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Understanding Pathophysiology 7th edition [Minkštas viršelis]

(Naujas leidimas: 9780323937283)
3.71/5 (212 ratings by Goodreads)
(Professor Emerita, College of Nursing, University of Utah, Salt Lake City, Utah), (Professor Emerita, College of Nursing, University of Utah, Salt Lake City, Utah)
  • Formatas: Paperback / softback, 1116 pages, aukštis x plotis: 276x216 mm, weight: 2240 g,

    Approx. 1,000 illus.

    ; Illustrations, Contains 1 Loose-leaf and 1 Paperback / softback
  • Išleidimo metai: 24-Jan-2025
  • Leidėjas: Mosby
  • ISBN-10: 0323639089
  • ISBN-13: 9780323639088 (Naujas leidimas: 9780323937283)
Kitos knygos pagal šią temą:
  • Formatas: Paperback / softback, 1116 pages, aukštis x plotis: 276x216 mm, weight: 2240 g,

    Approx. 1,000 illus.

    ; Illustrations, Contains 1 Loose-leaf and 1 Paperback / softback
  • Išleidimo metai: 24-Jan-2025
  • Leidėjas: Mosby
  • ISBN-10: 0323639089
  • ISBN-13: 9780323639088 (Naujas leidimas: 9780323937283)
Kitos knygos pagal šią temą:
Make difficult pathophysiology concepts come to life! Filled with vibrant illustrations, simplified language, and detailed online content Understanding Pathophysiology, 7th Edition delivers the most accurate information on treatments, manifestations, and mechanisms of disease across the lifespan. This new edition is fully revised and includes coverage of rare diseases and epigenetics to you with a thorough understanding of conditions affecting the human body. Plus, with over 30 new 3D animations on the companion Evolve site, quick check boxes at the end of each chapter, and disease progression algorithms, this text helps you engage with the fundamental knowledge you need to succeed in nursing school and in practice.Student resources include animations, review questions, answers to the Quick Check boxes (featured in the text), chapter summary reviews, and case study with answers for select chapters.Algorithms throughout the text clarify disease progression.Did You Know boxes highlight new developments in biologic research, diagnostic studies, preventive care, treatments, and more.Quick Check boxes tests your retention of important chapter concepts.Risk Factor boxes alert you to important safety considerations associated with specific diseases.Summary Review sections provide fast, efficient review of chapter content.Geriatric Considerations boxes and Pediatric Considerations boxes highlight key considerations for these demographics in relevant chapters.Consistent presentation helps you to better distinguish pathophysiology, clinical manifestations, and evaluation and treatment for each disease.Glossary of approximately 1,000 terms familiarizes you with the most difficult or important terminology related to pathophysiology. NEW! Chapters on Alterations in Immunity and Obesity and Disorders of Nutrition feature the latest coverage of these hot topics. NEW! Additional coverage of rare diseases and epigenetics gives you a comprehensive understanding of conditions and cell growths that affect the human body.NEW! Streamlined content and illustrations ensures content is at an appropriate level for undergraduate students.NEW! More than 1000 illustrations in the text and 30+ new 3D animations on companion Evolve site bring difficult concepts to life for a new perspective on disease processes.
Part 1 Basic Concepts of Pathophysiology
UNIT 1 The Cell
1 Cellular Biology
1(39)
Kathryn L. McCance
Prokaryotes and Eukaryotes
1(1)
Cellular Functions
1(1)
Structure and Function of Cellular Components
2(9)
Nucleus
3(1)
Cytoplasmic Organelles
3(1)
Plasma Membranes
4(6)
Cellular Receptors
10(1)
Cell-to-Cell Adhesions
11(2)
Extracellular Matrix and Basement Membrane
12(1)
Specialized Cell Junctions
12(1)
Cellular Communication and Signal Transduction
13(4)
Cellular Metabolism
17(1)
Role of Adenosine Triphosphate
17(1)
Food and Production of Cellular Energy
17(1)
Oxidative Phosphorylation
18(1)
Membrane Transport: Cellular Intake and Output
18(9)
Electrolytes as Solutes
20(3)
Transport by Vesicle Formation
23(3)
Movement of Electrical Impulses: Membrane Potentials
