| Contributors |
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ix | |
| Preface |
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xxiii | |
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PART I Clinical Evaluation of the Patient |
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1 Initial Approach to the Patient: History and Physical Examination |
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3 | (8) |
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2 Examination of Blood and Marrow Cells |
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11 | (20) |
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3 Consultative Hematology |
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31 | (16) |
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PART II The Organization of the Lymphohematopoietic Tissues |
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4 Structure of the Marrow and the Hematopoietic Microenvironment |
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47 | (32) |
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5 The Organization and Structure of Lymphoid Tissues |
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79 | (14) |
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PART III Epochal Hematology |
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6 Hematology of the Fetus and Newborn |
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93 | (18) |
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7 Hematology During Pregnancy |
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111 | (10) |
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8 Hematology in Older Persons |
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121 | (16) |
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PART IV Molecular and Cellular Hematology |
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9 Genetic Principles and Molecular Biology |
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137 | (12) |
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10 Genomics and Epigenomics |
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149 | (20) |
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11 Cytogenetic and Genetic Abnormalities |
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169 | (20) |
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12 Application of Big Data and Deep Learning in Hematology |
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189 | (18) |
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13 Metabolism of Hematologic Neoplastic Cells |
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207 | (14) |
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221 | (8) |
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15 Cell-Cycle Regulation and Hematologic Disorders |
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229 | (34) |
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16 Signal Transduction Pathways |
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263 | (10) |
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17 Hematopoietic Stem Cells, Progenitors, and Cytokines |
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273 | (22) |
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18 The Inflammatory Response |
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295 | (14) |
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309 | (16) |
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20 The Biology of Innate Lymphoid Cells and Natural Killer Cells |
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325 | (10) |
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21 Dendritic Cells and Adaptive Immunity |
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335 | (8) |
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PART V Therapeutic Principles |
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22 Immune Checkpoint Inhibitors |
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343 | (6) |
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23 Immune Cell Therapy: Chimeric Antigen Receptor T-Cell Therapy |
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349 | (12) |
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24 Immune Cell Therapy: Dendritic Cell and Natural Killer Cell Therapy |
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361 | (10) |
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371 | (6) |
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26 Gene Therapy for Hematologic Diseases |
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377 | (10) |
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27 Regenerative Medicine: Induced Pluripotent Stem Cells and Blood Cell Engineering |
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387 | (8) |
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Annelise Bennaceur-Griscelli |
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28 Pharmacology and Toxicity of Antineoplastic Drugs |
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395 | (44) |
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29 Hematopoietic Stem Cell Transplantation |
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439 | (30) |
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30 Therapeutic Apheresis: Indications, Efficacy, and Complications |
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469 | (10) |
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31 Treatment of Infections in the Immunocompromised Host |
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479 | (12) |
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32 Antithrombotic Therapy |
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491 | (22) |
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33 Structure and Composition of the Erythrocyte |
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513 | (16) |
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34 Erythropoiesis and Red Cell Turnover |
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529 | (24) |
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35 Clinical Manifestations and Classification of Erythrocyte Disorders |
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553 | (10) |
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36 Aplastic Anemia: Acquired and Inherited |
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563 | (28) |
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591 | (10) |
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38 Anemia of Chronic Disease |
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601 | (8) |
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39 Erythropoietic Effects of Endocrine Disorders |
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609 | (6) |
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40 The Hereditary Dyserythropoietic Anemias |
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615 | (10) |
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41 Paroxysmal Nocturnal Hemoglobinuria |
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625 | (14) |
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42 Folate, Cobalamin, and Megaloblastic Anemias |
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639 | (34) |
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673 | (12) |
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44 Iron Deficiency and Overload |
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685 | (24) |
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45 Anemia Resulting from Other Nutritional Deficiencies |
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709 | (8) |
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46 Anemia Associated with Marrow Infiltration |
