Klientų aptarnavimas: +370 652 87781

Pagalba | Naujas vartotojas | Prisijungti

Vitamin A [Minkštas viršelis]

International Agency for Research on Cancer

Formatas: Paperback / softback, 288 pages, aukštis x plotis: 240x170 mm, weight: 558 g, 9 line drawings, bibliography
Serija: Handbooks of Cancer Prevention v.3
Išleidimo metai: 28-Jan-1999
Leidėjas: International Agency for Research on Cancer
ISBN-10: 9283230035
ISBN-13: 9789283230038

Kitos knygos pagal šią temą:

Oncology - (Šiuo metu turimos knygos: 4 prekės)
Medical research - (Šiuo metu turimos knygos: 8 prekės)
Medical toxicology
Epidemiology & medical statistics - (Šiuo metu turimos knygos: 5 prekės)

Minkštas viršelis
Kaina: 46,45 €*
* Ši knyga nebeleidžiama, tačiau mes Jums pranešime naudoto egzemplioriaus kainą
Ši knyga nebeleidžiama, tačiau mes Jums pranešime naudoto egzemplioriaus kainą.
Kiekis:
- - 1
  - 2
  - 3
  - 4
  - 5
  - 6
  - 7
  - 8
  - 9
  - 10
Įdėti į krepšelį
Įtraukti į pageidavimų sąrašą

Formatas: Paperback / softback, 288 pages, aukštis x plotis: 240x170 mm, weight: 558 g, 9 line drawings, bibliography
Serija: Handbooks of Cancer Prevention v.3
Išleidimo metai: 28-Jan-1999
Leidėjas: International Agency for Research on Cancer
ISBN-10: 9283230035
ISBN-13: 9789283230038

Kitos knygos pagal šią temą:

Oncology - (Šiuo metu turimos knygos: 4 prekės)
Medical research - (Šiuo metu turimos knygos: 8 prekės)
Medical toxicology
Epidemiology & medical statistics - (Šiuo metu turimos knygos: 5 prekės)

Pastovi nuoroda: https://www.kriso.lt/db/9789283230038.html

Since the 1970s there has been an intense interest in studying vitamin A as an active chemopreventive agent. Observational epidemiological studies have not shown consistent cancer-preventive effects. Vitamin A, often in combination with other compounds, has been studied in several randomized trials. Overall, there is little evidence that supplementation for a few years would reduce the risk of any type of cancer. This book summarizes and evaluates the existing evidence on the cancer-preventive activity of vitamin A following the meeting of a working group of international experts in Lyon, on the 13-19 May 1998, to evaluate the existing evidence on the cancer-preventive activity of retinol and retinyl esters.

List of Participants

(2)

Abbreviations

(2)

Preamble

(12)

General Remarks

(6)

Chemical and physical characteristics of vitamin A

(4)

Retinol

Name

(1)

Structural and molecular formulae and relative molecular mass

(1)

Physical and chemical properties

(1)

Technical properties

(1)

Retinyl acetate

(1)

Name

(1)

Structural and molecular formulae and relative molecular mass

(1)

Physical and chemical properties

(1)

Technical products

(1)

Retinyl palmitate

(1)

Name

(1)

Structural and molecular formulae and relative molecular mass

(1)

Physical and chemical properties

(1)

Technical products

(1)

Retinal

(1)

Name

(1)

Structural and molecular formulae and relative molecular mass

(1)

Physical and chemical properties

(1)

Retinoic acid

(1)

Name

(1)

Structural and molecular formula and relative molecular mass

(1)

Physical and chemical properties

(1)

Occurrence, production, use, analysis and human exposure

(4)

Occurrence

(1)

Production

(1)

Use and application

(1)

Human exposure

(1)

Analysis

(2)

Functional methods

(1)

Night-blindness

(1)

Conjunctival impression cytology

(1)

Biochemical methods

(1)

Relative dose reponse

(1)

Modified relative dose response

(1)

Serum retinol

(1)

Vitamin A in food

(1)

Milk analysis

(1)

Metabolism, kinetics, tissue distribution and inter- and intra-species variation

(42)

Human studies

(8)

Introduction

(1)

Absorption

(1)

Transport

(1)

Factors affecting plasma retinoid concentrations

(2)

Uptake by tissues

(1)

Tissue distribution

(1)

Metabolism

(1)

Function

(1)

Excretion

(1)

Kinetics

(1)

Experimental models

(34)

Overview

(1)

Animal models

(1)

Vitamin A metabolism and transport

(1)

Intestinal uptake and metabolism of dietary vitamin A

(3)

Provitamin A carotenoid uptake and metabolism

(1)

Preformed vitamin A uptake and metabolism

(1)

Chylomicron delivery of postprandial vitamin A

(1)

Overview

(1)

Hepatic clearance

(1)

Extrahepatic tissue clearance

(1)

Hepatic storage and metabolism of vitamin A

(1)

Hepatic processing of dietary vitamin A

(1)

Vitamin A storage and metabolism in hepatocytes

(2)

Transfer of vitamin A between hepatocytes and stellate cells

(1)

Vitamin A storage and metabolism in hepatic stellate cells

(2)

Hepatic mobilization and plasma transport of retinol: retinol-binding protein

(1)

Hepatic retinoic acid formation and metabolism

(1)

Plasma transport of vitamin A

(1)

Retinol delivery to target tissues

(1)

Plasma retinoic acid

(1)

Plasma 13-cis-retinoic acid

(1)

