This text offers a concise background in HPLC methodology and includes illustrative examples of some of the key advances made in the receptor field through application of this chromatographic technique. A brief historical overview puts into perspective the specific state-of-the-art of HPLC laboratory applications that are contained in the book's chapters. Technical contributions discuss how best to select the HPLC mode for a particular biochemical problem, including the most effective use of a particularly sensitive technique, microbore HPLC for synthesis, purification and characterization of synthetic peptides. The text will benefit biochemists and molecular biologists.