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El. knyga: Unravelling Long COVID [Wiley Online]

(Oregon Health Sciences University Portland, OR, USA), (Emeritus University of Pennsylvania School of Medicine Philadelphia, PA, USA)
  • Formatas: 256 pages
  • Išleidimo metai: 15-Dec-2022
  • Leidėjas: Wiley-Blackwell
  • ISBN-10: 1119891337
  • ISBN-13: 9781119891338
Kitos knygos pagal šią temą:
  • Wiley Online
  • Kaina: 63,39 €*
  • * this price gives unlimited concurrent access for unlimited time
Unravelling Long COVIDDidesnis paveikslėlis
  • Formatas: 256 pages
  • Išleidimo metai: 15-Dec-2022
  • Leidėjas: Wiley-Blackwell
  • ISBN-10: 1119891337
  • ISBN-13: 9781119891338
Kitos knygos pagal šią temą:
Wiley Online E-booksMore info about Wiley Online
Partnerių interneto svetainė: https://onlinelibrary.wiley.com/doi/book/10.1002/9781119891338
Unravelling Long COVID An authoritative medical reference on the various ways in which Long-COVID presents and an in-depth discussion of its mechanisms and potential therapeutic options.

Unravelling Long COVID aims to provide a better awareness and understanding of the persistent health problems that can arise following SARS-CoV-2 infection. Variously described as Long-COVID, Long-Haulers Syndrome, and Post-Acute Sequelae of SARS-CoV-2, this newly-designated disorder is estimated to have affected somewhere between 50 to 250 million people. It is in fact considered by many as the next global public health disaster.

With such a broad and important topic, the authors of Unravelling Long COVID have focused primarily on two major problems in the current understanding of Long-COVID: 1.) the failure to distinguish patients with organ damagehere called Long-COVID Disease and those with unexplained, persistent symptomswhat is termed Long-COVID syndrome, and 2.) the failure of current medical approaches to comprehend and treat those persistent unexplained symptoms.

Unravelling Long COVID is:





One of the first books focused specifically on defining and understanding Long-COVID with the goal of establishing optimal management A unique reference to distinguish patients with organ damage caused by Long-COVID disease from those with unexplained, persistent symptoms that manifest as Long-COVID syndrome An in-depth exploration of neuroimmune pathways to help clarify the previously unexplained symptoms of Long-COVID

Unravelling Long COVID isan essential reference for anyone interested in Long-COVID and the impact that this condition has had on the population. It will be a useful resource for both patients suffering from the Long-Covid syndrome, their physicians and for the growing number of Long-COVID clinics that have been established across the US, the UK, and other countries.

