the Risk Discussion
59(1)
3.3 New Features of Synthetic Biology Relevant for Risk Evaluation
60(2)
3.3.1 Depth of Intervention, Complexity and Predictability
60(1)
3.3.1.1 Depth of Intervention
60(1)
3.3.1.2 Predictability: Safety Concepts of Synthetic Biology
61(1)
3.3.2 Risk Assessment Challenged: Familiarity Principle and Speed of Developments
62(1)
3.4 Special Cases of Risks Assessment in Synthetic Biology
62(5)
3.4.1 "The Farther, the Safer"?
63(1)
3.4.2 Sense Codon Reassignment in the Genetic Code and Its Possible Consequences
64(1)
3.4.2.1 Natural Background
65(1)
3.4.2.2 Adaptive Features
66(1)
3.4.2.3 Technological Risk and Benefits
66(1)
3.4.3 The Innocence of Protocells
67(1)
3.5 Summary and Outlook
67(4)
References
68(3)
4 The Concept of Life in Synthetic Biology
71(18)
Georg Toepfer
4.1 Four Episodes in the History of Artificial Life Research
74(5)
4.2 Modes of Artificiality in Artificial Life Research
79(1)
4.3 Artificial Systems as Models for Living Systems
80(2)
4.4 Modes of Vitality in Artificial Life Research
82(2)
4.5 Can Artificially Designed Systems Be Instantiations of Life?
84(5)
References
86(3)
5 New Debates in Old Ethical Skins
89(38)
Christian Illies
5.1 Ethics of Technology
90(1)
5.2 Synthetic Biology---A Philosophical View
91(6)
5.2.1 Synthetic Biology as a Climax of Modern Science and Technology
91(3)
5.2.2 The Ethical Relevance of Synthetic Biology
94(3)
5.3 Ethical Issues of Synthetic Biology
97(13)
5.3.1 Does Synthetic Biology Need a New Ethics?
97(1)
5.3.2 Risk
98(2)
5.3.3 Global Justice
100(1)
5.3.4 The `Playing God' Argument
101(5)
5.3.5 Acting Under Uncertainty
106(4)
5.3.6 New or Old Ethics?
110(1)
5.4 The Need for New Ethical Debate and Its Problems
110(7)
5.4.1 The Need for Debate
110(1)
5.4.2 The Lack of a Public Debate
111(1)
5.4.3 The Conceptual Challenge for Ethicists
111(3)
5.4.4 The Silence of the Labs?
114(1)
5.4.5 Scientific and Public Language
115(2)
5.5 The Three Moral Laws
117(10)
5.5.1 A Moral Proposal
117(1)
5.5.2 First Law: A Biotic Artefact May not Injure a Human Being
118(1)
5.5.3 Second Law: A Biotic Artefact Must Be Strictly Functional
119(2)
5.5.4 Third Law: A Biotic Artefact Must Be Protected
121(1)
5.5.5 Short Conclusion
122(1)
References
122(5)
6 Synthetic Biology: Public Perceptions of an Emergent Field
127(44)
Rafael Pardo Avellaneda
Kristin Hagen
6.1 Introduction
128(1)
6.2 The Space and Role of Public Perceptions of Emergent Technoscientific Areas
128(4)
6.3 An Enlightenment Assumption: Resistance to Science as a Function of Lack of Knowledge
132(2)
6.4 Changes in the Institutional and Cultural Framework for the Development of New Areas of Science
134(10)
6.5 Positive Attitudes to Science and Reservations About Biotechnology
144(3)
6.6 Public Views on an Emergent and Fuzzy Object: Synthetic Biology
147(18)
6.6.1 Low Level of Salience and the Study of Public Views
148(3)
6.6.2 Early Characterizations of Public Views on Synthetic Biology in the United States
151(3)
6.6.3 Vistas on European Perceptions of Synthetic Biology
154(1)
6.6.3.1 Awareness of Synthetic Biology in Europe
154(2)
6.6.3.2 Relative Weight of Different Criteria in the Evaluation of Synthetic Biology
156(1)
6.6.3.3 Global Positions on the Acceptance of Synthetic Biology
157(1)
6.6.3.4 The Regulatory Regime for Synthetic Biology
158(5)
6.6.4 Synthetic Biology, Unnaturalness and "Playing God"
163(2)
6.7 Conclusion
165(6)
References
166(5)
7 In Search for a Legal Framework for Synthetic Biology
171
Gerd Winter
7.1 Introduction
172(2)
7.2 Enabling and Regulating Synthetic Biology in View of Environmental and Health Risks
174(23)
7.2.1 Constitutional Freedoms and the Regulation of Synthetic Biology
174(3)
7.2.2 Preventive Administrative Regulation
177(1)
7.2.2.1 Applicability to Synthetic Biology of the GMO Regime
178(4)
7.2.2.2 Adequacy of the GMO Regime
182(13)
7.2.3 Regulation Ex Post
195(1)
7.2.4 Conclusion
196(1)
7.3 Promoting Synthetic Biology Through the Granting of Intellectual Property Rights
197(7)
7.3.1 Patenting Life Forms
197(2)
7.3.2 Patent---A Stimulus of What?
199(2)
7.3.3 Applying Patent Law to Synthetic Biology
201(2)
7.3.4 Copy Right for Synthetic Biology Programs?
203(1)
7.4 Redistributing Benefits from Synthetic Biology
204(2)
7.5 Summary
206
References
209