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717 | (4) |
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47 Erythrocyte Membrane Disorders |
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721 | (28) |
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48 Erythrocyte Enzyme Disorders |
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749 | (36) |
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49 Thalassemia: A Disorder of Globin Synthesis |
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785 | (40) |
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50 Disorders of Hemoglobin Structure: Sickle Cell Anemia and Related Abnormalities |
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825 | (34) |
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51 Methemoglobinemia and Other Dyshemoglobinemias |
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859 | (12) |
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52 Fragmentation Hemolytic Anemia |
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871 | (8) |
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53 Erythrocyte Disorders as a Result of Toxic Agents |
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879 | (6) |
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54 Hemolytic Anemia Resulting from Infections with Microorganisms |
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885 | (8) |
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55 Hemolytic Anemia Resulting from Immune Injury |
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893 | (24) |
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56 Alloimmune Hemolytic Disease of the Fetus and Newborn |
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917 | (16) |
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57 Hypersplenism and Hyposplenism |
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933 | (8) |
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58 Primary and Secondary Erythrocytoses/Polycythemias |
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941 | (20) |
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961 | (26) |
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60 Polyclonal and Hereditary Sideroblastic Anemias |
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987 | (10) |
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PART VII Neutrophils, Eosinophils, Basophils, and Mast Cells |
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61 Structure and Composition of Neutrophils, Eosinophils, and Basophils |
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997 | (16) |
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62 Classification and Clinical Manifestations of Neutrophil Disorders |
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1013 | (8) |
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63 Neutropenia and Neutrophilia |
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1021 | (16) |
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64 Disorders of Neutrophil Function |
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1037 | (44) |
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65 Eosinophils and Their Disorders |
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1081 | (12) |
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66 Basophils and Mast Cells and Their Disorders |
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1093 | (20) |
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PART VIII Monocytes and Macrophages |
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67 Structure, Receptors, and Functions of Monocytes and Macrophages |
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1113 | (30) |
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68 Production, Distribution, and Activation of Monocytes and Macrophages |
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1143 | (14) |
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69 Classification and Clinical Manifestations of Disorders of Monocytes and Macrophages |
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1157 | (6) |
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70 Monocytosis and Monocytopenia |
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1163 | (6) |
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71 Inflammatory and Malignant Histiocytosis |
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1169 | (20) |
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72 Gaucher Disease and Related Lysosomal Storage Diseases |
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1189 | (16) |
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PART IX Lymphocytes and Plasma Cells |
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73 The Structure of Lymphocytes and Plasma Cells |
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1205 | (10) |
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1215 | (12) |
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75 Functions of B Lymphocytes and Plasma Cells In Immunoglobulin Production |
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1227 | (16) |
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76 Functions of T Lymphocytes: T-Cell Receptors for Antigen |
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1243 | (12) |
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77 Classification and Clinical Manifestations of Lymphocyte and Plasma Cell Disorders |
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1255 | (6) |
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78 Lymphocytosis and Lymphocytopenia |
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1261 | (14) |
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79 Immunodeficiency Diseases |
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1275 | (32) |
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80 Hematologic Manifestations of Human Immunodeficiency Virus and the Acquired Immunodeficiency Syndrome |
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1307 | (24) |
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81 Mononucleosis Syndromes |
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1331 | (12) |
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PART X Malignant Myeloid Diseases |
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82 Classification and Clinical Manifestations of the Clonal Myeloid Disorders |
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1343 | (18) |
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1361 | (16) |
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84 Essential Thrombocythemia |
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1377 | (12) |
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1389 | (22) |
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86 Myelodysplastic Syndromes |
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1411 | (34) |
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87 Acute Myelogenous Leukemia |
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1445 | (78) |
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88 Chronic Myelogenous Leukemia and Related Disorders |
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1523 | (58) |
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PART XI Malignant Lymphoid Diseases |
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89 Classification of Malignant Lymphoid Disorders |
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1581 | (12) |
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90 Acute Lymphoblastic Leukemia |
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1593 | (24) |
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91 Chronic Lymphocytic Leukemia |