This book is paired with a long-COVID blog, updated regularly by the authors, so the reader will be kept up to date with new clinical and research findings, in real time. To visit this site, follow this link: unravellinglongcovid.com providing the latest information on long-COVID
Introduction x
Section 1 Long-COVID Disease
1(54)
1 Long-COVID Disease or Long-COVID Syndrome?
3(21)
Defining Long COVID
3(1)
Long-COVID Disease or Syndrome?
4(4)
Long COVID in Hospitalized Patients
8(3)
Long COVID in Non-hospitalized Patients
11(3)
Comparing Hospitalized and Non-hospitalized Patients
14(1)
Long COVID in Children
15(3)
Long-term Outcomes
16(2)
Summary
18(2)
References
20(4)
2 Lung, Heart Disease, and Other Organ Damage
24(15)
Lung Disease
24(3)
Persistent Dyspnea, Not Always Correlated with Pulmonary Damage
26(1)
The Heart
27(5)
Is There Unanticipated Long-term Cardiac Damage?
30(2)
Other Organ Disease
32(1)
Summary
33(1)
References
34(5)
3 COVID-19 Direct Effects on the Central Nervous System
39(16)
Introduction
39(2)
There are Multiple Ways for Infections to Disturb the Nervous System
40(1)
Overview
41(11)
Loss of Senses of Smell and Taste
42(3)
Strokes
45(2)
Hypoxic Brain Damage and the Post-ICU Syndrome
47(3)
Guillian-Barre Syndrome and Other Neuropathies - Effects of COVID-19 on Peripheral Nerves
50(1)
Other Neurological Disorders Due to Acute COVID-19
51(1)
Summary
52(1)
References
52(3)
Section 2 Long-COVID Syndrome and Unexplained Symptoms
55(44)
4 Unexplained Symptoms: Medicine's Blind Spot
57(21)
Overview
57(2)
Fatigue
59(4)
Chronic Fatigue in the General Population
59(3)
Chronic Fatigue in Long-COVID Syndrome
62(1)
Cognitive Disturbances
63(3)
Cognitive Disturbances in the General Population
63(1)
Cognitive Disturbances in Long-COVID Syndrome
64(2)
Dyspnea
66(1)
In the General Population
66(1)
Unexplained Dyspnea in Long COVID
66(1)
Chronic Pain
67(2)
Chronic Pain in the General Population
67(1)
Chronic Pain in Long-COVID Syndrome
68(1)
Headaches
69(1)
Headaches in the General Population
69(1)
Headaches in Long-COVID Syndrome
69(1)
Sleep Disturbances
70(1)
Sleep Disturbances in the General Population
70(1)
Sleep Disturbances in Long-COVID Syndrome
71(1)
Mood Disturbances
71(1)
In the General Population
71(1)
Mood Disturbances in Long COVID
71(1)
Summary
72(1)
References
73(5)
5 Historical Perspectives, Including Chronic Fatigue Syndrome/Myalgic Encephalomyelitis and Fibromyalgia
78(21)
Chronic Fatigue Syndrome, Myalgic Encephalomyelitis (CFS/ME)
78(2)
Fibromyalgia Syndrome
80(2)
CFS/ME, Fibromyalgia in Long-COVID
82(1)
Post-treatment Lyme-disease Syndrome (PTLDS)
83(2)
Similar Patient Characteristics
85(1)
Shared Illness Mechanisms
86(2)
Lessons Learned from CFS/ME, Fibromyalgia, PTLDS
88(2)
Syndrome, Disease, and Diagnostic Labels
88(2)
Infection and Causation
90(1)
Patient-Physician Information and Misinformation
91(2)
Mind or Body?
93(1)
Summary
94(1)
References
95(4)
Section 3 Mechanisms and Pathways
99(38)
6 Brain Homeostasis Run Amok
101(19)
Brain Homeostasis in Health and Disease
101(1)
Our Physical Brain Regulates Our Thoughts
102(1)
Brain Circuits and Networks
103(2)
Neuroplasticity
105(2)
Brain Dysfunction
107(2)
Detecting Structural and Functional Brain Changes
109(4)
Changes in the Autonomic Nervous System, Neurohormones, and the Stress Response
113(4)
Summary
117(1)
References
117(3)
7 Neuroimmune Dysfunction
120(17)
Is Long COVID an Autoimmune Disease?
120(3)
Evidence that Long-COVID Syndrome is a Neuroimmune Disorder
123(2)
Cytokines and the Brain
125(2)
Autoantibodies in Long-COVID Syndrome
127(2)
Can Vaccines also Cause Autoimmune Reactions?
129(1)
Immune Tests for Long COVID
129(2)
Neuroimmune Studies in CFS/ME, Fibromyalgia, and Depression
131(1)
Is a Unifying Theory of How Long-COVID Syndrome Develops Possible?
131(2)
Summary
133(1)
References
134(3)
Section 4 Evaluation and Management
137(95)
8 Patient Evaluation and Research
139(18)
Need: Widely Accepted Long-COVID Term and Case Definition
139(1)
Need: Uniform Symptom and Outcome Measures
140(2)
Initial Evaluation, Primary Care Role
142(3)
Long-COVID Clinics
145(4)
Research
149(2)
General Clinical Research
151(1)
Basic Research
152(1)
Summary
153(1)
References
153(4)
9 Patient Management and Rethinking Healthcare Amid Long COVID
157(21)
Management
157(1)
General Issues
157(1)
Pulmonary and Physical Rehabilitation
158(1)
Exercise
159(2)
Evaluate and Treat Autonomic Dysfunctions and Postural Orthostatic Tachycardia Syndrome
161(1)
Psychological Rehabilitation
162(1)
Medications and Other Therapies
163(1)
SARS-CoV-2 Vaccine
164(1)
Health Coverage, Disability
165(1)
Rethinking Healthcare Amid Long COVID
166(1)
Dealing with Medical Uncertainty
166(1)
Patient Advocacy
167(3)
Integrated, Patient-centric Care
170(1)
A Biopsychosocial Illness Model
171(3)
References
174(4)
10 The Way Forward: For Patients, Healthcare Providers, and Research
178(54)
For Patients
178(2)
Do I have Long COVID?
178(2)
Where Do I Go for a Diagnosis?
180(1)
Assessing Illness Severity
180(1)
General Principles You Should Know
181(1)
Who Do You Listen To?
182(1)
Avoiding Misinformation and Disinformation
183(2)
Disability and Disability Insurance
185(1)
Biopsychological Perspectives to Remember
186(1)
For Healthcare Providers
187(4)
Making the Diagnosis
187(4)
Specialty Care
191(2)
Research, Patients, and the Public
193(8)
Basic Scientific Issues
193(2)
Bringing Long-COVID Patients and Researchers Together
195(3)
Treatment Trials
198(3)
A New Chronic Illness Strategy
201(3)
Summary
204(1)
References
205(3)
Appendix A Long-COVID Clinics in the US and Europe
208(9)
Appendix B Suggestions for Future Research Focused on the Cellular and Molecular Basis of Long-COVID Syndrome
217(15)
Hypothesis 1 Brain-restricted Autoimmunity causes Long-COVID Syndrome
217(1)
Background
217(1)
Evidence in Long-COVID
218(1)
How Else Might SARS-CoV-2 Infection Influence the Immune Response Leading to Long COVID?
219(3)
Hypotheses 2 SARS-CoV-2 Infection Alters the Microbiome, which in turn Initiates Long-COVID Syndrome
222(1)
What is the Microbiome and How does it Affect Immunity and the Brain?
222(2)
The Microbiome in COVID-19 Patients and in Individuals with Long-COVID Syndrome
224(2)
Hypothesis 3 Long-COVID Syndrome is Related to Persistent SARS-CoV-2 Virus or Virus Fragments Sequestered in Brain Cells
226(1)
Background
226(3)
References
229(3)
Index 232
Don Goldenberg, MD, is Emeritus Professor of Medicine at Tufts University School of Medicine, Boston, MA, USA, and Adjunct Faculty, Departments of Medicine, Nursing at Oregon Health Sciences University, Portland, OR, USA.

Marc Dichter, MD, PhD, is Emeritus Professor of Neurology at the University of Pennsylvania School of Medicine, Philadelphia, PA, USA.
Pastovi nuoroda: https://www.kriso.lt/db/9781119891338_pe.html
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