26(1)
Cellular Reproduction: The Cell Cycle
27(1)
Phases of Mitosis and Cytokinesis
27(1)
Control of Cell Division and Cell Growth: Mitogens, Growth Factors, and Survival Factors
28(1)
DNA Damage Response: Blocks Cell Division
28(1)
Tissues
28(12)
Tissue Formation and Differentiation
29(11)
2 Genes and Genetic Diseases
40(24)
Lynn B. Jorde
DNA, RNA, and Proteins: Heredity at the Molecular Level
40(4)
Definitions
40(1)
From Genes to Proteins
41(3)
Chromosomes
44(7)
Chromosome Aberrations and Associated Diseases
44(7)
Elements of Formal Genetics
51(1)
Phenotype and Genotype
51(1)
Dominance and Recessiveness
51(1)
Transmission of Genetic Diseases
51(7)
Autosomal Dominant Inheritance
52(2)
Autosomal Recessive Inheritance
54(2)
X-Linked Inheritance
56(2)
Linkage Analysis and Gene Mapping
58(1)
Classic Pedigree Analysis
58(1)
Complete Human Gene Map: Prospects and Benefits
58(1)
Multifactorial Inheritance
59(5)
3 Epigenetics and Disease
64(9)
Diane P. Genereux
Epigenetic Mechanisms
64(1)
DNA Methylation
64(1)
Histone Modifications
64(1)
Epigenetics and Human Development
65(1)
Epigenetics in Genomic Imprinting
66(1)
Prader-Willi and Angelman Syndromes
66(1)
Beckwith-Wiedemann Syndrome
67(1)
Russell-Silver Syndrome
67(1)
Environmental Impacts on Epigenetic Information
67(2)
Epigenetics and Nutrition
67(1)
Epigenetics and Maternal Care
68(1)
Twin Studies Provide Insights on Epigenetic Modification
68(1)
Molecular Approaches to Understand Epigenetic Disease
68(1)
Epigenetics and Cancer
69(2)
DNA Methylation and Cancer
69(1)
Epigenetic Screening for Cancer
70(1)
Emerging Strategies for the Treatment of Epigenetic Disease
70(1)
Future Directions
71(2)
4 Altered Cellular and Tissue Biology
73(38)
Kathryn L. McCance
Lois E. Brenneman
Cellular Adaptation
74(3)
Atrophy
74(1)
Hypertrophy
75(1)
Hyperplasia
75(1)
Dysplasia: Not a True Adaptive Change
76(1)
Metaplasia
76(1)
Cellular Injury
77(17)
General Mechanisms of Cell Injury
77(1)
Ischemic and Hypoxic Injury
77(1)
Ischemia-Reperfusion Injury
78(1)
Free Radicals and Reactive Oxygen Species---Oxidative Stress
79(3)
Chemical or Toxic Injury
82(8)
Unintentional and Intentional Injuries
90(3)
Infectious Injury
93(1)
Immunologic and Inflammatory Injury
94(1)
Manifestations of Cellular Injury
94(5)
Cellular Manifestations: Accumulations
94(1)
Water
95(1)
Lipids and Carbohydrates
95(1)
Glycogen
96(1)
Proteins
96(1)
Pigments
97(1)
Calcium
97(2)
Urate
99(1)
Systemic Manifestations of Cellular Injury
99(1)
Cellular Death
99(5)
Necrosis
100(2)
Apoptosis
102(1)
Autophagy
103(1)
Aging and Altered Cellular and Tissue Biology
104(2)
Normal Life Span and Life Expectancy
105(1)
Frailty
105(1)
Somatic Death
106(5)
5 Fluids and Electrolytes, Acids and Bases
111(22)
Lois E. Brenneman
Sue E. Huether
Distribution of Body Fluids and Electrolytes
111(2)
Water Movement Between Plasma and Interstitial Fluid
112(1)
Water Movement Between ICF and ECF
113(1)
Alterations in Water Movement
113(2)
Edema
113(2)
Sodium, Chloride, and Water Balance
115(2)
Alterations in Sodium, Chloride, and Water Balance
117(3)
Isotonic Fluid Alterations
118(1)
Hypertonic Fluid Alterations
118(1)
Hypotonic Fluid Alterations
119(1)
Alterations in Potassium and Other Electrolytes
120(3)
Potassium
120(3)
Other Electrolytes---Calcium, Phosphate, and Magnesium
123(1)
Acid--Base Balance
123(7)
Hydrogen Ion and pH
123(2)
Buffer Systems
125(2)
Acid-Base Imbalances
127(3)
Pediatric Considerations: Distribution of Body Fluids
130(1)
Geriatric Considerations: Distribution of Body Fluids
130(3)
UNIT 2 Mechanisms of Self-Defense
6 Innate Immunity: Inflammation and Wound Healing
133(23)
Valentina L. Brashers
Lois E. Brenneman
Human Defense Mechanisms
133(1)
Innate Immunity
133(13)
First Line of Defense: Physical and Biochemical Barriers and the Human Microbiome
133(2)
Second Line of Defense: Inflammation
135(4)
Cellular Components of Inflammation
139(7)
Acute and Chronic Inflammation
146(1)
Local Manifestations of Acute Inflammation
146(1)
Systemic Manifestations of Acute Inflammation
146(1)
Chronic Inflammation
147(1)
Wound Healing
147(5)
Phase I Hemostasis (Coagulation)
149(1)
Phase II Inflammation
149(1)
