Titanium Alloys for Biomedical Development and Applications: Design, Microstructure, Properties and Application systematically introduces basic theories and progress in the research of biomedical -Ti alloys achieved by researchers from different fields. It focuses on a high-strength and low elastic modulus biomedical -Ti alloy (TLM), etc. designed by the authors. The alloy design methods, microstructural characteristics, mechanical properties, surface treatment methods and biocompatibility of the TLM alloy are discussed in detail, along with a concise description of the medical devices made from this alloy and the application examples.
This book will appeal to researchers as well as students from different disciplines, including materials science, biology, medicine and engineering fields.
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vii | |
| Preface |
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ix | |
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1 Overview of the development and application of biomedical metal materials |
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1 | (26) |
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1.1 Biomedical stainless steels |
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1 | (4) |
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1.2 Biomedical CoCr alloys |
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5 | (4) |
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1.3 Biomedical shape memory alloys |
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9 | (2) |
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1.4 Biomedical noble metals |
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11 | (2) |
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1.5 Biomedical refractory metals |
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13 | (4) |
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17 | (2) |
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19 | (8) |
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24 | (3) |
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2 Design and physical metallurgy of biomedical β-Ti alloys |
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27 | (28) |
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2.1 Overview of design methods of biomedical Ti alloys |
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27 | (5) |
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2.2 Overview of composition design of biomedical Ti alloys |
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32 | (2) |
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2.3 Overview of the design and development of typical biomedical β-Ti alloys |
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34 | (5) |
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2.4 Smelting and physical metallurgical properties of typical β-Ti alloys |
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39 | (6) |
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2.5 Design and physical metallurgical properties of novel TLM alloy |
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45 | (10) |
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51 | (4) |
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3 Processing, heat treatment, microstructure, and property evolution of TLM alloy |
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55 | (36) |
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3.1 Overview of processing and heat treatment of β-Ti alloys |
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55 | (1) |
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3.2 Billets and semifinished products of TLM alloy |
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56 | (2) |
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3.3 Plates and strips of TLM alloy |
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58 | (7) |
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3.4 Bars and rods of TLM alloy |
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65 | (6) |
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71 | (6) |
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3.6 TLM alloy products with special specifications |
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77 | (6) |
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83 | (8) |
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88 | (3) |
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4 Biological and mechanical evaluation of TLM alloy |
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91 | (34) |
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4.1 Biological evaluation of TLM alloy |
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91 | (18) |
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4.2 Biomechanical compatibility of TLM alloy |
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109 | (16) |
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123 | (2) |
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5 Surface modification and functionalization of TLM alloy |
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125 | (38) |
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5.1 Surface modification of Ti alloys |
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125 | (3) |
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5.2 Surface functionalization of Ti alloys |
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128 | (6) |
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5.3 Surface dealloying of TLM alloy |
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134 | (3) |
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5.4 Bioactive coatings on TLM alloy |
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137 | (7) |
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5.5 Wear-resistant coatings on TLM alloy |
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144 | (4) |
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5.6 Anticoagulant coatings on TLM alloy |
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148 | (5) |
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5.7 Antimicrobial coatings on TLM alloy |
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153 | (10) |
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159 | (4) |
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6 Development and application of TLM alloy for the replacement and repair of surgical implants |
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163 | (36) |
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6.1 Development and application of traditional Ti implants |
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163 | (2) |
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6.2 Design and novel manufacture of Ti implants |
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165 | (5) |
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6.3 Implants for orthopedics and trauma repair |
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170 | (4) |
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6.4 Implants for joint repair and replacement |
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174 | (11) |
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6.5 Implants for oral and maxillofacial repair and replacement of TLM alloy |
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185 | (10) |
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6.6 Medical devices of TLM alloy for spine repair |
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195 | (4) |
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196 | (3) |
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7 Development and application of TLM alloy for treatment of soft tissue with minimally invasive surgery |
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199 | (28) |
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7.1 Development and application survey of minimally invasive devices |
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199 | (2) |
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7.2 Design and manufacture survey of interventional devices |
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201 | (3) |
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7.3 Coronary stents of TLM alloy |
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204 | (8) |
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7.4 Nonvascular stents and related devices of TLM alloy |
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212 | (4) |
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7.5 Shell of brain and heart active devices of TLM alloy |
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216 | (6) |
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7.6 Other minimally invasive and interventional devices of TLM alloy |
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222 | (5) |
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223 | (4) |
| Index |
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227 | |
Dr. Zhentao Yu is currently working as Professor and Director at the Biomedical Materials Technology Research Center, Jinan University (JU), Guangzhou, China, and part-time with Northwest Institute for Nonferrous Metal Research (NIN), Xian, China. He was elected as a managing director of the Chinese Society for Biomaterials (CSBM) and was the Vice Director of the Biomedical Metal Materials Branch of the CSBM. He is a board member of the Biological Evaluation of Medical Devices and Tissue Engineering Medical Device Products Board, China. In 2018, he was identified by Shaanxi Province as the first batch of top talents in natural science and key leaders in technology innovation. He had undertaken more than 39 scientific projects, including the State 863 Plan, 973 Plan (China) and other significant projects. His research outcomes have been recognised through 11 provincial science and technology prizes. Over the past 17 years, Dr Yu has led the development of 3 new biomedical -titanium alloys, referred to as TLM (Ti-3Zr-2Sn-3Mo-25Nb), TiB12 (Ti-6Zr-4Sn-10Mo-3Nb), TLE (Ti-5Zr-6Mo-20Nb) etc., which possesses high strength, low modulus, good plasticity and excellent biocompatibility. On this basis, he and him team have manufactured them into different product forms such as tube, rod, plate and wires etc., and also eight different types of medical devices, such as teeth implants, joints, stents, blade plate and bone screw. His team circumvented a range of scientific problem`s and developed the key processing technologies for the manufacture of TLM alloy medical devices. Dr Yu has 52 patents and more than 220 peer-reviewed publications. In addition, he has edited and co-edited four technical books.
