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  • Formatas: 680 pages
  • Išleidimo metai: 14-Jul-2005
  • Leidėjas: National Academies Press
  • Kalba: eng
  • ISBN-13: 9780309165228

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Sixth in a series of congressionally mandated studies, this book is an updated review and evaluation of the available evidence regarding the statistical assoication between exposure to herbicides used in Vietnam and various adverse health outcomes suspected to be linked with such exposure.





This book builds upon the information contained in the earlier books in the series:



Veterans and Agent Orange: Health Effects of Herbicides Used in Vietnam (1994) Veterans and Agent Orange: Update 1996 Veterans and Agent Orange: Update 1998 Veterans and Agent Orange: Update 2000 Veterans and Agent Orange: Update 2002





Veterans and Agent Orange: Herbicides and Dioxin Exposure and Type 2 Diabetes (2000)

Veterans and Agent Orange: Herbicide/Dioxin Exposure and Acute Myelogenous Leukemia in the Children of Vietnam Veterans (2002)





Veterans and Agent Orange: Update 2004 focuses primarily on scientific studies and other information developed since the release of these earlier books. The previous volumes have noted that sufficient evidence exists to link chronic lymphocytic leukemia, soft-tissue sarcoma, non-Hodgkin's lymphoma, Hodgkin's disease, and chloracne with exposure. The books also noted that there is "limited or suggestive" evidence of an association between exposure and respiratory cancers, prostate cancer, multiple myeloma, the metabolic disorder porphyria cutanea tarda, early-onset transient peripheral neuropathies, Type 2 diabetes, and the congenital birth defect spinal bifida in veterans' children. This volume will be critically important to both policymakers and physicians in the federal government, Vietnam veterans and their families, veterans' organizations, researchers, and health professionals. Table of Contents



Front Matter Executive Summary 1 Introduction 2 Evaluating the Evidence 3 Toxicology 4 Epidemiology 5 Exposure Assessment 6 Cancer 7 Reproductive and Developmental Effects 8 Neurologic Disorders 9 Other Health Effects 10 Research Recommendations Appendix A: Epidemiologic Tables for Chapter 4 Appendix B: Agendas of Public Meetings Appendix C: International Classification of Diseases (ICD-9) Codes for Cancers of Interest Appendix D: Committee and Staff Biographies Index
Executive Summary 1(10)
Introduction
11(9)
Charge to the Committee
12(1)
Conclusions of Previous Veterans and Agent Orange Reports
13(5)
Organization of this Report
18(1)
References
18(2)
Evaluating the Evidence
20(13)
Choice of Health Outcomes
20(1)
Identification of Relevant Literature
20(2)
Committee's Approach
22(3)
Evaluation of the Evidence
25(6)
References
31(2)
Toxicology
33(85)
Highlights of Previous Reports
34(1)
Toxicity Profile Update of 2,4-D
34(7)
Toxicity Profile Update of 2,4,5-T
41(1)
Toxicity Profile Update of Cacodylic Acid
41(2)
Toxicity Profile Update of Picloram
43(1)
Toxicity Profile Update of TCDD
44(44)
Summary of Toxicity Profiles
88(5)
Relevance to Human Health
93(1)
References
94(24)
Epidemiology
118(47)
Occupational Studies
120(9)
Environmental Studies
129(5)
Vietnam-Veteran Studies
134(8)
References
142(23)
Exposure Assessment
165(36)
Exposure Assessment for Epidemiology
165(4)
Occupational Exposure to Herbicides and TCDD
169(8)
Environmental Exposure to Herbicides and TCDD
177(5)
Military Use of Herbicides in Vietnam
182(4)
Exposure Assessment in Studies of Vietnam Veterans
186(5)
References
191(10)
Cancer
201(153)
Gastrointestinal Tract Cancers
203(18)
Hepatobiliary Cancers
221(5)
Oral, Nasal, and Pharyngeal Cancer
226(4)
Laryngeal Cancer
230(4)
Lung Cancer
234(8)
Bone and Joint Cancer
242(3)
Soft-Tissue Sarcomas
245(6)
Skin Cancer---Melanoma
251(10)
Skin Cancer---Basal-Cell and Squamous-Cell (Non-melanoma)
261(4)
Breast Cancer
265(5)
Cancers of the Female Reproductive System
270(5)
Prostate Cancer
275(8)
Testicular Cancer
283(3)
Urinary Bladder Cancer
286(6)
Renal Cancer
292(4)
Brain Tumors
296(7)
Non-Hodgkin's Lymphoma
303(10)
Hodgkin's Disease
313(6)
Multiple Myeloma
319(6)
Leukemia
325(9)
Chronic Lymphocytic Leukemia
334(3)
Summary
337(5)
References
342(12)
Reproductive and Developmental Effects
354(50)
Birth Defects
355(10)
Fertility
365(7)
Spontaneous Abortion
372(6)
Stillbirth, Neonatal Death, and Infant Death
378(1)
Birthweight and Preterm Delivery
379(4)
Childhood Cancer
383(6)
Sex Ratio
389(5)
Summary
394(4)
References
398(6)
Neurologic Disorders
404(32)
Neurobehavioral Disorders (Cognitive or Neuropsychiatric)
406(4)
Movement Disorders
410(13)
Peripheral Neuropathy
423(6)
Summary
429(2)
References
431(5)
Other Health Effects
436(55)
Chloracne
437(2)
Porphyria Cutanea Tarda
439(1)
Respiratory Disorders
440(3)
Immune System Disorders
443(5)
Diabetes
448(9)
Lipid and Lipoprotein Disorders
457(6)
Gastrointestinal and Digestive Disease, Including Liver Toxicity
463(4)
Circulatory Disorders
467(4)
AL Amyloidosis
471(2)
Endometriosis
473(5)
Thyroid Homeostasis
478(3)
Summary
481(5)
References
486(5)
Research Recommendations
491(89)
Vietnam Veteram Studies
491(2)
Studies of Vietnamese
493(1)
Other Research
493(1)
References
494(1)
APPENDIXES
A Epidemiologic Tables for
Chapter 4
495(74)
B Agendas of Public Meetings
569(2)
C International Classification of Diseases (ICD-9) Codes for Cancers of Interest
571(4)
D Committee and Staff Biographies
575(5)
Index 580
Committee to Review the Health Effects in Vietnam Veterans of Exposure to Herbicides(Fifth Biennial Update)