Provides comprehensive up-to-date information on current topics in protein-protein interaction drug discovery.
1. Overview of protein-protein interaction (PPI) systems
2. Overview of drug discovery targeting PPI systems
3. Bioluminescence resonance energy transfer (BRET) assay for PPI study
4. Mass spectrometry (MS) for PPI study
5. Proximity ligation assay (PLA) for PPI study
6. Surface plasma resonance (SPR) assay for PPI study
7. Computational methods for PPI study
8. Peptidomimetics for PPI drug discovery
9. AApeptides for PPI drug discovery
10. Stapled peptides for PPI drug discovery
11. Cyclic peptides for PPI drug discovery
12. PPI drug discovery targeting B cell lymphoma (BCL) family
13. PPI drug discovery targeting MDM2-p53
14. PPI drug discovery targeting APC-Asef
15. Computational methods applied to drug discovery for PPI systems
16. Allosteric modulation of PPI systems for drug discovery
17. Current Challenges and Future Directions
Jian Zhang received a BM degree in Pharmacology in 2002 from Peking University and a PhD in 2007 from Shanghai Institute of Materia Medica, Chinese Academy of Sciences. Then he moved to the University of Michigan to carry out postdoctoral research in Prof. Shaomeng Wang's group. In 2009, he joined Shanghai Jiao Tong University, School of Medicine, where he is a distinguished professor and doctoral supervisor. Currently, he is also the director of the Medicinal Bioinformatics Center. His fields of research include first-in-class drug design and chemical biology mainly pertaining to protein-protein interactions and allostery and their application in drug discovery.
