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Veterans and Agent Orange: Update 2010 [Kietas viršelis]

  • Formatas: Hardback, 836 pages, aukštis x plotis: 229x152 mm
  • Išleidimo metai: 12-Feb-2012
  • Leidėjas: National Academies Press
  • ISBN-10: 0309214475
  • ISBN-13: 9780309214476
Kitos knygos pagal šią temą:
  • Formatas: Hardback, 836 pages, aukštis x plotis: 229x152 mm
  • Išleidimo metai: 12-Feb-2012
  • Leidėjas: National Academies Press
  • ISBN-10: 0309214475
  • ISBN-13: 9780309214476
Kitos knygos pagal šią temą:
Because of continuing uncertainty about the long-term health effects of the sprayed herbicides on Vietnam veterans, Congress passed the Agent Orange Act of 1991. The legislation directed the Secretary of Veterans Affairs (VA) to request the Institite of Medicine to perform a comprehensive evaluation of scientific and medical information regarding the health effects of exposure to Agent Orange and other herbicides used in Vietnam to be followed by biennial updates. The 2010 update recommends further research of links between Vietnam service and specific health outcomes, most importantly COPD, tonsil cancer, melanoma, brain cancer, Alzheimer's disease, and paternally transmitted effects to offspring.

Table of Contents



Front Matter Summary 1 Introduction 2 Evaluating the Evidence 3 Exposure to the Herbicides Used in Vietnam 4 Information Related to Biologic Plausibility 5 Epidemiologic Studies: Compendium of New Publications and Background on Multiple Referenced Populations 6 Immune-System Disorders 7 Cancer 8 Reproductive Effects and Impacts on Future Generations 9 Neurologic Disorders 10 Cardiovascular and Metabolic Effects 11 Other Health Effects 12 Conclusions and Recommendations Appendix A: Agendas of Public Meetings Held by the Committee to Review the Health Effects in Vietnam Veterans of Exposure to Herbicides (Eighth Biennial Update) Appendix B: Short-Term Adverse Health Responses Appendix C: Clarification of Cancer Groupings Used in Reporting Results, with Correspondence to NIOSH Cause-of-Death Codes and ICD Codes for Cancers Appendix D: Biographies of Committee to Review the Health Effects in Vietnam Veterans of Exposure to Herbicides (Eighth Biennial Update) and Staff
Abbreviations And Acronyms xxiii
SUMMARY
1(772)
Charge to the Committee
2(1)
Committee's Approach to Its Charge
3(2)
Evidence Reviewed by the Committee
5(2)
The Committee's Conclusions
7(5)
Committee Recommendations
12(2)
1 Introduction
14(17)
Charge to the Committee
5(11)
Issues Raised in Public Sessions
16(5)
Conclusions of Previous Veterans and Agent Orange Reports
21(6)
Organization of This Report
27(2)
References
29(2)
2 Evaluating The Evidence
31(23)
Choice of Health Outcome
31(1)
Identification of Relevant Literature
32(6)
Committee's Approach
38(5)
Evaluation of the Evidence
43(9)
References
52(2)
3 Exposure To The Herbicides Used In Vietnam
54(22)
Military Use of Herbicides in Vietnam
55(2)
TCDD in Herbicides Used in Vietnam
57(2)
Exposure of Vietnam Veterans
59(4)
Exposure of the Vietnamese Population
63(1)
Models for Characterizing Herbicide Exposure
64(2)
Methodologic Issues in Exposure Assessment
66(5)
References
71(5)
4 Information Related To Biologic Plausibility
76(44)
Picloram
78(3)
Cacodylic Acid
81(4)
Phenoxy Herbicides: 2,4-D and 2,4,5-T
85(3)
TCDD
88(15)
Limitations of Extrapolating Laboratory Studies to Human Responses
103(2)
