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Transfusion and Transplantation Science [Minkštas viršelis]

Edited by (Former Head of the National Blood Service's Red Cell Immunohaematology Division)
  • Formatas: Paperback / softback, 304 pages, aukštis x plotis x storis: 246x189x12 mm, weight: 651 g, 96 line illustrations and 24 half-tones
  • Serija: Fundamentals of Biomedical Science
  • Išleidimo metai: 20-Sep-2012
  • Leidėjas: Oxford University Press
  • ISBN-10: 0199533288
  • ISBN-13: 9780199533282
Kitos knygos pagal šią temą:
  • Formatas: Paperback / softback, 304 pages, aukštis x plotis x storis: 246x189x12 mm, weight: 651 g, 96 line illustrations and 24 half-tones
  • Serija: Fundamentals of Biomedical Science
  • Išleidimo metai: 20-Sep-2012
  • Leidėjas: Oxford University Press
  • ISBN-10: 0199533288
  • ISBN-13: 9780199533282
Kitos knygos pagal šią temą:
Biomedical scientists are the foundation of modern healthcare, from cancer screening to diagnosing HIV, from blood transfusion for surgery to food poisoning and infection control. Without biomedical scientists, the diagnosis of disease, the evaluation of the effectiveness of treatment, and research into the causes and cures of disease would not be possible.

The Fundamentals of Biomedical Science series is written to reflect the challenges of practicing biomedical science today. It draws together essential basic science with insights into laboratory practice to show how an understanding of the biology of disease is coupled to the analytical approaches that lead to diagnosis.

Assuming only a minimum of prior knowledge, the series reviews the full range of disciplines to which a Biomedical Scientist may be exposed - from microbiology to cytopathology to transfusion science. Alongside volumes exploring specific biomedical themes and related laboratory diagnosis, an overarching Biomedical Science Practice volume gives a grounding in the professional and experimental skills with which any Biomedical Scientist must be equipped.

The series: · Understands the complex roles of Biomedical Scientists in the modern practice of medicine · Understands the development needs of employers and the Profession · Addresses the need for understanding of a range of fundamental sciences in the context of Biomedicine · Places the theoretical aspects of Biomedical Science in their practical context

The series is developed in partnership with and endorsed by the Institute of Biomedical Science. See ibms.org for more information.

The science of transfusion and transplantation demands a multifaceted understanding of immunology, haematology, and genetics from the biomedical scientist. Transfusion and Transplantation Science coherently synthesises the essential concepts of these subjects and presents them within the practical framework of the hospital banking and transplantation centre, thereby furnishing the reader with the knowledge and skills required to specialize in this discipline.

Beginning with an overview of potential immune responses to transfusion and transplantation, the text goes on to explain the aetiology behind these responses with a view to the prediction, diagnosis, and mitigation of adverse effects on the patient. It then outlines issues of quality, but also regulatory and legal concerns, that need to be considered when collecting, preparing, and storing products for transfusion or transplantation.

Online Resource Centre The Online Resource Centre to accompany Transfusion and Transplantation Science features:

For registered adopters of the book: · Figures from the book, available to download

