| Preface |
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xi | |
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PART I INITIAL CLINICAL EVALUATION |
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1 Approach to the Patient |
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1 | (10) |
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PART II DISORDERS OF RED CELLS |
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2 Classification of Anemias and Erythrocytoses |
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11 | (5) |
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3 Aplastic Anemia: Acquired and Inherited |
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16 | (9) |
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25 | (4) |
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5 Anemia of Chronic (Inflammatory, Neoplastic, and Renal) Disease |
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29 | (3) |
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6 Erythropoietic Effects of Endocrine Disorders |
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32 | (2) |
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7 Congenital Dyserythropoietic Anemias |
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34 | (4) |
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8 Folate, Cobalamin, and Megaloblastic Anemias |
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38 | (8) |
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9 Iron Deficiency and Iron Overload |
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46 | (9) |
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10 Anemia Resulting from Other Nutritional Deficiencies |
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55 | (4) |
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11 Hereditary and Acquired Sideroblastic Anemias |
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59 | (3) |
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12 Anemia Resulting from Marrow Infiltration |
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62 | (2) |
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13 Erythrocyte Membrane Disorders |
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64 | (7) |
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14 Hemolytic Anemia Related to Red Cell Enzyme Defects |
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71 | (4) |
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75 | (9) |
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16 The Sickle Cell Diseases and Other Hemoglobinopathies |
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84 | (7) |
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17 Unstable Hemoglobins and Hemoglobins with Altered Oxygen Affinity |
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91 | (3) |
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18 Methemoglobinemia and Other Dyshemoglobinemias |
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94 | (4) |
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19 Fragmentation Hemolytic Anemia |
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98 | (6) |
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20 Hemolytic Anemia Resulting from a Chemical or Physical Agent |
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104 | (3) |
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21 Hemolytic Anemia Resulting from Infectious Agents |
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107 | (6) |
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22 Hemolytic Anemia Resulting from Warm-Reacting Antibodies |
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113 | (6) |
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23 Cryopathic Hemolytic Anemia |
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119 | (4) |
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24 Drug-Induced Hemolytic Anemia |
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123 | (5) |
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25 Alloimmune Hemolytic Disease of the Newborn |
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128 | (7) |
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26 Hypersplenism and Hyposplenism |
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135 | (6) |
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27 Polyclonal Erythrocytoses (Primary and Secondary) |
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141 | (5) |
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146 | (9) |
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PART III DISORDERS OF GRANULOCYTES |
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29 Classification and Clinical Manifestations of Neutrophil Disorders |
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155 | (4) |
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30 Neutropenia and Neutrophilia |
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159 | (9) |
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31 Disorders of Neutrophil Function |
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168 | (10) |
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32 Eosinophils and Their Disorders |
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178 | (5) |
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33 Basophils, Mast Cells and Their Disorders |
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183 | (6) |
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PART IV DISORDERS OF MONOCYTES AND MACROPHAGES |
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34 Classification and Clinical Manifestations of Monocyte and Macrophage Disorders |
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189 | (2) |
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35 Monocytosis and Monocytopenia |
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191 | (4) |
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36 Inflammatory and Malignant Histiocytosis |
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195 | (8) |
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37 Gaucher Disease and Related Lysosomal Storage Diseases |
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203 | (6) |
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PART V PRINCIPLES OF THERAPY FOR NEOPLASTIC HEMATOLOGIC DISORDERS |
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38 Pharmacology and Toxicity of Antineoplastic Drugs |
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209 | (13) |
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39 Principles of Hematopoietic Cell Transplantation |
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222 | (7) |
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40 Immune Cell Therapy: Genetically Engineered T Cells |
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229 | (8) |
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PART VI THE CLONAL MYELOID DISORDERS |
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41 Classification and Clinical Manifestations of the Clonal Myeloid Disorders |
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237 | (11) |
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248 | (6) |
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43 Essential Thrombocythemia |
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254 | (6) |
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44 Paroxysmal Nocturnal Hemoglobinuria |
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260 | (3) |
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45 Myelodysplastic Syndromes |
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263 | (12) |
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46 The Acute Myelogenous Leukemias |