Phase III Proliferation and New Tissue Formation
149(1)
Phase IV Remodeling and Maturation
150(1)
Dysfunctional Wound Healing
150(2)
PEDIATRIC CONSIDERATIONS: Age-Related Factors Affecting Innate Immunity in the Newborn Child
152(1)
GERIATRIC CONSIDERATIONS: Age-Related Factors Affecting Innate Immunity in the Elderly
153(3)
7 Adaptive Immunity
156(18)
Valentina L. Brashers
Kathryn L. McCance
Overview of Adaptive Immunity
156(1)
Antigens and Immunogens
157(1)
Immune Response: Collaboration of B Cells and T Cells
157(6)
Generation of Clonal Diversity
157(4)
Clonal Selection
161(2)
Humoral Immunity (Antibodies)
163(5)
Classes of Antibodies
163(3)
Antigen-Antibody Binding
166(1)
Function of Antibodies
166(2)
Cell-Mediated Immunity
168(3)
T-Lymphocyte Function
169(2)
Pediatric Considerations: Age-Related Factors Affecting Mechanisms of Self-Defense in the Newborn Child
171(1)
Geriatric Considerations: Age-Related Factors Affecting Mechanisms of Self-Defense in the Elderly
171(3)
8 Alterations in Immunity
174(22)
Valentina L. Brashers
Sue E. Huether
Hypersensitivity Reactions
174(1)
Immunologic Mechanisms of Hypersensitivity Reactions
174(12)
Mechanisms of Hypersensitivity Reactions
175(6)
Allergy
181(1)
Autoimmunity
182(1)
Alloimmunity
183(3)
Deficiencies in Immunity
186(10)
Initial Clinical Presentation
186(1)
Primary (Congenital) Immune Deficiencies
186(2)
Secondary (Acquired) Immune Deficiencies
188(8)
9 Infection
196(14)
Valentina L. Brashers
Sue E. Huether
Microorganisms and Humans: a Dynamic Relationship
196(3)
The Process of Infection
196(2)
Stages of Infection
198(1)
Infectious Disease
199(7)
Bacterial Infection
199(2)
Viral Infection
201(3)
Fungal Infection
204(1)
Parasitic Infection
204(2)
Antibiotic/Antimicrobial Resistance
206(1)
Vaccines and Protection Against Infection
207(3)
Active Immunization
207(1)
Passive Immunotherapy
208(2)
10 Stress and Disease
210(17)
Lorey K. Takahashi
Kathryn L. McCance
Background and General Concepts of Stress
210(1)
Traditional Overview of Stress
210(1)
Modern Overview of Stress: Allostasis and Allostatic Overload
211(1)
The Stress Systems
211(7)
Regulation of the Hypothalamic-Pituitary-Adrenal Axis
213(3)
The Autonomic Nervous System
216(1)
Role of the Immune System
217(1)
Chronic Stress at an Early Age Increases the Risk of Developing Long-Lasting Pathophysiologic Alterations Linked to Poor Health and to Disease
218(3)
Negative Effects of Stress on Telomere Length, Aging, and Disease
221(1)
Coping and Intervention Strategies
221(6)
Staying on the Good Side of the Stress Spectrum
221(2)
Effects of Exercise
223(1)
Mindfulness Therapy
223(4)
UNIT 3 Cellular Proliferation: Cancer
11 Cancer Biology
227(31)
Kathryn L. McCance
Neal S. Rote
Cancer Terminology and Characteristics
227(1)
Tumor Classification and Nomenclature
227(1)
The Biology of Cancer Cells
228(19)
Sustained Proliferative Signaling
232(3)
Evading Growth Suppressors
235(3)
Genomic Instability
238(1)
Enabling Replication Immortality
238(1)
Cellular Adaptations
239(1)
Reprogramming Energy Metabolism
239(2)
Resistance to Destruction
241(3)
Activating Invasion and Metastasis
244(3)
Clinical Manifestations of Cancer
247(2)
Paraneoplastic Syndromes
247(1)
Molecular Mechanisms of Cachexia
247(2)
Diagnosis and Staging of Cancer
249(3)
Histologic Staging
249(3)
Classification of Tumors: Immunohistochemical and Genetic Analysis
252(1)
Treatment of Cancer
252(6)
Classic Approaches
252(6)
12 Cancer Epidemiology
258(33)
Kathryn L. McCance
Lois E. Brenneman
Genetics, Epigenetics, and Tissue
258(6)
Incidence and Mortality Trends
264(1)
In Utero and Early Life Conditions
264(1)
Environmental-Lifestyle Factors
265(26)
Tobacco Use
265(2)
Diet
267(1)
Nutrition, Obesity, Alcohol Consumption, and Physical Activity: Impacts on Cancer
267(7)
Air Pollution
274(2)
Ionizing Radiation
276(4)
Ultraviolet Radiation
280(2)
Electromagnetic Radiation
282(1)
Infection, Sexual and Reproductive Behavior
282(1)
Other Viruses and Microorganisms
283(1)
Chemical and Occupational Hazards as Carcinogens
283(8)
13 Cancer in Children and Adolescents
291(7)
Lauri A. Under
Incidence, Etiology, and Types of Childhood Cancer
291(5)
