| Preface |
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ix | |
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PART I INITIAL CLINICAL EVALUATION |
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1 Approach to the Patient |
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1 | (10) |
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PART II DISORDERS OF RED CELLS |
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2 Classification of Anemias and Polycythemias |
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11 | (5) |
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3 Aplastic Anemia: Acquired and Inherited |
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16 | (8) |
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24 | (4) |
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5 Anemia of Chronic Disease |
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28 | (3) |
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6 Anemia of Endocrine Disorders |
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31 | (2) |
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7 Congenital Dyserythropoietic Anemias |
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33 | (4) |
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8 Folate, Cobalamin, and Megaloblastic Anemias |
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37 | (8) |
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9 Iron-Deficiency Anemia and Iron Overload |
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45 | (9) |
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10 Anemia Resulting from Other Nutritional Deficiencies |
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54 | (4) |
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11 Hereditary and Acquired Sideroblastic Anemias |
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58 | (3) |
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12 Anemia Resulting from Marrow Infiltration |
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61 | (2) |
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13 Erythrocyte Membrane Disorders |
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63 | (7) |
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14 Hemolytic Anemia Related to Red Cell Enzyme Defects |
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70 | (3) |
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73 | (8) |
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16 The Sickle Cell Diseases and Related Disorders |
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81 | (7) |
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17 Hemoglobinopathies Associated with Unstable Hemoglobin |
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88 | (2) |
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18 Methemoglobinemia and Other Dyshemoglobinemias |
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90 | (4) |
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19 Fragmentation Hemolytic Anemia |
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94 | (6) |
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20 Hemolytic Anemia Resulting from a Chemical or Physical Agent |
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100 | (3) |
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21 Hemolytic Anemia Resulting from Infectious Agents |
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103 | (6) |
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22 Hemolytic Anemia Resulting from Warm-Reacting Antibodies |
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109 | (6) |
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23 Cryopathic Hemolytic Anemia |
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115 | (4) |
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24 Drug-Induced Hemolytic Anemia |
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119 | (5) |
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25 Alloimmune Hemolytic Disease of the Newborn |
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124 | (8) |
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26 Hypersplenism and Hyposplenism |
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132 | (6) |
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27 Polyclonal Polycythemias (Primary and Secondary) |
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138 | (5) |
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143 | (10) |
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PART III DISORDERS OF GRANULOCYTES |
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29 Classification and Clinical Manifestations of Neutrophil Disorders |
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153 | (3) |
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30 Neutropenia and Neutrophilia |
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156 | (9) |
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31 Disorders of Neutrophil Functions |
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165 | (10) |
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32 Eosinophils and Related Disorders |
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175 | (6) |
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33 Basophils, Mast Cells, and Related Disorders |
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181 | (6) |
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PART IV DISORDERS OF MONOCYTES AND MACROPHAGES |
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34 Classification and Clinical Manifestations of Monocytes and Macrophages |
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187 | (2) |
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35 Monocytosis and Monocytopenia |
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189 | (4) |
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36 Inflammatory and Malignant Histiocytosis |
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193 | (12) |
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37 Gaucher Disease and Related Lysosomal Storage Diseases |
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205 | (6) |
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PART V PRINCIPLES OF THERAPY FOR NEOPLASTIC HEMATOLOGIC DISORDERS |
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38 Pharmacology and Toxicity of Antineoplastic Drugs |
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211 | (12) |
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39 Principles of Hematopoietic Cell Transplantation |
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223 | (8) |
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PART VI THE CLONAL MYELOID DISORDERS |
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40 Classification and Clinical Manifestations of the Clonal Myeloid Disorders |
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231 | (10) |
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241 | (5) |
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42 Essential (Primary) and Familial Thrombocythemia |
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246 | (6) |
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43 Paroxysmal Nocturnal Hemoglobinuria |
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252 | (3) |
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44 Myelodysplastic Syndromes (Clonal Cytopenias and Oligoblastic Myelogenous Leukemia) |
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255 | (12) |
