Contributors |
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Preface |
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xxi | |
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PART I Clinical Evaluation of the Patient |
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1 Initial Approach to the Patient: History and Physical Examination |
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3 | (8) |
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2 Examination of Blood Cells |
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11 | (16) |
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3 Examination of The Marrow |
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27 | (14) |
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4 Consultative Hematology |
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41 | (12) |
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PART II The Organization of the Lymphohematopoietic Tissues |
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5 Structure of the Marrow and the Hematopoietic Microenvironment |
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53 | (32) |
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6 The Organization and Structure of Lymphoid Tissues |
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85 | (14) |
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PART III Epochal Hematology |
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7 Hematology of the Fetus and Newborn |
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99 | (20) |
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8 Hematology during Pregnancy |
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119 | (10) |
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9 Hematology in Older Persons |
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129 | (16) |
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PART IV Molecular and Cellular Hematology |
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10 Genetic Principles and Molecular Biology |
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145 | (10) |
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155 | (10) |
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165 | (8) |
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13 Cytogenetics and Genetic Abnormalities |
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173 | (18) |
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14 Metabolism of Hematologic Neoplastic Cells |
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191 | (12) |
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15 Apoptosis Mechanisms: Relevance to the Hematopoietic System |
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203 | (10) |
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16 Cell-Cycle Regulation and Hematologic Disorders |
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213 | (34) |
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17 Signal Transduction Pathways |
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247 | (10) |
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18 Hematopoietic Stem Cells, Progenitors, and Cytokines |
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257 | (22) |
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19 The Inflammatory Response |
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279 | (14) |
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293 | (14) |
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21 Dendritic Cells and Adaptive Immunity |
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307 | (8) |
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PART V Therapeutic Principles |
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22 Pharmacology and Toxicity of Antineoplastic Drugs |
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315 | (38) |
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23 Hematopoietic Cell Transplantation |
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353 | (30) |
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24 Treatment of Infections in The Immunocompromised Host |
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383 | (10) |
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25 Antithrombotic Therapy |
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393 | (16) |
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409 | (12) |
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421 | (6) |
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28 Therapeutic Apheresis: Indications, Efficacy, and Complications |
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427 | (10) |
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29 Gene Therapy for Hematologic Diseases |
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437 | (10) |
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30 Regenerative Medicine: Multipotential Cell Therapy for Tissue Repair |
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447 | (14) |
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31 Structure and Composition of the Erythrocyte |
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461 | (18) |
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479 | (16) |
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495 | (8) |
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34 Clinical Manifestations and Classification of Erythrocyte Disorders |
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503 | (10) |
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35 Aplastic Anemia: Acquired and Inherited |
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513 | (26) |
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539 | (10) |
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37 Anemia of Chronic Disease |
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549 | (10) |
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38 Erythropoietic Effects of Endocrine Disorders |
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559 | (4) |
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39 The Congenital Dyserythropoietic Anemias |
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563 | (8) |
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40 Paroxysmal Nocturnal Hemoglobinuria |
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571 | (12) |
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41 Folate, Cobalamin, and Megaloblastic Anemias |
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583 | (34) |
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617 | (10) |
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43 Iron Deficiency and Overload |
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627 | (24) |
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44 Anemia Resulting from Other Nutritional Deficiencies |
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651 | (6) |
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45 Anemia Associated with Marrow Infiltration |
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657 | (4) |
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46 Erythrocyte Membrane Disorders |
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661 | (28) |
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47 Erythrocyte Enzyme Disorders |
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689 | (36) |
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48 The Thalassemias: Disorders of Globin Synthesis |
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725 | (34) |
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49 Disorders of Hemoglobin Structure: Sickle Cell Anemia and Related Abnormalities |
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759 | (30) |
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50 Methemoglobinemia and Other Dyshemoglobinemias |
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789 | (12) |
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51 Fragmentation Hemolytic Anemia |
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801 | (8) |
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52 Erythrocyte Disorders as a Result of Chemical and Physical Agents |
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809 | (6) |
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53 Hemolytic Anemia Resulting from Infections with Microorganisms |
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815 | (8) |
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54 Hemolytic Anemia Resulting from Immune Injury |
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823 | (24) |
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55 Alloimmune Hemolytic Disease of the Fetus and Newborn |
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847 | (16) |
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56 Hypersplenism and Hyposplenism |
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863 | (8) |
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57 Primary and Secondary Erythrocytoses |
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871 | (18) |
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889 | (26) |
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59 Polyclonal and Hereditary Sideroblastic Anemias |
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915 | (10) |
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PART VII Neutrophils, Eosinophils, Basophils, and Mast Cells |
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60 Structure and Composition of Neutrophils, Eosinophils, and Basophils |
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925 | (14) |
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61 Production, Distribution, and Fate of Neutrophils |
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939 | (8) |
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62 Eosinophils and Related Disorders |
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947 | (18) |
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63 Basophils, Mast Cells, and Related Disorders |
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965 | (18) |
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64 Classification and Clinical Manifestations of Neutrophil Disorders |
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983 | (8) |
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65 Neutropenia and Neutrophilia |
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991 | (14) |
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66 Disorders of Neutrophil Function |
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1005 | (40) |
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PART VIII Monocytes and Macrophages |
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67 Structure, Receptors, and Functions of Monocytes and Macrophages |
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1045 | (30) |
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68 Production, Distribution, and Activation of Monocytes and Macrophages |
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1075 | (14) |