Etiology
292(1)
Genetic and Genomic Factors
293(2)
Environmental Factors
295(1)
Prognosis
296(2)
Part 2 Body Systems and Diseases
UNIT 4 The Neurologic System
14 Structure and Function of the Neurologic System
298(29)
Sue E. Huether
Overview and Organization of the Nervous System
298(1)
Cells of the Nervous System
298(3)
Neurons
299(1)
Neuroglia
300(1)
Nerve Injury and Regeneration
300(1)
The Nerve Impulse
301(2)
Synapses
302(1)
Neurotransmitters
302(1)
Central Nervous System
303(11)
Brain
303(5)
Spinal Cord
308(3)
Motor Pathways
311(1)
Sensory Pathways
311(1)
Protective Structures
311(3)
Blood Supply
314(3)
Blood Supply to the Brain
314(1)
Blood-Brain Barrier
315(1)
Blood Supply to the Spinal Cord
315(2)
Peripheral Nervous System
317(1)
Autonomic Nervous System
318(6)
Anatomy of the Sympathetic Nervous System
319(2)
Anatomy of the Parasympathetic Nervous System
321(1)
Neurotransmitters and Neuroreceptors
322(1)
Functions of the Autonomic Nervous System
322(2)
Geriatric Considerations: Aging and the Nervous System
324(3)
15 Pain, Temperature, Sleep, and Sensory Function
327(24)
George W. Rodway
Sue E. Huether
Pain
327(6)
Neuroanatomy of Pain
327(2)
Pain Modulation
329(1)
Clinical Descriptions of Pain
330(3)
Temperature Regulation
333(2)
Control of Body Temperature
333(1)
Temperature Regulation in Infants and Elderly Persons
333(1)
Pathogenesis of Fever
333(1)
Benefits of Fever
334(1)
Disorders of Temperature Regulation
335(1)
Sleep
335(3)
Sleep Disorders
336(2)
The Special Senses
338(6)
Vision
338(4)
Hearing
342(2)
Geriatric Considerations: Aging & Changes in Hearing
344(1)
Olfaction and Taste
344(1)
Geriatric Considerations: Aging & Changes in Olfaction and Taste
345(1)
Somatosensory Function
345(6)
Touch
345(1)
Proprioception
346(5)
16 Alterations in Cognitive Systems, Cerebral Hemodynamics, and Motor Function
351(33)
Barbara J. Boss
Sue E. Huether
Alterations in Cognitive Systems
351(16)
Alterations in Arousal
351(6)
Alterations in Awareness
357(2)
Data-Processing Deficits
359(6)
Seizure Disorders
365(2)
Alterations in Cerebral Hemodynamics
367(3)
Increased Intracranial Pressure
367(2)
Cerebral Edema
369(1)
Hydrocephalus
369(1)
Alterations in Neuromotor Function
370(8)
Alterations in Muscle Tone
370(2)
Alterations in Muscle Movement
372(3)
Upper and Lower Motor Neuron Syndromes
375(2)
Motor Neuron Diseases
377(1)
Amyotrophic Lateral Sclerosis
377(1)
Alterations in Complex Motor Performance
378(1)
Disorders of Posture (Stance)
378(1)
Disorders of Gait
379(1)
Disorders of Expression
379(1)
Extrapyramidal Motor Syndromes
379(5)
17 Disorders of the Central and Peripheral Nervous Systems and Neuromuscular Junction
384(30)
Barbara J. Boss
Sue E. Huether
Central Nervous System Disorders
384(21)
Traumatic Brain and Spinal Cord Injury
384(8)
Degenerative Disorders of the Spine
392(3)
Cerebrovascular Disorders
395(5)
Primary Headache Syndromes
400(1)
Infection and Inflammation of the Central Nervous System
401(2)
Demyelinating Disorders
403(2)
Peripheral Nervous System and Neuromuscular Junction Disorders
405(1)
Peripheral Nervous System Disorders
405(1)
Neuromuscular Junction Disorders
405(1)
Tumors of the Central Nervous System
406(8)
Brain Tumors
406(3)
Spinal Cord Tumors
409(5)
18 Alterations of Neurologic Function in Children
414(15)
Russell J. Butterfield
Sue E. Huether
Development of the Nervous System in Children
414(1)
Structural Malformations
415(5)
Defects of Neural Tube Closure
416(1)
Craniosynostosis
417(2)
Malformations of Brain Development
419(1)
Alterations in Function: Encephalopathies
420(3)
Static (Nonprogressive) Encephalopathies
420(1)
Inherited Metabolic Disorders of the Central Nervous System
421(1)
Intoxications of the Central Nervous System
422(1)
Infections of the Central Nervous System
422(1)
Cerebrovascular Disease in Children
423(1)
Perinatal Stroke
423(1)
Childhood Stroke
423(1)
Epilepsy and Seizure Disorders in Children
423(1)
Childhood Tumors
423(6)
Brain Tumors
423(1)
Embryonal Tumors
423(6)
UNIT 5 The Endocrine System
19 Mechanisms of Hormonal Regulation
429(18)
Valentina L. Brashers
Sue E. Huether
Mechanisms of Hormonal Regulation
429(4)
Regulation of Hormone Release