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45 The Acute Myelogenous Leukemias |
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267 | (16) |
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46 The Chronic Myelogenous Leukemias |
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283 | (16) |
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299 | (8) |
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PART VII THE POLYCLONAL LYMPHOID DISEASES |
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48 Classification and Clinical Manifestations of Polyclonal Lymphocyte and Plasma Cell Disorders |
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307 | (3) |
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49 Lymphocytosis and Lymphocytopenia |
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310 | (7) |
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50 Primary Immunodeficiency Syndrome |
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317 | (15) |
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51 Hematological Manifestations of the Acquired Immunodeficiency Syndrome |
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332 | (10) |
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52 The Mononucleosis Syndromes |
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342 | (7) |
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PART VIII THE CLONAL LYMPHOID AND PLASMA CELL DISEASES |
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53 Classification and Clinical Manifestations of the Malignant Lymphoid Disorders |
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349 | (13) |
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54 The Acute Lymphocytic Leukemias |
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362 | (14) |
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55 Chronic Lymphocytic Leukemia and Related Diseases |
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376 | (14) |
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390 | (7) |
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57 Large Granular Lymphocytic Leukemia |
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397 | (4) |
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58 General Considerations of Lymphoma: Epidemiology, Etiology, Heterogeneity, and Primary Extranodal Disease |
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401 | (6) |
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407 | (9) |
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60 Diffuse Large B-Cell Lymphoma and Related Diseases |
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416 | (10) |
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426 | (7) |
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433 | (8) |
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63 Marginal Zone B-Cell Lymphoma |
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441 | (3) |
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444 | (4) |
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65 Cutaneous T-Cell Lymphoma |
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448 | (8) |
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66 Mature T-Cell and Natural Killer Cell Lymphomas |
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456 | (7) |
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67 Essential Monoclonal Gammopathy |
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463 | (5) |
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468 | (13) |
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481 | (8) |
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489 | (3) |
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492 | (7) |
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PART IV DISORDERS OF PLATELETS AND HEMOSTASIS |
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72 Clinical Manifestations, Evaluation, and Classification of Disorders of Hemostasis |
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499 | (6) |
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505 | (16) |
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74 Reactive (Secondary) Thrombocytosis |
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521 | (1) |
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75 Hereditary Platelet Disorders |
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522 | (6) |
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76 Acquired Platelet Disorders |
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528 | (6) |
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534 | (5) |
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PART X DISORDERS OF COAGULATION PROTEINS |
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539 | (8) |
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79 Von Willebrand Disease |
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547 | (5) |
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80 Hereditary Disorders of Fibrinogen |
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552 | (2) |
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81 Inherited Deficiencies of Coagulation Factors II, V, V + VIII, VII, X, XI, and XIII |
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554 | (5) |
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82 Antibody-Mediated Coagulation Factor Deficiencies |
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559 | (2) |
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83 Hemostatic Dysfunction Related to Liver Diseases |
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561 | (2) |
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84 The Antiphospholipid Syndrome |
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563 | (3) |
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85 Disseminated Intravascular Coagulation |
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566 | (4) |
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86 Fibrinolysis and Thrombolysis |
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570 | (5) |
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PART XI THROMBOSIS AND ANTITHROMBOTIC THERAPY |
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87 Principles of Antithrombotic Therapy |
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575 | (10) |
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88 Hereditary Thrombophilia |
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585 | (5) |
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89 Venous Thromboembolism |
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590 | (5) |
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90 Antibody-Mediated Thrombotic Disorders: Thrombotic Thrombocytopenic Purpura and Heparin-Induced Thrombocytopenia |
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595 | (10) |
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PART XII TRANSFUSION AND HEMAPHERESIS |
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605 | (5) |
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92 Transfusion of Platelets |
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610 | (2) |
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93 Therapeutic Hemapheresis |
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612 | (5) |
| Table of Normal Values |
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617 | (4) |
| Index |
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621 | |
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