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69 Classification and Clinical Manifestations of Disorders of Monocytes and Macrophages |
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1089 | (6) |
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70 Monocytosis and Monocytopenia |
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1095 | (6) |
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71 Inflammatory and Malignant Histiocytosis |
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1101 | (20) |
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72 Gaucher Disease and Related Lysosomal Storage Diseases... |
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1121 | (16) |
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PART IX Lymphocytes and Plasma Cells |
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73 The Structure of Lymphocytes and Plasma Cells |
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1137 | (12) |
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1149 | (10) |
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75 Functions of B Lymphocytes and Plasma Cells in Immunoglobulin Production |
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1159 | (16) |
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76 Functions of T Lymphocytes: T-Cell Receptors for Antigen |
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1175 | (14) |
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77 Functions of Natural Killer Cells |
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1189 | (6) |
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78 Classification and Clinical Manifestations of Lymphocyte and Plasma Cell Disorders |
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1195 | (4) |
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79 Lymphocytosis and Lymphocytopenia |
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1199 | (12) |
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80 Immunodeficiency Diseases |
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1211 | (28) |
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81 Hematologic Manifestations of Acquired Immunodeficiency Syndrome |
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1239 | (22) |
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82 Mononucleosis Syndromes |
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1261 | (14) |
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PART X Malignant Myeloid Diseases |
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83 Classification and Clinical Manifestations of the Clonal Myeloid Disorders |
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1275 | (16) |
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1291 | (16) |
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85 Essential Thrombocythemia |
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1307 | (12) |
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1319 | (22) |
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87 Myelodysplastic Syndromes |
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1341 | (32) |
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88 Acute Myelogenous Leukemia |
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1373 | (64) |
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89 Chronic Myelogenous Leukemia and Related Disorders |
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1437 | (56) |
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PART XI Malignant Lymphoid Diseases |
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90 Classification of Malignant Lymphoid Disorders |
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1493 | (12) |
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91 Acute Lymphoblastic Leukemia |
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1505 | (22) |
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92 Chronic Lymphocytic Leukemia |
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1527 | (26) |
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1553 | (10) |
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94 Large Granular Lymphocytic Leukemia |
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1563 | (6) |
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95 General Considerations for Lymphomas: Epidemiology, Etiology, Heterogeneity, and Primary Extranodal Disease |
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1569 | (18) |
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96 Pathology of Lymphomas |
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1587 | (16) |
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1603 | (22) |
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98 Diffuse Large B-Cell Lymphoma and Related Diseases |
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1625 | (16) |
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1641 | (12) |
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1653 | (10) |
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101 Marginal Zone B-Cell Lymphomas |
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1663 | (8) |
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1671 | (8) |
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103 Cutaneous T-Cell Lymphoma (Mycosis Fungoides and Sezary Syndrome) |
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1679 | (14) |
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104 Mature T-Cell and Natural Killer Cell Lymphomas |
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1693 | (14) |
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105 Plasma Cell Neoplasms: General Considerations |
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1707 | (14) |
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106 Essential Monoclonal Gammopathy |
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1721 | (12) |
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1733 | (40) |
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108 Immunoglobulin Light-Chain Amyloidosis |
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1773 | (12) |
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1785 | (18) |
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1803 | (12) |
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Dietlind L. Wahner-Roedler |
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PART XII Hemostasis and Thrombosis |
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111 Megakaryopoiesis and Thrombopoiesis |
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1815 | (14) |
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112 Platelet Morphology, Biochemistry, and Function |
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1829 | (86) |
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113 Molecular Biology and Biochemistry of the Coagulation Factors and Pathways of Hemostasis |
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1915 | (34) |
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114 Control of Coagulation Reactions |
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1949 | (18) |
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115 Vascular Function in Hemostasis |
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1967 | (18) |
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116 Classification, Clinical Manifestations, and Evaluation of Disorders of Hemostasis |
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1985 | (8) |
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1993 | (32) |
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118 Heparin-Induced Thrombocytopenia |
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2025 | (10) |
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119 Reactive Thrombocytosis |
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2035 | (4) |
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120 Hereditary Qualitative Platelet Disorders |
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2039 | (34) |
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121 Acquired Qualitative Platelet Disorders |
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2073 | (24) |
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122 The Vascular Purpuras |
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2097 | (16) |
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123 Hemophilia A and Hemophilia B |
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2113 | (20) |
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124 Inherited Deficiencies of Coagulation Factors II, V, V+VIII, VII, X, XI, and XIII |
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2133 | (18) |
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125 Hereditary Fibrinogen Abnormalities |
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2151 | (12) |
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126 Von Willebrand Disease |
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2163 | (20) |
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127 Antibody-Mediated Coagulation Factor Deficiencies |
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2183 | (8) |
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128 Hemostatic Alterations in Liver Disease and Liver Transplantation |
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2191 | (8) |
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129 Disseminated Intravascular Coagulation |
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2199 | (22) |
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130 Hereditary Thrombophilia |
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2221 | (12) |
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131 The Antiphospholipid Syndrome |
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2233 | (20) |
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132 Thrombotic Microangiopathies |
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2253 | (14) |
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2267 | (14) |
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134 Atherothrombosis: Disease Initiation, Progression, and Treatment |
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2281 | (22) |
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135 Fibrinolysis and Thrombolysis |
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2303 | (26) |
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PART XIII Transfusion Medicine |
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136 Erythrocyte Antigens and Antibodies |
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2329 | (24) |
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137 Human Leukocyte and Platelet Antigens |
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2353 | (12) |
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138 Blood Procurement and Red Cell Transfusion |
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2365 | (16) |
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139 Preservation and Clinical Use of Platelets |
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2381 | (12) |
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Index |
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