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1617 | (20) |
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1637 | (10) |
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93 Large Granular Lymphocytic Leukemia |
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1647 | (8) |
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94 General Considerations of Lymphomas: Incidence Rates, Etiology, Diagnosis, Staging, and Primary Extranodal Disease |
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1655 | (16) |
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95 Pathology of Lymphomas |
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1671 | (12) |
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1683 | (30) |
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97 Diffuse Large B-Cell Lymphoma and Related Diseases |
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1713 | (18) |
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1731 | (16) |
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1747 | (10) |
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100 Marginal Zone B-Cell Lymphomas |
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1757 | (10) |
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1767 | (8) |
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102 Cutaneous T-Cell Lymphoma (Mycosis Fungoides and Sezary Syndrome) |
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1775 | (16) |
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103 Mature T-Cell and Natural Killer Cell Lymphomas |
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1791 | (14) |
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104 Plasma Cell Neoplasms: General Considerations |
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1805 | (12) |
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105 Essential Monoclonal Gammopathy |
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1817 | (14) |
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1831 | (42) |
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107 Immunoglobulin Light Chain Amyloidosis |
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1873 | (12) |
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1885 | (18) |
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1903 | (12) |
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Dietlind L. Wahner-Roedler |
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PART XIII Hemostasis and Thrombosis |
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110 Megakaryopoiesis and Thrombopoiesis |
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1915 | (16) |
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111 Platelet Morphology, Biochemistry, and Function |
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1931 | (86) |
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112 Molecular Biology and Biochemistry of the Coagulation Factors and Pathways of Hemostasis |
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2017 | (34) |
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113 Control of Coagulation Reactions |
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2051 | (16) |
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114 Vascular Function in Hemostasis |
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2067 | (18) |
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115 Classification, Clinical Manifestations, and Evaluation of Disorders of Hemostasis |
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2085 | (8) |
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2093 | (32) |
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117 Heparin-Induced Thrombocytopenia |
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2125 | (14) |
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118 Hereditary and Reactive Thrombocytosis |
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2139 | (4) |
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119 Inherited Platelet Disorders |
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2143 | (30) |
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120 Acquired Qualitative Platelet Disorders |
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2173 | (22) |
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121 The Vascular Purpuras |
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2195 | (14) |
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122 Hemophilia A and Hemophilia B |
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2209 | (20) |
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123 Inherited Deficiencies of Coagulation Factors II, V, V+VIII, VII, X, XI, and XIII |
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2229 | (20) |
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124 Hereditary Fibrinogen Abnormalities |
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2249 | (12) |
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125 Von Willebrand Disease |
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2261 | (24) |
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126 Antibody-Mediated Coagulation Factor Deficiencies |
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2285 | (6) |
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127 Disseminated Intravascular Coagulation |
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2291 | (22) |
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128 Thrombotic Microangiopathies |
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2313 | (16) |
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129 Hemolytic Uremic Syndrome |
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2329 | (12) |
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130 Hemostatic Alterations in Liver Diseases and Liver Transplantation |
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2341 | (8) |
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131 Hereditary Thrombophilia |
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2349 | (12) |
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132 The Antiphospholipid Syndrome |
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2361 | (22) |
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2383 | (16) |
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134 Atherothrombosis: Disease Initiation, Progression, and Treatment |
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2399 | (16) |
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135 Fibrinolysis and Thrombolysis |
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2415 | (28) |
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PART XIII Transfusion Medicine |
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136 Erythrocyte Antigens and Antibodies |
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2443 | (24) |
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137 Human Leukocyte and Platelet Antigens |
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2467 | (16) |
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138 Blood Procurement and Red Cell Transfusion |
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2483 | (18) |
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139 Preservation and Clinical Use of Platelets |
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2501 | (12) |
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140 Using Plasma and Plasma Component Therapy |
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2513 | (10) |
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| Index |
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2523 | |
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