The Textbook of Ion Channels is a set of three volumes providing a wide-ranging reference source on ion channels for students, instructors, and researchers. Ion channels are membrane proteins that control the electrical properties of neurons and cardiac cells, mediate the detection and response to sensory stimuli like light, sound, odor, and taste, and regulate the response to physical stimuli like temperature and pressure. In non-excitable tissues, ion channels are instrumental for the regulation of basic salt balance that is critical for homeostasis. Ion channels are located at the surface membrane of cells, giving them the unique ability to communicate with the environment, as well as the membrane of intracellular organelles, allowing them to regulate internal homeostasis. Ion channels are fundamentally important for human health and diseases, and are important targets for pharmaceuticals in mental illness, heart disease, anesthesia, pain and other clinical applications. The modern methods used in their study are powerful and diverse, ranging from single ion-channel measurement techniques to models of ion channel diseases in animals, and human clinical trials for ion channel drugs.
All three volumes give the reader an introduction to fundamental concepts needed to understand the mechanism of ion channels, a guide to the technical aspects of ion channel research, offer a modern guide to the properties of major ion channel families, and include coverage of key examples of regulatory, physiological, and disease roles for ion channels.
This three-volume textbook provides a wide-ranging reference source on ion channels for students, instructors, and researchers. They give an introduction to fundamental concepts, a guide to technical research aspects and the properties of major ion channel families, and coverage of key roles.
Volume I
1. Ion Selectivity and Conductance
2. Voltage-Dependent Gating
of Ion Channels
3. Ligand-Dependent Gating Mechanism
4. Mechanosensitive
Channels and Their Emerging Gating Mechanisms
5. Inactivation and
Desensitization
6. Ion Channel Inhibitors
7. Expression of Channels in
Heterologous Systems and Voltage Clamp Recordings of Macroscopic Currents
8.
Patch Clamping and Single-Channel Analysis
9. Patch Clamp Recordings from
Native Cells and Isolation of Membrane Currents
10. Models of Ion Channel
Gating
11. Investigating Ion Channel Structure and Dynamics Using
Fluorescence Spectroscopy
12. Ion Channel Structural Biology in the Era of
Single Particle Cryo-EM
13. Protein Crystallography
14. Rosetta Structural
Modeling
15. Molecular Dynamics
16. Genetic Models and Transgenics
17. EPR
and DEER Spectroscopy Volume II
1. Taxonomy and Evolution of Ion Channels
2.
Voltage-Gated Sodium Channels
3. Voltage-Gated Calcium Channels
4.
Voltage-Gated Potassium Channels
5. ERG Family of K Channels
6. KCNQ Channels
7. BK Channels
8. Small-Conductance Calcium-Activated Potassium (SK) Channels
9. Inward Rectifier Potassium Channels
10. Two-Pore Domain Potassium Channels
11. Cyclic Nucleotide-Gated Channels
12. HCN Channels
13. CLC Chloride
Channels and Transporters
14. Ca-Activated Cl- Channels 15: Acetylcholine
Receptors
16. Ionotropic Glutamate Receptors
17. 5-HT3 Receptors
18. GABAA
Receptors
19. Glycine Receptors
20. Acid Sensing Ion Channels 21: ENaC
Channels
22. TRPC Channels
23. TRPM Channels
24. TRPV Channels
25.
Store-Operated CRAC Channels
26. Piezo Channels
27. Ryanodine Receptors
28.
Proton Channels
29. P2X Receptors Volume III
1. Alternative Splicing
2.
Calmodulin Regulation of Ion Channels
3. Mechanism of G-protein Regulation of
Ion Channels
4. Regulation of Ion Channels by Membrane Lipids
5. Ion Channels
of the Heart
6. Ion Channels in Sperm and Eggs
7. Ion Channels in Immune
Cells
8. Ion Channels in Epilepsy
9. Ion Channels in Pain
10. Cystic Fibrosis
and the CFTR Anion Channels
11. CLC-Related Proteins in Diseases
12. KATP
Channels and the Regulation of Insulin Secretion
Jie Zheng, PhD, is a professor at the University of California Davis School of Medicine, where he has served as a faculty member in the Department of Physiology and Membrane Biology since 2004. Dr. Zheng earned a bachelors degree in physiology and biophysics (1988) and a masters degree in biophysics (1991) at Peking University. He earned a PhD in physiology (1998) at Yale University, where he studied with Dr. Fredrick J. Sigworth on patch-clamp recording, single-channel analysis, and voltage-dependent activation mechanisms. He received his postdoctoral training at the Howard Hughes Medical Institute (HHMI) and the University of Washington during 19992003, working with Dr. William N. Zagotta on the cyclic nucleotide-gated channels activation mechanism and novel fluorescence techniques for ion channel research. Currently, Dr. Zhengs research focuses on temperature-sensitive TRP channels.
Matthew C. Trudeau, PhD, is a professor in the Department of Physiology at the University of Maryland School of Medicine in Baltimore, Maryland. He earned a bachelors degree in biochemistry and molecular biology in 1992 and a PhD in physiology in 1998 while working with Gail Robertson, PhD, at the University of Wisconsin-Madison. His thesis work was on the properties of voltage-gated potassium channels in the human ether-aģ-go-go related gene (hERG) family and the role of these channels in heart disease. Dr. Trudeau was a postdoctoral fellow with William Zagotta, PhD, at the University of Washington and the Howard Hughes Medical Institute (HHMI) in Seattle from 1998 to 2004, where he focused on the molecular physiology of cyclic nucleotide-gated ion channels, the mechanism of their modulation by calcium-calmodulin, and their role in an inherited form of vision loss. Currently, Dr. Trudeaus work focuses on hERG potassium channels, their biophysical mechanisms, and their role in cardiac physiology and cardiac arrhythmias.
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