|
1 The New Worlds of Synthetic Biology---Synopsis |
|
|
1 | (26) |
|
|
|
|
|
|
|
|
|
1.1 Attraction of Synthetic Biology |
|
|
2 | (1) |
|
1.2 A Mosaic-like Field on the Move |
|
|
3 | (3) |
|
1.3 Challenges to the Societal and Ethical Evaluation |
|
|
6 | (1) |
|
1.4 Relevant Features and Concepts of Synthetic Biology |
|
|
7 | (1) |
|
|
8 | (2) |
|
1.6 Challenge to the Concept of "Life" |
|
|
10 | (2) |
|
|
12 | (4) |
|
1.8 Synthetic Biology as an Object of Public Perceptions |
|
|
16 | (3) |
|
|
19 | (3) |
|
1.9.1 Law Enabling and Regulating Synthetic Biology |
|
|
20 | (1) |
|
1.9.2 Law Fostering Synthetic Biology |
|
|
21 | (1) |
|
1.9.3 Law Ensuring Benefit Sharing |
|
|
22 | (1) |
|
|
22 | (5) |
|
|
23 | (4) |
|
2 Synthetic Biology: Diverse Layers of Live |
|
|
27 | (24) |
|
|
|
|
|
28 | (2) |
|
2.2 The Main Research Agendas of Synthetic Biology |
|
|
30 | (6) |
|
2.2.1 The Engineering Branch of Synthetic Biology |
|
|
31 | (1) |
|
|
32 | (3) |
|
2.2.3 Protocell Biology---Recapitulation of Evolution |
|
|
35 | (1) |
|
2.3 A Layer Model to Describe and Classify Natural and Synthetic Organisms in Different Fields of Synthetic Biology |
|
|
36 | (11) |
|
2.3.1 Layer of Genetically Modified and Artificially Designed Cells |
|
|
40 | (3) |
|
2.3.2 Layer of Orthogonal Cells (Xenobiology) |
|
|
43 | (3) |
|
2.3.3 Layer of Simple Life Forms and Protocells |
|
|
46 | (1) |
|
|
47 | (4) |
|
|
47 | (4) |
|
3 Old and New Risks in Synthetic Biology: Topics and Tools for Discussion |
|
|
51 | (20) |
|
|
|
|
3.1 Synthetic Biology in the Risk Discussion |
|
|
52 | (7) |
|
3.1.1 Background: The Mosaic-like Structure of the Field |
|
|
53 | (2) |
|
3.1.2 Dichotomy of the Attributes Novelty and Continuity |
|
|
55 | (1) |
|
3.1.2.1 Novelty in the Synthetic Biology Context |
|
|
56 | (1) |
|
3.1.2.2 Invalidity of the "Continuity Argument" in the Context of Risk Evaluation of Synthetic Biology |
|
|
57 | (1) |
|
3.1.3 Scope of the Synthetic Biology Politicized |
|
|
58 | (1) |
|
3.1.4 Time Point and Speed of the Scientific Development Differentiated |
|
|
58 | (1) |
|
3.2 Level of the Risk Discussion |
|
|
59 | (1) |
|
3.3 New Features of Synthetic Biology Relevant for Risk Evaluation |
|
|
60 | (2) |
|
3.3.1 Depth of Intervention, Complexity and Predictability |
|
|
60 | (1) |
|
3.3.1.1 Depth of Intervention |
|
|
60 | (1) |
|
3.3.1.2 Predictability: Safety Concepts of Synthetic Biology |
|
|
61 | (1) |
|
3.3.2 Risk Assessment Challenged: Familiarity Principle and Speed of Developments |
|
|
62 | (1) |
|
3.4 Special Cases of Risks Assessment in Synthetic Biology |
|
|
62 | (5) |
|
3.4.1 "The Farther, the Safer"? |
|
|
63 | (1) |
|
3.4.2 Sense Codon Reassignment in the Genetic Code and Its Possible Consequences |
|
|
64 | (1) |
|
3.4.2.1 Natural Background |
|
|
65 | (1) |
|
3.4.2.2 Adaptive Features |
|
|
66 | (1) |
|
3.4.2.3 Technological Risk and Benefits |
|
|
66 | (1) |
|
3.4.3 The Innocence of Protocells |
|
|
67 | (1) |
|
|
67 | (4) |
|
|
68 | (3) |
|
4 The Concept of Life in Synthetic Biology |
|
|
71 | (18) |
|
|
4.1 Four Episodes in the History of Artificial Life Research |
|
|
74 | (5) |
|
4.2 Modes of Artificiality in Artificial Life Research |
|
|
79 | (1) |
|
4.3 Artificial Systems as Models for Living Systems |
|
|
80 | (2) |
|
4.4 Modes of Vitality in Artificial Life Research |
|
|
82 | (2) |
|
4.5 Can Artificially Designed Systems Be Instantiations of Life? |
|
|
84 | (5) |
|
|
86 | (3) |
|