429(1)
Hormone Transport
430(1)
Hormone Receptors
430(3)
Structure and Function of the Endocrine Glands
433(11)
Hypothalamic-Pituitary System
433(4)
Pineal Gland
437(1)
Thyroid and Parathyroid Glands
437(2)
Endocrine Pancreas
439(2)
Adrenal Glands
441(3)
Geriatric Considerations: Aging and Its Effects on Specific Endocrine Glands
444(3)
20 Alterations of Hormonal Regulation
447(27)
Valentina L. Brashers
Sue E. Huether
Mechanisms of Hormonal Alterations
447(1)
Alterations of the Hypothalamic-Pituitary System
447(5)
Diseases of the Posterior Pituitary
447(2)
Diseases of the Anterior Pituitary
449(3)
Alterations of Thyroid Function
452(4)
Thyrotoxicosis/Hyperthyroidism
452(2)
Hypothyroidism
454(1)
Thyroid Carcinoma
455(1)
Alterations of Parathyroid Function
456(1)
Hyperparathyroidism
456(1)
Hypoparathyroidism
456(1)
Dysfunction of the Endocrine Pancreas: Diabetes Mellitus
457(10)
Types of Diabetes Mellitus
457(4)
Acute Complications of Diabetes Mellitus
461(3)
Chronic Complications of Diabetes Mellitus
464(3)
Alterations of Adrenal Function
467(7)
Disorders of the Adrenal Cortex
467(3)
Tumors of the Adrenal Medulla
470(4)
21 Obesity, Starvation, and Anorexia of Aging
474(10)
Sue E. Huether
Adipose Tissue
474(2)
Adipose Tissue as an Endocrine Organ
475(1)
Regulation of Food Intake and Energy Balance
475(1)
Obesity
476(4)
Starvation
480(1)
Anorexia of Aging
480(4)
UNIT 6 The Hematologic System
22 Structure and Function of the Hematologic System
484(21)
Sue E. Huether
Components of the Hematologic System
484(6)
Composition of Blood
484(4)
Lymphoid Organs
488(2)
Development of Blood Cells
490(6)
Bone Marrow
490(1)
Cellular Differentiation
490(1)
Hematopoiesis
491(5)
Mechanisms of Hemostasis
496(3)
Function of Blood Vessels
496(1)
Function of Platelets
497(1)
Function of Clotting Factors
498(1)
Control of Hemostatic Mechanisms
498(1)
Retraction and Lysis of Blood Clots
498(1)
Pediatrics and Blood
499(1)
Aging and Blood
499(6)
23 Alterations of Hematologic Function
505(43)
Kathryn L. McCance
Anemia
505(9)
Classification and General Characteristics
505(2)
Anemias of Blood Loss
507(1)
Anemias of Diminished Erythropoiesis
507(7)
Myeloproliferative Red Cell Disorders
514(3)
Polycythemia Vera
514(2)
Iron Overload
516(1)
Alterations of Leukocyte Function
517(10)
Quantitative Alterations of Leukocytes
517(10)
Alterations of Lymphoid Function
527(7)
Lytnphadenopathy
527(1)
Malignant Lymphomas
527(4)
Plasma Cell Malignancy
531(3)
Alterations of Splenic Function
534(1)
Hemorrhagic Disorders and Alterations of Platelets and Coagulation
535(13)
Disorders of Platelets
536(3)
Alterations of Platelet Function
539(1)
Disorders of Coagulation
539(9)
24 Alterations of Hematologic Function in Children
548(15)
Lauri A. Under
Kathryn L. McCance
Disorders of Erythrocytes
548(9)
Acquired Disorders
548(3)
Inherited Disorders
551(6)
Disorders of Coagulation and Platelets
557(1)
Inherited Hemorrhagic Disease
557(1)
Antibody-Mediated Hemorrhagic Disease
557(1)
Neoplastic Disorders
558(5)
Leukemia
558(1)
Lymphomas
559(4)
UNIT 7 The Cardiovascular and Lymphatic Systems
25 Structure and Function of the Cardiovascular and Lymphatic Systems
563(28)
Kathryn L. McCance
Circulatory System
563(1)
Heart
563(14)
Structures That Direct Circulation Through the Heart
564(3)
Structures That Support Cardiac Metabolism: Coronary Circulation
567(1)
Structures That Control Heart Action
568(6)
Factors Affecting Cardiac Output
574(3)
Systemic Circulation
577(8)
Structure of Blood Vessels
577(1)
Factors Affecting Blood Flow
577(4)
Regulation of Blood Pressure
581(4)
The Lymphatic System
585(6)
26 Alterations of Cardiovascular Function
591(48)
Valentina L. Brashers
Diseases of the Veins
591(1)
Varicose Veins and Chronic Venous Insufficiency
591(1)
Thrombus Formation in Veins
591(1)
Superior Vena Cava Syndrome
592(1)
Diseases of the Arteries
592(19)
Hypertension
592(4)
Orthostatic (Postural) Hypotension
596(1)
Aneurysm
596(1)
Thrombus Formation
597(1)
Embolism
598(1)
Peripheral Vascular Disease
598(1)
Atherosclerosis
599(2)
Peripheral Artery Disease
601(1)
Coronary Artery Disease, Myocardial Ischemia, and Acute Coronary Syndromes
602(9)
