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El. knyga: Translational Vascular Medicine: Pathogenesis, Diagnosis, and Treatment

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  • Formatas: PDF+DRM
  • Išleidimo metai: 19-Nov-2011
  • Leidėjas: Springer London Ltd
  • Kalba: eng
  • ISBN-13: 9780857299208
  • Formatas: PDF+DRM
  • Išleidimo metai: 19-Nov-2011
  • Leidėjas: Springer London Ltd
  • Kalba: eng
  • ISBN-13: 9780857299208

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This book details advances in such topics as surgery and non-pharmacological treatments for atherosclerotic disease of the aorta, pulmonary arterial hypertension, cytoprotective mechanisms in the vasculature and the “Broken Heart Syndrome”.

Translational medicine underpins vascular medicine. It is fundamental to understanding how we treat patients with vascular disease and more importantly, how to prevent it. It is the rationale for drug design and production. Vascular medicine and translational medicine will take over and become the main reason for referring patients to hospital. Therefore, hospital-based clinicians working with basic scientists need to know about translational medicine, which educates and informs them about vascular medicine and how management should be based.This book is a primer for translational vascular medicine and discusses the evolving and exciting areas of basic science applied to vascular medicine. The book is based on the third vascular biology conference held at The Royal College of Physicians in 2008. It provides a large amount of new basic and clinical information and the contributors are world leaders.
Section I Hot Topics in Vascular Biology
1 Pericytes: Adaptable Vascular Progenitors
3(14)
Gareth D. Hyde
Ann E. Canfield
2 Benefits and Risks of Manipulating the HIF Hydroxylase Pathway in Ischemic Heart Disease
17(10)
Tammie Bishop
Peter J. Ratcliffe
3 Cytoprotective Mechanisms in the Vasculature
27(18)
Justin C. Mason
4 Notch Signaling in Vascular Development
45(16)
Shalini Jadeja
Marcus Fruttiger
Section II Novel Molecular Mediators Regulating Cardiovascular System
5 The Therapeutic Potential of Dimethylarginine Dimethylaminohydrolase-Mediated Regulation of Nitric Oxide Synthesis
61(28)
James Leiper
F. Arrigoni
B. Ahmetaj
6 Potassium Channels Regulating the Electrical Activity of the Heart
89(22)
Andrew Tinker
Stephen C. Harmer
7 Free Radicals, Oxidative Stress, and Cardiovascular Disease
111(18)
K. Richard Bruckdorfer
Section III Clinical Aspects of Cardiovascular Disease
8 The Takotsubo (Broken Heart Syndrome)
129(8)
Lawrence S. Cohen
9 Lymphatic Vessels in Health and Disease
137(14)
Elisabetta Weber
Francesca Sozio
Erica Gabbrielli
Antonella Rossi
10 Importance of Subtype Selectivity for Endothelin Receptor Antagonists in the Human Vasculature
151(22)
Janet J. Maguire
Anthony P. Davenport
11 Non-Pharmacological Treatment of Peripheral Vascular Disease
173(14)
Janice Tsui
George Hamilton
12 Surgical Approaches to Abdominal Aortic Aneurysm Repair
187(16)
Matt Thompson
Peter Holt
Rob Hinchliffe
Ian Loftus
Section IV Clinical and Translational Aspects of Pulmonary Vascular Disease
13 Understanding the Pathobiology of Pulmonary Vascular Disease
203(10)
Kristin B. Highland
14 Inflammation in Pulmonary Arterial Hypertension
213(18)
Frederic Perros
Sylvia Cohen-Kaminsky
Peter Dorfmuller
Alice Huertas
Marie-Camille Chaumais
David Montani
Marc Humbert
15 Endothelin Receptor Antagonists in Cardiovascular Medicine: Challenges and Opportunities
231(30)
Matthias Barton
Index 261