5 New Debates in Old Ethical Skins |
|
|
89 | (38) |
|
|
|
90 | (1) |
|
5.2 Synthetic Biology---A Philosophical View |
|
|
91 | (6) |
|
5.2.1 Synthetic Biology as a Climax of Modern Science and Technology |
|
|
91 | (3) |
|
5.2.2 The Ethical Relevance of Synthetic Biology |
|
|
94 | (3) |
|
5.3 Ethical Issues of Synthetic Biology |
|
|
97 | (13) |
|
5.3.1 Does Synthetic Biology Need a New Ethics? |
|
|
97 | (1) |
|
|
98 | (2) |
|
|
100 | (1) |
|
5.3.4 The `Playing God' Argument |
|
|
101 | (5) |
|
5.3.5 Acting Under Uncertainty |
|
|
106 | (4) |
|
|
110 | (1) |
|
5.4 The Need for New Ethical Debate and Its Problems |
|
|
110 | (7) |
|
5.4.1 The Need for Debate |
|
|
110 | (1) |
|
5.4.2 The Lack of a Public Debate |
|
|
111 | (1) |
|
5.4.3 The Conceptual Challenge for Ethicists |
|
|
111 | (3) |
|
5.4.4 The Silence of the Labs? |
|
|
114 | (1) |
|
5.4.5 Scientific and Public Language |
|
|
115 | (2) |
|
|
117 | (10) |
|
|
117 | (1) |
|
5.5.2 First Law: A Biotic Artefact May not Injure a Human Being |
|
|
118 | (1) |
|
5.5.3 Second Law: A Biotic Artefact Must Be Strictly Functional |
|
|
119 | (2) |
|
5.5.4 Third Law: A Biotic Artefact Must Be Protected |
|
|
121 | (1) |
|
|
122 | (1) |
|
|
122 | (5) |
|
6 Synthetic Biology: Public Perceptions of an Emergent Field |
|
|
127 | (44) |
|
|
|
|
128 | (1) |
|
6.2 The Space and Role of Public Perceptions of Emergent Technoscientific Areas |
|
|
128 | (4) |
|
6.3 An Enlightenment Assumption: Resistance to Science as a Function of Lack of Knowledge |
|
|
132 | (2) |
|
6.4 Changes in the Institutional and Cultural Framework for the Development of New Areas of Science |
|
|
134 | (10) |
|
6.5 Positive Attitudes to Science and Reservations About Biotechnology |
|
|
144 | (3) |
|
6.6 Public Views on an Emergent and Fuzzy Object: Synthetic Biology |
|
|
147 | (18) |
|
6.6.1 Low Level of Salience and the Study of Public Views |
|
|
148 | (3) |
|
6.6.2 Early Characterizations of Public Views on Synthetic Biology in the United States |
|
|
151 | (3) |
|
6.6.3 Vistas on European Perceptions of Synthetic Biology |
|
|
154 | (1) |
|
6.6.3.1 Awareness of Synthetic Biology in Europe |
|
|
154 | (2) |
|
6.6.3.2 Relative Weight of Different Criteria in the Evaluation of Synthetic Biology |
|
|
156 | (1) |
|
6.6.3.3 Global Positions on the Acceptance of Synthetic Biology |
|
|
157 | (1) |
|
6.6.3.4 The Regulatory Regime for Synthetic Biology |
|
|
158 | (5) |
|
6.6.4 Synthetic Biology, Unnaturalness and "Playing God" |
|
|
163 | (2) |
|
|
165 | (6) |
|
|
166 | (5) |
|
7 In Search for a Legal Framework for Synthetic Biology |
|
|
171 | |
|
|
|
172 | (2) |
|
7.2 Enabling and Regulating Synthetic Biology in View of Environmental and Health Risks |
|
|
174 | (23) |
|
7.2.1 Constitutional Freedoms and the Regulation of Synthetic Biology |
|
|
174 | (3) |
|
7.2.2 Preventive Administrative Regulation |
|
|
177 | (1) |
|
7.2.2.1 Applicability to Synthetic Biology of the GMO Regime |
|
|
178 | (4) |
|
7.2.2.2 Adequacy of the GMO Regime |
|
|
182 | (13) |
|
|
195 | (1) |
|
|
196 | (1) |
|
7.3 Promoting Synthetic Biology Through the Granting of Intellectual Property Rights |
|
|
197 | (7) |
|
7.3.1 Patenting Life Forms |
|
|
197 | (2) |
|
7.3.2 Patent---A Stimulus of What? |
|
|
199 | (2) |
|
7.3.3 Applying Patent Law to Synthetic Biology |
|
|
201 | (2) |
|
7.3.4 Copy Right for Synthetic Biology Programs? |
|
|
203 | (1) |
|
7.4 Redistributing Benefits from Synthetic Biology |
|
|
204 | (2) |
|
|
206 | |
|
|
209 | |