Disorders of the Heart Wall
611(9)
Disorders of the Pericardium
611(2)
Disorders of the Myocardium: the Cardiomyopathies
613(1)
Disorders of the Endocardium
614(6)
Manifestations of Heart Disease
620(4)
Heart Failure
620(3)
Dysrhythmias
623(1)
Shock
624(15)
Impairment of Cellular Metabolism
624(3)
Clinical Manifestations of Shock
627(1)
Treatment for Shock
628(1)
Types of Shock
628(4)
Multiple Organ Dysfunction Syndrome
632(7)
27 Alterations of Cardiovascular Function in Children
639(16)
Nancy Pike
Jennifer Peterson
Congenital Heart Disease
639(11)
Defects With Increased Pulmonary Blood Flow
640(3)
Obstructive Defects
643(2)
Defects With Decreased Pulmonary Blood Flow
645(1)
Mixing Defects
646(3)
Heart Failure
649(1)
Acquired Cardiovascular Disorders
650(5)
Kawasaki Disease
650(1)
Systemic Hypertension
650(5)
UNIT 8 The Pulmonary System
28 Structure and Function of the Pulmonary System
655(15)
Valentina L. Brashers
Structures of the Pulmonary System
655(5)
Conducting Airways
655(1)
Gas-Exchange Airways
656(1)
Pulmonary and Bronchial Circulation
657(2)
Control of the Pulmonary Circulation
659(1)
Chest Wall and Pleura
659(1)
Function of the Pulmonary System
660(8)
Ventilation
660(1)
Neurochemical Control of Ventilation
660(2)
Mechanics of Breathing
662(2)
Gas Transport
664(4)
Geriatric Considerations: Aging and the Pulmonary System
668(2)
29 Alterations of Pulmonary Function
670(27)
Valentina I. Brashers
Sue E. Huether
Clinical Manifestations of Pulmonary Alterations
670(6)
Signs and Symptoms of Pulmonary Disease
670(2)
Pain
672(1)
Conditions Caused by Pulmonary Disease or Injury
672(2)
Disorders of the Chest Wall and Pleura
674(1)
Pleural Abnormalities
674(2)
Pulmonary Disorders
676(21)
Restrictive Lung Diseases
676(4)
Obstructive Lung Diseases
680(6)
Respiratory Tract Infections
686(3)
Pulmonary Vascular Disease
689(1)
Malignancies of the Respiratory Tract
690(7)
30 Alterations of Pulmonary Function in Children
697(15)
Valentina L. Brashers
Disorders of the Upper Airways
697(3)
Infections of the Upper Airways
697(2)
Aspiration of Foreign Bodies
699(1)
Obstructive Sleep Apnea
700(1)
Disorders of the Lower Airways
700(9)
Surfactant Deficiency Disorder (Respiratory Distress Syndrome of the Newborn)
700(2)
Bronchopulmonary Dysplasia
702(1)
Respiratory Tract Infections
703(1)
Pneumonia
704(2)
Aspiration Pneumonitis
706(1)
Asthma
706(1)
Acute Respiratory Distress Syndrome
707(1)
Cystic Fibrosis
707(2)
Sudden Infant Death Syndrome
709(3)
UNIT 9 The Renal and Urologic Systems
31 Structure and Function of the Renal and Urologic Systems
712(16)
Sue E. Huether
Structures of the Renal System
712(5)
Structures of the Kidney
712(4)
Urinary Structures
716(1)
Renal Blood Flow and Glomerular Filtration
717(2)
Autoregulation of Intrarenal Blood Flow
717(1)
Neural Regulation of Renal Blood Flow
717(1)
Hormones and Other Factors Regulating Renal Blood Flow
717(2)
Kidney Function
719(4)
Nephron Function
719(3)
Hormones and Nephron Function
722(1)
Renal Hormones
722(1)
Tests of Renal Function
723(2)
Renal Clearance
723(1)
Urinalysis
724(1)
Pediatric Considerations: Pediatrics & Renal Function
725(1)
Geriatric Considerations: Aging & Renal Function
725(3)
32 Alterations of Renal and Urinary Tract Function
728(23)
Sue E. Huether
Urinary Tract Obstruction
728(6)
Upper Urinary Tract Obstruction
728(2)
Lower Urinary Tract Obstruction
730(3)
Tumors
733(1)
Urinary Tract Infection
734(3)
Causes of Urinary Tract Infection
734(1)
Types of Urinary Tract Infection
734(3)
Glomerular Disorders
737(5)
Glomerulonephritis
737(3)
Nephrotic and Nephritic Syndromes
740(2)
Acute Kidney Injury
742(2)
Classification of Kidney Dysfunction
742(1)
Acute Kidney Injury
742(2)
Chronic Kidney Disease
744(7)
Creatinine and Urea Clearance
746(1)
Fluid and Electrolyte Balance
746(1)
Calcium, Phosphate, and Bone
746(1)
Protein, Carbohydrate, and Fat Metabolism
746(1)
Cardiovascular System
746(1)
Pulmonary System
746(2)
Hematologic System
748(1)
Immune System
748(1)
Neurologic System
748(1)
Gastrointestinal System
748(1)
Endocrine and Reproductive Systems
748(1)
Integumentary System
748(3)
33 Alterations of Renal and Urinary Tract Function in Children