Plasma 9-cis-retinoic acid

(1)

Retinoid glucuronides

(1)

Other metabolites of retinol

(1)

Lipoprotein-bound retinyl ester

(1)

Extrahepatic vitamin A storage and metabolism

(2)

Adipose tissue

(1)

Kidney

(1)

Testis

(1)

Lung

(1)

Bone marrow

(1)

Eye

(1)

Other tissues and species

(1)

Retinoic acid metabolism

(1)

Retinoic acid formation in tissues

(5)

Synthesis of retinoic acid from carotenoids within tissues

(1)

Metabolism of retinoic acid

(2)

Preventive effects

(87)

Humans

(34)

Epidemiological studies

(1)

Methodological issues

(1)

Assessment of exposure

(2)

Vitamin A and specific cancer sites

(15)

Intervention trials with cancer as an endpoint

(1)

Primary prevention trials

(9)

Prevention of second primary cancers

100

(2)

Preneoplastic lesions and intermediate end-points

102

(1)

Oral premalignancy

102

(1)

Reversal of oral premalignancy

103

(1)

Larynx

104

(1)

Oesophagus and stomach

104

(1)

Colorectum

105

(1)

Lung

105

(1)

Cervical dysplasia

105

(1)

Systemic biomarkers

106

(1)

Summary

107

(1)

Experimental models

107

(48)

Tumour induction

107

(1)

Lung

107

(2)

Mammary gland

109

(4)

Urinary bladder

113

(1)

Skin

114

(2)

Oesophagus and forestomach

116

(2)

Large intestine

118

(1)

Liver

118

(1)

Thyroid

119

(1)

Other sites

119

(1)

Intermediate biomarkers

119

(6)

In-vitro models

125

(1)

Modulation of cell proliferation and differentiation

125

(10)

In-vitro inhibition of genetic and related effects

135

(20)

Mechanism of cancer-prevention

155

(5)

Inhibition of events associated with carcinogenesis

155

(1)

Effects of premalignant lesions

155

(1)

Inhibition of transformation

156

(1)

Inhibition of DNA synthesis and cell proliferation

156

(1)

Inhibition of ornithine decarboxylase induction

157

(1)

Restoration of normal differentiation

157

(1)

Restoration of gap junctional communication

157

(1)

Inhibition of prostaglandin production

157

(1)

Modulation of cell adhesion and migration

158

(1)

Inhibition of angiogenesis

158

(1)

Modulation of immune responses

158

(2)

Other mechanisms

160

(1)

Other beneficial effects

160

(5)

Conditions related to vitamin A deficiency

160

(1)

Night-blindness and xerophthalmia

160

(1)

Growth

160

(1)

Cystic fibrosis

160

(1)

Psoriasis and other skin conditions

160

(1)

Anaemia

161

(1)

Eclampsia and abruptio placentae

161

(1)

Infectious disease and mortality

161

(2)

Effects on vascular or heart disese

163

(1)

Other preventive actions

164

(1)

Degenerative condition of ageing

164

(1)

Arthritis

164

(1)

Other protective antioxidant effects

164

(1)

Lung function

164

(1)

Carcinogenicity

165

(2)

Human studies

165

(2)

Experimental models

167

(1)

Other toxic effects

167

(28)

Adverse effects

167

(6)

Human studies

167

(1)

Mucocutaneous toxicity

168

(1)

Circulatory toxicity

169

(1)

Internal organ toxicity

169

(1)

Neurological toxicity

170

(1)

Musculo-skeletal toxicity

170

(1)

Experimental studies

170

(1)

Mucocutaneous toxicity

171

(1)

Circulatory toxicity

171

(1)

Internal organ toxicity

171

(2)

Musculo-skeletal toxicity

173

(1)

Reproductive and developmental effects

173

(17)

Human studies

173

(2)

Experimental studies

175

(1)

Effects on embryonic development

175

(5)

Interspecies comparison of the metabolism and bioactivation of vitamin A following teratogenic doses

180

(9)

Role of vitamin A in reproduction, in particular spermatogenesis

189

(1)

Possible metabolic basis of retinoid-induced teratogenicity

189

(1)

Genetic and related effects

190

(5)

Human studies

190

(1)

Experimental studies

190

(5)

Summary of data

195

(6)

Chemistry, occurrence and human exposure

195

(1)

Metabolism and kinetic properties in humans and animals

195

(1)

Cancer-preventive effects

196

(3)

Human studies

196

(2)

Experimental studies

198

(1)

Mechanisms of cancer-prevention

199

(1)

Other beneficial effects

199

(1)

Carcinogenic effects

199

(1)

Human studies

199

(1)

Experimental animals

199

(1)

Toxic effects

199

(2)

Human studies

199

(1)

Experimental studies

200

(1)

Recommendations for future research

201

(1)

Evaluation

202

(3)

Cancer-preventive activity

202

(1)

Humans

202

(1)

Experimental animals

202

(1)

Overall evaluation

202

(3)

References

205

(46)

Appendix
1. Interconversion of units for vitamin A

251

(1)

Appendix
2. Three-letter codes used in activity profiles

252

(1)

Appendix
3. The concept of activity profiles of antimutagens

253

(3)

Appendix
4. Activity profiles for genetic and related effects

256

Vitamin A [Minkštas viršelis]

Paskyra ir nustatymai

Paieška

Ieškoti duomenų bazėje

Patikslinti paiešką

Temos Temos anglų kalba

Pasirinkti pirkinių krepšelį