Contributors |
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xi | |
Preface |
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xix | |
Acknowledgments |
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xxi | |
Introduction |
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xxiii | |
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PART I Laboratory Hematology |
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Examination of the Blood and Bone Marrow |
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1 | (20) |
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21 | (29) |
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50 | (20) |
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Molecular Biology and Hematology |
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70 | (9) |
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Rebecca L. Shattuck-Brandt |
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PART II The Normal Hematologic System |
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Origin and Development of Blood Cells |
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79 | (27) |
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106 | (20) |
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126 | (30) |
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Destruction of Erythrocytes |
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156 | (14) |
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Granulocytes and Monocytes |
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170 | (44) |
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214 | (22) |
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Solomon O. (Wole) Odemuyiwa |
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Basophilic Leukocytes: Mast Cells and Basophils |
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236 | (13) |
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249 | (32) |
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281 | (19) |
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Lymphocytes and Lymphatic Organs |
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300 | (26) |
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326 | (32) |
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T Lymphocytes and Natural Killer Cells |
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358 | (44) |
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Effector Mechanisms in Immunity |
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402 | (66) |
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468 | (22) |
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Platelet Structure and Function in Hemostasis and Thrombosis |
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490 | (38) |
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Blood Coagulation and Fibrinolysis |
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528 | (92) |
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Endothelium: Angiogenesis and the Regulation of Hemostasis |
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620 | (11) |
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PART III Therapeutic Modalities |
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Red Cell, Platelet, and White Cell Antigens |
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631 | (41) |
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672 | (50) |
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Hematopoietic Stem Cell Transplantation |
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722 | (27) |
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Gene Therapy for Hematologic Disorders |
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749 | (30) |
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PART IV Disorders of Red Cells |
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Anemia: General Considerations |
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779 | (31) |
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Disorders of Iron Metabolism and Heme Synthesis |
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Iron Deficiency and Related Disorders |
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810 | (25) |
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835 | (22) |
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857 | (24) |
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881 | (30) |
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Hereditary Spherocytosis, Hereditary Elliptocytosis, and Other Disorders Associated with Abnormalities of the Erythrocyte Membrane |
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911 | (22) |
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Hereditary Hemolytic Anemias Due to Red Blood Cell Enzyme Disorders |
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933 | (23) |
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Autoimmune Hemolytic Anemia |
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956 | (22) |
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Alloimmune Hemolytic Disease of the Fetus and Newborn |
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978 | (20) |
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Paroxysmal Nocturnal Hemoglobinuria |
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998 | (23) |
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Acquired Nonimmune Hemolytic Disorders |
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1021 | (17) |
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Hereditary Disorders of Hemoglobin Structure and Synthesis |
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Sickle Cell Anemia and Other Sickling Syndromes |
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1038 | (45) |
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Thalassemias and Related Disorders: Quantitative Disorders of Hemoglobin Synthesis |
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1083 | (49) |
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Hemoglobins with Altered Oxygen Affinity, Unstable Hemoglobins, M-Hemoglobins, and Dyshemoglobinemias |
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1132 | (11) |
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Other Red Cells Disorders |
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Megaloblastic Anemias: Disorders of Impaired DNA Synthesis |
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1143 | (30) |
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Inherited Aplastic Anemia Syndromes |
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1173 | (12) |
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1185 | (11) |
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1196 | (16) |
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Congenital Dyserythropoietic Anemias |
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1212 | (9) |
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Sunitha N. Wickramasinghe |
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Anemias Secondary to Chronic Disease and Systemic Disorders |
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1221 | (18) |
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Anemias During Pregnancy and the Postpartum Period |
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1239 | (8) |
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Anemias Unique to the Newborn Period |
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1247 | (14) |
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1261 | (12) |
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PART V Disorders of Hemostasis and Coagulation |
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Diagnostic Approach to the Bleeding Disorders |
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1273 | (16) |
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Thrombocytopenia: Pathophysiology and Classification |
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1289 | (3) |
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Thrombocytopenia Caused by Immunologic Platelet Destruction |
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1292 | (22) |
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Thrombotic Thrombocytopenic Purpura, Hemolytic-Uremic Syndrome, and Related Disorders |
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1314 | (12) |