For students: · An interactive Digital Microscope, encouraging the exploration of tissue samples · Self-assessment modules to help you to check and reinforce understanding of the basic science introduced in each volume · Video podcasts including interviews with practicing biomedical scientists, and 'in the lab' footage showing biomedical science in practice
1 Introduction to Basic Immunology and Techniques
1(18)
Robin Knight
Introduction
1(3)
1.1 Basic immunology and techniques
4(2)
1.2 Antibody structure
6(2)
1.3 Antibody function
8(1)
1.4 Antigen-antibody reactions
9(1)
1.5 Antibody mediated red cell destruction
10(3)
1.6 In vitro detection of antigen-antibody reactions
13(4)
1.7 Techniques
17(2)
Chapter summary
18(1)
2 Human Erythrocyte Antigens or Blood Groups
19(26)
Malcolm Needs
Introduction
19(2)
2.1 The ABO, H, and Lewis blood group systems
21(5)
2.2 The Lewis blood group system and secretor
26(1)
2.3 The MNS blood group system
27(2)
2.4 The Rh, RHAG, and LW blood group systems
29(6)
2.5 The Lutheran blood group system
35(2)
2.6 The Kell and Kx blood group systems
37(2)
2.7 The Duffy blood group system
39(2)
2.8 The Kidd blood group system
41(1)
2.9 The P1PK blood group system
42(1)
2.10 Other blood groups
42(3)
Chapter summary
43(1)
Further reading
44(1)
3 Donors and Donation: Collection and Processing
45(24)
Lionel Mohabir
Introduction
45(1)
3.1 Blood donation
46(5)
3.2 Donor/donation linking
51(1)
3.3 Component preparation
52(9)
3.4 Pathogen reduction
61(4)
3.5 Component validation and labelling
65(4)
Chapter summary
67(1)
Further reading
68(1)
4 Blood Donation Testing
69(29)
Lionel Mohabir
Introduction
69(1)
4.1 Mandatory testing
70(11)
4.2 Additional (discretionary) testing
81(3)
4.3 Microbiology serology testing
84(4)
4.4 Microbiology positive screen and confirmatory testing
88(2)
4.5 Bacterial contamination
90(2)
4.6 West Nile virus (WNV)
92(1)
4.7 Other threats to the blood supply
93(1)
4.8 Quality control/British working standards
94(4)
Chapter summary
96(1)
Further reading
97(1)
5 Clinical Use of Blood Components
98(19)
Karen Madgwick
Bill Chaffe
Introduction
98(1)
5.1 Structure and function of blood
99(1)
5.2 Normal physiological response to anaemia and/or bleeding
99(1)
5.3 Blood components available and their appropriate use
100(5)
5.4 Blood products
105(1)
5.5 Special requirements
106(1)
5.6 Decision making, who needs a transfusion, risks and benefits
107(2)
5.7 Alternatives to donor blood
109(5)
5.8 Case history examples
114(3)
Chapter summary
115(1)
Further reading
115(2)
6 Compatibility Testing and Adverse Effects
117(25)
Carol Cantwell
Tony Davies
Introduction
117(1)
6.1 Compatibility testing (serological and non-serological)
118(8)
6.2 Selection of plasma products
126(1)
6.3 Selection of cellular components
127(1)
6.4 Visual inspection and labelling of the units
128(1)
6.5 Traceability of blood components
129(1)
6.6 Adverse effects of transfusion
129(3)
6.7 Monitoring the patient during transfusion
132(2)
6.8 Investigation of transfusion reactions
134(2)
6.9 Haemovigilance in the UK
136(6)
Chapter summary
140(1)
Further reading
141(1)
7 Immune Red Cell Destruction
142(20)
Robin Knight
Introduction
142(1)
7.1 What is immune (antibody mediated) red cell destruction?
143(2)
7.2 Clinical significance of red cell antibodies
145(2)
7.3 Haemolytic transfusion reactions
147(2)
7.4 Autoimmune haemolytic anaemias
149(5)
7.5 Haemolysis post-transplantation bone marrow/stem cell transplant
154(1)
7.6 Haemolytic disease of the newborn or foetus (HDN)
155(7)
Chapter summary
160(1)
Further reading
160(2)
8 Human Leucocyte Antigens and Their Clinical Significance
162(25)
Colin Brown
Introduction
162(1)
8.1 A brief history of transplantation
163(1)
8.2 Human leucocyte antigens
163(7)
8.3 The detection and definition of human leucocyte antigens, alleles, and antibodies
170(4)
8.4 Clinical significance of human leucocyte antigens in transplantation
174(7)
8.5 Clinical significance of human leucocyte antigens in transfusion
181(6)
Chapter summary
185(1)
Further reading
186(1)
Discussion questions
186(1)
9 Human Platelet Antigens (HPA) and Human Neutrophil Antigens (HNA) and Their Clinical Significance
187(30)
Geoff Lucas
Introduction
188(1)
9.1 Overview of platelet and granulocyte antigens
188(2)
9.2 Human platelet antigens (HPA)
190(6)
9.3 Human neutrophil antigens (HNA)
196(3)
9.4 Antibody detection
199(6)
9.5 Clinical significance of HPA alloantibodies
205(7)
9.6 Clinical significance of HNA antibodies
212(5)
Chapter summary
215(1)
Further reading
215(1)
Discussion questions
216(1)
10 Haemopoietic Stem Cell Banking
217(19)
Robert Walters
Introduction
217(1)
10.1 Stem cells
218(2)
10.2 Major histocompatibility complex and human lymphocyte antigens
220(2)
10.3 Sources of haemopoietic stem cells
222(2)
10.4 Stem cell collection and processing
224(6)
10.5 Reinfusion and engraftment
230(1)
10.6 Complications
231(2)
10.7 Health and safety, and statutory requirements
233(1)
10.8 The future of stem cell therapy
234(2)
Chapter summary
235(1)
Further reading
235(1)
11 Tissue Banking
236(22)
Richard Lomas
Introduction
236(1)
11.1 Types of graft
237(1)
11.2 Which tissues are banked and how are they used?
238(2)
11.3 How are donors selected, screened, and consented?
240(3)
11.4 How are tissues retrieved?
243(4)
11.5 Tissue processing and preservation
247(7)
11.6 Storage and distribution
254(1)
11.7 The future-regenerative medicine
255(3)
Chapter summary
256(1)
Further reading
257(1)
12 Quality Issues
258(14)
John Barker
Joan Jones
Introduction
258(1)
12.1 Evolution of quality
258(3)
12.2 Quality management systems
261(3)
12.3 Blood safety and quality regulations
264(3)
12.4 The In Vitro Diagnostic Medical Devices Directive
267(1)
12.5 Clinical laboratory accreditation
267(1)
12.6 The Blood Stocks Management Scheme
268(1)
12.7 Other legislation and regulatory bodies
269(1)
12.8 Guidelines
270(1)
12.9 Haemovigilance
270(2)
Chapter summary
271(1)
Further reading
271(1)
Glossary 272(4)
Abbreviations 276(3)
Index 279
Robin Knight is former Head of the National Blood Service's Red Cell Immunohaematology division. During his 44 years of experience in clinical laboratories, 35 have largely been in blood transfusion in both hospitals, large and small, and the National Blood Service. For many years Robin was actively engaged in lecturing on HNC, BSc and MSc courses at the University of Westminster. Robin was until recently the Chief Examiner in Transfusion Science for the Institute of Biomedical Science, and initiated the British Blood Transfusion Society's Specialist Certificate Examination. He has been the author or co-author of 14 papers published in peer reviewed journals, and is the co-author of the BBTS publication 'Introduction to blood transfusion science and blood bank practice' which is now in its 5th edition, and is the key book for trainee scientists in transfusion in the UK.

He has also co-authored two World Health Organisation [ WHO] guidelines and a section of their Safe Blood Distance Learning materials. Robin is still actively involved, as a specialist advisor, with a number of Blood Transfusion Services in Africa.