Emerging Subjects in Disease Etiology
105(3)
References
108(12)
5 Epidemiologic Studies: Compendium Of New Publications And Background On Multiple Referenced Populations
120(120)
New Epidemiologic Publications
121(12)
Study Populations: Previously Addressed or Having Multiple Health Outcomes
133(2)
Vietnam-Veteran Studies
135(17)
Occupational Studies
152(25)
Environmental Studies
177(19)
Case-Control Studies
196(4)
References
200(40)
6 Immune-System Disorders
240(25)
Conclusion from VAO and Previous Updates
244(10)
Update of the Epidemiologic Literature and Human Studies
254(1)
Biologic Plausibility
255(1)
Synthesis
256(1)
Translation Between Animal and Human Studies
257(1)
Subjects for Future Research
258(1)
References
259(6)
7 Cancer
265(275)
Organization of Cancer Groups
268(1)
Biologic Plausibility
269(3)
The Committee's View of "General" Human Carcinogens
272(1)
Oral, Nasal, and Pharyngeal Cancer
273(10)
Cancers of the Digestive Organs
283(49)
Esophageal Cancer
285(5)
Stomach Cancer
290(11)
Colorectal Cancer
301(14)
Hepatobiliary Cancer
315(9)
Pancreatic Cancer
324(8)
Laryngeal Cancer
332(7)
Lung Cancer
339(14)
Bone and Joint Cancer
353(4)
Soft-Tissue Sarcomas
357(11)
Skin Cancer---Melanoma
368(10)
Skin Cancer---Basal-Cell Cancer and Squamous-Cell Cancer (Nonmelanoma Skin Cancers)
378(5)
Breast Cancer
383(10)
Cancers of the Female Reproductive System
393(7)
Prostate Cancer
400(14)
Testicular Cancer
414(7)
Bladder Cancer
421(9)
Renal Cancer
430(7)
Brain Cancer
437(10)
Endocrine Cancers
447(6)
Lymphohematopoietic Cancers
453(60)
Hodgkin Lymphoma
456(10)
Non-Hodgkin Lymphoma
466(23)
Multiple Myeloma
489(8)
AL Amyloidosis
497(2)
Leukemia
499(14)
Summary
513(2)
References
515(25)
8 Reproductive Effects And Impacts On Future Generations
540(71)
Biologic Plausibility of Reproductive Effects
541(2)
Endometriosis
543(5)
Fertility
548(16)
Spontaneous Abortion
564(5)
Stillbirth, Neonatal Death, and Infant Death
569(2)
Birth Weight and Preterm Delivery
571(2)
Birth Defects
573(12)
Childhood Cancer
585(8)
Effects Occurring Later in Offspring's Life or in Later Generations
593(3)
Summary
596(1)
References
597(14)
9 Neurologic Disorders
611(35)
Neurobehavioral (Cognitive or Neuropsychiatric) Disorders
613(3)
Neurodegenerative Diseases
616(14)
Chronic Peripheral System Disorders
630(4)
Hearing Loss
634(2)
Summary
636(2)
References
638(8)
10 Cardiovascular And Metabolic Effects
646(62)
Type 2 Diabetes
647(17)
Lipid and Lipoprotein Disorders
664(1)
Circulatory Disorders
664(33)
Summary
697(2)
References
699(9)
11 Other Health Effects
708(51)
Respiratory Disorders
709(20)
Gastrointestinal and Digestive Disease, Including Liver Toxicity
729(6)
Thyroid Homeostasis
735(11)
Eye Problems
746(1)
Bone Conditions
747(2)
Summary
749(2)
References
751(8)
12 Conclusions And Recommendations
759(14)
Synopsis of Committee Conclusions
759(4)
Committee Recommendations
763(8)
References
771(2)
APPENDIXES
A Agendas of Public Meetings Held by the Committee to Review the Health Effects in Vietnam Veterans of Exposure to Herbicides (Eighth Biennial Update) 773(4)
B Short-Term Adverse Health Responses 777(13)
C Clarification of Cancer Groupings Used in Reporting Results, with Correspondence to NIOSH Cause-of-Death Codes and ICD Codes for Cancers 790(10)
D Biographies of Committee to Review the Health Effects in Vietnam Veterans of Exposure to Herbicides (Eighth Biennial Update) and Staff 800