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Miscellaneous Causes of Thrombocytopenia |
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1326 | (9) |
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Other Disorders of Primary Hemostasis |
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Bleeding Disorders Caused by Vascular Abnormalities |
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1335 | (17) |
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Essential Thrombocythemia and Thrombocytosis |
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1352 | (9) |
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Qualitative Disorders of Platelet Function |
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1361 | (18) |
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Inherited Coagulation Disorders |
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1379 | (46) |
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Acquired Coagulation Disorders |
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1425 | (39) |
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Thrombosis and Antithrombotic Therapy |
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1464 | (45) |
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PART VI Nonmalignant Disorders of Leukocytes, the Spleen, and/or Immunoglobins |
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Diagnostic Approach to Malignant and Nonmalignant Disorders of the Phagocytic and Immune Systems |
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1509 | (18) |
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1527 | (21) |
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Qualitative Disorders of Leukocytes |
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1548 | (17) |
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Abnormalities of the Monocyte-Macrophage System: The Lysosomal Storage Diseases |
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1565 | (7) |
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Langerhans Cell Histiocytosis |
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1572 | (10) |
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Pathology of Langerhans Cell Histiocytosis and Other Histiocytic Proliferations |
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1582 | (7) |
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Infectious Mononucleosis and Other Epstein-Barr Virus-Related Disorders |
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1589 | (23) |
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Primary Immunodeficiency Syndromes |
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1612 | (11) |
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Acquired Immunodeficiency Syndrome |
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1623 | (14) |
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1637 | (18) |
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1655 | (8) |
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PART VII Hematologic Malignancies |
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Hematopoietic Tumors: Principles of Pathologic Diagnosis |
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1663 | (6) |
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Complications of Hematopoietic Neoplasms |
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1669 | (25) |
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Principles and Pharmacology of Chemotherapy |
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1694 | (27) |
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1721 | (26) |
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Supportive Care in Hematologic Malignancies |
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1747 | (44) |
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Molecular Genetics of Acute Leukemia |
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1791 | (17) |
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Diagnosis and Classification of the Acute Leukemias and Myelodysplastic Syndrome |
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1808 | (12) |
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Acute Lymphoblastic Leukemia in Adults |
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1820 | (23) |
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Acute Myeloid Leukemia in Adults |
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1843 | (46) |
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Acute Lymphoblastic Leukemia in Children |
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1889 | (29) |
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Acute Myelogenous Leukemia in Children |
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1918 | (20) |
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Acute Promyelocytic Leukemia |
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1938 | (18) |
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Myelodysplastic Syndromes |
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1956 | (32) |
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Myeloproliferative Disorders |
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Pathology of the Myeloproliferative Diseases |
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1988 | (18) |
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2006 | (25) |
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2031 | (14) |
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2045 | (9) |
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2054 | (17) |
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Lymphoproliferative Disorders |
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Diagnosis and Classification of Lymphomas |
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2071 | (32) |
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Molecular Genetic Aspects of Non-Hodgkin Lymphomagenesis |
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2103 | (41) |
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Non-Hodgkin Lymphoma in Adults |
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2144 | (51) |
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Non-Hodgkin Lymphoma in Children |
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2195 | (19) |
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Chronic Lymphocytic Leukemia |
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2214 | (42) |
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2256 | (20) |
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Cutaneous T-Cell Lymphoma: Mycosis Fungoides and Sezary Syndrome |
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2276 | (35) |
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2311 | (31) |
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Practical Aspects of the Clinical Approach to Patients with Monoclonal Immunoglobulin Disorders |
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2342 | (10) |
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Monoclonal Gammopathies of Undetermined Significance and Smoldering Multiple Myeloma |
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2352 | (20) |
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2372 | (67) |
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Immunoglobulin Light-Chain Amyloidosis (Primary Amyloidosis) |
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2439 | (32) |
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Waldenstrom Macroglobulinemia |
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2471 | (13) |
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Cryoglobulinemia and Heavy Chain Disease |
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2484 | |
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Appendix A. Clusters of Differentiation |
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2497 | (86) |
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Appendix B. Normal Blood Values: Selected Health-associated Values for Neonatal, Pediatric, and Adult Populations |
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2583 | (12) |
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Appendix C. Comparative Hematology |
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2595 | |
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Index |
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1 | |