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El. knyga: Tu Youyou And The Discovery Of Artemisinin: 2015 Nobel Laureate In Physiology Or Medicine

Edited by (Peking Univ, China), Edited by (Peking Univ, China), Edited by (Peking Univ, China)
  • Formatas: 224 pages
  • Išleidimo metai: 28-Sep-2016
  • Leidėjas: World Scientific Publishing Co Pte Ltd
  • Kalba: eng
  • ISBN-13: 9789813109919
  • Formatas: 224 pages
  • Išleidimo metai: 28-Sep-2016
  • Leidėjas: World Scientific Publishing Co Pte Ltd
  • Kalba: eng
  • ISBN-13: 9789813109919

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Nobel laureate Tu Youyou won the 2015 prize for Medicine/Physiology for the discovery of artemisinin, a drug therapy for malaria that has saved millions across the globe.This book traces the path of discovery beginning with Chairman Mao's 1964 instruction to Chinese researchers to find a cure for malaria, a disease that plagued the military and civilians alike in endemic regions. It chronicles the years of painstaking research to find effective anti-malarial drugs, and how an entry in a collection of traditional Chinese medicine prescriptions gave Tu Youyou the clue which led her to successfully extract artemisinin from the plant, Artemisia annua.Gathering together information from a variety of sources including first-hand accounts, this book describes the contributions of the many organisations, scientists, doctors and countless others who played a part in the process of discovery and clinical testing. It also provides insights into the challenges of carrying out such an extensive research project with limited resources during the upheavals of the Cultural Revolution. An inspirational read for young scientists.Includes the translation of Professor Tu Youyou's 2015 Nobel Lecture.
Authors ix
Preface The Deer Bleat "Youyou" While They Feed on Wild Hao xi
Chapter 1 Project 523 and Artemisinin
1(28)
The Mandate for Project 523
2(12)
The Organisational Structure of Project 523
14(15)
Chapter 2 The Discovery of Artemisinin
29(34)
Rediscovering the Anti-Malarial Properties of Artemisia Annua
30(7)
The Extraction and Naming of the Effective Monomer of A. Annua
37(4)
The Structure of Artemisinin
41(4)
Clinical Trials
45(12)
Collaboration in the Discovery of Artemisinin
57(6)
Chapter 3 Scientific Research Collaboration during a Special Historical Period
63(16)
Several Important Meetings
64(9)
Collaboration between Personnel and Work Units
73(6)
Chapter 4 Artemisinin's History and Future
79(22)
From the Past to the Present
80(6)
Health Benefits of Artemisinin and Future Research
86(15)
Chapter 5 The Nobel Prize and Beyond
101(40)
The Revolution is not Yet Over
102(17)
The Importance of Scientific Thinking
119(7)
Chinese Medicine is a Treasure Chest
126(5)
Artemisinin and Malaria
131(10)
Appendices
141(66)
Appendix 1 Timeline of Project 523 (1964 to 1981)
142(16)
Appendix 2 Milestones in Artemisinin Research (1967 to 2003)
158(5)
Appendix 3 Artemisinin --- Patents and Collaboration
163(10)
Appendix 4 Organisations Named
173(8)
Appendix 5 List of Plants
181(2)
Appendix 6 Tu Youyou's Nobel Lecture 7 Dec 2015
183(24)
Editors Epilogue 207