751(9)
Patricia Ring
Sue E. Huether
Structural Abnormalities
751(3)
Hypoplastic/Dysplastic Kidneys
751(1)
Polycystic Kidney Disease
751(1)
Renal Agenesis
752(1)
Ureteropelvic Junction Obstruction
752(1)
Hypospadias
753(1)
Epispadias and Exstrophy of the Bladder
753(1)
Bladder Outlet Obstruction
754(1)
Glomerular Disorders
754(1)
Glomerulonephritis
754(1)
Immunoglobulin A Nephropathy
754(1)
Nephrotic Syndrome
754(1)
Hemolytic Uremic Syndrome
755(1)
Nephroblastoma
755(1)
Bladder Disorders
756(1)
Urinary Tract Infections
756(1)
Vesicoureteral Reflux
757(1)
Urinary Incontinence
757(3)
UNIT 10 The Reproductive Systems
34 Structure and Function of the Reproductive Systems
760(20)
George W. Rodway
Sue E. Huether
Development of the Reproductive Systems
760(2)
Sexual Differentiation in Utero
760(1)
Puberty and Reproductive Maturation
761(1)
The Female Reproductive System
762(8)
External Genitalia
763(1)
Internal Genitalia
764(3)
Female Sex Hormones
767(1)
Menstrual (Ovarian) Cycle
768(2)
Structure and Function of the Breast
770(2)
Female Breast
770(2)
Male Breast
772(1)
The Male Reproductive System
772(4)
External Genitalia
772(2)
Internal Genitalia
774(1)
Spermatogenesis
775(1)
Male Sex and Reproductive Hormones
775(1)
Aging and Reproductive Function
776(4)
Aging and the Female Reproductive System
776(1)
Aging and the Male Reproductive System
777(3)
35 Alterations of the Female Reproductive System
780(50)
Kathryn L. McCance
Abnormalities of the Female Reproductive Tract
780(1)
Alterations of Sexual Maturation
781(2)
Delayed or Absent Puberty
781(1)
Precocious Puberty
782(1)
Disorders of the Female Reproductive System
783(24)
Hormonal and Menstrual Alterations
783(5)
Infection and Inflammation
788(4)
Pelvic Organ Prolapse
792(1)
Benign Growths and Proliferative Conditions
793(4)
Cancer
797(9)
Sexual Dysfunction
806(1)
Impaired Fertility
807(1)
Disorders of the Female Breast
807(23)
Galactorrhea
807(1)
Benign Breast Disease and Conditions
808(2)
Breast Cancer
810(20)
36 Alterations of the Male Reproductive System
830(28)
George W. Hodway
Alterations of Sexual Maturation
830(1)
Delayed or Absent Puberty
830(1)
Precocious Puberty
830(1)
Disorders of the Male Reproductive System
831(21)
Disorders of the Urethra
831(1)
Disorders of the Penis
831(3)
Disorders of the Scrotum, Testis, and Epididymis
834(4)
Disorders of the Prostate Gland
838(11)
Sexual Dysfunction
849(3)
Disorders of the Male Breast
852(1)
Gynecomastia
852(1)
Carcinoma
852(1)
Sexually Transmitted Infections
853(5)
UNIT 11 The Digestive System
37 Structure and Function of the Digestive System
858(21)
Sue E. Huether
The Gastrointestinal Tract
858(11)
Mouth and Esophagus
858(3)
Stomach
861(3)
Small Intestine
864(3)
Large Intestine
867(2)
The Gastrointestinal Tract and Immunity
869(1)
Intestinal Microbiome
869(1)
Splanchnic Blood Flow
869(1)
Accessory Organs of Digestion
869(7)
Liver
869(4)
Gallbladder
873(1)
Exocrine Pancreas
874(2)
Geriatric Considerations: Aging & the Digestive System
876(3)
38 Alterations of Digestive Function
879(37)
Sue E. Huether
Disorders of the Gastrointestinal Tract
879(17)
Clinical Manifestations of Gastrointestinal Dysfunction
879(4)
Disorders of Motility
883(4)
Gastritis
887(1)
Peptic Ulcer Disease
888(3)
Malabsorption Syndromes
891(2)
Inflammatory Bowel Disease
893(2)
Diverticular Disease of the Colon
895(1)
Appendicitis
896(1)
Mesenteric Vascular Insufficiency
896(1)
Disorders of the Accessory Organs of Digestion
896(10)
Common Complications of Liver Disorders
897(4)
Disorders of the Liver
901(3)
Disorders of the Gallbladder
904(1)
Disorders of the Pancreas
905(1)
Cancer of the Digestive System
906(10)
Cancer of the Gastrointestinal Tract
906(4)
Cancer of the Accessory Organs of Digestion
910(6)
39 Alterations of Digestive Function in Children
916(17)
Sharon Sables-Baus
Sara J. Fidanza
Congenital Impairment of Motility in the Gastrointestinal Tract
916(4)
Mouth and Esophagus
916(2)
Stomach
918(1)
Small Intestine
918(2)
Large Intestine, Rectum, and Anus
920(1)
Acquired Impairment of Motility in the Gastrointestinal Tract
920(2)
Gastroesophageal Reflux (GER) and Gastroesophageal Reflux Disease (GERD)