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275 | (19) |
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47 The Chronic Myelogenous Leukemias |
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294 | (15) |
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309 | (8) |
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PART VII THE POLYCLONAL LYMPHOID DISEASES |
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49 Classification and Clinical Manifestations of Polyclonal Lymphocyte and Plasma Cell Disorders |
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317 | (4) |
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50 Lymphocytosis and Lymphocytopenia |
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321 | (7) |
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51 Primary Immunodeficiency Syndrome |
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328 | (16) |
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52 Hematologic Manifestations of the Acquired Immunodeficiency Syndrome |
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344 | (9) |
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53 The Mononucleosis Syndromes |
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353 | (8) |
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PART VIII THE CLONAL LYMPHOID AND PLASMA CELL DISEASES |
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54 Classification and Clinical Manifestations of the Neoplastic Lymphocytic Disorders |
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361 | (15) |
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55 The Acute Lymphoblastic Leukemias |
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376 | (14) |
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56 The Chronic Lymphocytic Leukemias |
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390 | (14) |
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404 | (6) |
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58 Large Granular Lymphocytic Leukemia |
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410 | (4) |
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59 General Considerations of Lymphoma: Epidemiology, Etiology, Heterogeneity, and Primary Extranodal Disease |
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414 | (8) |
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422 | (8) |
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61 Diffuse Large B-Cell Lymphoma and Related Diseases |
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430 | (10) |
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440 | (9) |
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449 | (7) |
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64 Marginal Zone B-Cell Lymphoma |
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456 | (4) |
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460 | (4) |
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66 Cutaneous T-Cell Lymphoma |
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464 | (9) |
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67 Mature T-Cell and Natural Killer Cell Lymphomas |
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473 | (7) |
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68 Essential Monoclonal Gammopathy |
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480 | (4) |
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484 | (13) |
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497 | (8) |
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505 | (3) |
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508 | (5) |
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PART IX DISORDERS OF PLATELETS AND HEMOSTASIS |
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73 Clinical Manifestations, Evaluation and Classification of Disorders of Hemostasis |
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513 | (6) |
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519 | (16) |
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75 Hereditary and Reactive (Secondary) Thrombocytosis |
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535 | (2) |
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76 Hereditary Platelet Disorders |
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537 | (6) |
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77 Acquired Platelet Disorders |
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543 | (6) |
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549 | (6) |
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PART X DISORDERS OF COAGULATION PROTEINS |
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555 | (9) |
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80 Von Willebrand Disease |
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564 | (5) |
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81 Hereditary Disorders of Fibrinogen |
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569 | (2) |
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82 Inherited Deficiencies of Coagulation Factors II, V, VII, X, XI, and XIII and Combined Deficiencies of Factor V and VIII and of Vitamin K-Dependent Factors |
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571 | (6) |
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83 Antibody-Mediated Coagulation Factor Deficiencies |
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577 | (2) |
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84 Hemostatic Dysfunction Related to Liver Diseases |
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579 | (2) |
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85 The Antiphospholipid Syndrome |
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581 | (4) |
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86 Disseminated Intravascular Coagulation |
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585 | (4) |
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87 Fibrinolysis and Thrombolysis |
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589 | (4) |
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PART XI THROMBOSIS AND ANTITHROMBOTIC THERAPY |
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88 Principles of Antithrombotic and Antifibrinolytic Therapy |
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593 | (11) |
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89 Hereditary Thrombophilia |
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604 | (5) |
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90 Venous Thromboembolism |
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609 | (6) |
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91 Antibody-Mediated Thrombotic Disorders: Thrombotic Thrombocytopenic Purpura and Heparin-Induced Thrombocytopenia |
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615 | (8) |
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PART XII TRANSFUSION AND HEMAPHERESIS |
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623 | (5) |
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93 Transfusion of Platelets |
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628 | (3) |
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94 Plasma and Plasma Component Therapy |
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631 | (8) |
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95 Therapeutic Hemapheresis |
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639 | (4) |
| Table of Normal Values |
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643 | (4) |
| Index |
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647 | |
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