920(1)
Intussusception
921(1)
Appendicitis
922(1)
Impairment of Digestion, Absorption, and Nutrition
922(5)
Cystic Fibrosis
922(1)
Celiac Disease
923(2)
Malnutrition
925(1)
Faltering Growth (Failure to Thrive)
926(1)
Necrotizing Enterocolitis
926(1)
Diarrhea
927(1)
Acute Infectious Diarrhea
927(1)
Primary Lactose Intolerance
927(1)
Disorders of the Liver
927(6)
Disorders of Biliary Metabolism and Transport
927(1)
Inflammatory Disorders
928(1)
Metabolic Disorders
929(4)
UNIT 12 The Musculoskeletal and Integumentary Systems
40 Structure and Function of the Musculoskeletal System
933(22)
Geri C. Reeves
Structure and Function of Bones
933(7)
Elements of Bone Tissue
933(4)
Types of Bone Tissue
937(1)
Characteristics of Bone
938(1)
Maintenance of Bone Integrity
939(1)
Structure and Function of Joints
940(3)
Fibrous Joints
940(1)
Cartilaginous Joints
940(3)
Synovial Joints
943(1)
Structure and Function of Skeletal Muscles
943(9)
Whole Muscle
943(4)
Components of Muscle Function
947(4)
Tendons and Ligaments
951(1)
Aging 8c the Musculoskeletal System
952(3)
Aging of Bones
952(1)
Aging of Joints
952(1)
Aging of Muscles
952(3)
41 Alterations of Musculoskeletal Function
955(44)
Benjamin A. Smallheer
Musculoskeletal Injuries
955(9)
Skeletal Trauma
955(4)
Support Structures
959(5)
Disorders of Bones
964(9)
Metabolic Bone Diseases
964(7)
Infectious Bone Disease: Osteomyelitis
971(2)
Disorders of Joints
973(11)
Osteoarthritis
973(3)
Classic Inflammatory Joint Disease
976(8)
Disorders of Skeletal Muscle
984(6)
Secondary Muscular Dysfunction
984(1)
Fibromyalgia
984(1)
Chronic Fatigue Syndrome
985(1)
Disuse Atrophy
985(2)
Muscle Membrane Abnormalities
987(1)
Metabolic Muscle Diseases
987(1)
Inflammatory Muscle Diseases: Myositis
988(1)
Myopathy
989(1)
Toxic Myopathies
989(1)
Musculoskeletal Tumors
990(9)
Bone Tumors
990(4)
Muscle Tumors
994(5)
42 Alterations of Musculoskeletal Function in Children
999(15)
Kathryn L. McCance
Congenital Defects
999(2)
Clubfoot
999(1)
Developmental Dysplasia of the Hip
999(1)
Osteogenesis Imperfecta
1000(1)
Bone and Joint Infection
1001(2)
Osteomyelitis
1001(2)
Septic Arthritis
1003(1)
Juvenile Idiopathic Arthritis
1003(1)
Osteochondroses
1003(3)
Legg-Calve-Perthes Disease
1004(1)
Osgood-Schlatter Disease
1005(1)
Sever Disease
1006(1)
Scoliosis
1006(1)
Neuromuscular Disorders
1006(3)
Duchenne Muscular Dystrophy
1007(1)
Spinal Muscular Atrophy
1008(1)
Facioscapulohumeral Muscular Dystrophy
1008(1)
Myotonic Muscular Dystrophy
1008(1)
Musculoskeletal Tumors
1009(1)
Benign Bone Tumors
1009(1)
Malignant Bone Tumors
1009(1)
Nonaccidental Trauma
1010(4)
Fractures in Nonaccidental Trauma
1010(4)
43 Structure, Function, and Disorders of the Integument
1014(30)
Sue Ann McCann
Sue E. Huether
Structure and Function of the Skin
1014(8)
Layers of the Skin
1014(2)
Clinical Manifestations of Skin Dysfunction
1016(6)
Disorders of the Skin
1022(17)
Inflammatory Disorders
1022(1)
Papulosquamous Disorders
1023(3)
Vesiculobullous Diseases
1026(1)
Infections
1027(3)
Vascular Disorders
1030(1)
Benign Tumors
1031(1)
Skin Cancer
1032(3)
Burns
1035(3)
Cold Injury
1038(1)
Disorders of the Hair
1039(1)
Alopecia
1039(1)
Hirsutism
1039(1)
Disorders of the Nail
1039(1)
Paronychia
1039(1)
Onychomycosis
1039(1)
Geriatric Considerations: Aging & Changes in Skin Integrity
1040(4)
44 Alterations of the Integument in Children
1044
Noreen Heer Nicol
Sue E. Huether
Acne Vulgaris
1044(1)
Dermatitis
1045(1)
Atopic Dermatitis
1045(1)
Diaper Dermatitis
1045(1)
Infections of the Skin
1046(5)
Bacterial Infections
1046(1)
Fungal Infections
1047(1)
Viral Infections
1048(3)
Insect Bites and Parasites
1051(1)
Scabies
1051(1)
Pediculosis (Lice Infestation)
1051(1)
Fleas
1051(1)
Bedbugs
1051(1)
Cutaneous Hemangiomas and Vascular Malformations
1052(1)
Cutaneous Hemangiomas
1052(1)
Cutaneous Vascular Malformations
1053(1)
Other Skin Disorders
1053
Miliaria
1053(1)
Erythema Toxicum Neonatorum
1053
Professor Emeritus Sue E. Huether works in the College of Nursing at University of Utah, Salt Lake City, UT, USA Professor Kathryn L. McCance works at the College of Nursing at University of Utah, Salt Lake City, UT, USA.